• Title/Summary/Keyword: Ets-1

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Ets-1 enhances tumor migration through regulation of CCR7 expression

  • Fang, Li-Wen;Kao, Ying-Hsien;Chuang, Ya-Ting;Huang, Huey-Lan;Tai, Tzong-Shyuan
    • BMB Reports
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    • v.52 no.9
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    • pp.548-553
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    • 2019
  • Ets-1 is a prototype of the ETS protein family. Members of the ETS protein family contain a unique ETS domain. Ets-1 is associated with cancer progression and metastasis in many types of cancer. Many studies have shown a link between elevated expression of Ets-1 in cancer biopsies and poor survival. CCR7 is a chemokine that binds to specific ligand CCL21/CCL19. CCR7 expression is associated with tumor metastasis and infiltration into lymph nodes. The objective of this study was to test whether Ets-1 could regulate CCR7 expression and enhance tumor metastasis. Our data showed that CCR7 expression was downregulated in Ets-1-deficient T cells upon T-cell stimulation. Overexpression of Ets-1 increased CCR7 expression in breast cancer cell lines. In contrast, knockdown of Ets-1 reduced CCR7 expression. Ets-1 could directly bind to CCR7 promoter and mediate CCR7 expression in luciferase reporter assays and chromatin immunoprecipitation assays. Transactivation activity of Ets-1 was independent of the Pointed domain of Ets-1. Ets-1 could also enhance $NF-{\kappa}B$ and CBP transactivation of CCR7 promoter. Our results also showed that Ets-1 could modulate cancer cell transmigration by altering CCR7 expression in transwell assay and wound healing assay. Taken together, our data suggest that Ets-1 can enhance CCR7 expression and contribute to tumor cell migration.

The physicochemical Characterization of ETS (Environmental Tobacco Smoke) (Environmental Tobacco Smoke의 이화학적 특성)

  • 이문수
    • Journal of the Korean Society of Tobacco Science
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    • v.17 no.1
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    • pp.79-97
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    • 1995
  • On the basis of the literature, which is at present still scientific information improvable, the results of research done so far into the occurrence and analytical methodology of major markers of environmental tobacco smoke(ETS) have been summarized. Key areas addressed are: differences in physicochemical composition between mainstream smoke, sidestream smoke and ETS: techniques for field measurement of ETS: relationship between indoor air quality with ETS and its distribution view of US EPA and its problems: biological effects and concerning estimation of ETS exposure.

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The Effects of Initial pH on the Crystallization of Zeolitic ETS-Series (초기 pH가 제올라이트성 ETS-계열의 결정화반응에 미치는 영향)

  • Kim, Wha Jung;Kim, Youn Sang
    • Applied Chemistry for Engineering
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    • v.9 no.1
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    • pp.33-37
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    • 1998
  • The effects of initial pH on the synthesis of new microporus zeolitic materials, ETS-4 and ETS-10 were investigated with the initial pH from 10.4 to 11.5. The results showed that initial pH significantly affect the type of ETS-series materials to be crystallized ; that is, pure ETS-10 at 10.4 of pH, mixture of ETS-10 and ETS-4 at intermediate pH, and pure ETS-4 at pH. Micrographs show that the morphology of final solid product changes from the shape contacting the bottom sides of two truncated pyramids to the plane-like shape as initial pH increases.

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밀폐된 공간에서 환기에 의한 ETS 성분 제거

  • 황건중;이문수;나도영
    • Journal of the Korean Society of Tobacco Science
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    • v.21 no.1
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    • pp.102-108
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    • 1999
  • This study was conducted to evaluate the ventilation to remove gases, vapor and particles of environmental tobacco smoke(ETS) in a closed room. The ventilation rate choosed were 0.445 ㎥/min, 0.528 ㎥/min, and 0.625 ㎥/min. ETS components measured were total suspended particle(TSP), ultraviolet particulate matter(UVPM), fluorescent particulate matter(FPM), solanesol, carbon dioxide($CO_2$), carbon monoxide(CO), nicotine, and 3-ethenylpyri-dine(3-EP). The concentration of ETS components measured rapidly decreased as increasing ventilation rate, but the removal efficiency by ventilation was different from each ETS compounds. The $CO_2$, and CO, gaseous components of ETS, were dominant components to be removed from the room by ventilation. The ventilation with 0.528 ㎥/min for 1 hr was enough to remove over 99% of those gaseous components. Nicotine and 3-EP needed the ventilation for 2 hrs to reduce over 95 % of those components. As the same ventilation rate, 99 % of TSP and solanesol concentration were removed from the room within 2 hrs, UVPM and FPM concentration decreased 90 %.

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A Study of the International Dispute on EU ETS Aviation Directive (EU ETS 항공 부분 지침에 따른 국제 분쟁에 관한 소고)

  • Hur, Yun-Seok;Pak, Myong-Sub;Woo, Jung-Wouk;Youn, Jae-Woong
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.54
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    • pp.261-282
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    • 2012
  • The European Union (EU) has introduced the EU Emissions Trading Scheme (EU ETS) as one of the key policies to reduce the level of greenhouse gas emissions and in July 2008, they decided to include aviation in the scheme. As soon as the decision was announced the EU ETS was met by sharp opposition from world governments and international aviation. A group of US airlines, in particular, dropped a lawsuit against the British government over aviation's inclusion in the EU ETS. On 21 December, the Court of Justice of the European Union (CJEU) ruled that aviation's inclusion in the EU ETS which covers all flights arriving into and departing from the EU is legal and does not contravene international law. The scheme eventually came into effect on 1 January 2012. However, most countries are in opposition to the EU ETS and have agreed on counter-measures to undermine the EU's plan which may bring chaos to the aviation industry if such measures were to put into practice. This study therefore will analyze the likely effects that may be brought to the Korean aviation industry as a result of the inclusion of aviation in the EU ETS. Further, it hopes to contribute to the Korean aviation industry by studying other countries' counter-measures in advance.

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The Effects of Open Endotracheal Suctioning(ETS) and Close ETS on Oxygen Saturation and Heart Rate in Premature Infants with Respiratory Distress Syndrome (개방형과 폐쇄형 기관지 흡인술이 호흡곤란 미숙아의 산소포화도와 심박동수에 미치는 영향에 대한 비교연구)

  • 김미순;안영미;박인옥;최숙자;유미영
    • Journal of Korean Academy of Nursing
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    • v.28 no.3
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    • pp.529-539
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    • 1998
  • Prematurity is the main cause for respiratory distress syndrome (RDS) in neonates. The goal in the treatment of RDS is to maintain respiration with adequate oxygenation. ETS needs to be performed to remove lung secretions in the ventilated premature infants with RDS. Oxygen saturation(SpO$_2$) and heart rate(HR) were compared in 22 premature infants with RDS using two types of ETS : open ETS versus close ETS. The results showed there was no significant difference in the SpO$_2$ and HR responses between open ETS and close ETS. The SpO$_2$ and HR returned to the baseline within 1 minute after suctioning. But in some case, there was a significantly greater incidence in the decrease of SpO$_2$ below 90% occured in the open ETS than in the close ETS. It implies that closed ETS may be beneficial to the premature infants who tend to develop desaturation easily.

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Status of Korea ETS and Strategies to improve in One Year After Launching - Through Comparing with EU ETS - (한국의 탄소배출권 거래제 시행 1년 후 현황과 개선방안 - EU 배출권 거래제와 비교를 통하여 -)

  • Chae, Jong Oh;Park, Sun-Kyoung
    • Journal of Climate Change Research
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    • v.7 no.1
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    • pp.41-48
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    • 2016
  • Korea has introduced Korea Emissions Trading Scheme (Korea ETS) since 2015. However, not many companies voluntarily participate in the emissions trading. The goal of this paper is to provide the way to improve the Korea ETS. This study compares the Korea ETS with EU Emissions Trading System, which has been practiced for a decade, and suggests three strategies to activate the Korea Emissions Trading Scheme. The first thing is to encourage more companies to participate in the emissions trading since the number of companies in the emissions trading in Korea is quite limited compared with that of EU. The second thing is to activate the trading of Korean Credit Unit in order to stimulate various emission reduction mechanisms. Currently, the most of the trading in the emissions market is through the Korean Allowance Unit. The third thing is to establish concrete measures to continuously improve the Korea ETS. A comprehensive evaluation of the Korea ETS is needed along with the ongoing convergence with the associated comments. The improvement of Korea ETS would be one of the most efficient ways to compete the climate change, and would also play a role to raise the status of Korea.

The effect of international linkage of emissions trading markets on Korean industries (배출권거래제의 국제적 적용이 한국산업과 무역에 미치는 효과)

  • Kyungsoo Oh
    • Korea Trade Review
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    • v.47 no.1
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    • pp.115-130
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    • 2022
  • In this study, I focus on analyzing how the effects of implementing ETS are different depending on whether Korean ETS linking with carbon markets in other countries. The global computable general equilibrium (CGE) model built in this study analyzes the chages in the production and trade of industrial sectors according to the international linkage of ETS compared to the reference scenario of emissions reduction targets and implementation of ETS. From the analysis of internatioanl linkage of carbon markets scenarios, Annex B countries-South Korea carbon market linkage with individual ETS in China worse the economic outcomes in South Korea the most. This means South Korea lose the international competitiveness compared to China in this scenario. On the other hand, Annex B-China carbon market linkage with Korean individual ETS implementation reduce the decreases in production and trading. The most effective way is to join a global emissions trading market with China. The results are consistent in most industries of South Korea. These results are caused by that the supply of emission allowance is increased and the price of emissions allowances is dropped by China's participation to the carbon market, which can be understood to reduce the carbon reduction cost for industrial sectors. In addition, it can be also concluded that the determinant of the negative impact of ETS on changes in production and trade is more sensitive to the price of emissions allowances than to the characteristics of production and trade structure.

A Study of Policy Change on K-ETS and its Objective Conformity (한국 배출권거래제 정책 변동의 목적 부합성 연구)

  • Oh, Il-Young;Yoon, Young Chai
    • Journal of Climate Change Research
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    • v.9 no.4
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    • pp.325-342
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    • 2018
  • The Korea Emissions Trading Scheme ( K-ETS), which manages roughly 70% of the greenhouse gas emissions in South Korea, was initiated in 2015, after implementation of its 1st basic plan and the 1st allocation plan (2014) for the 1st phase (2015-2017). During the three and a half years since the launch of K-ETS, there have been critical policy change such as adjustment of the institutions involved, development and revision of the 2030 national GHG reduction roadmap, and change in the allocation plans. Moreover, lack of liquidity and fluctuation of carbon prices in the K-ETS market during this period has forced the Korean government to adjust the flexibility mechanism and auction permits of the market stability reserve. To evaluate the policy change in the K-ETS regarding conformance to its objectives, this study defines three objectives (Environmental Effectiveness, Cost Effectiveness and Economic Efficiency) and ten indicators. Evaluation of Environmental Effectiveness of K-ETS suggests that the national GHG reduction roadmap, coverage of GHG emitters and credibility of MRV positively affect GHG mitigation. However, there was a negative policy change implemented in 2017 that weakened the emission cap during the 1st phase. In terms of the Cost Effectiveness, the K-ETS policies related to market management and flexibility mechanism (e.g. banking, borrowing and offsets) were improved to deal with the liquidity shortage and permit price increase, which were caused by policy uncertainty and conservative behavior of firms during 2016-2018. Regarding Economic Efficiency, K-ETS expands benchmark?based allocation and began auction-based allocation; nevertheless, free allocation is being applied to sectors with high carbon leakage risk during the 2nd phase (2018-2020). As a result, it is worth evaluating the K-ETS policies that have been developed with respect to the three main objectives of ETS, considering the trial?and?error approach that has been followed since 2015. This study suggests that K-ETS policy should be modified to strengthen the emission cap, stabilize the market, expand auction-based allocation and build K-ETS specified funds during the 3rd phase (2021-2025).

Effect of Anion Generating Air Cleaner on the Components of ETS in a Closed Room (음이온 발생 공기청정기에 의한 밀폐된 실내공간에서의 ETS성분 변화)

  • Hwang, Keon-Joong;Rhee, Moon-Soo;Ra, Do-Young
    • Journal of the Korean Society of Tobacco Science
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    • v.20 no.1
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    • pp.124-130
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    • 1998
  • This study was conducted to evaluate the ability of anion generating air cleaner to remove gases, vapor and particles from closed room contaminated with environmental tobacco smoke (ETS). The measurements covered particle sizes of 13.8-542.5nm, particle concentration, surface area, volumes UVPM, FPM, solanesol, and the following gases and vapor; carbon dioxide, carbon monoxide, nicotine, and 3-ethenylpyridine. Tobacco smoke was generated and mixed in a closed room in which the airflow rates were in the range of 0.00-0.04 m/s. The anion generating air cleaner was startedl and the decay rates for the gases, vapor and particles were measured, When the use of anion generating air cleaner, solid components of ETS, such as respirable suspended particle (RSP), utraviolet particulate matter (UVPM, fluorescent particulate matter (FPM) and solanesol was sharply decreased, and vapor phase components of ETS, such as nicotines 3-ethenylpyidine were modelately decreased by time elapse. Even the use of anion generation air cleaner, the decreasing rate of carbon dioxide concentration was similar with control, and the decreasing rate of carbon monoxide was slower than that of control. Our results indicated that the use of anion generting air cleaner had an effect on reduction of solid and vapor components from ETs, but it had no effect on gaseous components of ETS.

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