• Journal of Korean Medical classics
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• v.22 no.3
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• pp.133-144
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• 2009

Objective : We try to find out the literature and clinical evidences of seasonal formula through the analysis of the addition and subtraction of medical herbs in the formula according to the season. Method : In this study, we analyzed 122 seasonal prescriptions from "Dong-uibogam(東醫寶鑑)", "Bang-yakhappyeon(方藥合編)", "Jeongchijunsueng(證治準繩)", "Dangyesimbeop(丹溪心法)", "Uihakimmun(醫學入門)", "Uihakjeongjeon(醫學正傳)", "Gyeong-akjeonseo(景岳全書)" and "Taepyeonghyeminhwajegukbang(太平惠民和劑局方)". Results : In spring, pungent-warm herbs such as the dried rhizome of cnidium officinale Makino, the dried root of SEdebouriella divaricata (Turcz.) Schischk. are used. In summer, bitter-cold such as the dried root of Scutellaria baicalensis Georgi, the dried rhizome of Coptis chinensis Franch. or pungent herbs such as the dried aerial part of Elsholtzia splendens Nakai, the dried ripe seed of Dolichos lablab L. are added. In fall and winter, pungent-bitter-hot herbs such as the dried ripe fruit of Evodia rutaecarpa Benth., the dried rhirome of Zingiber officinale Rosc. are used. Conclusions : In this paper, we have shown that several medical herbs could be added and subtracted in the formula according to the season because they have the seasonal characteristic Gi or treat seasonal pathogens.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.3
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• pp.316-322
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• 2019

Helicobacter pylori, a gram-negative bacterium, is one of the risk factors that induces gastritis and gastric cancer. Therefore, much attention has been paid to the compounds that inhibit bacterial growth or eradicate bacteria. Evodiae fructus (EF), the fruit of Evodia rutaecarpa, has been used for treating diarrhea and abdominal pain. EF extract was already found to inhibit the growth of H. pylori. However, to the best of our knowledge, the effect of EF on the virulence factors of H. pylori has not been reported. In this study, when comparing the minimum inhibitory concentration (MIC) of the different methanol concentration extracts, the 95% methanol extract (EF95) showed the lowest MIC value. EF95 extract suppressed the expressions of cagA, vacA and ureB, but interestingly, it up-regulated the expression of ureA. A decrease in production of ammonia in the culture medium and the cell lysates indicated that EF95 inhibited the urease activity in H. pylori, which was the result of EF95 inhibiting the ureB expression. Although the mechanism by which EF95 extract regulates the virulence factors in H. pylori needs further study, EF95 could be used for treatment of gastric troubles induced by H. pylori.