• 대한소아치과학회지
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• 제42권2호
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• pp.172-179
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• 2015

치근 형성은 매우 복잡한 과정이며, 유전적으로 그 형태가 정해져 있다. 유전이나 환경적인 요인이 치근발달과정에 영향을 줄 수 있다. 본 연구에서는 제1대구치의 치근형성이상을 주소로 내원한 12명의 환아들에 대하여 보고하고자 한다. 임상적으로 이들 치아는 정상적인 치관의 형태를 보이고 있었다. 그러나 방사선학적 검사상 치근이 얇고 꼬여있으며 불규칙한 길이를 나타내었다. 그리고 백악법랑경계에서 치근이개부까지의 길이는 짧았으며, 치수강은 협착되어 있었다. 이들 중 6명의 환아에서는 제2유구치의 치근형성이상이 함께 나타났으며, 3명의 환아에서는 상악 중절치의 치관형태이상이 함께 나타났다. 이들 대부분에서 조산, 뇌신경계 감염, 선천성 심질환 등의 의학적 병력이 생후 1년 이내에 관찰되었다. 제1대구치에서 특징적으로 발생하는 치근형태이상에 대한 보고는 희소하며, 본 증례에서 열두 명의 환아에서 동시에 발생한 제1대구치의 치근형성이상은 임상가들에게 새로운 증례의 발견 및 진단함에 의의가 있다.

• 대한두개안면성형외과학회지
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• 제13권1호
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• pp.68-71
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• 2012

Purpose: Eczema herpeticum, caused by herpes simplex virus, is an infectious disease involving skin and internal organs. Varieties of physiologic, psychosocial, or environmental stress reactivate reservoir virus which exists in the trigeminal nerve ganglia. Authors report rare cases of nasal eczema herpeticum following corrective rhinoplasty. Methods: First case, 22-year-old female underwent corrective rhioplasty through an external approach in a local clinic. She developed progressive and painful erythema, nodules and vesicles on nose on the 9th day postoperatively. This unfamiliar lesion lead to a misdiagnosis as a bacterial infection, and had accelerated its progress to the trigeminal innervation of the nasal unit. Second case, a 23-year-old female underwent corrective rhinoplasty by external lateral osteotomy. Ten days after the surgery, disruption occurred on the external osteotomy site, and the ulceration gradually worsened. The surgeon misdiagnosed it as secondary bacterial infection and only an antibacterial agent was applied. Results: Both cases were healed effectively without any complication with proper wound dressing and antiviral therapy, and show no sequelae during an 8-month follow-up period. Conclusion: Eczema herpeticum is rare in the field of plastic surgery, but it should be kept in mind that secondary bacterial infections may lead to serious complications such as full-thickness skin loss. Thus, acknowledgement of the patient's past history regarding perioral or intraoral lesion may provide the surgeon with the possible expectancy of eczema herpeticum. Thus, if anyone develops eczema herpeticum, following facial plastic surgery, early diagnosis and immediate proper antiviral therapy will allow fast recovery without serious complications.

• 한국응용곤충학회지
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• 제59권3호
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• pp.209-215
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• 2020

최근 소나무재선충의 매개충을 방제하기 위한 방제법으로 널리 이용되고 있는 항공방제의 환경 영향에 대한 논의가 계속되고 있다. 본 연구에서는 2017년 경남 양산 금정산 일대를 무처리구와 처리구(3회 살포 및 5회 살포)로 구분한 뒤, 유인항공기로 살포된 티아클로프리드가 비표적 절지동물인 무당거미의 생물적 형질(체중, 체장, 머리가슴의 폭 및 뒷다리 전체 길이)에 미치는 영향을 조사하였다. 2017년 10월 11일에 각 조사구에서 성숙한 무당거미 암컷 성충을 채집하였다. 조사 결과, 무당거미의 생물적 형질은 살충제 살포 여부에 따라 통계적으로 유의하게 달라졌는데, 특히 체장, 머리가슴의 폭, 그리고 뒷다리의 전체 길이는 항공방제구에서 채집된 무당거미가 무처리구에서 잡힌 개체에 비해 짧은 것으로 나타났다. 그러나 살충제 살포 횟수에 따른 차이는 관찰되지 않았다. 결론적으로 무당거미의 형태적 특성은 살충제 살포에 의해 직접적 또는 간접적으로 영향을 받았을 가능성이 있으며, 이는 장기적으로 개체군의 건강성에 영향을 줄 것이라 생각된다. 따라서 향후 장기적으로 살충제(직접 효과)와 먹이 가용성(간접 효과)에 대한 무당거미의 반응에 대한 모니터링이 수행되어야 할 것이다.

• 혜화의학회지
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• 제18권1호
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• pp.29-41
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• 2009

Wished to examine closely effect that SoPungDoJeokTang-KaMi (SPDJTK) medicines used to atopy dermatitis disease patient get in atopy eruption control experimentally. SPDJTK medicines controlled $CD4^+/IFN-\gamma$, and $CD4^+/CD25^+/foxp3^+$ revelation that an experiment that motive allergy immune reponse because an in vitro experiment stimulates T cells of a NC/Nga mouse same time by anti-CD40/rmIL-4, and interleukin-$1{\beta}$, IL-6, TNF-$\alpha$, and TGF-$\beta$ mRNA outturn that bear in T and B cells decreased remarkably by SPDJTK medicines. Intracellular staining of splenocytes anti-CD40/rmIL-4 plus rmIL-4 stimulated as described in a, assessed after 24 h, SPDJTK exerts a mainly immunosuppressive effect that acts at least partially through suppression of the transcription factor GATA3 expression in $CD4^+$ T cells. Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. However, the exact etiology of AD has been unclear. To further explore the pathogenesis and treatment of AD, a suitable animal model is required. We found that skin lesions, which were clinically and histologically very similar to human AD, mite antigen-induced dermatitis on the face, neck, ears and dorsal skin of inbred NC/Nga mice. Result that Th1 cell and Th2 cell observe to be shifted by cytokine expression with $CD4^+/CD25^+/foxp3^+$ Treg cells induction by SPDJTK medicines could know that SPDJTK medicines can use usefully in allergy autoimmnune diease.

• 한국컴퓨터정보학회논문지
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• 제17권12호
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• pp.241-249
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• 2012

현재 정보통신의 비약적인 발전은 의료서비스 전달체계에서도 큰 변화와 진전을 야기하고 있으며 세계적으로 점차 확대되어가고 있는 추세이다. 이는 의료정보화라는 이름으로 환자에게는 질병의 진단, 치료에 있어서 보다 신속, 세밀하고 정확히 판단할 수 있게 하여 수준 높은 보건의료서비스를 제공하는 한편 의료기관 및 관련기관은 업무의 효율성을높여가고 있다. 그 중 원격의료는 의료기관의 방문 없이 대기시간의 단축, 일률적인 고도의 의료수준을 기대할 수 있는 등의 장점이 있는 제도이다. 특히 장소와 시간에 구애받지 않고 방대한 의학에 관한 정보접근성이 높아질 수 있다는 점이다. 그러나 현대 과학 기술의 발달의 속도에 비해 운용상의 제반 규정과 마인드가 부족한 것이 현실이다. 현행 우리 의료법에서는 원격의료를 규정하고는 있으나 그 내부적 관계에 따르는 세부적인 법률관계의 부재 및 현장에서 이루어지는 의료행위가 아닌 정보통신망을 이용한 비대면접촉에 의한 특수한 형태라는 측면에서 제도적, 시설적, 환경적 제약이 있음을 부인할 수 없다. 따라서 본 논문에서는 현행 원격의료의 발전 잠재 가능성이 무한함을 전제로 법적 문제점 및 개선점을 고찰해보고 이를 통한 원격의료를 활성화할 수 있는 활로를 모색하고자 한다.

• 지역사회간호학회지
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• 제11권2호
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• pp.358-372
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• 2000

The purpose of this study was to describe the way of life (such as smoking habits, alcohol consumption, exercise, duration of sleep, eating habits etc.), physical. psychological and overall health complaints and to identify the relationship between the way of life and health complaints of the nursing students. Data was collected with the self-administered OMI( Okayama Medical Index Health Questionnaire, devised Cornell Medical Index) from 766 nursing students and was analyzed. For data analysis, descriptive statistics and an ANOVA with an SPSS/PC+ program were used. The results were as follows: 1. The mean age of subjects was 21.0557(2.7618) years old in their 1st, 2nd, 3rd and 4th year-classes of nursing departments and college students in 4 regions of Korea. 62.1% of subjects were of the proper body weight, 2.0% were overweight, and 28.3% were underweight. Most subjects did not have a past history of disease, but 1.8% of subjects had experienced a blood transfusion. 2. 28.3% of the subjects had averaged 7 hours of sleep, 98.5% were nonsmokers, 91.2% were nondrinkers, 74.7% of subjects had milk intake sometimes, 53.7% of the subjects had an average salt intake, 49.6% of the subjects usually had a green vegetable intake, 45.4% of the subjects sometimes had fatty food intake, 64.8% of the subjects had good taste, 29.5% of the subjects enjoyed physical exercise. 3. The highest percentages of 'yes' among physical. psychological and overall health complaints were observed in the question 'Do you have gastric pain?'(60.2%), 'Are you confused of disorderly?' (37.2%), 'Physical body was burdensome and fatigued.'(57.3%). 4. The total O.M.I. score ranged from 1 to 89 with an average of 22.91(SD=12.10). A statistically significant difference was observed for the physical. psychological complaints for alcohol consumption. and for the psychological complaints for salt and fatty food intake. These conclusions should provide grounds for future studies of strategies for health promoting lifestyle for nursing students and their health concerns. Further research is required to investigate the life environmental and psychological factors affecting the way of life for nursing students and their health status, to analyze the health behavior of nursing students related with their culture and consciousness. Also epidemiologic research methodology, such as prospective cohort study should be considered to explore the performing process of nursing student's health behavior related with the occurrence of diseases.

• 지역사회간호학회지
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• 제14권3호
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• pp.397-406
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• 2003

The purpose of this study is to provide the basic data in order to improve the quality of charged recuperation facilities which are specialized in the old. after finding out the satisfaction degree for the services which are provided in the current charged recuperation facilities specialized in the old and surveying the services which are demanded by users. As for the research method. the subjects were 88 family members of the users in the five charged recuperation facilities, which are specialized in the old and located in Seoul and Incheon. The survey research was executed from 27th July to 15th September, 2002. Then the collected data were analyzed by using the SPSS 10.0 for windows program. The research results are as follows. Firstly, in the satisfaction degree of the user's family about the daily service showed the highest satisfaction degree for the kind service of the staff to the users. In the satisfaction degree about the specialized service of the user's family, the satisfaction degree was high in bedsore prevention, periodical health care, proper medical treatment, family counsel, and adequate disease management. In the satisfaction degree about the facility and environmental service, the satisfaction degree about the surrounding environment of the facility or safety facility, and the comfort condition was high. In the satisfaction degree about the services related to the local society, it was high in the hospital and medical-related field. Secondly, in the demanded services, the demanding degree for worship, mental and spiritual nursing, hospice, funeral service, family meeting, and support for the special vehicle were not so high, but it was shown that they were generally demanded. Thirdly, it was shown that the provided services had an overall high satisfaction degree. In the service satisfaction degree according to the general characteristics of the user's family, it was recognized that there was a significant difference between the distinction of sex and local society related services. Also, there was a significant difference in the satisfaction degree between age and specialized service. Through the above research results, detailed rehabilitation programs such as linguistic treatment and working treatment should be more and more compensated in order to supplement the insufficient points of the services provided by the charged recuperation facility specialized in the old. Additionally, the correlation with the local society such as education and training for specialized human labor, close cooperation among the facilities, and positive participation in local society events are thought to be reinforced.

• 대한예방한의학회지
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• 제14권3호
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• pp.1-12
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• 2010

Objective : Samulatang (herbal description) is much used for women's disease in Korean Traditional Medicine. The aim of this study is to evaluate reproductive toxic effect by Samultang in pregnant rats and fetuses, and ascertain a dose-response relationship Method : Pregnant Sprague-Dawley rats were administered with the Samultang at single, double and quadruple dose for 20 days, orally. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Live fetuses of gestation were randomly selected and fixed in 95% ethanol. Fetuses were stained with alcian blue and alizarin red S. We observe maternal body weight,, index associated pregnancy, and skeletal malformations in fetus Result : Maternal body weight of Samultang treated group has increased, side effect was not found in maternal body compared to that of control group. There were no significant difference in internal and reproductive organs. Double concentration administered group had lowest value in number of implantation, live fetuses, implantation rate and delivery rate, Also double concentration administered group showed higher early and late resorption rate than the other group. But, these are not significant. In the sex ratio, number of females, bigger than number of males in all Samultang administered groups. The fetuses of dams treated with Samultang didn't showed external and skeletal malformation. Vertebral and sternal variations were observed in single, double and quadruple concentration administered group but, compared to the control, those variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumber, sacral and caudal vertebrae Conclusion : Samultang is not expected to affect on pregnant rats and fetus about maternal body weight and number of live fetuses. There were no significant changes in organ weight, reproductive organs. Although skeletal variations were showed in vertebrae and sternum, treated groups were shown insignificant changes in skeletal variation

• 한국산학기술학회논문지
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• 제17권1호
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• pp.597-604
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• 2016

본 논문에서는 항공 방제 시 균일 방제를 통하여 병해충에 의한 농산물 생산량 저하 및 농약이 과도 살포된 농작물 생산을 방지하고자 하였다. 항공 방제가 실시되는 비행 고도 3m와 속도 15km/h를 유지하는 것은 사용자의 조종 습관 및 방법, 바람의 변화 같은 환경적 요인이 작용하여 대단히 어렵다. 따라서 무인 헬리콥터로부터 비행 데이터를 전송받아 비행속도 및 고도의 변화에 따라 붐의 각도와 DC 펌프의 제어가 가능하도록 살포 장치 및 제어기를 설계 및 제작하였고 무성항공사의 무인 헬리콥터 Rmax에 탑재하여 살포 성능을 검증했다. 실험은 가로 10m, 세로 50m의 농지에서 감수지를 한 열에 1.25m 간격으로 9장씩 5열을 5m의 위치에서부터 10m 간격으로 배치하고, 방제 실험 시 제작된 항공 살포 시스템을 이용하여 살포하였다. 무인 헬리콥터는 최저속도 7.2km/h부터 최고속도 17.6km/h, 최저높이 2.32m부터 최고 3.47m까지 최고 10.4km/h의 속도 변화와 1.15m 고도 변화를 보이며 비행하였고, 각 열이 평균 46423개의 입자개수의 분포로 7.5m의 유효 살포 영역을 형성함을 보여 제안된 항공 살포시스템이 균일 방제에 효과가 있음을 증명한다.

• Genomics & Informatics
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• 제8권3호
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• pp.108-115
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• 2010

Hypertension is the most prevalent disease worldwide and is itself a risk factor for cerebral, cardiac, and renal diseases. The inconsistency of candidate genes suggested by previous genomewide association studies (GWASs) may be due to not only differences in study design and genetic or environmental background but also the difference in the power of analysis between continuous traits and discrete traits. We analyzed 352,228 single nucleotide polymorphisms (SNPs) in 8842 unrelated Koreans obtained from Ansan and Ansung cohorts. We performed a series of GWA analyses using three different phenotype models; young hypertensive cases (278 subjects) versus elderly normotensive controls (680 subjects); the upper 25% (2211 hypertensive cases) versus the lower 25% of the SBP distribution (2211 hypotensive controls); and finally SBP and DBP as continuous traits (8842 subjects). The numbers of young hypertensive cases and elderly normotensive controls were not large enough to achieve genomewide significance. The model comparing the upper 25% subjects to the lower 25% of subjects showed a power that was approximate to that of QTL analysis. Two neighboring SNPs of the ATP2B1 gene, rs17249754 (SBP, p=$2.53^{-10}$; DBP, p=$1.28{\times}10^{-8}$) and rs7136259 (SBP, p=$1.30{\times}10^{-9}$; DBP, p=$6.41{\times}10^{-8}$), were associated with both SBP and DBP. Interestingly, a SNP of the RPL6 gene, rs11066280, revealed a significant genomewide association with SBP in men only (p=$3.85{\times}10^{-8}$), and four SNPs located near the MAN2A1 gene showed a strong association with DBP only in elderly men aged 60-70 years (e.g., rs6421827, p=$4.86{\times}10^{-8}$). However, we did not observe any gene variant attaining genomewide significance consistently in the three phenotype models except for the ATP2B1 gene variants. In general, the association signal with blood pressure was stronger in women than in men. Genes identified in GWASs are expected to open the way for prevention, early diagnosis, and personalized treatment of hypertension.