• Molecules and Cells
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• v.45 no.10
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• pp.749-760
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• 2022

Osteoclast generation from monocyte/macrophage lineage precursor cells needs to be tightly regulated to maintain bone homeostasis and is frequently over-activated in inflammatory conditions. PARK2, a protein associated with Parkinson's disease, plays an important role in mitophagy via its ubiquitin ligase function. In this study, we investigated whether PARK2 is involved in osteoclastogenesis. PARK2 expression was found to be increased during the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. PARK2 gene silencing with siRNA significantly reduced osteoclastogenesis induced by RANKL, LPS (lipopolysaccharide), TNFα (tumor necrosis factor α), and IL-1β (interleukin-1β). On the other hand, overexpression of PARK2 promoted osteoclastogenesis. This regulation of osteoclastogenesis by PARK2 was mediated by IKK (inhibitory κB kinase) and NF-κB activation while MAPK (mitogen-activated protein kinases) activation was not involved. Additionally, administration of PARK2 siRNA significantly reduced osteoclastogenesis and bone loss in an in vivo model of inflammatory bone erosion. Taken together, this study establishes a novel role for PARK2 as a positive regulator in osteoclast differentiation and inflammatory bone destruction.

• Journal of The Korean Society of Agricultural Engineers
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• v.65 no.3
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• pp.29-42
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• 2023

Universal Soil Loss Equation (USLE) is suggested and employed in the policy to conserve soil resources and to manage the impact of development, since soil loss is very essential to nonpoint source pollution management. The equation requires only five factors to estimate average annual potential soil loss, USLE is simplicity provides benefits in use of the equation. However, it is also limitation of the model, since the estimated results are very sensitive to the five factors. There is a need to examine the application procedures. Three approaches to estimate potential soil loss were examined, In the first approach, all factors were prepared with raster data, soil loss were computed for each cell, and sum of all cell values was determined as soil loss for the watersheds. In the second approach, the mean values for each factor were defined as representing USLE factors, and then the five factors were multiplied to determine soil loss for the watersheds. The third approach was same as the second approach, except that the Vegetative and Mechanical measure was used instead of the Cover and management factor and Support practice factor. The approaches were applied in 38 watersheds, they displayed significant difference, moreover no trends were detected for the soil loss at watersheds with the approaches. Therefore, it was concluded that there is a need to be developed and provided a typical guideline or public systems so that soil loss estimations have consistency with the users.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.199-199
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• 2022

선행 연구들을 통해 미세지형이 유역에서의 유사 유출량에 영향을 끼침을 알 수 있다. 그러나 여전히 유사-유출에 대한 미세지형의 영향이 불분명하여 유역 내 토양 침식 과정에서 미세지형적 거칠기를 고려할 때 혼란이 야기될 수 있다. 따라서, 유사유출량과 토양침식량에 대한 보다 정확한 예측 및 산정을 위해 미세지형이 토양 침식에 미치는 영향을 명확하게 하는 것이 필요하다. 본 연구에서는 Hairsine-Rose 침식 모형과 동역학파(Dynamic wave) 모형을 사용하여 강우-유출에 따른 미세지형의 유사-유출 과정을 수치적으로 모의하였다. 모의 결과에 따르면, 미세지형은 동일 강우 및 유출 조건에서도 유역 내 유사 유출량을 변화시켰다. 또한, 본 연구의 모의조건 하에서 지반이 비교적 미세토사로 구성된 경우 미세지형이 거칠수록 침식률이 증가하는 반면 지반의 토사가 대부분 굵은 입경을 가질 때는 매끄러운 지형보다 거친 미세지형에서 토양 침식률이 감소함을 확인하였다. 따라서, 지형의 미세지형 변동 정도와 토양침식률 사이에 비례 또는 반비례 관계가 형성됨을 보이고, 이러한 관계를 형성하는 과정에 입경 분포가 미치는 영향을 제시하였다. 마지막으로, 본 연구 결과를 통해 장갑화(armoring) 과정이 입경 분포뿐만 아니라 미세지형의 거칠기에 따라 유역별로 다르게 나타나는 것을 확인하였다. 따라서 유사-유출에 대한 미세지형의 영향을 적절하게 고려하기 위해 부상(Pick-up), 이류 및 퇴적 등 입경 별 퇴적물 이동이 다중 물리적으로 고려되어야 한다는 점을 강조한다. 본 연구를 통해 지표면의 미세지형적 거칠기 및 토양 입경에 대한 정확한 정보가 필요함을 알 수 있으며, 이를 충분히 고려한다면 강우 유출에 의한 토양 침식 메커니즘에 대한 이해도와 토양침식량에 대한 정량적 예측의 정확도가 향상될 것으로 예상된다.

• Restorative Dentistry and Endodontics
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• v.47 no.3
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• pp.29.1-29.10
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• 2022

Objectives: This study aimed to investigate the anti-erosive/abrasive effect of resin infiltration of previous deproteinized dentin. Materials and Methods: Dentin slabs were randomly assigned to 3 groups (n = 15): Control (no deproteinization; no resin infiltrant applied), RI (no deproteinization; resin infiltrant applied), and DRI (deproteinization; resin infiltrant applied). After undergoing the assigned treatment, all slabs were subjected to an in vitro cycling model for 5 days. The specimens were immersed in citric acid (0.05 M, pH = 3.75; 60 seconds; 3 times/day) and brushed (150 strokes). Between the challenges, the specimens were exposed to a remineralizing solution (60 minutes). The morphological alterations were analyzed by mechanical profilometry (㎛) and scanning electron microscopy (SEM). Data were submitted to one-way analysis of variance (ANOVA) and Tukey tests (p < 0.05). Results: Control and RI groups presented mineral wear and did not significantly differ from each other (p = 0.063). DRI maintained a protective layer preserving the dentin (p < 0.001). After erosive/abrasive cycles, it was observed that in group RI, only 25% of the slabs partially evidenced the presence of the infiltrating, while, in the DRI group, 80% of the slabs presented the treated surface entirely covered by a resin-component layer protecting the dentin surface as observed in SEM images. Conclusions: The removal of the organic content allows the resin infiltrant to efficiently protect the dentin surface against erosive/abrasive lesions.

• Tribology and Lubricants
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• v.40 no.4
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• pp.111-117
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• 2024

Due to global CO₂ emission reductions and fuel efficiency regulations, the trend toward transitioning from internal combustion engine vehicles to electric vehicles (EVs) has accelerated. Consequently, the problem of EV failures has become a focal point of active research. The parasitic capacitance generated during motor-shaft rotation induces voltage that deteriorates the raceway and ball surfaces of bearings, causing electrical damage in EVs. Despite numerous attempts to address this issue, most studies have been conducted under high viscosity lubricant and low load conditions. However, due to factors such as high-speed operation, rapid acceleration and deceleration, motor heating, and motor system-decelerator integration, current EV applications have shown diminished stability in lubrication films of motor bearings, thereby leveraging the investigation to address the risk of electrical damage. This study investigates the electrical damage to rolling bearing elements in EV motor drive systems. The experimental analysis focuses on the effects of electric currents and operational loads on bearing integrity. A test rig is designed to generate high-rate voltage specific to a motor system's parasitic capacitance, and bearing samples are exposed to these currents for specified durations. Component evaluation involves visual inspections and vibration measurements. In addition, a predictive model for electrical failure is developed based on accumulated data, which demonstrates the ability to predict the likelihood of electrical failure relative to the duration and intensity of current exposure. This in turn reduces uncertainties in practical applications regarding electrical erosion modes.

• Korean Chemical Engineering Research
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• v.55 no.3
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• pp.322-331
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• 2017

District heating was first introduced in Korea in 1985. As the service life of the underground thermal piping network has increased for more than 30 years, the maintenance of the underground thermal pipe has become an important issue. A variety of complex technologies are required for periodic inspection and operation management for the maintenance of the aged thermal piping network. Especially, it is required to develop a model that can be used for decision making in order to derive optimal maintenance and replacement point from the economic viewpoint in the field. In this study, the analysis was carried out based on the repair history and accident data at the operation of the thermal pipe network of five districts in the Korea District Heating Corporation. A failure probability model was developed by introducing statistical techniques of qualitative analysis and binomial logistic regression analysis. As a result of qualitative analysis of maintenance history and accident data, the most important cause of pipeline damage was construction erosion, corrosion of pipe and bad material accounted for about 82%. In the statistical model analysis, by setting the separation point of the classification to 0.25, the accuracy of the thermal pipe breakage and non-breakage classification improved to 73.5%. In order to establish the failure probability model, the fitness of the model was verified through the Hosmer and Lemeshow test, the independent test of the independent variables, and the Chi-Square test of the model. According to the results of analysis of the risk of thermal pipe network damage, the highest probability of failure was analyzed as the thermal pipeline constructed by the F construction company in the reducer pipe of less than 250mm, which is more than 10 years on the Seoul area motorway in winter. The results of this study can be used to prioritize maintenance, preventive inspection, and replacement of thermal piping systems. In addition, it will be possible to reduce the frequency of thermal pipeline damage and to use it more aggressively to manage thermal piping network by establishing and coping with accident prevention plan in advance such as inspection and maintenance.

• Journal of Acupuncture Research
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• v.33 no.2
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• pp.21-34
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• 2016

Objectives : The aim of the present study is to examine the effect and mechanism of Erycibae Caulis and Corydalis Tuber Pharmacopuncture (ECP) on a mouse model with collagen induced rheumatoid arthritis (CIA). Methods : We evaluated the Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Creatinine, and the Blood urea nitrogen (BUN) of serum to examine the safety of this study. In vivo, we compared the results of the non-treated group, the normal saline pharmacopuncture treated control group, the indomethacin treated group and the ECP group. We evaluated rheumatoid arthritis manifestation and the Rheumatoid Arthritis Index (AI). Also, immune cells in blood affected by ECP were evaluated by calculating the level of white blood cells (WBC), neutrophil, lympocytes and monocytes. Next, the level of Immunoglobulin M (IgM), Immunoglobulin G (IgG), Interleukin (IL)-$1{\beta}$, IL-6, IL-17, Tumor Necrosis Factor (TNF)-${\alpha}$ and Granulocyte-macrophage Stimulating Factor (GM-CSF)in serum were measured. We examined the imaging of cartilage degeneration using micro CT-arthrography of the hind paw. Additionally, we examined the effects of reducing bone volume (BV) ratio and bone surface/bone volume (BS/BV) ratio with 3D Micro-CT. Finally, we did a histopathologic examination analysis. Results : The absence of liver and kidney toxicity was evident. In vivo, edema of the joints of the ECP group decreased greatly in macroscopic observation. AI measurement of the ECP group also decreased significantly compared to the control group. The level of WBC, neutrophil, lympocytes, and monocytes in the blood decreased but there was no statistical significance of this data. IgM of the ECP group decreased significantly compared to the control group. IL-$1{\beta}$, IL-6, TNF-${\alpha}$, and GM-CSF production of the ECP group decreased significantly compared to the control group. As a result of examining joint condition with 3D micro CT, deformation and destruction of the joint was shown to have decreased. Bone density of ECP group increased at a statistically significant level compared to the control group. Degree of joint inflammation of ECP group decreased significantly compared to the control group. After H&E and M-T staining, infiltration of immune cells, subsidence of the cartilage, damage to the synovial cells and joint erosion decreased. Conclusion : This study showed that ECP hindered the process of rheumatoid arthritis and protected joints and cartilage.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.5
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• pp.147-153
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• 2008

Tractive forces by flowing water and ship generated waves are items that affect the stability of the low flow revetments among various external forces exerting on those revetments. Bank revetment stability by these external forces is analysed in this study. The study area is the section of the test construction area changing the artificial revetments to ecological revetments in Han river. Tractive forces are computed using the calculated flow velocity using RMA-2 model. The stability is analyzed comparing the calculated tractive forces with permissible tractive forces of the revetments in the study area. The calculated tractive forces at section number 93 is higher than permissible tractive forces in that section, so the section is estimated hydraulically unstable. The calculated tractive forces for the storm of 10th August 2007 are small compared to the permissible tractive forces in all sections. The sections are considered to be hydraulically stable, but have been eroded in some parts. The reason for the erosion is considered to have insufficient time for the plants taking root, and be exerted composite forces such as forces by ship generated waves. Ship generated waves by the excursion boats and small boats called river taxi was calculated. Wave forces by these calculated waves are computed and compared with the supporting forces of the revetment material. The external forces exerted by the ships in Han River on the revetments is very little compared with the permissible supporting forces of the revetments, so the revetments are estimated hydraulically stable. But considering the composite forces are exerted simultaneously, the stability consideration should include these composite forces.

• Journal of Korean Society for Geospatial Information Science
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• v.18 no.3
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• pp.3-10
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• 2010

The development of various spatial information and GIS has led to the research on interpretation of natural phenomena and correlational studies. This study is aimed to analyze the correlation between RUSLE(Revised Universal Soil Loss Equation) around Nakdong River area during the period of 1955 to 2005 and the amount of area change in the islets at the estuary terrain calculated in the study "Change Detection at the Nakdong Estuary Delta using Satellite Image and GIS". For the calculation of RUSLE, The 'Revised-USLE' model, a modified USLE model commonly used in Korea was used. For the rainfall erosion factor to calculate and compare the area of islets, the actual observation data for one year before the observation of satellite image from all observatories across Korea was used. The correlation coefficient between RUSLE and area change of islets was 0.57 for Jinwoo Islet; 0.7 for Sinja Islet; 0.87 for Doyodeung. This results showed that there was a great influence from Doyodeung where the main water way of Nakdong River runs. This study showed that the study using USLE for various fields and through identifying the characteristics of each factor is useful to understand natural phenomenon in practice.

• Economic and Environmental Geology
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• v.10 no.1
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• pp.37-48
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• 1977

The earth's crust is unceasingly undergoing deformations because of the forces acting upon it. The relationship between the tectonic forces and the resulting deformations are found from the states of stresses in the earth's crust induced by these forces. The study has been attempted to analyze the deformations of the overlying sedimentary layers, which are deformed by the magma intrusion along its lower boundary. The elastic model is constructed to analyze the geologic structures, by means of the theory of elasticity, and then the appropriate boundary conditions are given. The solution of the Airy stress function which satisfies the given boundary conditions is derived from the analytic method. The internal stress distributions of the deformed elastic model layer are portrayed by principal stress trajetories, and then the corresponding potential faults and joints systems are predicted from the Coulomb-Mohr failure criterion. The internal displacement distributions are shown by the calculated displacement components vectors, namely horizontal, vertical and net components. Results of the numerical calculations show the developments of some geologic structures as follows; (1) one set of shear joints and or two sets of shear joints which are oppisite directions, and one set of extension joints parallel to the ${\sigma}_1$ direction, (2) one set of high angle thrusts and normal faults, (3) symmetric fold; both limbs are dipping in opposite direction with low angle. The field work at the Wall-A San area, located near Jinju City, in southern Korea, had accomplished to compare the field structures with the predicted ones. The results of the comparison exhibits the developments of joint and fault systems satisfactorily consistent with each others. But the area does not show any type of folding, in spite of the intrusion of a granodiorite massif, this fact is one of the important features of the whole Kyungsang sedimentary basins of Mesozoic age distributed at the south-eastern parts of Korea. For this reason, it is thought that the magma intrusion had occurred with extremly low pressure. The geologic structures have been modified by the erosion and weathering throughout the geologic time, and the conditions of the sedimentary layers (width, thickness and radius of magma) are not the same as before, being intruded by the magma. To enlighten this, it is preferable to study these geologic structures with analyses of various types of rheological models.