• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3627-3629
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• 2016

Background: Activation and inactivation of nuclear factor of kappa light chain gene enhancer in B cells (NFKB) is tightly regulated to ensure effective onset and cessation of defensive inflammatory signaling. However, mutations within NFKB, or change in activation and inactivation molecules have been reported in a few cancers. Although oral squamous cell carcinoma is one of the most prevalent forms of cancer in India, with a development associated with malignant transformation of precancerous lesions, the genetic status of NFKB and relative rates of change in oral precancerous lesions remain unknown. Hence in the present study we investigated all twenty four exons of NFKB gene in two precancerous lesions, namely oral submucous fibrosis (OSMF) and oral leukoplakia (OL) to understand its occurrence, incidence and assess its possible contribution to malignant transformation. Materials and Methods: Chromosomal DNA isolated from twenty five each of OSMF and OL tissue biopsy samples were subjected to PCR amplification with intronic primers flanking twenty four exons of the NFKB gene. The PCR amplicons were subsequently subjected to direct sequencing to elucidate the mutation status. Results: Sequence analysis identified a novel heterozygous mutation, c.419T>A causing substitution of leucine with glutamine at codon 140 (L140Q) in an OL sample. Conclusions: The identification of a substitution mutation L140Q within the DNA binding domain of NFKB in OL suggests that NFKB mutation may be relatively an early event during transformation. To the best of our knowledge, this study is the first to have identified a missense mutation in NFKB in OL.

• Economic and Environmental Geology
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• v.36 no.6
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• pp.491-499
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• 2003

The Okinawa Trough is a rift basin formed by extension. Analysis of multichannel seismic reflection profiles from the northwestern margin of the northern Okinawa Trough reveal that the trough is characterized by a series of tilted fault blocks bounded by listric normal faults and half-grabens developed between blocks, showing typical rifted structures. The trough display three kinds of sedimentary sequences with different seismic reflection characteristics: prerift, synrift and postrift sediments. The prerift sequence develops parallel to the dip direction of tilted fault blocks. The synrift sediments, mostly deposited in the half-grabens between tilted fault blocks, are generally well characterized by divergence of the reflectors towards the blocks indicating contemporaneous deposition during tilting. The postrift sediments are featured by continuous and parallel reflectors. The width of the half-graben and the throw-displacement rate of the basin bounding fault are closely connected. The throw-displacement rate is the maximum when the rifting event is the most active and the width of the half-graben is proportional to the rate.

• Sleep Medicine and Psychophysiology
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• v.17 no.2
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• pp.75-84
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• 2010

The cyclic alternating pattern (CAP) is a periodic EEG activity in NREM sleep, characterized by sequences of transient electrocortical events that are distinct from background EEG activities. A CAP cycle consists of two periodic EEG features, phase A and subsequent phase B whose durations are 2-60 s. At least two consecutive CAP cycles are required to define a CAP sequence. The CAP phase A is a phasic EEG event, such as delta bursts, vertex sharp transients, K-complex sequences, polyphasic bursts, K-alpha, intermittent alpha, and arousals. Phase B is repetitive periods of background EEG activity. The absence of CAP more than 60 seconds or an isolated phase A is classified as non-CAP. Phase A activities can be classified into three subtypes (A1, A2, and A3), based on the amounts of high-voltage slow waves (EEG synchrony) and low-amplitude fast rhythms (EEG desynchrony). CAP rate, the percentage of CAP durations in NREM sleep is considered to be a physiologic marker of the NREM sleep instability. In insomnia, the frequent discrepancy between self-reports and polysomnographic findings could be attributed to subtle abnormalities in the sleep tracing, which are overlooked by the conventional scoring methods. The conventional scoring scheme has superiority in analysis of macrostructure of sleep but shows limited power in finding arousals and transient EEG events that are major component of microstructure of sleep. But, it has recently been found that a significant correlation exists between CAP rate and the subjective estimates of the sleep quality in insomniacs and sleep-improving treatments often reduce the amount of CAP. Thus, the extension of conventional sleep measures with the new CAP variables, which appear to be the more sensitive to sleep disturbance, may improve our knowledge on the diagnosis and management of insomnia.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.284-289
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• 2016

In recent years, the earthquake sequence in Christchurch, New Zealand (NZ) was unprecedented in terms of repeated earthquake shocks with substantial levels of ground motion affecting modern infrastructure, and in particular, broad and precise reports for liquefaction-induced permanent ground deformation (PGD) and repairs of wastewater (WW) pipelines were collected. In this study, a geographical information system (GIS) and linear regression analysis were performed using data for the length and repair points of earthenware (EW) and concrete (CONC) wastewater pipelines acquired after the MW 6.2 February 22, 2011 earthquake. The repair rates (repairs/km) for the EW and CONC wastewater pipelines were evaluated inside the areas of PGD, and both angular distortion of ground and lateral ground strain were calculated from the high resolution LiDAR data acquired before and after the seismic event. The research results showed that both pipelines have similar trends of damage but the CONC wastewater pipeline with higher stiffness showed less damage. The results of linear regression analyses can be used to predict the repair rates for EW and CONC wastewater pipelines inside the areas of PGD induced by future earthquakes.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.9
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• pp.111-119
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• 2008

As the penetration of distributed generation systems is recently high, there have been metering errors, trips of protective devices in KEPCO distribution systems including an occurrence of false fault-indicator in distribution automation system. The cause of malfunctions was the reverse-power-flow phenomenon due to transformer wiring types. By the effect of the reverse-power-flow, each of phase's fundamental currents was added by about 3 times on the neutral line. A new method based on the analysis of the reverse-power-flow is proposed in this paper. Fault currents on each section were analyzed by the proposed method, and the effect of types of transformer wiring was examined experimentally. In order to reduce the malfunctions due to the reverse-power-flow, controlling the zero-sequence impedance of transformer was designed and verified by using PSCAD/EMTDC software.

• International Journal of Industrial Entomology and Biomaterials
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• v.43 no.2
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• pp.67-77
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• 2021

Salurnis marginella Guérin-Méneville, 1829 (Hemiptera: Flatidae) is an invasive species first reported in 2003 in Iksan, which is located in the mid-western region of South Korea, and subsequently found in the nearby regions in 2005. However, molecular-perspective reports on their invasive characteristics are not yet available. In this study, population genetic characteristics of Korean S. marginella were evaluated using the mitochondrial COI region and sequencing 124 individual samples collected in 11 Korean localities. A total of 12 haplotypes were identified with a maximum sequence divergence of 1.368% (9 bp). Haplotype diversity was relatively higher than that of other insect species invaded into Korea, providing 2-6 haplotypes per populations, indicating that introduction to Korea may have happened rather extensively and consistently. Nucleotide diversity (π) was the highest in Iksan but owing to the limited sample size (three individuals) from this locality, additional studies are required for drawing conclusive inference regarding the place of entry to Korea. Ulsan, the easternmost population in the present study, revealed nearly the lowest diversity estimates, such as the lowest H and the second-lowest π; a unique haplogroup with a higher frequency; and an independent genetic cluster, suggesting that the introduction of S. marginella to Ulsan was an independent event. Further collection in Korea and neighboring countries, including the original distributional range is necessary to elucidate the invasive dynamics of S. marginella

• Journal of Radiation Protection and Research
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• v.29 no.4
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• pp.263-268
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• 2004

Using the Monte Carlo simulation, a study on the lion-proportionality of the prototype phoswich detector with $2'{\times}2'$ CSI(Tl) and plastic scintillator, which was made by KAERI, has been carried. The defector response functions (DRFs) calculated by simulations were compared with the experimental measurement on the $^{137}Cs\;and\;^{60}Co$. To precisely simulate the DRF for the phoswich, the CSI(Tl) non-proportionality was calculated using the electron response and the simplified electron cascade sequence for treating the photoelectric absorption event. The resulting DRFs of $^{137}Cs\;and\;^{60}Co$ sources obtained by simulations were compared with experiments for verification. For $^{137}Cs$, gamma-ray responses simulated by MCNP5 are generally good agreement with the measured ones. But the DRF of $^{60}Co$ does not match well with the results of experiment in the energy region below second peak due to the coincidence effect of two gamma-rays (1.17 MeV and 1.33 MeV). Through the analysis of the non-proportionality of CsI(Tl) in the prototype phoswich, the improved DRFs considering non-proportionality were produced and the simulation results were verified using the experimental measurements. However, to more precisely reproduce the DRF for the phoswich, further studies in relation to the electron channeling effect and the Doppler broadening effect of a scintillator are still needed as well as considering that effect of the transfer contribution.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.10
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• pp.1471-1477
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• 2017

Objective: Since athletic performance is a most importance trait in horses, most research focused on physiological and physical studies of horse athletic abilities. In contrast, the molecular analysis as well as the regulatory pathway studies remain insufficient for evaluation and prediction of horse athletic abilities. In our previous study, we identified AXL receptor tyrosine kinase (AXL) gene which was expressed as alternative spliced isoforms in skeletal muscle during exercise. In the present study, we validated two AXL alternative splicing transcripts (named as AXLa for long form and AXLb for short form) in equine skeletal muscle to gain insight(s) into the role of each alternative transcript during exercise. Methods: We validated two isoforms of AXL transcripts in horse tissues by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned the transcripts to confirm the alternative locus and its sequences. Additionally, we examined the expression patterns of AXLa and AXLb transcripts in horse tissues by quantitative RT-PCR (qRT-PCR). Results: Both of AXLa and AXLb transcripts were expressed in horse skeletal muscle and the expression levels were significantly increased after exercise. The sequencing analysis showed that there was an alternative splicing event at exon 11 between AXLa and AXLb transcripts. 3-dimentional (3D) prediction of the alternative protein structures revealed that the structural distance of the connective region between fibronectin type 3 (FN3) and immunoglobin (Ig) domain was different between two alternative isoforms. Conclusion: It is assumed that the expression patterns of AXLa and AXLb transcripts would be involved in regulation of exercise-induced stress in horse muscle possibly through an $NF-{\kappa}B$ signaling pathway. Further study is necessary to uncover biological function(s) and significance of the alternative splicing isoforms in race horse skeletal muscle.

• Economic and Environmental Geology
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• v.25 no.1
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• pp.61-72
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• 1992

The Danyang area consists of the thrust and folded sedimentary rocks of Paleozoic and Mesozoic Era. The area is bounded by major tectonic units which are the Gagdong Thrust to the west and the Okdong Fault to the east. According to the structural analyses, the area is affected by polyphase deformation. This study establishes deformational sequence in the area. Mylonite zone along the Okdong Fault corresponds to the first generation of structures ($D_1$). $D_1$-structures are discrete shear zone in the Jangsan Formation and bedding parallel extensional deformation in the Cambro-Ordovician sequences. $D_2$-structures were formed prior to the sedimentation of the Jurassic Bansong Group, which are the NW-trending fold and linear structures. After sedimentation of the Bansong Group, the area is strongly affected by the Daebo Orogeny which produces NE-trending thrusts, folds and linear structures. Earlier structures were tightened and rotated toward NE. Some thrust faults did not propagate into the Bansong Group. It is suggested either the Bansong Group acted as a decoupling horizon or rest on unconformably on the thrust faults. The area is weakly affected by $D_4$-event of which structures are E-W trending folds and faults. The Jugryeong Fault clearly cut the earlier folds and thrust faults. The rocks within the fault zone were sliced and rotated during the strike-slip movements. Block rotation and transpressional features can be commonly observed.

• Sleep Medicine and Psychophysiology
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• v.5 no.2
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• pp.119-133
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• 1998

Attentional processes facilitate cognitive and behavioral performance in several ways. Attention serves to reduce the amount of information to receive. Attention enables humans to direct themselves to appropriate aspects of external environmental events and internal operations. Attention facilitates the selection of salient information and the allocation of cognitive processing appropriate to that information. Attention is not a unitary process that can be localized to a single neuroanatomical region. Before the cortical registration of sensory information, activation of important subcortical structures occurs, which is called as an orienting response. Once sensory information reaches the sensory cortex, a large number of perceptual processes occur, which provide various levels of perceptual resolution of the critical features of the stimuli. After this preattentional processing, information is integrated within higher cortical(heteromodal) systems in inferior parietal and temporal lobes. At this stage, the processing characteristics can be modified, and the biases of the system have a direct impact on attentional selection. Information flow has been traced through sensory analysis to a processing stage that enables the new information to be focused and modified in relation to preexisting biases. The limbic and paralimbic system play significant roles in modulating attentional response. It is labeled with affective salience and is integrated according to ongoing pressures from the motivational drive system of the hypothalamus. The salience of information greatly influences the allocation of attention. The frontal lobe operate response selection system with a reciprocal interaction with both the attention system of the parietal lobe and the limbic system. In this attentional process, the search with the spatial field is organized and a sequence of attentional responses is generated. Affective, motivational and appectitive impulses from limbic system and hypothalamus trigger response intention, preparation, planning, initiation and control of frontal lobe on this process. The reticular system, which produces ascending activation, catalyzes the overall system and increases attentional capacity. Also additional energetic pressures are created by the hypothalamus. As psychophysiological measurement, skin conductance, pupil diameter, muscle tension, heart rate, alpha wave of EEG can be used. Event related potentials also provide physiological evidence of attention during information process. NI component appears to be an electrophysiological index of selective attention. P3 response is developed during the attention related to stimulus discrimination, evaluation and response.