• Journal of Korean Society of Transportation
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• v.28 no.4
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• pp.141-156
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• 2010

In this paper, understanding there is a limitation with a comprehensive and network approach for the evaluation of existing vehicle and pedestrian environments, the authors focus on developing an integrated approach to assessing these environments. The network evaluation here means the assessment at a three-dimensional level that includes evaluation methods of lines/axes in a spatial concept as well as integration of evaluation indicators being used for vehicles and the walking environment. Grey System Theory (GST) was applied based on the theoretical background for network and comprehensive integrated evaluation, and the evaluation of the vehicle and pedestrian environment was performed by assigning target areas to walking preference zones. As a result of the comprehensive evaluation and analysis by GST, even if the service level is the same as the operating indicators (Highway Capacity Manual) of the vehicle and pedestrian environment, or relatively better, it was identified that the total score could be varied over Grey Category because the observed data are calculated after considering the weights between evaluation indicators by the range of Grey Category on the comprehensive evaluation. Considering comprehensively these points, although the indicators on the operation of roads are relatively good, in the event that the indicators on the safety of roads are bad, it was known that the scores over Grey Category also could be changed. The result is that this evaluation method can be used to evaluate the network concept per lane (per axis) as well as to diagnose the current state by type of urban street in the future.

• Korean Journal of Applied Biomechanics
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• v.21 no.5
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• pp.541-550
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• 2011

The purpose of this study was to investigate the kinematic characteristics of the $5^{th}$ and $6^{th}$ hurdle clearances during the final of the 100-m hurdles event at the IAAF World Championships, Daegu 2011. To this end, the hurdling motions of the top 4 ranked female hurdlers in the competition were analyzed. A total of 12 cameras were used to record their motions, with a sampling frequency of 120 Hz. The cameras were calibrated using $11{\times}2{\times}1\;m$ control objects that covered all of the lanes ($1^{st}{\sim}8^{th}$ lanes). After analyzing all the data, we arrived at the following results. For the take-off phase, a negative relationship between the take-off time (CT) and athlete's rank was found. In addition, the average distances from the hurdle to take-off (L1) were shown to be 2.23 m and 2.17 m for the $5^{th}$ and $6^{th}$ hurdles, respectively. For the distance from the hurdle to landing (L2), Pearson ($1^{st}$ rank) and Carruthers($2^{nd}$ rank) showed inconsistent patterns whereas Harper ($3^{rd}$ rank) and Porter ($4^{th}$ rank) showed consistent patterns. All althetes revealed similar 3 steps patterns between hurdles, which consisted of a shorter $1^{st}$ step, longer $2^{nd}$ step and shorter $3^{rd}$ step.

• Journal of Gastric Cancer
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• v.3 no.4
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• pp.214-220
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• 2003

Purpose: The aim of this study was to investigate the frequency of loss of heterozygosity and the microsatellite instability at multiple tumor suppressor gene loci in gastric adenocarcinomas. Materials and Methods: Loss of heterozygosity and the microsatellite instability at several tumor suppressor gene loci were analyzed in 29 primary gastric carcinomas by using microdissection and the polymerase chain reaction. Results: Twenty-three ($79\%$) of the 29 cases demonstrated loss of heterozygosity at one or more loci. The frequency of loss of heterozygosity at the p53 locus was the highest ($63\%$) and those at the VHL, APC, p16, Rb, MEN1, BRCA1, DPC4, 3p21, and 16p13 region were $41\%,\;36\%,\;19\%,\;29\%,\;33\%,\;26\%,\;21\%,\;32\%,\;and\;11\%$, respectively. Compared with histological type, loss of heterozygosity was more common in diffuse-type gastric cancer (P<0.01). Interestingly, 9 of 10 tumors with allelic deletion at the p53 locus showed loss of heterozygosity at other tumor suppressor gene loci. The microsatellite instability was also detected in 6 ($20\%$) of the 29 cases at one or more loci. Conclusion: These data suggest that frequent loss of heterozygosity and the microsatellite instability at multiple tumor suppressor genes might be required for the development and the progression of gastric carcinomas and that p53 allelic loss may be the most frequent event in the development of gastric carcinomas.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3435-3441
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• 2014

Background: Axillary lymph node status at diagnosis remains the strongest predictor of long-term survival in breast cancer. Patients with more than ten axillary lymph nodes at diagnosis have a poor long-term survival. In this single institutional study, we set out to evaluate the prognosis of this high-risk group in the era of multimodality therapy. Materials and Methods: In this retrospective study, we looked at all breast cancer patients with greater than ten axillary lymph nodes diagnosed at Mount Sinai Medical Center (MSMC) from January 1st 1990 to December 31st 2007 (n=161). In the univariate analysis, descriptive frequencies, median survival, and 5- and 10-year survival rates were estimated for common prognostic factors. A multivariate prognostic analysis for time-to-event data, using the extended Cox regression model was carried out. Results: With a median and mean follow-up of 70 and 89.9 months, respectively, the overall median survival was estimated to be 99 months. The five-year disease-free survival (DFS) was 59.3% and the ten-year DFS was 37.9%, whereas the five- and ten-year overall survival (OS) was 66.6% and 43.9%, respectively. Multivariate analysis revealed a significant improvement in DFS among black patients compared to whites (p=0.05), improved DFS and OS among young patients (ages 21-45) compared to elderly patients (age greater than 70) (p=0.00176, p=0.0034, respectively), and improved DFS and OS among patients whose tumors were ER positive (p=0.049, p=0.0034). Conclusions: In this single institution study of patients with greater than 10 positive axillary nodes, black patients had a significantly improved DFS compared with white patients. Young age and ER tumor positivity was associated with improved outcomes. Using multivariate analysis, there were no other variables associated with statistically significant improvements in DFS or OS including date of diagnosis. Further work is needed to improve breast cancer survival in this subgroup of patients.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.4
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• pp.157-165
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• 2015

The purpose of this study is to suggest a successful operating strategy of co-working space. Therefore, the operating elements were identified through a literature research. And then, verified through site investigation and interview of operation managers. We found out that the high level operating elements are 'Co-working management', 'Membership management' and 'Supporting management' And the low level elements of Co-working management are 'Relationship facilitation', 'Networking event & Party' and 'Community & Communication', Membership management's are 'Service diversity & Price plan', 'Promotion & PR' and 'Alliance & Partnership', Supporting management's are 'Space & Interior', 'Facility & Device, Solution' and 'Mentoring & Education'. And the questionnaire was designed and conducted to Co-working space operators through the AHP method. As a result of the collected data analyzing, the highest priority was the operational element 'Community & Communication', and 'space and interior' is next, 'Service diversity & Price plan' is the third. The results were discussed with the relevant experts and it presents the following operating strategies. First, to create an environment suitable to voluntary coworking is the most important element. In particular, good management of 'Community & Communication' should be considered as a high priority operations strategy in a coworking space. Second, interior and space utilization helps in making the environment and atmosphere conducive to coworking. Office devices and facilities such as IT infra, printer, fax, scan, paper...etc are also important elements. But the reason why these necessary items are given a low priority is that these items don't need any special strategy. Third, in order to create a stable profit, 'Service diversity & Price plan' should be the characteristics of each coworking space because it will attract and secure enough customers. This study is valuable, it could be a great guideline for coworking space in an early stage to adopt operating model and strategy

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3223-3227
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• 2015

Objective: We evaluated the association of body mass index (BMI) with perioperative outcomes in patients who underwent laparoscopic or open radical nephroureterectomy. Materials and Methods: This retrospective single-center study included 113 patients who had been diagnosed with upper urinary tract cancer from January 1998 to June 2013 and were treated with laparoscopic nephroureterectomy (Lap group, n=60) or open nephroureterectomy (Open group, n=53). Laparoscopic nephroureterectomy was performed via a retroperitoneal approach following an open partial cystectomy. The two surgical groups were stratified into a normal-BMI group (<25) and a high-BMI group ($BMI{\geq}25$). The high-BMI group included 27 patients: 13 in the Lap group and 14 in the Open group. Results: Estimated blood loss (EBL) in the Lap group was much lower than that in the Open group irrespective of BMI (p<0.01). Operative time was significantly prolonged in normal-BMI patients in the Lap group compared to those in the Open group (p=0.03), but there was no difference in operative time between the Open and Lap groups among the high-BMI patients. Multivariate logistic regression analysis of the data for all the cohorts revealed that the open procedure was a significant risk factor for high EBL (p<0.0001, hazard ratio 8.02). Normal BMI was an independent predictor for low EBL (p=0.01, hazard ratio 0.25). There was no significant risk factor for operative time in multivariate analysis. There were no differences in blood transfusion rates or adverse event rates between the two surgical groups. Conclusions: Laparoscopic radical nephroureterectomy via a retroperitoneal approach can be safely performed with significantly reduced EBL even in obese patients with upper urinary tract cancer.

• Journal of Distribution Research
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• v.16 no.5
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• pp.43-61
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• 2011

In this research, we analyze about the effect of the traditional market supporting policy about 16 large unit self-governing bodies and effeciency through DEA analysis. The plan for supports of the traditional market were shown. Now, the object of the traditional market supporting policy was any more not improvement of facilities and the thing which is the attraction of customer activity for the sales increase of the traditional market could be confirmed. For the sales increase, supporting of the field like the client information center, source indicator, autonomic packing stand, and the broadcasting facility are effective more. In addition, for the visiting customer inducement activation, we could know that supporting of the field like client information center, broadcasting facility, broadcasting advertisement, and the premium event for gift certificate were required. The method including the customer distribution service operation, which is the various product development and cross sellings and client friendly based on data which it investigates the actual conditions the market merchant on the Incheon area and consumer with the concrete plan for support gift certificate activation, the market information system construction, and etc. was shown.

• Clinical and Experimental Pediatrics
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• v.56 no.9
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• pp.401-406
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• 2013

Purpose: We performed a pilot study to determine the benefit of high-dose chemotherapy and autologous peripheral blood stem cell transplantation (HDCT/autoPBSCT) for patients with Ewing sarcoma family of tumors. Methods: We retrospectively analyzed the data of patients who received HDCT/autoPBSCT at Korea Cancer Center Hospital. Patients with relapsed, metastatic, or centrally located tumors were eligible for the study. Results: A total of 9 patients (3 male, 6 female), with a median age at HDCT/autoPBSCT of 13.4 years (range, 7.1 to 28.2 years), were included in this study. Patients underwent conventional chemotherapy and local control either by surgery or radiation therapy, and had achieved complete response (CR, n=7), partial response (n=1), or stable disease (n=1) prior to HDCT/autoPBSCT. There was no transplant-related mortality. However, the median duration of overall survival and event-free survival after HDCT/autoPBSCT were 13.3 months (range, 5.3 to 44.5 months) and 6.2 months (range, 2.1 to 44.5 months), respectively. At present, 4 patients are alive and 5 patients who experienced adverse events (2 metastasis, 2 local recur, and 1 progressive disease) survived for a median time of 2.8 months (range, 0.1 to 10.7 months). The 2-year survival after HDCT/autoPBSCT was $44.4%{\pm}16.6%$ and disease status at the time of HDCT/autoPBSCT tended to influence survival ($57.1%{\pm}18.7%$ of cases with CR vs. 0% of cases with non-CR, P=0.07). Conclusion: Disease status at HDCT/autoPBSCT tended to influence survival. Further studies are necessary to define the role of HDCT/autoPBSCT and to identify subgroup of patients who might benefit from this investigational treatment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.57-64
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• 2020

The leading technologies of the ADAS (Advanced Driver Assist System) are ACC (Advanced Cruise Control), LKAS (Lane Keeping Assist System), and AEB (Autonomous Emergency Braking). LKAS is a system that uses cameras and infrared sensors to control steering and return to its running lane in the event of unintentional deviations. The actual test is performed for a safety evaluation and verification of the system. On the other hand, research on the system evaluation method is insufficient when an additional steering angle is applied. In this study, a model using Prescan was developed and simulated for the scenarios proposed in the preceding study. Comparative analyses of the simulation and the actual test were performed. As a result, the modeling validity was verified. A difference between the front wheels and the lane occurred due to the return velocity. The results revealed a maximum error of 0.56 m. The error occurred because the lateral velocity of the car was relatively small. On the other hand, the distance from wheels to the lanes displayed a tendency of approximately 0.5 m. This can be verified reliably.

• Korean Journal of Cognitive Science
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• v.16 no.2
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• pp.141-154
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• 2005

The purpose of this study was to investigate the effects of implicit and explicit situation awareness instruction on decision making and event related brain potentials. Psychophysiological data obtained from 36 intermediated level tennis players whose National Tennis Rating Program(NTTP) belong 2 to 2.5 were compared. Participants were randomly assigned to one of three experimental groups: (1) implicit situation awareness, (2) explicit situation awareness, and (3) control group. A total of 90 clips were presented via a beam project screen, and participants pressed one of three jelly bean buttons to indicate the direction of ball hit. Dependent measures were the latencies and amplitudes of P300 on Pz, Cz, and Fz. The results of this study indicated that participants in the implicit situation awareness produced tenser P300, than participants in the explicit situation awareness group. The findings also indicated that single defense showed longer P300 latencies than single attack as well as double defense. The P300-amplitude of treatment groups were longer than control group. The Cz area showed shorer P300 latencies than Pz and Fz areas. In addition, single defense situation demonstrated longer P300 latencies than single attack and double defence situations. Based on this study, it is believed that implicit and explicit situation awareness instruction influence decision making in different ways.