• Korean Journal of Health Education and Promotion
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• v.33 no.4
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• pp.79-87
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• 2016

Objectives: This study aims to identify participants-focused health education approaches for the management of metabolic syndrome. Methods: Data for metabolic parameters of 855,282 Koreans in 2012 were extracted and analysed from the data base of Korea Association of Health Promotion. Literature and documents including study protocols, program contents, evaluation reports and published articles were reviewed in relation to increasing effectiveness and efficiency of health education for managing metabolic syndrome. Results: Health education program should be based on participants-focused perspectives, in which clients' demographic characteristics, composition patterns of metabolic risk factors, and readiness of change are appreciated. Development of theory-based strategies for healthy behavior change and evidence-based program components are also important factors in designing and conducting health education intervention. Multiple health behavior intervention can offer a new paradigm for more comprehensive and efficient health education. Implementation fidelity needs to be systematically evaluated and strengthened to improve the validity of the health education efforts. Conclusion: Enhancing participants-focused health education is the responsibility of health education specialists in promoting the management of metabolic syndrome.

• BMB Reports
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• v.47 no.11
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• pp.609-618
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• 2014

DNA methylation at cytosines (5mC) is a major epigenetic modification involved in the regulation of multiple biological processes in mammals. How methylation is reversed was until recently poorly understood. The family of dioxygenases commonly known as Ten-eleven translocation (Tet) proteins are responsible for the oxidation of 5mC into three new forms, 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Current models link Tet-mediated 5mC oxidation with active DNA demethylation. The higher oxidation products (5fC and 5caC) are recognized and excised by the DNA glycosylase TDG via the base excision repair pathway. Like DNA methyltransferases, Tet enzymes are important for embryonic development. We will examine the mechanism and biological significance of Tet-mediated 5mC oxidation in the context of pronuclear DNA demethylation in mouse early embryos. In contrast to its role in active demethylation in the germ cells and early embryo, a number of lines of evidence suggest that the intragenic 5hmC present in brain may act as a stable mark instead. This short review explores mechanistic aspects of TET oxidation activity, the impact Tet enzymes have on epigenome organization and their contribution to the regulation of early embryonic and neuronal development.

• Journal of the Korean Society of Costume
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• v.38
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• pp.337-358
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• 1998

Underlying principles on the origin and establishment of the concept fo Right-and-Left (R-&-L) in Korean traditional costume is studied in this paper. Among Korean traditional costumes, ordinary and funeral costumes are considered in this study. Thed concept of R-&-L expanded into different elements of daily life among Korean people is also considered as a process of conceptual development : starting from astron-omy principle, then developed to pragmatism principle, and expanded to abstraction principle. No evidence on the case where the astro-omy principle was directly applied to was found in this study. In most cases, pragmatism and abstraction principles are observed as underly-ing principles. In ordinary costumes, pragmatism principle is the fundamental base for R-&-L through right-hand-use rule. Even though abstraction prin-ciple was found in some ordinary costumes, we believe that this was generated for adding more meanings in addition to the pragmatism principle. In funeral costumes, pragmatism principle was almost totally ignored unlike in ordinary costumes because the funeral rite was performed though formality with abstract thoughts. The abstraction principle was exercised with the form of simple-discrimination rule based on the dual system along with Yin-Yang related cultural rules such as‘Yang-left-and-Yin-right’or‘father-left-and-mother-right’. However, the case where‘left-male-and-right-female’rule is applied to was not found in this study.

• Women's Health Nursing
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• v.23 no.3
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• pp.155-165
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• 2017

Purpose: The aim of this study was to understand the hand-on breast massage techniques used by well-known experts in breastfeeding clinics. Methods: A qualitative multiple-case design was applied that involved a feasibility test. Four experts sampling qualitative data collected by observing participants and in individual interviews were analyzed by content analysis, linking data to the propositions, and cross-case pattern matching. This study explored differences within and between cases, and the possibilities of replicating findings across cases. Thirty-nine postpartum women participated voluntarily in the feasibility test, which investigated the usability of four massage techniques. Results: The four techniques showed considerable similarities in terms of the application of stimulation to the breast base and increased flexibility of the wired flexible body, which was the core mechanism underlying the techniques. The breast management strategies were consistent with existing practice guidelines with the exception of using cold cabbage to control engorgement pain. There was insufficient scientific evidence for supporting the massage techniques used by the experts. All of the techniques showed 100% education completeness, but application rates were higher for self-control-oriented techniques. Conclusion: The massage techniques applied by experts in breastfeeding were based on hypotheses and self-control techniques are feasible to apply in practice.

• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.74-77
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• 2002

Collet-Sicard Syndrome is one of the variant of the jugular foramen syndromes in which the last four cranial nerves are involved whereas the sympathetic plexus is spared. The possible causes of these multiple lower cranial nerve palsy are variable, including metastasis of systemic malignancy to the base of skull, primary tumor of head and neck, vascular complication, trauma and so on. We experienced two men visited to our clinic with symptoms of headache, hoarsness, swallowing difficulty and showed the evidence of cranial nerve palsy on neurologic examination. Magnetic resonance imaging and computed tomography demonstrated oropharyngeal and hypopharyngeal tumor and electrodiagnostic study supported the diagnosis.

• Journal of Korean Neurosurgical Society
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• v.46 no.2
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• pp.156-160
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• 2009

Solitary extramedullary plasmacytomas are isolated plasma cell tumors of soft tissue that typically do not metastasize. They are rare and account for 4% of all plasma cell tumors. To our knowledge, only 14 cases of solitary extramedullary plasmacytomas in the sphenoid sinus have been reported. A 32-year-old man presented to our department with complaint of ocular pain in the right eyeball and diplopia. Physical and neurological examinations revealed intact and prompt direct and indirect light reflexes in both pupils and limitation of extraocular muscle movement seen with the lateral gaze of the right eyeball. Magnetic resonance imaging suggested the presence of mucocele or mycetoma, therefore surgical resection was performed with endoscopic endonasal transsphenoidal approach. Histopathology was consistent with plasmacytoma. Systemic work-up did not show any evidence of metastasis and the sphenoid sinus was the sole tumor site, and therefore the diagnosis of solitary extramedullary plasmacytoma was confirmed. We report a rare case of solitary extramedullary plasmacytoma in the sphenoid sinus with successful treatment using the endoscopic endonasal transsphenoidal resection and adjuvant radiotherapy.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.2
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• pp.64-71
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• 2018

Objectives The purpose of this study is to examine the correlation of antibiotics administration duration and antimicrobial resistance by reviewing domestic and foreign literatures. Methods We searched literatures dated up to 23 February, 2018 in PubMed and Cochrane Library using terms of "Anti-Bacterial Agents", "Carrier State", "Nasopharynx", "Drug Administration Schedule", and also searched via RISS (Research Information Service System), KISS (Koreanstudies Information Service System), DBpia (DataBase Periodical Information Academic) using terms of antibiotics, resistance, and dose. Results In comparison with shortened and standard antibiotic course, longer treatment duration is associated with greater antimicrobial resistance or non-significant difference, but we cannot find literature that shortened antibiotic course increases antimicrobial resistance on human nasopharyngeal flora. Conclusions Currently, there is no evidence that completing the standard antibiotic course reduces antimicrobial resistance. It can be a strategy for reducing antibiotic use to apply Korean medicine treatment, as well as short-course antibiotic therapy or delayed antibiotic prescription. Additional well-designed trials should be conducted in domestic and foreign settings about the appropriate duration of antibiotic therapy.

• The Journal of Korean Physical Therapy
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• v.21 no.4
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• pp.51-56
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• 2009

Purpose: This study examined the difference in the static balance ability according to the visual cues and postural tasks in normal subjects. Methods: Thirty participants (12 male, 18 female; mean age $24.63\pm1.43$ years) stood barefoot on a force platform in a one-legged stance, tandem Romberg stance and tandem Romberg with neck extension stance with a visual cue open and closes. The static balance was assessed by the center of pressure (CoP), surface electromyography root mean square (RMS) of the leg muscles according to the stance position. Results: In the CoP tests, the difference in the unit path length and circumference area was affected by the visual cue according to the stance posture (p<0.01). In the RMS tests, the difference in the tibialis anterior and medial gastrocnemius muscle was affected by visual cue in accordance with the stance posture (p<0.01). Conclusion: The visual cue and postural task affect the balance ability in normal subjects. Therefore, this study provides clinical evidence that the balance and postural control can be improved. Therapeutic intervention, such as an obstacle course, and a lower leg muscle performance program with a change in the base of support can affect the balance and postural control.

• Proceedings of the KIEE Conference
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• 1997.07b
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• pp.606-608
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• 1997

In this paper, Neuro-Fuzzy Controller(NFC), a fuzzy system realized using a neural network, is to adopt for the multivariable system. In the multivariable system, the interactive effects between the variables should be taken into account. A simple compensator, using the steady-state information can be obtained for open-loop stable systems, is presented to cope with this problem. However, it should be supposed that the plant is unknown to the control system designer, but an estimate of the DC gain has been obtained by carrying out experiments on the plant. Also, if the variables are not combinated completely, it is difficult to design the controller. Therefore, we design a neuro-fuzzy controller which controls a multivariable system with only input output informations, and compare its performance with that of a PI controller. In the proposed controller, the construction of the membership functions and rule base, which is highly heuristic, can be achieved using a training process. This allows the combination of knowledge of human experts and evidence from input-output data.

• Korean Journal of Veterinary Research
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• v.44 no.3
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• pp.329-334
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• 2004

Ischemia/reperfusion(I/R) injury of the rat testis causes germ cell death and infiltration of inflammatory cells. To investigate the mechanism of germ cell death in torsion of the rat testis, apoptosis and macrophage activation were studied using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL) method and immunohistochemistry in the testes of Sprague-Dawley rats subjected to 1.5 h of ischemia, followed by 0, 1, 3, 6, 12, 24, 48 and 96 h of reperfusion. Apoptotic, TUNEL-positive cells were found at the base of the seminiferous epithelia after I/R. TUNEL-positive cells were significantly increased 6 h after repair of the torsion, and there was a significant peak in apoptosis 24 h after reperfusion, as compared with normal or sham-operated controls. In contrast, histological evidence of germ cell necrosis in the seminiferous tubules was first visible 24 h after reperfusion. In the testis of sham-operated rats, ED2-positive resident macrophages were found diffusely in the interstitial space, while ED1-positive monocyte-like macrophages were rarely found. After I/R, ED1-positive cells were significantly increased beginning 12 h after reperfusion, while ED2-positive immunoreactivity did not change during the experimental period. Together, the results of this study confirmed that increased numbers of ED1-positive macrophages, but not resident ED2-positive macrophages, infiltrated the interstitial space surrounding damaged tubules and induced germcell death.