• 대한건축학회논문집:구조계
• /
• 제35권2호
• /
• pp.3-11
• /
• 2019

The recent earthquake of Pohang (M5.4) and the Gyeongju earthquake (M5.8) suggested the possibility of a strong earthquake in Korea and reminded us that the Korea is no longer an earthquake-safe zone. In the disaster recovery stage in a disaster like an earthquake, the investigation of the damage situation and the safety assessment of the building serve to provide important information for the initial action such as establishment of the recovery strategy and rescue of the survivor. However, the research that depends on manpower can not cope with the difficulty of processing a large number of doses in a short time, and the expertise of the manpower must be taken into consideration, which may result in delayed initial action. In this study, we propose an rapid safety evaluation technique of building using unmanned aerial vehicle which evaluates the performance and safety of buildings by integrating conventional safety inspection method with unmanned aerial vehicle technology and developed evaluation method of each evaluation factor. In order to verify this, the buildings damaged by the earthquake in Pohang were checked and compared using this system. The results are consistent with the results of the existing emergency earthquake risk assessment. As a result, the possibility of checking the emergency safety using the unmanned aerial vehicle for the damaged structures in case of a large-scale disaster such as an earthquake was confirmed.

• 대한토목학회논문집
• /
• 제41권3호
• /
• pp.297-304
• /
• 2021

국내 공공시설물의 유지관리체계는 시설물의 안전을 유지하기 위한 진단 및 보수 개념에서 시설물의 성능을 평가하여 유지관리하는 성능평가 방법으로 전환되고 있다. 그러나 국내에서는 시설물의 유지관리를 위한 성능평가 방법이 정립되지 않아 성능평가가 적절하게 이루어지고 있지 못하고 있다. 본 연구에서는 현재 시설물의 안전관리 위주로 한 단순 유지관리전략을 보완하기 위해 성능평가 개념을 도입한 자산관리 모델을 제안한다. 본 모델은 시설물의 유지관리 정보를 수집하는 방법으로 WBS를 활용하는 방법을 제안하여 기존 모델과의 차별화를 이루었다. 또한, 본 모델에는 시설물의 성능평가에서 가장 중요한 서비스 수준 평가방법과 성능척도 요소를 제안하였으며, 사례분석을 하여 본 모델의 적절성을 평가하였다.

• The Journal of Korean Physical Therapy
• /
• 제33권3호
• /
• pp.168-177
• /
• 2021

Purpose: This study applies the ICF to identify the patient's body function, structure, and participation, evaluates the patient's environmental factors and individual factors, and is a high level of movement to return to the society of patients with multiple ligament injury of the knee joint. Methods: Progressive strength training and ROM exercise were performed 30 minutes a day, 5 times a week for 6 weeks. The evaluation was performed by examining the ROM, length, MMT, instability, dynamic balance, pain and depression. Results: The ROM of the knee joint was improved from 110° to 135° after intervention, and the knee flexion length decreased from 69 cm to 45 cm. Knee flexor is Good after intervention from Poor-, and knee extensor is Good+ after intervention from Poor, and the plantar flexor of the ankle joint improved from Poor- before intervention to Good after intervention and dorsi-flexor of the ankle joint improve to Good from Poor. Pain index was moderate before and after the intervention, with a score of 3, 2 after the intervention, and when maintaining the sitting cross-legged, the before intervention score was 7 to 4 after the intervention. Conclusion: The patient's posture of sitting cross-legged was maintained from 30 seconds before intervention to 14 minutes after intervention. These results were able to set the hypothesis design, intervention method and goal that the multifaceted approach of environment and individual factors as well as body function and structure area, activity and participation area using ICF checklists, it is helped the patient to return to daily life.

• Ocean and Polar Research
• /
• 제44권1호
• /
• pp.13-27
• /
• 2022

The Yeongsan River estuary was altered by a sea dike built in 1981 and the sluice gates in the dike were extended recently in 2014. The construction has caused changes in water properties and hydrodynamics and also produced disturbances including hypoxia and algal blooms. We analyzed the water quality and chlorophyll-a data (2009-2018) collected seasonally at 3 stations (Sts. 1-3) along the channel of the estuary by the Marine Environmental Monitoring System. Variations in water quality and chlorophyll-a (an index of phytoplankton biomass) were examined and their stressors were also identified by statistics including correlation and multivariate principal component analyses (PCA). The water quality was mainly affected by freshwater discharge from the dike. Salinity, nutrients and chlorophyll-a were especially affected by the discharge and the effect enhanced during summer and at the upper region near the sea dike decreasing downstream. Three factors were extracted for each station in the PCA accounting for 66.07-72.42% of the variations. The first was an external factor associated with freshwater discharge and the second and third were seasonal or biological factors. The results indicate that the water quality is more affected by short-termed and episodic events such as freshwater discharge than seasonal events and the influence of freshwater discharge on water quality is more extensive than that previously reported. This suggests that the boundary of the estuary should be extended to take into account the findings of this study and a management strategy linked to the freshwater zone is required to manage the integrity and water quality of the Yeongsan River estuary.

• East Asian Economic Review
• /
• 제26권1호
• /
• pp.49-91
• /
• 2022

Recent years have witnessed renewed interest in Africa and public diplomacy has emerged as the vital tool being used to cultivate these relations. China has been leading in pursuing stronger economic partnership with Africa while middle powers such as Korea are also intensifying engagement with the continent. While previous studies have analyzed the implications of China's activities in Africa on advanced powers, none has examined them from the paradigm of middle powers. This study fills this gap by assessing China's activities in Africa, their economic engagement and implications for Korea's interest in Africa. The analysis is qualitative based on secondary data from various sources and literature. The study shows that China's public diplomacy strategy involves a high degree of innovation and has evolved to encompass new tools and audiences. China has institutionalized a cooperative model that permeates many aspects of governance institutions in Africa, enabling it to strengthen their relations. This could also be helping China to adjust faster leadership transitions in Africa. Whereas the US is still the most influential country in Africa, China is influential in economic policies and has outstripped the US in infrastructure diplomacy. This could be because African policy makers align more with China's economic model than the US' mainstream economics. Chinese aid to Africa has been diversified to social sectors that are more responsive to the needs of Africa. Trade and investment relations between China and Africa have deepened, but so does trade imbalance since 2010. China mainly imports natural resources and raw materials from Africa. But this product portfolio is not different from Korea and the US. China's energetic insertion in Africa using various strategies has significant implications for countries with ambitions in Africa. Korea can achieve its ambitions in Africa by focusing resources in areas it can leverage its core strengths-such as education and vocational training, environmental policy and development cooperation.

• 한국정보통신학회논문지
• /
• 제25권11호
• /
• pp.1495-1504
• /
• 2021

초소형 바이너리 발전 플랜트는 열원과 냉각원 사이의 저온도차 열에너지를 이용하여 열에너지를 전력으로 변환한다. 실제 발전환경에서 플랜트의 특성치는 환경 조건이나 관련 장비의 부식과 같은 부정적인 영향으로 인해 변동하고, 플랜트 특성치의 변동은 PID 파라미터가 고정된 종래의 PID 제어시스템에서 불안정한 터빈 출력으로 이어진다. 본 논문에서는 플랜트의 특성치 변동에 따라 PID 파라미터를 적응적으로 조정하는 신경망 기반의 Neuro PID 제어시스템을 제안한다. 초소형 바이너리 발전 플랜트의 동작점 근방에서 동특성을 나타내는 이산시간 전달함수 모델을 도출하고, 제안된 제어시스템의 설계 전략을 기술한다. 제안된 Neuro PID 제어시스템을 종래의 PID 제어시스템과 비교하고, 시뮬레이션 결과를 통해 그 유효성을 보인다.

• 한국동물위생학회지
• /
• 제44권4호
• /
• pp.185-194
• /
• 2021

Polyglutamine extension in the coding sequence of mutant huntingtin causes neuronal degeneration associated with the formation of insoluble polyglutamine aggregates in Huntington's disease (HD). Mutant huntingtin can form aggregates within the nucleus and processes of neurons possibly due to misfolding of the proteins. To better understand the mechanism by which an elongated polyglutamine causes aggregates, we have developed an in vitro binding assay system of polyglutamine tract from truncated huntingtin. We made GST-HD exon1 fusion proteins which have expanded polyglutamine epitopes (e.g., 17, 23, 32, 46, 60, 78, 81, and 94 CAG repeats). In the present emergence of new study adjusted nanotechnology on protein chip such as surface plasmon resonance strategy which used to determine the substance which protein binds in drug discovery platform is worth to understand better neurodegenerative diseases (i.e., Alzheimer disease, Parkinson disease and Huntington disease) and its pathogenesis along with development of therapeutic measures. Hence, we used strengths of surface plasmon resonance (SPR) technology which is enabled to examine binding specificity and explore targeted molecular epitope using its electron charged wave pattern in HD pathogenesis utilize conjugated mutant epitope of HD protein and its interaction whether wild type GST-HD interacts with mutant GST-HD with maximum binding affinity at pH 6.85. We found that the maximum binding affinity of GST-HD17 with GST-HD81 was higher than the binding affinities of GST-HD17 with other mutant GST-HD constructs. Furthermore, our finding illustrated that the mutant form of GST-HD60 showed a stronger binding to GST-HD23 or GST-HD17 than GST-HD60 or GST-HD81. These results indicate that the binding affinity of mutant huntingtin does not correlate with the length of polyglutamine. It suggests that the aggregation of an expanded polyglutamine might have easily occurred in the presence of wild type form of huntingtin.

• Journal of Microbiology and Biotechnology
• /
• 제32권6호
• /
• pp.681-698
• /
• 2022

The Nile tilapia Oreochromis niloticus, Atlantic salmon Salmo salar, rainbow trout Oncorhynchus mykiss, olive flounder Paralichthys olivaceus, common carp Cyprinus carpio, grass carp Ctenopharyngodon idella and rohu carp Labeo rohita are farmed commercially worldwide. Production of these important finfishes is rapidly expanding, and intensive culture practices can lead to stress in fish, often reducing resistance to infectious diseases. Antibiotics and other drugs are routinely used for the treatment of diseases and sometimes applied preventatively to combat microbial pathogens. This strategy is responsible for the emergence and spread of antimicrobial resistance, mass killing of environmental/beneficial bacteria, and residual effects in humans. As an alternative, the administration of probiotics has gained acceptance for disease control in aquaculture. Probiotics have been found to improve growth, feed utilization, immunological status, disease resistance, and to promote transcriptomic profiles and internal microbial balance of host organisms. The present review discusses the effects of single and multi-strain probiotics on growth, immunity, heamato-biochemical parameters, and disease resistance of the above-mentioned finfishes. The application and outcome of probiotics in the field or open pond system, gaps in existing knowledge, and issues worthy of further research are also highlighted.

• Journal of Forest and Environmental Science
• /
• 제38권2호
• /
• pp.102-109
• /
• 2022

This study was conducted to test the significant difference of fertility variation among families and to select superior families for acorn production in the breeding seedling seed orchards (BSSOs) of Quercus acuta and Quercus glauca. The seed orchards were located in Jeju island and established by seedlings raised from selected parents for genetic testing in 2006. In the spring of 2021, the numbers of female and male flower were counted from 5 to 10 individuals per family in the BSSOs. To test statistical significance of which parameter is not satisfied through the normality test, we used a nonparametric analysis. Correlation analysis was performed to quantify the association between female and male flower production. As the results, the significant difference of flower production among families was found in both seed orchards. The averages of female flower production were 65.3 and 181.9 in Q. acuta and Q. glauca. The positive Spearman's rank correlation was existed between male and female flower production. Broad-sense heritability on female and male flower production were 0.191 and 0.147 in Q. acuta, and 0.285 and 0.068 in Q. glauca, respectively. Sexual asymmetry (e.g., maleness index) between female and male, and contribution variation among families (e.g., parental balance) were analyzed to find reasonable alternatives in the management of seed orchards. Effective population size of seed crops was predicted as a concept of status number. Loss of gene diversity (accumulation of group coancestry) would not be alarming in the BSSOs. Our results would be helpful to select breeding materials for establishing new seed orchards and to supply genetically improved seeds of evergreen oaks, which is one of the backbones of the strategy of carbon sink in the 2050 Carbon Neutrality of Korea Forest Service.

• BMB Reports
• /
• 제55권7호
• /
• pp.354-359
• /
• 2022

MitoNEET, a mitochondrial outer membrane protein containing the Asn-Glu-Glu-Thr (NEET) sequence, controls the formation of intermitochondrial junctions and confers autophagy resistance. Moreover, mitoNEET as a mitochondrial substrate undergoes ubiquitination by activated Parkin during the initiation of mitophagy. Therefore, mitoNEET is linked to the regulation of autophagy and mitophagy. Mitophagy is the selective removal of the damaged or unnecessary mitochondria, which is crucial to sustaining mitochondrial quality control. In numerous human diseases, the accumulation of damaged mitochondria by impaired mitophagy has been observed. However, the therapeutic strategy targeting of mitoNEET as a mitophagy-enhancing mediator requires further research. Herein, we confirmed that mitophagy is indeed activated by mitoNEET inhibition. CCCP (carbonyl cyanide m-chlorophenyl hydrazone), which leads to mitochondrial depolarization, induces mitochondrial dysfunction and superoxide production. This, in turn, contributes to the induction of mitophagy; mitoNEET protein levels were initially increased before an increase in LC3-II protein following CCCP treatment. Pharmacological inhibition of mitoNEET using mitoNEET Ligand-1 (NL-1) promoted accumulation of Pink1 and Parkin, which are mitophagy-associated proteins, and activation of mitochondria-lysosome crosstalk, in comparison to CCCP alone. Inhibition of mitoNEET using NL-1, or mitoNEET shRNA transfected into RAW264.7 cells, abrogated CCCP-induced ROS and mitochondrial cell death; additionally, it activated the expression of PGC-1α and SOD2, regulators of oxidative metabolism. In particular, the increase in PGC-1α, which is a major regulator of mitochondrial biogenesis, promotes mitochondrial quality control. These results indicated that mitoNEET is a potential therapeutic target in numerous human diseases to enhance mitophagy and protect cells by maintaining a network of healthy mitochondria.