• 대한한방내과학회지
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• 제19권2호
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• pp.88-106
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• 1998

This study was designed to elucidate the antiinflammatory, cardiovascular, antithrombotic, and analgesic effect of Sambitang. The antiinflammatory effects was measured by the method of carrageenin induced edema, protein leakage test using CMC-pouch, and the effect of Sambitang on the cardiovascular system was observed by the change of flow rate of Ringer solution in the vascular system in the ear of rabbit, and the contraction and dilatation of rat tail artery. Death rate, platelet aggregation, plasma coagulation activity was observed for the measurement of the anticoagurative effect of Sambitang, and the analgesic effect was measured by the acetic acid method and hot plate method. The result was as follows: 1. Sambitang administration, edema and protein leakage was significantly decreased. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which was led to thromboembo- lism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The slight anagesic effect of Sambitang extract was confirmed by the observation of writhing syndrome, paw licking time, and escape time.

• 생약학회지
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• 제51권1호
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• pp.70-77
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• 2020

Mentha arvensis is used traditional medicine to treat various disorders. In the present study, M. arvensis were extracted by the solid-phase microextraction (SPME) method and analyzed by gas chromatograph-mass spectrometry (GC-MS). We investigated the protective effects and mechanisms of a M. arvensis extract on scopolamine-induced cognitive and memory impairment. Mice were orally pretreated with a M. arvensis extract or normal saline, and then behavior tests were conducted 30 min after scopolamine injection. The antioxidant capacities were analyzed by free radical scavenging (DPPH and ABTS). Acetylcholinesterase (AChE) activity were also measured using Ellman's method ex vivo test. In behavior tests, percent of spontaneous alteration, escape latency and swimming time in target quadrant were improved by the administration of the M. arvensis extract, which suggests that the M. arvensis extract improves memory function in the scopolamine-treated mice model. In addition, M. arvensis extract showed inhibition of the free radical and AChE activity. The results of the present study suggest that the M. arvensis extract ameliorates scopolamine-induced cognitive and memory deficits through the inhibition of free radicals and AChE activity. Therefore, M. arvensis may be a promising neuroprotective agent for management of learning and memory improvements in human dementia patients.

• 한국화재소방학회논문지
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• 제24권5호
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• pp.79-86
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• 2010

본 연구는 국내 고층건물 특별피난계단의 부속실에 설치되는 급기가압 제연시스템의 방연 풍속 기류 가화재 발생 시 피난을 위하여 출입문이 개방되었을 경우 거실 방향으로 정상적으로 형성되지 않고 부속실 내부로 역류되는 현상을 개선하기위해 실 모형실험을 통해 출입구 상부로 역류하지 않는 조건을 개발하였다. 부속실 바닥 면적이 $2m^2$와 $4m^2$인 두개의 실물 모형을 제작하여 실험을 실시한 결과, 방연풍속의 기류 특성은 바닥 면적이 $2m^2$인 경우 심하게 출입문 상부로 기류가 역류되었다. 다만, 급기댐퍼의 설치위치가 출입문 맞은편의 경우 날개각도가 45도 상향인 경우는 출입문 상부로는 역 기류 현상은 없었지만 하부로는 일부 역류 되었다. 부속실 면적이 $4m^2$ 인 경우는 출입문에서 거실방향으로 정상적인 기류 분포를 보였다. 부속실 바닥 면적이 작게 설계될 경우에는 성능위주 설계가 될 수 있도록 하여야 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3815-3819
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• 2012

The CD4+CD25+ regulatory T cell (Treg) is a special kind of T cell subset. Studies have showed that Treg cells are involved in a number of physiological processes and pathologic conditions such as autoimmune diseases, transplantation tolerance and cancer. Tregs with unique capacity for immune inhibition can impair anti-tumour immunity and help tumor cells to escape from immune surveillance. The aim of our study was to investigate whether Tregs are involved in hepatocellular carcinoma (HCC). A BABL/C mouse with HCC in situ model was established to evaluate the Treg existence in carcinoma tissues and the changes of Tregs in spleen using flow cytometry and immunohistochemistry methods. Granzyme B expression in carcinoma tissues was analyzed by immunohistochemistry to investigate the tumor local immune status.The proportion of CD4+CD25+/CD4+ spleen lymphocytes of tumor bearing mice ($18.8%{\pm}1.26%$) was found to be significantly higher than that in normal mice ($9.99%{\pm}1.90%$) (P<0.01 ). Immunohistochemistry of spleen tissue also confirmed that there was an increase in Treg in tumor-bearing mice, while in carcinomas it showed Treg cells to be present in tumor infiltrating lymphocyte areas while Granzyme B was rarely observed. Anti-tumour immunity was suppressed, and this might be associated with the increase of Tregs. Our observations suggest that the CD4+CD25+Treg/CD4+ proportion in spleen lymphocytes can be a sensitive index to evaluate the change of Tregs in hepatocellular carcinoma mice and the Treg may be a promising therapeutic target for cancer.

• Journal of Ginseng Research
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• 제31권1호
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• pp.44-50
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• 2007

Ginseng powerfully tonifies the original Qi. Ginseng used for insomnia, palpitations with anxiety, restlessness from deficient Qi and blood and mental disorientation. In order to investigate whether Ginseng cerebral ischemia-induced neuronal and cognitive impairments, we examined the effect of Ginseng on ischemia-induced cell death in the hippocampus, and on the impaired learning and memory in the Morris water maze and passive avoidance in rats. Ginseng when administered to rat at a dose of 200 mg/kg i.p. water extracts to 0 minutes and 90 minutes after 4-VO, significantly neuroprotective effects by 86.4% in the hippocampus of treated rats. For behavior test, rats were administered Ginseng (200mg/kg p.o.) daily for two weeks, followed by their training to the tasks. Treatment with Ginseng produced a marked improvement in escape latency to find the platform in the Morris water maze. Ginseng reduced the ischemia-induced learning disability in the passive avoidance. Consistent with behavioral data, treatments with Ginseng reduced jschemia-induced cell death in the hippocampal CA1 area. Oxidative stress is a causal factor in the neuropathogenesis of ischemic-reperfusion injury. Oxidative stress was examined in a rat model of global brain ischemia. The effects of Ginseng on lipid peroxidation (inhibition of the production of malondialdehyde, MDA) in different regions of the rat brain were studied. Ferrous sulfate and ascorbic acid (FeAs) were used to induce lipid peroxidation. The antiperoxidative effect showed 48-72% protection from tissue damage as compared with untreated animals. These results showed that Ginseng have a protective effect against ischemia-induced neuronal loss and learning and memory damage.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권9호
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• pp.3231-3249
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• 2014

Deniable encryption, introduced in 1997 by Canetti, Dwork, Naor, and Ostrovsky, guarantees that the sender or the receiver of a secret message is able to "fake" the message encrypted in a specific ciphertext in the presence of a coercing adversary, without the adversary detecting that he was not given the real message. Sender - side deniable encryption scheme is considered to be one of the classification of deniable encryption technique which defined as resilient against coercing the sender. M. H. Ibrahim presented a sender - side deniable encryption scheme which based on public key and uncertainty of Jacobi Symbol [6]. This scheme has several problems; (1) it can't be able to derive the fake message $M_f$ that belongs to a valid message set, (2) it is not secure against Quadratic Residue Problem (QRP), and (3) the decryption process is very slow because it is based dramatically on square root computation until reach the message as a Quadratic Non Residue (QNR). The first problem is solved by J. Howlader and S. Basu's scheme [7]; they presented a sender side encryption scheme that allows the sender to present a fake message $M_f$ from a valid message set, but it still suffers from the last two mentioned problems. In this paper we present a new sender-side deniable public-key encryption scheme with fast decryption by which the sender is able to lie about the encrypted message to a coercer and hence escape coercion. While the receiver is able to decrypt for the true message, the sender has the ability to open a fake message of his choice to the coercer which, when verified, gives the same ciphertext as the true message. Compared with both Ibrahim's scheme and J. Howlader and S. Basu's scheme, our scheme enjoys nice two features which solved the mentioned problems: (1) It is semantically secure against Quadratic Residue Problem; (2) It is as fast, in the decryption process, as other schemes. Finally, applying the proposed deniable encryption, we originally give a coercion resistant internet voting model without physical assumptions.

• Nuclear Engineering and Technology
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• 제47권7호
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• pp.791-803
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• 2015

The effective cross sections (XSs) in the direct whole core calculation code nTRACER are evaluated by the equivalence theory-based resonance-integral-table method using the WIMS-based library as an alternative to the subgroup method. The background XSs, as well as the Dancoff correction factors, were evaluated by the enhanced neutron-current method. A method, with pointwise microscopic XSs on a union-lethargy grid, was used for the generation of resonance-interference factors (RIFs) for mixed resonant absorbers. This method was modified by the intermediate-resonance approximation by replacing the potential XSs for the non-absorbing moderator nuclides with the background XSs and neglecting the resonance-elastic scattering. The resonance-escape probability was implemented to incorporate the energy self-shielding effect in the spectrum. The XSs were improved using the proposed method as compared to the narrow resonance infinite massbased method. The RIFs were improved by 1% in $^{235}U$, 7% in $^{239}Pu$, and >2% in $^{240}Pu$. To account for thermal feedback, a new feature was incorporated with the interpolation of pre-generated RIFs at the multigroup level and the results compared with the conventional resonance-interference model. This method provided adequate results in terms of XSs and k-eff. The results were verified first by the comparison of RIFs with the exact RIFs, and then comparing the XSs with the McCARD calculations for the homogeneous configurations, with burned fuel containing a mixture of resonant nuclides at different burnups and temperatures. The RIFs and XSs for the mixture showed good agreement, which verified the accuracy of the RIF evaluation using the proposed method. The method was then verified by comparing the XSs for the virtual environment for reactor applicationbenchmark pin-cell problem, as well as the heterogeneous pin cell containing burned fuel with McCARD. The method works well for homogeneous, as well as heterogeneous configurations.

• Journal of the Korean Data Analysis Society
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• 제20권6호
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• pp.3069-3085
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• 2018

본 연구에서는 구직기간과 근속기간에 미치는 비인지적 요인의 영향을 살펴보았다. 한국노동연구원의 노동패널 18차 삶의 인식에 대한 부가조사자료에는 개인의 비인지적 특성을 묻는 질문 문항이 들어있다. 노동패널자료를 사용하여 big5 성격특성과 통제소재 변인에 대한 내적일치도를 살펴보고, 분석방법으로는 구직기간과 근속기간 등 절단(censored)이 있는 표본을 포함하고 있는 자료의 분석에 적합한 비례위험해저드모형을 사용하였다. 추정결과 성격특성과 통재소재 등 비인지적 요인이 개인의 노동시장 성과에 영향을 미치는 것을 확인하였다. 구직기간 분석에서 성격요인 중 성실성이 성인구직자의 구직기간을 길게 하여 실업탈출률을 낮추는 것으로 나타났다. 이는 실업과 같은 불확실한 상황에서는 성실성으로 표현되는 신중함이 구직에 필요한 정보해석을 잘못하거나 왜곡할 수 있고, 결단성의 결여로 실업탈출에 제약이 되는 것으로 보인다. 근속기간 분석에서는 내적통재 소재자의 경우 근속기간이 길어 직장이탈가능성이 낮았다. 내적통재소재자는 내가 열심히 하면 조직에서 성공과 승진이 가능하다고 믿는 경향이 강하기 때문에 조직에 의해 더 선호될 수 있으며, 내적통제 경향이 강할수록 스스로의 행동에 대한 동기부여와 자제심이 크기 때문에 한 직장에 오래 머물 수 있는 요인이 되는 것으로 보인다.

• Journal of Korean Biological Nursing Science
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• 제21권3호
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• pp.217-223
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• 2019

Purpose: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence. Methods: The animals were divided into three groups: a "vehicle" group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a "Day 1" group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a "Day 14" group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats'activity levels, anxiety, and cognitive function. Results: High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition. Conclusion: These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety-like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.

• 한국의류산업학회지
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• 제22권6호
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• pp.752-761
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• 2020

This study analyzes the type of preferred shopping items based on tourism shopping value pursued by tourists through shopping at travel destinations as well as verifies their impact on satisfaction. A survey on 310 adult men and women aged 20 to 69 collected data samples representing tourism shoppers in Korea. Based on the collected data, a factor analysis and a structural model equation analysis were performed using SPSS 25.0 and AMOS. Tourism shopping value was divided into functional value, emotional value, exploratory value, and shared value. In addition, shopping items were categorized as physical materials and experience materials to identify the difference in preferred item types according to the value that tourists perceive. It also confirmed the adjustment effect of tourism motivation that affects tourism shopping behavior. According to the analysis results, the more tourists perceive functional and emotional values when shopping, the more physical material they prefer, and the more they perceive exploratory values, the higher the preference for experience goods. However, the shared value affected both physical materials and experience materials. Based on escape-seeking motivation, the adjustment effect of tourism motivation (a major variable to understand the behavior of tourists) on tourism shopping behavior was confirmed. Based on the academic and practical implications of this study, we hope to broaden our understanding of tourism shopping and revitalize research on tourism shopping.