• Journal of Korea Technology Innovation Society
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• v.21 no.1
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• pp.64-91
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• 2018

This study explores the interactive pattern among social issue, academic research, and governmental policy on science and technology during the last 20 years. In particular, we try understand wether the science and technology policy research and governmental policy meets social needs appropriately. In order to do this, we have collected text data from news articles, papers, and governmental documents. Based on these data, social network analysis and cluster analysis has been carried out. According to the results, we have found that science and technology policy researches tend to focus on fragmented technological innovation meeting urgent practical needs at the initial stage. However, recently, the main characteristics of science and technology policy research shows co-evolutionary patterns responding to society. Furthermore, time lag also has been observed in the process of interaction among the three bodies. Based on these results, we put forward some suggestions for upcoming researches in science and technology policy. Firstly, analysis levels are needed to be shifted from micro level to mezo or macro level. Secondly, more research efforts are required to be focused on policy process in science technology and its public management. Finally, we have to enhance the sensitiveness to social issues through studies on agenda setting in science and technology policy.

• Korean journal of communication and information
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• v.17
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• pp.61-84
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• 2001

Discussions and debates over media education abound in Korra as the number of both institutions that provide media related education and students enrollment for these programs increases rapidly in recent years. In spite of this rather impressive expansion, however, many have raised serious questions about media education of Korea for its not being able to meet the need of the Industry and students, and, moreover, inability to face the challenges brought by new communication related technologies. Who teaches What for what purposes are some of the fundamental questions underlying these heated debates and discussions. To understand these rather complex and interrelated issues more clearly, it is attempted to delineate the nature of these debates by exploring the evolutionary process of media education. The issues related to debates over purposes of media education, curriculum, and faculty qualification have changed through the history of media education, but the nature of the debates, that is the struggle between professionalism and academism, or the tension between practice and theory, has not. Upon this understanding, some argue that what distinguishes opposing sets of dichotomies, such as skills vs. knowledge, training vs. education, now-how vs. know-why. professional vs. academic, practice vs. theory, is more a reflection of social class division and group interests which have privileged theory over practice than a rational scholastic distinction. In addition, it has been often pointed out that the media studies have failed to establish ties with specific industries, and furthermore academic studies seriously lack solid theoretical and practical bases. In the case of the United States, leaders of the industry had contributed much for the Initiation of journalism education in a college setting. However, once inaugurated,, the process of its evolution has depended heavily on academicians. In a country like Korea, where academic and theoretical orientation is much stronger, these problems of media studies and education are even more acute. In this study, it is suggested that academicians and educators be more open-hearted to the realities of changing world, practices of the industries, and recruitment of professionals and practitioners to fill the gap between practice and theory, for the sake of the future of media studies and education.

• BMB Reports
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• v.51 no.11
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• pp.584-589
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• 2018

Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in oropharyngeal squamous cell carcinoma (OPSCC). Whole-exome (WES) and whole-genome (WGS) sequencing were performed on peripheral blood and adjacent non-tumor and tumor specimens obtained from eight Korean HNSCC patients from 2013 to 2015. Next-generation sequencing yielded an average coverage of $94.3{\times}$ for WES and $35.3{\times}$ for WGS. In comparative genomic analysis of non-tumor and tumor tissue pairs, we were unable to identify common cancer-associated early mutations and copy number alterations (CNA) except in one pair. Interestingly, in this case, we observed that non-tumor tonsillar crypts adjacent to HPV-positive OPSCC appeared normal under a microscope; however, this tissue also showed weak p16 expression. WGS revealed the infection and integration of high-risk type HPV16 in this tissue as well as in the matched tumor. Furthermore, WES identified shared and tumor-specific genomic alterations for this pair. Clonal analysis enabled us to infer the process by which this transitional crypt epithelium (TrCE) evolved into a tumor; this evolution was accompanied by the subsequent accumulation of genomic alterations, including an ERBB3 mutation and large-scale CNAs, such as 3q27-qter amplification and 9p deletion. We suggest that HPV16-driven OPSCC carcinogenesis is a stepwise evolutionary process that is consistent with a multistep carcinogenesis model. Our results highlight the carcinogenic changes driven by HPV16 infection and provide a basis for the secondary prevention of OPSCC.

• Journal of Technology Innovation
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• v.25 no.3
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• pp.115-154
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• 2017

This article offers a review of the major literature about sectoral innovation studies of Korea and its implications over the past 30 years. The literature on the sectoral innovation studies in Korea has focused on analysing successful technological catch-up from an evolutionary perspective and most of research has centered on the issues about entry strategies, learning mechanisms. Recently "Emerging economies" like Korea in the 2000s face major challenges as they make a transition from (a) a phase of economic development characterised by 'catching up' with the global technological frontier, involving technological "imitation", to (b) a phase of continuing development based on the development of new knowledge for globally leading (post catch-up) product and process innovation. This paper reviews those bodies of literature of patterns of sectoral innovation, technological capability accumulation and catch-up process, catch-up innovation and institutions, and patterns of growth dynamics. Finally, given the importance of sectoral innovation studies, we suggest that industrial upgrading, transition towards leadership, dark side of catch-up issues are needed for future research directions.

• 한국균학회소식:학술대회논문집
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• 2014.10a
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• pp.13-13
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• 2014

Species belonging to the genus Fusarium are widely distributed and cause diseases in many plants. Isolation of fungal strains from air or cereals is necessary for disease forecasting, disease diagnosis, and population genetics [1]. Previously we showed that Fusarium species are resistant to toxoflavin produced by the bacterial rice pathogen Burkholderia glumae while other fungal genera are sensitive to the toxin, resulting in the development of a selective medium for Fusarium species using toxoflavin [2]. In this study, we have tried to elucidate the resistant mechanism of F. graminearum against toxoflavin and interaction between the two pathogens in nature. To test whether B. glumae affects the development of F. graminearum, the wild-type F. graminearum strains were incubated with either the bacterial strain or supernatant of the bacterial culture. Both conditions increased the conidial production five times more than when the fungus was incubated alone. While co-incubation resulted in dramatic increase of conidial production, conidia germination delayed by either the bacterial strain or supernatant. These results suggest that certain factors produced by B. glumae induce conidial production and delay conidial germination in F. graminearum. To identify genes related to toxoflavin resistance in F. graminearum, we screened the transcriptional factor mutant library previously generated in F. graminearum [3] and identified one mutant that is sensitive to toxoflavin. We analyzed transcriptomes of the wild-type strain and the mutant strain under either absence or presence of toxoflavin through RNAseq. Expression level of total genes of 13,820 was measured by reads per kilobase per million mapped reads (RPKM). Under the criteria with more than two-fold changes, 1,440 genes were upregulated and 1,267 genes were down-regulated in wild-type strain than mutant strain in response to toxoflavin treatment. A comparison of gene expression profiling between the wild type and mutant through gene ontology analysis showed that genes related to metabolic process and oxidation-reduction process were highly enriched in the mutant strain. The data analyses will focus on elucidating the resistance mechanism of F. graminearum against toxoflavin and the interaction between the two pathogens in rice. Further evolutionary history will be traced through figuring out the gene function in populations and in other filamentous fungi.

• Journal of Korea Technology Innovation Society
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• v.14 no.3
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• pp.516-551
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• 2011

This study analysed the institutional evolution of Korea's international cooperation of science and technology (S&T) from the viewpoint of the historical institutionalism. For this, it examined Korea's institutions for international S&T cooperation by dividing the whole period from the Korean war to the present into five sub-periods; period of technology aids, technology transfer, mutual cooperation, expanded cooperation, and highly sophisticated cooperation, respectively. It, then, reviewed the evolving process and characteristics of each period. In this study, the structure (environment), the actor (government), the institution of higher rank (science & technology policy) were considered as variables influencing upon the institutions of the international S&T cooperation. Upon this assumption, this study analysed how and through what evolutionary process the international S&T cooperation institutions have evolved so far. This study obtained the following conclusions; First, the study confirmed the existence of the "institutional layering" in the institutions of the international S&T cooperation in Korea. The momentums for the change of the institutions of the international S&T cooperation stem from international environment and domestic economic environment. They influence upon economic policy, industrial policy, and S&T policy, which, together with the actor (the government), again brings about the institutional evolution of the international S&T cooperation. Second, the institutional evolution of the international S&T cooperation is taking place gradually. As mentioned above, the momentums for the change of the institutions of the international S&T cooperation originate from international and domestic macro environment. These momentums do not directly influence upon the institutions of the international S&T cooperation, rather they give indirect influence, through other related institutions, upon the institutions of the international S&T cooperation and make its gradual change or evolution. This is because the institutions of the international S&T cooperation have the "institutional layering".

• Journal of the Korean Geographical Society
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• v.51 no.5
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• pp.691-711
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• 2016

Recently, Economic spaces around the world have changed dynamically. Creative arts and cultural actors have begun to emerge in old industrial neighborhoods of major metropolitan cities. These new actors can be seen as creative actors in arts and culture, as well as non-economic actors that have been somewhat overlooked in the traditional approaches of economic geography. They contribute to overcoming regional economic crisis, as these actors bring a particular deviant and creative atmosphere in the neighborhood. Especially, informal gatherings of artistic communities play a pivotal role in knowledge platforms for dynamics of knowledge creation and creativity, which has a significant effect on shaping a creative milieu in the initial stage of formation of a regional ecosystem. In this regard, this paper will investigate the fundamental mechanisms and driving forces of urban spatial restructuring through a case study of the creative arts and cultural ecosystem in Seongsu-dong, Seoul, Korea. Thus, the main purpose of this study is to identify the formation process and key drivers behind the development of the early arts and cultural ecosystem in Seongsu-dong from an evolutionary perspective.

• Cartoon and Animation Studies
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• s.25
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• pp.155-175
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• 2011

The cultural cluster in Chuncheon was initiated in the late 1990s with the combination of diverse components, which were companies, a local government entity, educational institutions, and human resources. In order to hold ability of standing on its own way in a hard time when the local cultural industries could not had developed by themselves, it urgently required the encouragement policy in the name of industry development. GIMC (Gangwon Information & Multimedia Corporation) was established in this situation, and policy strategies for promoting the cultural cluster was decided on the basis of GIMC's strategies. This article analyzes the evolution process of the local cluster and suggests characteristics of its every stage--initiation, development, and decline--on the basis of cluster competition concept because of the problem to deal with the evolution process of cluster from the existing viewpoint. This article finds out that Chuncheon cluster embarked on cultural cluster strategies without concerning basic elements which had to be prepared from the initial stage. This problem worked as the serious obstacle hampering development of Chunchen cluster. This problem was the matter of policies in providing a direction of industry development as well as leading a local cultural cluster and led to a result of weakening the connection among cluster components. As a result, this article shows that the current status of Chuncheon cultural cluster is being entered the decline stage, and, therefore, suggests that the advanced policy to promote cluster for a next round is urgently needed. Stable closing the first round of cultural cluster policies and thorough preparation for the second round is the only practical solution to minimize side effects of cluster decline. It is the prerequisite to restore trust and, at the same time, reinforce relationship between members who consist of Chuncheon cultural cluster.

• 기호학연구
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• no.56
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• pp.71-107
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• 2018

The purpose of this study was to find out the presentation of food and cooking process shown through the media and its cultural implications by comparing and analyzing seasons 1 and 2 of , tvN's reality program which has gained high viewer ratings and sympathy from the viewers. In light of the existing documents, the research reviewed the social and cultural meanings implied through a series of processes of "the act of cooking- the act of providing food - the act of having a meal."The authors concerned narrative structure of the program, paradigmatic analysis, actantial analysis, and analysis by applying the culinary triangle of $L{\acute{e}}vi$-Strauss were conducted, in order to find out the difference between seasons 1 and 2 of the . As a result of semiotic analysis on the programs, by focusing on the value of composure and slowness which may be felt through the simple everyday lives and travelling by running a Korean restaurant in a foreign country, the reality program revealed the changed consumption behaviors for Korean food, and the evolutionary process of cooking and the act of providing food reflecting the above. Meanwhile, the transformation of the Korean food may mean the "statelessness of Korean food" hidden under the name of localization or globalization. Furthermore, although the program intended to put up globalization of Korean food, the uniqueness of the Korean food wash armed, and this is the reason why it needs to be examined whether Korean food was used simply for entertainment in the program. Also, the program showed limitations such as drawing cultural inferiority as the motive for watching the program.

• Journal of Life Science
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• v.21 no.5
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• pp.631-646
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• 2011

Mesenchymal stem cells (MSC) are multipotent and can be isolated from diverse human tissues including bone marrow, fat, placenta, dental pulp, synovium, tonsil, and the thymus. They function as regulators of tissue homeostasis. Because of their various advantages such as plasticity, easy isolation and manipulation, chemotaxis to cancer, and immune regulatory function, MSCs have been considered to be a potent cell source for regenerative medicine, cancer treatment and other cell based therapy such as GVHD. However, relating to its supportive feature for surrounding cell and tissue, it has been frequently reported that MSCs accelerate tumor growth by modulating cancer microenvironment through promoting angiogenesis, secreting growth factors, and suppressing anti-tumorigenic immune reaction. Thus, clinical application of MSCs has been limited. To understand the underlying mechanism which modulates MSCs to function as tumor supportive cells, we co-cultured human adipose tissue derived mesenchymal stem cells (ASC) with cancer cell lines H460 and U87MG. Then, expression data of ASCs co-cultured with cancer cells and cultured alone were obtained via microarray. Comparative expression analysis was carried out using DAVID (Database for Annotation, Visualization and Integrated Discovery) and PANTHER (Protein ANalysis THrough Evolutionary Relationships) in divers aspects including biological process, molecular function, cellular component, protein class, disease, tissue expression, and signal pathway. We found that cancer cells alter the expression profile of MSCs to cancer associated fibroblast like cells by modulating its energy metabolism, stemness, cell structure components, and paracrine effect in a variety of levels. These findings will improve the clinical efficacy and safety of MSCs based cell therapy.