• Toxicological Research
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• v.5 no.2
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• pp.111-121
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• 1989

Subacute toxicity of Hantabax, epidemic hemorrhagic fever vaccine, was investigated in ICR mice with subcutaneous injection. Any significant toxic symptom was not observed in the treated mice during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in all organs examined.

• Toxicological Research
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• v.5 no.2
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• pp.123-133
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• 1989

Subacute toxicity of Hantabax, epidemic hemorrhagic fever vaccine, was investigated in Sprague-Dawley rats with subcutaneous injection. Any significant toxic clinical symptom was not observed in the treated rats during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in organs examined.

• Communications of Mathematical Education
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• v.24 no.4
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• pp.877-889
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• 2010

Mathematical modelling is a useful method for reinterpreting the real world and for solving real problems. In this paper, we introduced a theory on mathematical modelling. Further, we developed a mathematical model of the H1N1 influenza with Excel. Then, we analyzed the model which tells us what role it can play in an appropriate prediction of the future and in the decision of accompanied policies.

• Journal of Korean Medical classics
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• v.21 no.1
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• pp.295-302
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• 2008

Until the middle of the 20th century, exogenous febrile disease was the most common disease that threatened the human health. For a long time, oriental medicine doctors developed many ways to cure this disease by studying pathogenic factors. The phthogenic factors and treatments of exogenous febrile disease with time are as followings. "Naegyeong(內經)" : Cold pathogen. Diaphoretic therapy, purgation therapy. Hwata : Cold pathogen. Diaphoretic therapy, emetic therapy, purgation therapy. Jangjunggyeong(張仲景) : Cold pathogen. Eight principal therapeutic methods except diaphoretic therapy with pungent and cool properties. Yuhagan(劉河間) : Fire pathogen. Diaphoretic therapy with pungent and cool properties. Idongwon(李東垣) : Improper diet and overstrain. Reinforcing therapy. Ouga(吳又可) : Epidemic pathogenic factors. Diaphoretic therapy with pungent and cool properties, Heat-reducing therapy. purgation therapy Seopcheonsa(葉天士) : Warm pathogen. diaphoretic therapy, Heat-reducing therapy, expel Heat therapy, cooling the blood and eliminating stagnation of blood. Oguktong(吳鞠通) : Six pathogenic factors. Eight principal therapeutic methods including diaphoretic therapy with pungent and cool properties.

• Clinical and Experimental Pediatrics
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• v.64 no.10
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• pp.511-518
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• 2021

The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence, severe obesity is associated with an increased prevalence and incidence of the early stages of kidney disease. Importantly, children born to obese mothers are also at increased risk of developing obesity and CKD later in life. The potential mechanisms underlying the association between obesity and CKD include hemodynamic factors, metabolic effects, and lipid nephrotoxicity. Weight reduction via increased physical activity, caloric restriction, treatment with angiotensin-converting enzyme inhibitors, and judicious bariatric surgery can be used to control obesity and obesity-related kidney disease. Preventive strategies to halt the obesity epidemic in the healthcare community are needed to reduce the widespread deleterious consequences of obesity including CKD development and progression.

• Journal of Integrative Natural Science
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• v.14 no.3
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• pp.130-138
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• 2021

The outbreak of COVID-19 has had a huge impact on human life. The World Bank group (WBG) has stated that 2020 is the worst year since World War II for economic growth. An epidemic of an infectious disease such as COVID-19 is classified as a "social disaster" by law. The social disaster caused by COVID-19 puts certain industries, occupations and vulnerable groups at risk of exclusion and isolation. This paper intends to examine the fluctuations in the consumer price index in the cultural, sports and tourism sector before and after the onset of COVID-19. In addition, it predicts the consumer price index by sector until December 2021 and reveals its implications.

• Journal of Veterinary Science
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• v.22 no.2
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• pp.26.1-26.6
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• 2021

Fourteen African swine fever (ASF) outbreaks occurred in the pig farms in the northwestern region of South Korea, near the border with North Korea, from September 16, 2019 to October 9, 2019. Active and passive surveillance on the ASF-infected farms indicated that the infection was limited only to pigsties where the infected pigs were detected on the farm for the first time before further transmission to other pigsties and farms. This early detection could be one of the pivotal factors for the prompt eradication of ASF in domestic pig farms within 1 month in the northwestern region of South Korea.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.11
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• pp.4145-4162
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• 2021

During the period of epidemic prevention and control, contact tracing systems are developed in many countries, to stop or slow down the progression of COVID-19 contamination. However, the privacy issues involved in the use of contact tracing apps have also attracted people's attention. First, we divide contact tracing techniques into two types: Bluetooth Low Energy (BLE) based and Global Positioning System (GPS) based techniques. In order to clear understand the system structure and its elements, we create data flow diagram (DFD) of each types. Second, we analyze the possible privacy threats contained in various types of contact tracing apps by applying LINDDUN, which is a threat modeling technique for personal information protection. Third, we make a comparison and analysis of various contact tracing techniques from privacy point of view. These studies can facilitate improve tracing and security performance to contact tracing apps through comparisons between different types.

• Journal of Korea Multimedia Society
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• v.22 no.6
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• pp.684-694
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• 2019

Information spread in networks is universal in many real-world phenomena such as propagation of infectious diseases, diffusion of a new technology, computer virus/spam infection in the internet, and tweeting and retweeting of popular topics. The problem of finding the information source is to pick out the true source if information spread. It is of practical importance because harmful diffusion can be mitigated or even blocked e.g., by vaccinating human or installing security updates. This problem has been much studied, where it has been shown that the detection probability cannot be beyond 31% even for regular trees if the number of infected nodes is sufficiently large. In this paper, we study the impact of an anti-information spreading on the original information source detection. We consider an active defender in the network who spreads the anti-information against to the original information simultaneously and propose an inverse Voronoi partition based inference approach, called Voronoi Inference to find the source. We perform various simulations for the proposed method and obtain the detection probability that outperforms to the existing prior work.

• Communications of the Korean Mathematical Society
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• v.34 no.2
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• pp.685-699
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• 2019

This research is focused on a continuous epidemic model of transmission of Plasmodium vivax malaria with a time delay. The model is represented as a system of ordinary differential equations with delay. There are two equilibria, which are the disease-free state and the endemic equilibrium, depending on the basic reproduction number, $R_0$, which is calculated and decreases with the time delay. Moreover, the disease-free equilibrium is locally asymptotically stable if $R_0<1$. If $R_0>1$, a unique endemic steady state exists and is locally stable. Furthermore, Hopf bifurcation is applied to determine the conditions for periodic solutions.