• Toxicological Research
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• v.8 no.2
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• pp.317-329
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• 1992

Fifty chemicals are currently classified as human carcinogens based on epidemiologic and animal data. Humans are daily exposed to them from various sources of exposure via inhalation, dermal contact and oral ingestion. To reduce cancer risk to man, these human carcinogens should be appropriately regulated and monitored environmentally or biologically for routine human cancer risk assessment. A number of mathematical risk assessment models have been introduced, but any realistic and relevant model system is not available for humans. A mechanistic process for human cancer risk assessment was comprehensively reviewed and problems were also discussed. Here, a new conceptual approach using epidemiology and biological human monitoring was suggested for the most relevant method to study human cancer risk assessment.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.198-198
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• 2002

Occurrence of Chinese Herbs Nephropathy (CHN) has been reported in young women who had taken a slimming pills containing some chinese herbs. Aristolochic acid (AA) known as a carcinogen, was suspected as the major causal factor of CHN. AA is major component of fruit of A. contorta was used in Korean Traditional Medicine.(omitted)

• Journal of Environmental Health Sciences
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• v.46 no.2
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• pp.136-149
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• 2020

Objectives: The purpose of this study was to perform an aggregate human risk assessment for benzene in an industrial complex using the CalTOX model and to improve the reliability and predictability of the model by analyzing the uncertainty and sensitivity of the predicted assessment results. Methods: The CalTOX^TM 4.0 beta model was used to evaluate a selected region, and @Risk 7.6 software was used to analyze uncertainty and sensitivity. Results: As a result of performing the aggregate risk assessment on the assumption that 6.45E+04 g/d of benzene would be emitted into the atmosphere over two decades, 3% of the daily source term to air remained in the selected region, and 97% (6.26E+04 g/d) moved out of the region. As for exposure by breathing, the predicted LADD_inhalation was 2.14E-04 mg/kg-d, and that was assessed as making a 99.99% contribution to the LADD_total. Regarding human Risk_cancer assessment, the predicted human cancer risk was 5.19E-06 (95% CI; 4.07E-06-6.81E-06) (in the 95th percentile corresponding to the highest exposure level, a confidence interval of 90%). As a result of analyzing sensitivity, 'source term to air' was identified as the most influential variable, followed by 'exposure time, active indoors (h/day)', and 'exposure duration (years)'. Conclusions: As for the results of the human cancer risk assessment for the selected region, the predicted human cancer risk was 5.19E-06 (95% CI; 4.07E-06-6.81E-06) (in the 95th percentile, corresponding to the highest exposure level, a confidence interval of 90%). As a result of analyzing sensitivity, 'source term to air' was found to be most influential.

• Structural Engineering and Mechanics
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• v.69 no.3
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• pp.317-326
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• 2019

This research aims to assess the tight seismic risk curve of the intake tower at Geumgwang reservoir by considering the recorded historical earthquake data in the Korean Peninsula. The seismic fragility, a significant part of risk assessment, is updated by using Bayesian inference to consider the uncertainties and computational efficiency. The reservoir is one of the largest reservoirs in Korea for the supply of agricultural water. The intake tower controls the release of water from the reservoir. The seismic risk assessment of the intake tower plays an important role in the risk management of the reservoir. Site-specific seismic hazard is computed based on the four different seismic source maps of Korea. Probabilistic Seismic Hazard Analysis (PSHA) method is used to estimate the annual exceedance rate of hazard for corresponding Peak Ground Acceleration (PGA). Hazard deaggregation is shown at two customary hazard levels. Multiple dynamic analyses and a nonlinear static pushover analysis are performed for deriving fragility parameters. Thereafter, Bayesian inference with Markov Chain Monte Carlo (MCMC) is used to update the fragility parameters by integrating the results of the analyses. This study proves to reduce the uncertainties associated with fragility and risk curve, and to increase significant statistical and computational efficiency. The range of seismic risk curve of the intake tower is extracted for the reservoir site by considering four different source models and updated fragility function, which can be effectively used for the risk management and mitigation of reservoir.

• Proceedings of the KSEEG Conference
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• 2000.04a
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• pp.59-60
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• 2000

• Environmental Analysis Health and Toxicology
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• v.26
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• pp.2.1-2.7
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• 2011

Objectives: N-Nitrosodimethylamine (NDMA) is classified as a probable human carcinogen by the United States Environmental Protection Agency (US EPA) and is formed during the chlorination of municipal drinking water. In this study, selected nitrosamines were measured in chlorinated drinking water collected from Chuncheon, Kangwon-do, Republic of Korea, and a risk assessment for NDMA was conducted. Methods: Twelve water samples were collected from 2 treatment plants and 10 household taps. Samples were analyzed for 6 nitrosamines via solid-phase extraction cleanup followed by conversion to dansyl derivatives and high-performance liquid chromatography-fluorescence detection (HPLC-FLD). Considering the dietary patterns of Korean people and the concentration change of NDMA by boiling, a carcinogenic risk assessment from ingestion exposure was conducted following the US EPA guidelines. Results: NDMA concentrations ranged between 26.1 and 112.0 ng/L. NDMA in water was found to be thermally stable, and thus its concentration at the end of boiling was greater than before thermal treatment owing to the decrease in water volume. The estimated excess lifetime carcinogenic risk exceeded the regulatory baseline risk of $10^{-5}$. Conclusions: This result suggests that more extensive studies need to be conducted on nitrosamine concentration distributions over the country and the source of relatively high nitrosamine concentrations.

• Journal of Environmental Impact Assessment
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• v.18 no.6
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• pp.367-376
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• 2009

This paper proposes an application methodology of AHP(Analytic Hierarchy Process) based decision making theory for improvement priority by assessment of various risk factors affecting on deterioration of water supply systems, as major social infrastructure. AHP method is organized with three level of hierarchy which is introduced for multi-criteria decision making in this study. In the first level, assessment outputs are calculated by AHP for each affecting factor. In the second level, criteria are estimated by using assessment results with respect to structural and environmental factors. Consequently, ranking decision is performed in the third level. In order to present the effectiveness, a proposed method is compared with FCP(Fuzzy Composite Programming) for decision making. Since the results of the proposed method show better performance with consistent results, it can be applied as an efficient information for the determination for improvement priority of the study infrastructure.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 1994.04a
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• pp.86-86
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• 1994

• Toxicological Research
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• v.18 no.2
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• pp.107-116
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• 2002

Arsenic (As) is a ubiquitous element found in several forms in foods and water. Although certain foods, such as marine fish, contain substantial levels of organic arsenic forms, they are relatively low in toxicity compared to inorganic forms. in contrast, arsenic in drinking water is predominantly inorganic and highly toxic. Chronic ingestion of arsenic-contaminated drinking water is therefore the major pathway posing potential risk to human hearth. since the early 1990s in Bangladesh ozone, arsenic exposure has caused more than 7,000 deaths and uncounted thousands shout symptoms of long-term arsenic poisoning. Significant portion of world populations are exposed to low to moderate levels of arsenic of parts per billion (ppb) to hundreds of ppb. As a consequence, the World Health Organization (WHO) and U.S. environmental health agencies, such as the Environmental Protection Agency (EPA) made arsenic their highest priority. Recently, the WHO, European Union (EU), and US. EPA lowered an acceptable level of 10 ppb for arsenic in drinking water In this article, various health effects of arsenic in drinking water were reviewed and the current status for risk assessment to regulate arsenic in drinking water was discussed.

• Proceedings of the Korean Society of Toxicology Conference
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• 2006.05a
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• pp.82-89
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• 2006