• 동의생리병리학회지
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• 제23권4호
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• pp.765-771
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• 2009

The medical informatics for clustering Sasang types with collected clinical data is important for the personalized medicine, but it has not been thoroughly studied yet. The purpose of this study was to examine the usefulness of neural network data mining algorithm for traditional Korean medicine. We used Kohonen neural network, the Self-Organizing Map (SOM), for the analysis of biomedical information following data pre-processing and calculated the validity index as percentage correctly predicted and type-specific sensitivity. We can extract 12 data fields from 30 after data pre-processing with correlation analysis and latent functional relationship analysis. The profile of Myers-Briggs Type Inidcator and Bio-Impedance Analysis data which are clustered with SOM was similar to that of original measurements. The percentage correctly predicted was 56%, and sensitivity for So-Yang, Tae-Eum and So-Eum type were 56%, 48%, and 61%, respectively. This study showed that the neural network algorithm for clustering Sasang types based on clinical data is useful for the sasang type diagnostic test itself. We discussed the importance of data pre-processing and clustering algorithm for the validity of medical devices in traditional Korean medicine.

• Genomics & Informatics
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• 제7권2호
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• pp.107-110
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• 2009

In Sasang constitutional medicine, both disease susceptibility and drug response are considered to be related to the characteristics of an individual's physiology and psychology: a theory which is central to traditional Korean medicine. Based on such observable characteristics, Sasang constitutional medicine classifies people into four constitutional types. Genetic studies of Sasang constitution would help reveal the inheritance patterns and models of the typological traits and, moreover, help with traditional medical diagnosis and treatment. To investigate the heritable aspect of Sasang constitution, we collected various pedigrees from South Korea. The study population has 101 pedigrees composed of 593 individuals. The determination of the Sasang constitution type of each individual was performed by doctors who diagnose the Sasang constitutional type of individuals as part of their professional practice. We calculated estimates of familial correlation and heritability. Parent-Offspring pairs showed the strongest familial correlation of Sasang constitutional type, with the correlation values of 0.21 and 0.28, followed by sibling pairs with the value ranging between 0.14 and 0.25. From the heritability analysis conducted with the Variance-Component method, the heritability of TE (Tae-Eum) type, SY (So-Yang) type, and SE (So-Eum) type were 55%, 41%, and 47%, respectively. This pattern of heritability was consistent with different set of analyses, which suggest the robustness of our result. Our result clearly shows that the Sasang constitution type is heritable, and further genetic analysis based on our result will shed light on the biological mechanism of Sasang constitution.

• 동의생리병리학회지
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• 제20권5호
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• pp.1089-1101
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• 2006

Following conclusions are drawn from study about Yukmigiwhangwon through referring to literatures and reviewing in the point of Hyungsang medicine. Yukmigiwhangwon was prescribed by Jeon Eul in order to cure five kinds of flaccidity of infants, but after since then it has been basically applied to symptoms which was caused by deficiency of the kidney not only infants but also adult. The deficiency of kidney is the lack of vital essence and body fluid stored in kidney, it happens because infants are born in the conditions of lack of receiving in the womb. And it happens because adults infringe the rules of life, especially the sexual life. Main symptoms of the poverty of renal functions are emptiness of the brain marrow, dizziness, forgetfulness, tinnitus, deafness, vertigo and dim eyesight, insomnia, the low back and knees aching and limping, heat on the legs, tibia aching, nocturnal emission, dry mouth, reddened tongue and little coating or non coating of the 'tongue, weak blood meridians. the treating method is nourishing Eum and supplementing kidney. In Dongeuibogam Yukmigiwhangwon is mentioned in the parts of vital essence, blood, voice, kidney, urine, eye, ear, the low back, hair, fire, exhaustion syndrome, cough, polydipsia, infant, etc. The shapes which Yukmigiwhangwon is applied to are the Dam Body Doing deficiency of Eum due to excess of Yang, man, infant, Jung type, Fish group, reverse triangular shape, big headed man, big eared man, big mouthed man, man having prominent cheekbones, man having long waist, man having big hips, man with thick hair or white hair, man with bald on the head, etc. In color it is applied to darkish complexion, flushed tip of the nose, or flushed cheek bones. Through inquiring into the clinical cases on the points of Hyungsang medicine Yukmigiwhangwon is efficacious cure to lumbago, symptoms of tendons and bones, symptoms of eyes and ears, symptoms of respiratory organs, dermatopathia, headache, polydipsia, urinary disorders, etc.

• 동의생리병리학회지
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• 제19권2호
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• pp.304-314
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• 2005

The major concept of Sasang typology is that the disease susceptibility and drug response as well as physiological characteristics are presumed to be different depending on their Sasang types. Although characterizing fundamental basis of their traits are crucial in this research field, only pathological susceptibility and physical appearances were thoroughly studied. We evaluated their physiological characteristics by tapping psychological, physical and genetic traits of each Sasang types. After determining the Sasang type of one hundred three college students based on the Questionnaire for the Sasang Constitution Classification, the psychological, physical and genetic traits of each type were analyzed with the Myers-Briggs Type Indicator (MBTI), Bioelectrical Impedance Analysis and genetic polymorphism test, respectively. Each of the Sasang types showed significantly different profiles (Generalized estimation equation, coef=11.88, z=2.13, p=0.033), and could be distinctively classified based on their MBTI scores (discriminant analysis Wilks Lambda=0.611, df=8, chi-square=36.7, p<0.001). Subjects with the So-Eum type (Introversion and Judging) and the So-Yang type (Extroversion and Perceiving) showed contrasting psychological features, however they had similar anthropometric characteristics. Subjects with the Tae-Eum type showed bigger Body Mass Index ($R^2$=0.22, df=4, 74, F=5.07, p=0.001) and body shape compared to others. Although there were no significant differences in G-protein beta-3 subunit polymorphism, angiotensin-converting enzyme polymorphism and Methylenetetrahydrofolate reductase polymprhisms among groups with Sasang types, it was shown that the dopamine system could be one for genetic marker for Sasang typology. These results demonstrated distinctive and essential traits of Sasang typology using reproducible psychometric, anthropometric and genetic evaluations. We also found that the Sasang typology was a bio-psychological typology which could show trait-specific guideline for individualized medicine.

• 사상체질의학회지
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• 제28권4호
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• pp.309-319
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• 2016

Objectives This study was aimed to analyze the reliability of vocal features and probabilities for being in Sasang constitutional types calculated from Sasang constitutional voice diagnosis system according to operator presence. Methods We acquired 96 voice recordings from one male and one female for 4 days. For the first 2 days, the subjects recorded their voice by themselves. For the last 2 days, they recorded according to the instruction of an operator following the standard operating procedure. We analyze the standard deviations of vocal features, probabilities for being three constitutional types, Tae-Eum (TE), So-Yang (SY), and So-Eum (SE) Results In the case of the female, coefficients of variations of the voice variables and the probabilities for being each constitutional type were all within 20%. In the case of the male, coefficients of variations were all within 20% except one variable. Even if there was no instruction from the operator, standard deviations of the probability did not increase for both genders. When recorded without the operator, for male, the probability for being SE decreased by 3.2%. For female, the probability for being TE increased by 5.438%, and that of SE decreased by 3.057%, and that of SY decreased by 2.394%. Conclusions When recorded without operators, for men, there was a significant difference in the probability for being SE. And for women, there were significant differences in the probabilities for all constitutional types.

• 사상체질의학회지
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• 제30권4호
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• pp.33-52
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• 2018

Objectives The purpose of this study was to analyze the clinical characteristics of patients with hyperhidrosis who visited a Korean medicine hospital, and provide information on treated hyperhidrosis, based on Sasang Constitutional medicine. Methods A retrospective review was made of the electronic medical record (EMR) charts for 157 Korean patients with hyperhidrosis (90 male, 67 female), who first visited hospital from January 1, 2013 to December 31, 2017. The following information was collected: sex, age, height, weight, body mass index (BMI) and clinical data (diagnosis, area of onset, duration of illness, aggravating factors, medication, healing process, et al). Results There were many patients with hyperhidrosis, in the other of So-Yang type (57.3%), Tae-Eum type (35.0%) and So-Eum type (7.6%). The proportion of male was higher than female. The most common area of hyperhidrosis was hands and feet (44.0%), followed by generalized whole body (27.4%) and head and face (25.5%). The cure rate of hyperhidrosis was 32.2%, and effectiveness rate of that was 72.7%. In individual patients, the better the usual health condition expressed by original symptoms, the higher the possibility of treatment success, with shortened duration of treatment and reduced total drug dose. The most frequent treatment modality in patients was that consistently improved, and this duration of treatment was statistically significantly shorter than that experienced worsening of excessive sweating during treatment period (p<0.001). Conclusions This study provides some original information on the Korean patients with hyperhidrosis, and suggests the suitability of Sasang Constitutional medicine as treatment methods for hyperhidrosis.

• 혜화의학회지
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• 제16권1호
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• pp.31-40
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• 2007

Hominis placenta have been studied as herbal acupuncture because of it's limitation of use. The properties of Hominis placenta are warm and supplement of Jeong-Hyeol, Jin-Ki and I thought that Hominis placenta have various effectiveness. So I considered Hominis placenta in Dong-Eui-Bo-Gam which is famous comprehensive korean traditional medical book. Hominis placenta was mentioned parts of Sin, Chung, Hwa, Heo-Ro, Bu-In and most of them are mentioned in Heo-Ro part. As a source book, Eui-Hak-Ib-Mun was used the most. Prescription used in various parts as mental disease, forgetfulness, tuberculosis, fever, various malnutrition disease, sterility, but it's basic principle action is all supplement of Heo-Ro. In management of Hominis placenta, most useing method is heating with steam and most of additional medicinal stuffs had action of supplying Eum, Yang, Ki, Hyeol in composition of prescription.

• 동아시아식생활학회지
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• 제14권3호
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• pp.196-206
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• 2004

The medicinal effects of 107 grains in $\boxDr$Dongeuebogam$\boxUl$ were studied for the development of healthy Korean traditional meal. Their efficacy, way of use, fact of taboo were mentioned in it. Grains were utilized and processed as tang(soup), jook(porridge), boonmal(powder), kunjo(drying), etc. Most of grains had sweet taste and mild nature(not hot and not cold) based on Eum-Yang-Oh-Haeng theory. The medicinal effects of grains described in $\boxDr$Dongeuebogam$\boxUl$ were the protection of stomach and intestine, enhancement of physical activity, protection of hair and skin, thirst elimination, treatment of several diseases, maintenance of health, etc.

• 동의생리병리학회지
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• 제18권6호
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• pp.1892-1895
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• 2004

The purpose of this study was to investigate the personality traits in constitutional types. The Questionnaire for the Sasang Constitution Classification Ⅱ and Eysenck Personality Questionnaire were completed by 155 university students. Statistical analyses of the Questionnaire for the Sasang Constitution Classification Ⅱ and Eysenck Personality Questionnaire scale scores and results are as follows : First, Personality differences in constitutional types are revealed significantly with respect to Eysenck Personality Questionnaire scales such as neuroticism, addiction, and criminality. Second, there is a significant difference between Eum(음) type and Yang(양) type along psychoticism and neuroticism. Third, sex difference is significant along the dimension of extraverion-intraversion.

• 대한한의학원전학회지
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• 제27권3호
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• pp.183-188
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• 2014

Objectives : The Phrase, Ki goes to Essence and Essence goes to Change in Eumyangeungsangdaeron in Suwen have contradiction in direction of Ki. Because this phrase linked to relation of Taste, Shape, Ki, Essence and Change, each others are supposed to be treated systematically. Methods : We will review on annotations of past doctors and new opinions of resent scholars. Results : Ki has two meanings in this phrase ; Ki of food and Ki of ability in human nature. Conclusions : From the Taste through Shape to Ki of food are the way of Eum aspect and from the Ki of ability through Essence to Change are the way of Yang aspect.