• Title/Summary/Keyword: Evidence Combination

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Overlapping Guillain-Barr$\acute{e}$ syndrome and Bickerstaff's brainstem encephalitis associated with Epstein Barr virus

  • Rho, Young Il
    • Clinical and Experimental Pediatrics
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    • v.57 no.10
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    • pp.457-460
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    • 2014
  • A flaccid tetraparesis in Bickerstaff's brainstem encephalitis (BBE) is presumed to be a sign of overlapping Guillain-Barr$\acute{e}$ syndrome (GBS). In addition, BBE and Fisher syndrome, which are clinically similar and are both associated with the presence of the immunoglobulin G anti-GQ1b antibody, represent a specific autoimmune disease with a wide spectrum of symptoms that include ophthalmoplegia and ataxia. A 2-year-old boy presented with rapidly progressive ophthalmoplegia, ataxia, hyporeflexia, weakness of the lower extremities, and, subsequently, disturbance of consciousness. He experienced bronchitis with watery diarrhea and had laboratory evidence of recent infection with Epstein-Barr virus (EBV). He was diagnosed as having overlapping GBS and BBE associated with EBV and received treatment with a combination of immunoglobulin and methylprednisolone, as well as acyclovir, and had recovered completely after 3 months. In addition, he has not experienced any relapse over the past year. We suggest that combinations of symptoms and signs of central lesions (disturbance of consciousness) and peripheral lesions (ophthalmoplegia, facial weakness, limb weakness, and areflexia) are supportive of a diagnosis of overlapping GBS and BBE and can be helpful in achieving an early diagnosis, as well as for the administration of appropriate treatments.

Surface modification and induced ultra high surface hardness by nitrogen ion implantation of low alloy steel

  • Olofinjana, A.O.;Bell, J.M.;Chen, Z.
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 2002.10b
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    • pp.157-158
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    • 2002
  • A surface hardenable low alloy carbon steel was implanted with medium energy (20 - 50KeV) $N_2^+$ ions to produced a modified hardened surface. The implantation conditions were varied and are given in several doses. The surface hardness of treated and untreated steels were measured using depth sensing ultra micro indentation system (UMIS). It is shown that the hardness of nitrogen ion implanted steels varied from 20 to 50GPa depending on the implantation conditions and the doses of implantation. The structure of the modified surfaces was examined by X-ray photoelectron spectroscopy (XPS). It was found that the high hardness on the implanted surfaces was as a result of formation of non-equilibrium nitrides. High-resolution XPS studies indicated that the nitride formers were essentially C and Si from the alloy steel. The result suggests that the ion implantation provided the conditions for a preferential formation of C and Si nitrides. The combination of evidences from nano-indentation and XPS, provided a strong evidence for the existence of $sp^3$ type of bonding in a suspected $(C,Si)_xN_y$ stoichiometry. The formation of ultra hard surface from relatively cheap low alloy steel has significant implication for wear resistance implanted low alloy steels.

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Evidence for Taxonomic Status of Pachydictyon coriaceum (Holmes) Okamura (Dictyotales, Phaeophyceae) Based on Morphology and Plastid Protein Coding rbcL, psaA, and psbA Gene Sequences

  • Hwang, Il-Ki;Kim, Hyung-Seop;Lee, Wook-Jae
    • ALGAE
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    • v.19 no.3
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    • pp.175-190
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    • 2004
  • The morphological and molecular characteristics of Pachydictyon coriaceum (Holmes) Okamura (1899) are described. Plants are collected from Korea all year round and have maximum height from August to September. The monthly variability of thallus growth is in the way with that of the seawater temperature. Two types of thallus structures, thick cortical layer tallus type and thin cortical cell layer type, are distinguished according to growing seasons. The habit of Korean plants is also classified into two thallus types, slender type and wide type, based on the length and the width of internodes, but this distinction between two types is not supported by either anatomical or molecular characteristics. P. coriaceum shares typical morphology in branching pattern and morphogenetic processes with the other species of Dictyota: 1) multi-cellular cortical and medullar layer in the partial of thallus, 2) same development of thallus from apical meristem cell, and 3) sub-lineage within Dictyota species lineage in rbcL, psaA and psbA gene sequences analyses. These characteristics lead to propose the new combination of Dictyota coriacea (Homes) I.K. Hwang, H.S. Kim et W.J. Lee, comb. nov.

Blue profile in different evolutionary stages of massive star forming regions

  • Jin, Mihwa;Lee, Jeong-Eun;Kim, Kee-Tae
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.1
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    • pp.68.1-68.1
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    • 2015
  • Gravitational collapse is a dynamical process associated with star formation. One observational evidence of such infall motion is so called "blue asymmetry" profile, which is the optically thick line profile with the intensity peak skewed blueward relative to the intensity peak of optically thin lines. We analyzed both HCN J=1-0 and HNC J=1-0 line profiles to study the inflow motion in different evolutionary stages of massive star formation; Infrared dark clouds (IRDCs), High-mass protostellar object (HMPOs), and Ultra-compact HII regions (UCHIIs). The infall asymmetry in the HCN spectra seems to be more prevalent than the HNC spectra throughout all the three evolutionary phases. The prevalence of the blue profile in the HCN spectra is found in every evolutionary stage, with IRDCs showing the largest blue excess. In the case of the HNC spectra, only IRDCs show the blue excess statistically significant. These results suggest that HCN may be a better infall tracer in massive star forming region. In addition, even though the characteristics of the blue profile largely depend on the suitable combination of optical depth and critical density, our analyses also indicate that IRDCs may have the most active infall process compared to other evolutionary phases.

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Social Capital and Corporate Performance: Evidence from State Capital Enterprises in Vietnam

  • NGO, Chin;NGUYEN, Quyen Le Hoang Thuy To;NGUYEN, Phong Thanh
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.6
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    • pp.409-416
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    • 2020
  • The research has been conducted to explore the combination of three intangible resources, including social capital, entrepreneurship, and resilience capability on the performance of State Capital Enterprises (SCEs) in Vietnam. Both qualitative and quantitative approaches are applied in the study. An in-depth interview of ten CEOs at SCEs in Vietnam was made to explore new indicators for the contextual latent variables in the research models. By employing the data from the authors' survey of 568 SCEs in Vietnam in 2019, using Cronbach's alpha, confirmatory factor analysis (CFA) and path analysis (SEM), the mechanism that social capital impacts on SCE performance has been analyzed. In addition to the direct role, social capital indirectly affects corporate performance through entrepreneurship and resilience capability. It was found that social capital has a larger impact on entrepreneurship than resilience capacity. However, the contribution of resilience capacity to the firm performance is much more than the entrepreneurship's in Vietnamese context. This study enriches the theory by proposing a measurement scale of the contextual latent variables as a result of in-depth interviews with experts using a qualitative analysis technique. In addition, the path analysis findings suggest practical implications for managers to effectively use their resources in SCEs.

Update of minimally invasive surfactant therapy

  • Shim, Gyu-Hong
    • Clinical and Experimental Pediatrics
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    • v.60 no.9
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    • pp.273-281
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    • 2017
  • To date, preterm infants with respiratory distress syndrome (RDS) after birth have been managed with a combination of endotracheal intubation, surfactant instillation, and mechanical ventilation. It is now recognized that noninvasive ventilation (NIV) such as nasal continuous positive airway pressure (CPAP) in preterm infants is a reasonable alternative to elective intubation after birth. Recently, a meta-analysis of large controlled trials comparing conventional methods and nasal CPAP suggested that CPAP decreased the risk of the combined outcome of bronchopulmonary dysplasia or death. Since then, the use of NIV as primary therapy for preterm infants has increased, but when and how to give exogenous surfactant remains unclear. Overcoming this problem, minimally invasive surfactant therapy (MIST) allows spontaneously breathing neonates to remain on CPAP in the first week after birth. MIST has included administration of exogenous surfactant by intrapharyngeal instillation, nebulization, a laryngeal mask, and a thin catheter. In recent clinical trials, surfactant delivery via a thin catheter was found to reduce the need for subsequent endotracheal intubation and mechanical ventilation, and improves short-term respiratory outcomes. There is also growing evidence for MIST as an alternative to the INSURE (intubation-surfactant-extubation) procedure in spontaneously breathing preterm infants with RDS. In conclusion, MIST is gentle, safe, feasible, and effective in preterm infants, and is widely used for surfactant administration with noninvasive respiratory support by neonatologists. However, further studies are needed to resolve uncertainties in the MIST method, including infant selection, optimal surfactant dosage and administration method, and need for sedation.

Static and dynamic load superposition in spacecraft structural analysis

  • Vaquer-Araujo, Xavier;Schottle, Florian;Kommer, Andreas;Konrad, Werner
    • Advances in aircraft and spacecraft science
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    • v.5 no.2
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    • pp.259-275
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    • 2018
  • In mechanical analysis of spacecraft structures situations appear where static and dynamic loads must be considered simultaneously. This could be necessary either by load definition or preloaded structures. The superposition of these environments has an impact on the load and stress distribution of the analysed structures. However, this superposition cannot be done by adding both load contributions directly. As an example, to compute equivalent Von Mises stresses, the phase information must be taken into account in the stress tensor superposition. Finite Element based frequency response solvers do not allow the calculation of superposed static and dynamic responses. A manual combination of loads in a post-processing task is required. In this paper, procedures for static and harmonic loads superposition are presented and supported by analytical and finite element-based examples. The aim of the paper is to provide evidence of the risks of using different superposition techniques. Real application examples such as preloaded mechanism structures and propulsion system tubing assemblies are provided. This study has been performed by the Structural Engineering department of Airbus Defence and Space GmbH Friedrichshafen.

Screening for Korean Vegetables with Anticarcinogenic Enzyme Inducing Activity Using Cell Culture System

  • Kim, Su-Mi;Ryu, Seung-Hee;Park, Hui-Don;Kim, Sung-Su;Kim, Jeong-Hwan;Kim, Jong-Sang
    • Preventive Nutrition and Food Science
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    • v.3 no.3
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    • pp.277-281
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    • 1998
  • There is extensive evidence suggesting the protective role of fruits and vegetables against chemically induced carcinogenesis. We have tested the ability of a representative range of Korean vegetables to act as blocking agents against neoplastic initiation by determining the induction level of quinone reductase , an anticarcinogenci marker enzyme, in hepalclc 7 cells exposed to vegetable extracts. Among thirty vegetables tested, Arcitum lappa(Burdock), Brassica juncea (Mustard leaf), Pteridium aguilinum (Bracken) and Chrysanthemum cornoratium(Crown daisy) caused a significant induction of quinone teductase activity with a limited increase in arylhdrocarbon hydroxylase activity. Combination of crown daisy with burdock had synergistic effect on quinone reductase induction. Quinone reductase-inducing activity was found mostly in hesane and ehtylactate fractions of MeOH extract of crown daisy while it ws not quinone reductase activity in liver, kideny, lung, and small intestine, confirming the presence of potent QR inducer (s) in crown daisy. These sata suggest that some vegetables including crown daisy induced QR merits further investigation as a potential cancer preventive agent in human.

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Trends of Molecular Biology Using Herbs in Cancer Research (한약물기반의 항암치료 유효성 검증을 위한 분자생물학적 시험관내 실험의 경향성 분석)

  • Ko Seong-Gyu
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.6
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    • pp.1752-1761
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    • 2004
  • Recently, Despite improvements of therapeutic methods on malignancy, the need of modalities on the treatment of cancer have been increasing nowadays and Traditional Oriental Medicine have been considered as alternatives and the uses of it have continued to increase in cancer therapy. The aims of this paper is to gain the evidence of entering to the mainstream of cancer therapy and get the clue to make herbal prescription and perform the clinical trials using herbal medicines. Cheong-yeol group herbs which was intimate thought have been used most frequently and leukemia cell lines and apoptosis-releated experiments were executed mostly. A distinguished experiments were about the combination therapy on cancer and comparison between herbs and active compound derived from the same herb. With these results, we knew that molecular biology using herbs have been gained the popularity more and more and we think that we can use these results in the laboratory work and clinical work to strengthen the utilization of Traditional Oriental Medicine.

A Comparative Study of Antegrade Cardioplegia Versus Retrograde Cardioplegia for Myocardial Protection during the Open Heart Surgery (순행성 관관류법과 역행성 관관류법의 임상적 비교연구)

  • 조완재
    • Journal of Chest Surgery
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    • v.22 no.4
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    • pp.609-619
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    • 1989
  • During aortic valve surgery, cardioplegic solution is delivered through direct cannulation of both coronary ostia. Since this approach may cause an intimal injury leading to acute dissection or late ostial stenosis, this study was undertaken to evaluate myocardial protective effect of retrograde perfusion of cardioplegia [RCSP <% RRAP] in 18 clinical cases, which were compared with antegrade perfusion of cardioplegia in 27 clinical cases. This study were investigated 1] cease and return of electromechanical activity after cardioplegia infusion 2] the myocardial temperature during operation 3] the aortic cross clamping time and total bypass time 4] frequency of DC shock for defibrillation 5] need for inotropic drugs after operation 6] electrocardiographic evidence of myocardial infarction or ventricular arrhythmia after operation 7] the enzymes activity during preoperative and postoperative period as an evaluation of myocardial ischemic injury and 8] operative mortality rate The combination of retrograde cardioplegia and topical cooling with ice slush yielded promptly hypothermia of myocardium and shorter aortic cross-clamping time compared with antegrade cardioplegia [P < 0.05]. The temperature of the interventricular septum was maintained below 20oC by continuous perfusion or intermittent perfusion of cold blood cardioplegia and other results were no statistically significant difference between the two methods [P >0.05]. This technique provides clear operative field and avoids some serious complications which are caused by coronary ostial cannulation. These results suggested that the retrograde perfusion of cardioplegia is a simple, safe, and effective means of myocardial protection during open heart surgery.

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