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Toxicology is a multidisciplinary field, and an important science that impacts both environmental health regulation and the development and practice of medicine. The rapid progress in cellular and molecular biology, like many other branches of biomedical research, toxicology is now experiencing a renaissance fueled by the application of "omic" technologies to gain a better understanding of the biological basis of toxicology of drugs and other environmental factors. In this review on current progress on toxicology, the future perspective, concept, approaches and applications of toxicogenomics as next generation promising technology in toxicology field will be described.