• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.3
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• pp.271-277
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• 2006

Injection molding process is the manufacturing process that can obtain a high quality products in large quantity to a low cost. Since there are many input factors in every situation that can influence part's quality, the method is difficult to save the exact simulation data. Latest, it deals with the CAE method that supports the experiment, it is applied to the Design of Experiment for the optimum injection molding process. If there are many factors, the interaction among those factors must be considered by applying Design of Experiment which is taken from the technique of minimizing the number of experiment. Without a real test, it is taken the simulation data using $Moldflow^(R)$ software. $Moldflow^(R)$ is used for the analysis of injection molding process, it is analyzed the factors that affect a warpage using the Taguchi method and then the optimal injection molding process is obtained.

• The Journal of Korean Medicine
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• v.37 no.1
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• pp.135-150
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• 2016

Research Methods: This research analyzed the data on those aged 20 and older from the Report on Korean Medicine Usage Research, which was conducted in 2011. The definitions of toxicity were defined by the presence of toxicity listed in the survey. The questions used in analysis were sex, age, household income, health insurance, medical fees, satisfaction rates on treatments, as well as the types of diseases and the presence of toxicity from treatments. The analysis was done through frequency analysis using SAS 9.2 and Fisher's Exact Test. Results: Toxicity occurred in 2.1% patients out of the 3518 studied. The types of toxicity were skin problems, such as hives and pruritus (34.7%), gastrointestinal problems (20.8%), neurological diseases (4.2%), liver(1.4%), kidney toxicity(1.4%), and others (22.2%). There were no differences in toxicity by sex, age, household income and the types of health insurances. However, toxicity were positively correlated with the increase in standard of education (p=0.0124). In addition, as treatment costs increased (p<0.0001) and satisfaction rates decreased, toxicity increased (p<0.0001). Toxicity increased in patients with low back pain (p=0.0429), hwabyung (p=0.0392), lumbar sprain (p=0.0004), correction body type (p=0.0118), growth (p=0.0045), and from motor accidents (p=0.0448). In logistic regression analysis, Toxicity were positively correlated with medical fees, and cancer treatment and negatively correlated with satisfaction rate on treatments. Conclusion: The toxicity that occurred in outpatients who used Korean medical clinics mostly happened in skin, digestive organs, nerves, livers, and kidneys toxicity. The occurrences differed by the Educational lengths, expensive costs of treatments, low satisfaction rates of the treatments, and cancer.

• Interdisciplinary Bio Central
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• v.4 no.4
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• pp.12.1-12.6
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• 2012

The advanced glycation endproducts receptor (AGE-R) is a signal transduction receptor for multiligand such as S100b and AGEs. S100b has been demonstrated to activate various cells with important links to atherosclerosis initiation and progression including endothelial cells, and smooth muscle cells via AGE-R, triggering activation of multiple signaling cascades through its cytoplasmic domain. Many studies have suggested AGE-R might even participate in the cardiovascular complications involved in the pathogenesis of type I diabetes. Recently, Small Ubiquitin-Related Modifier 1 (SURM-1 also known as SUMO-1) has been recognized as a protein that plays an important role in cellular post-translational modifications in a variety of cellular processes, such as transport, transcriptional, apoptosis and stability. Computer Database search with SUMOplot Analysis program identified the five potential SURMylation sites in human AGE-R: K43, K44, K123, and K273 reside within the extracellular domain of AGE-R, and lastly K374 resides with the cytosolic domain of AGE-R. The presence of the consensus yKXE motif in the AGE-R strongly suggests that AGE-R may be regulated by SURMylation process. To test this, we decided to determine if AGE-R is SURMylated in living vascular cell system. S100b-stimulated murine aortic vascular smooth muscle cells were used for western blot analysis with relevant antibodies. Taken together, bioinformatics database search and molecular biological approaches suggested AGE-R is SURMylated in living cardiovascular cell system. Whilst SURMylation and AGE-R undoubtedly plays an important role in the cardiovascular biology, it remains unclear as to the exact nature of this contribution under both physiological and pathological conditions.

• International Journal of Aeronautical and Space Sciences
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• v.15 no.1
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• pp.32-43
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• 2014

Automatic fiber placement (AFP) has become a popular processing technique for composites in the aerospace industry, due to its ability to place prepregs or tapes precisely in the exact position when complex parts are being manufactured. This paper presents the design, analysis, and manufacture of an AFP mandrel for composite aircraft fuselage skin fabrication. According to the design requirements, an AFP mandrel was developed and a numerical study was performed through the finite element method. Linear static load analyses were performed considering the mandrel structure self-weight and a 2940 N load from the AFP machine head. Modal analysis was also performed to determine the mandrel's natural frequencies. These analyses confirmed that the proposed mandrel meets the design requirements. A prototype mandrel was then manufactured and used to fabricate a composite fuselage skin. Material load tests were conducted on the AFP fuselage skin curved laminates, equivalent flat AFP, and hand layup laminates. The flat AFP and hand layup laminates showed almost identical strength results in tension and compression. Compared to hand layup, the flat AFP laminate modulus was 5.2% higher in tension and 12.6% lower in compression. The AFP curved laminates had an ultimate compressive strength of 1.6% to 8.7% higher than flat laminates. The FEM simulation predicted strengths were 4% higher in tension and 11% higher in compression than the flat laminate test results.

• Economic and Environmental Geology
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• v.30 no.5
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• pp.433-442
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• 1997

A dual-permeability fractal model of fluid flow is proposed. The model simulates groundwater flow in fissured dual aquifer system composed of Aquifer 1 and Aquifer 2. For this model. groundwater flow originates only from Aquifer 1 on the pumping well. The model considers wellbore storage and skin effects at the pumping well and then shows exact drawdown at the early time of pumping. Type curves for different flow dimensions and for two cases are presented and analyzed. The case 1 represents the aquifer system which consists of Aquifer 1 with low permeability and high specific storage and Aquifer 2 with high permeability and low specific storage. The case 2 is inverse to the case 1. Dimensionless drawdown curves in Aquifer 1 and Aquifer 2 shows characteristic trend each other. Consequently, the model will be useful to analyze pumping test data of different draw down patterns on the pumping well and observation wells.

• Journal of Korean society of Dental Hygiene
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• v.10 no.2
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• pp.425-440
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• 2010

목적 : 현재 우리 사회는 건강증진에 대한 욕구가 증가함에 따라 보건의료에서 질적 서비스향상이 요구되고 있고, 구강진료를 분담하는 치과위생사들도 보다 전문적인 역할을 수행하기 위해서는 지식과 기술의 수준향상이 필요하다. 이에 치과위생사의 질적 수준을 향상시키는 데 가장 빠르고 효과적인 방법이 국가시험제도이며 국가시험에서의 타당성과 신뢰성을 높이고 필요한 과목과 내용을 직무를 중심으로 조정한다면 가장 좋은 방법이라고 사료되어 현행 우리나라 치과위생사 국가시험제도에 따른 문제점을 파악하고 캐나다 국가시험 제도와의 비교를 통해 문제점을 분석하고 이에 따른 개선책을 알아보았다. 방법 : 전국 치과위생사 교육기관에 근무하는 교수와 의료기관에 종사하는 치과위생사 중에서 최근 국가시험 응시경험자를 대상으로 2008년 6월 9일부터 6월 23일까지 설문조사를 실시하였으며 E-mail 과 Fax를 이용하였다. 캐나다 국가시험제도는 National Dental Examinations American Dental Association. National Board Dental Hygiene Examination Candidate Guide자료를 사용하여 비교하였다. 자료의 분석은 SPSS통계프로그램(Version 11.0)을 이용, Chi-square 검정을 하였으며, Fisher's Exact Test에 의한 검정을 실시하였다. 결과 : 1. 국가시험과목구성은 현행 국가시험과목구성에 문제가 있는 것으로 사료되어 과목조정 필요성이 큰 것으로 나타났고, 특히 대학근무자가, 나이가 많을수록, 재직기간이 길수록 더 높았다. 2. 국가시험 문제의 유형은 암기해석 문제가 대부분이었고 난이도는 비교적 양호하였으며, 전문성도 있는 것으로 조사되었다. 3. 과목조정 필요성은 구강생물학개론, 치과임상학 순으로 상대적으로 높았다. 캐나다 국가시험과 비교해 보면 치과임상학과 구강위생학개론 분야의 조정이 더욱 필요한 것으로 나타났다. 4. 한국과 캐나다의 국가시험제도는 형식은 비슷하나 내용과 과목의 구성에서는 큰 차이가 있었다. 5. 캐나다의 국가시험과 비교 시 한국은 치과위생사의 포괄적인 치과위생관리능력을 평가하기 어려웠다. 결론 : 이상의 결과로 보면 현행 국가시험은 과목 구성이 부적절하므로 조정의 필요성이 시급한 것으로 조사되었으며, 캐나다 국가시험과는 과목구성에서 큰 차이가 있었고 치과위생사에게 요구되는 포괄적 치과위생관리능력을 평가할 수 없는 것으로 조사되어 현행 국가시험 개선이 요구되었다.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.1
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• pp.93-104
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• 2004

In order to have a comfortable vision without any asthenopia in work place, it is very necessary to make a complete binocular correction in addition to the perfect correction of refractive deficits. For this, At first, the exact understanding of the required corrective value of the existing angular ametropia(associated phoria) is needed. The fact likely seems fact that a correction of refractive deficits could not to be reached with single optotype, the corrections of angular ametropia(associated phoria) with single optotype is impossible. The reason is that a most ametropia(associated phoria) is accompanied with the fixation disparity. To make a perfect measurement of ametropia(associated phoria), at least, 3 kinds of optotype is essential. This fact could be explained by stating the fusional stimulus in the binocular refraction tests on each eye. If these types of three tests have not practical practice. The most of many cases may result in undercorrection.

• Journal of Korean Tunnelling and Underground Space Association
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• v.2 no.3
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• pp.59-69
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• 2000

Three-dimensional total station system which integrated the instrument with Target Pin and TEMS 3D software developed by SKEC R&D center was applied to a tunnel excavation for monitoring of convergence and crown settlement. The efficiency of the system was proved as the result in the aspects of exact monitoring and prediction of rock conditions ahead of the face. To monitor the behavior of tunnel lining at the maintenance stage, DOCS system was applied to the subway tunnel section. Such many effects as the vibration of sensors, verification of the system efficiency, the effect of test trains operation, the variation of temperature and the effect of high voltage was checked. Thus the management scheme for tunnel maintenance was laid out as a proposal.

• Journal of the Korea Computer Industry Society
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• v.2 no.2
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• pp.157-164
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• 2001

This paper studies on the processing of spatial joins. The spatial join operation is divided into filters and refinement steps in general. The processing of spatial joins can be greatly improved by the use of filters that reduce the polygons in order to find the intersecting ones. As a result, three possible sets of answers are identified: the positive one, the negative one and the inconclusive one. To identify all the interesting pairs of polygons with inconclusive answers, it is necessary to have access to the representation of polygons so that an exact geometry test can take place. We introduce a bit-map approximation technique to drastically reduce the computation required by the refinement step during refinement processing. Bit-map representation are used for the description of the internal, the external and the boundary regions of the polygon objects. The proposed scheme increases the chance of trivial acceptance and rejection of data objects, and reduces unnecessary disk accesses in query processing. It has been shown that the reference to the object data file can be cut down by as much as 60%.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.2
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• pp.180-188
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• 2018

Objective: The aim of this study was to investigate the effect of single nucleotide polymorphisms (SNPs) of the melanogenesis associated transcription factor (MITF) and dopachrome tautomerase (DCT) genes on plumage coloration in Asian native duck breeds. MITF encodes a protein for microphthalmia-associated transcription factor, which regulates the development and function of melanocytes for pigmentation of skin, hair, and eyes. Among the tyrosinase-related family genes, DCT is a pigment cell-specific gene that plays important roles in the melanin synthesis pathway and the expression of skin, feather, and retina color. Methods: Five Asian duck varieties (black Korean native, white Korean native, commercial Peking, Nageswari, and Bangladeshi Deshi white ducks) were investigated to examine the polymorphisms associated with plumage colors. Among previously identified SNPs, three synonymous SNPs and one indel of MITF and nine SNPs in exon regions of DCT were genotyped. The allele frequencies for SNPs of the black and white plumage color populations were estimated and Fisher's exact test was conducted to assess the association between the allele frequencies of these two populations. Results: Two synonymous SNPs (c.114T>G and c.147T>C) and a 14-bp indel (GCTGCAAAC AGATG) in intron 7 of MITF were significantly associated with the black- and white-colored breeds (p<0.001). One non-synonymous SNP [c.938A>G (p.His313Arg)] in DCT, was highly significantly associated (p<0.001) and a synonymous SNP (c.753A>G) was significantly associated (p<0.05) with black and white color plumage in the studied duck populations. Conclusion: The results of this study provide a basis for further investigations of the associations between polymorphisms and plumage color phenotypes in Asian duck breeds.