• 제목/요약/키워드: Env

검색결과 417건 처리시간 0.027초

JSRV Env가 세포의 전사 활성에 미치는 영향 (Effects on the transcriptional activity by the JSRV Env)

  • 김정우
    • 자연과학논문집
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    • 제15권1호
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    • pp.89-95
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    • 2005
  • 폐암을 일으키는 것으로 알려진 JSRV는 NIH3T3 세포를 transformation 시키는 성질이 있다는 것으로 알려져 있다. 이 바이러스 중 Envelope 단백질이 NIH3T3를 transformation시키는 것으로 알려져서 이것이 세포내에서 어떤 전사인자를 활성화시키는지를 luciferase 리포터 플라스미드를 이용한 transient transfection 방법으로 조사하였다. 그 결과 Envelope 단백질은 NF-kB와 AP-1의 활성을 높이는 것으로 밝혀졌다.

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용접부의 피로강도 시험평가 및 해외규격과의 비교연구 (Fatigue Tests of Welded Joints and Comparison Study of Foreign Codes)

  • 구병춘;김재훈
    • Journal of Welding and Joining
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    • 제25권1호
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    • pp.14-23
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    • 2007
  • A lot of fatigue tests on a material, JIS SM490A, with yielding strength of about 350 MPa and tensile strength of about 520 MPa were carried out. Various butt-welded specimens such as reinforcement removed, as-welded and weld toe ground, several types of fillet-welded specimens and full-size box type components were used. After having obtained S-N curves for the above- mentioned specimens, fatigue strengths were compared to those of foreign design codes, AWS, BS 7608 and ENV. It was found the fatigue strengths at low cycles are not in a good agreement with the foreign codes, but the fatigue limits are in a good agreement.

세장한 철근콘크리트 보의 병형기초 전단강도 모델 (Deformation-Based Shear Strength Model for Slender Reinforced Concrete Beams)

  • 최경규;박홍근
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 2005년도 봄학술 발표회 논문집(I)
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    • pp.391-394
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    • 2005
  • A theoretical model was developed to predict the shear strength of slender reinforced concrete beams. The shear force applied to a cross-section of the beam was assumed to be resisted primarily by the compressive zone of intact concrete rather than by the tensile zone. The shear capacity of the cross section was defined based on the material failure criteria of concrete: failure controlled by compression and failure controlled by tension. In the evaluation of the shear capacity, interaction with the normal stresses developed by the flexural moment in the cross section was considered. In the proposed strength model, the shear strength of the beam and the location of the critical section were determined at the intersection between the shear capacity and shear demand curves. The proposed strength model was verified by the comparisons to prior experimental results.

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ROBUST MEASURES OF LOCATION IN WATER-QUALITY DATA

  • Kim, Kyung-Sub;Kim, Bom-Chul;Kim, Jin-Hong
    • Water Engineering Research
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    • 제3권3호
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    • pp.195-202
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    • 2002
  • The mean is generally used as a point estimator in water-quality data. Unfortunately, the nonnormal and skewed distributions of data hinder the direct application of the mean, which is inappropriate statistics in this case. The use of robust statistics such as L, M, and R-estimators are recommended and become more efficient. The median (L-estimator), the biweight (M-estimator), and the Hodges-Lehmann method (R-estimator) are briefly introduced and applied in this paper. From the actual data analyses, it is known that the median does not guarantee robustness for a small number of data sets, and robust measures of location or the arithmetic mean without outliers are highly recommended if the distribution has tails or outliers. Care must be taken to measure the location because water quality level within a water body can change depending on the selected point estimator.

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Application of Toxicogenomic Analysis to the Monitoring of Environmental Toxicity Using Recombinant Bioluminescent Bacteria and Cultured Mammalian Cells

  • Choi, Sue Hyung;Gu, Man Bock;Yasuyuki, Sakai
    • 한국미생물생명공학회:학술대회논문집
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    • 한국미생물생명공학회 2003년도 2003 Annual Meeting, BioExhibition and International Symposium
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    • pp.129-131
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    • 2003
  • Recombinant bioluminescent bacteria and cultured human cells were applied for toxicogenomic analysis of environmentally hazardous chemicals. Recombinant bioluminescent biosensing cells were used to detect and classify the toxicity caused by various chemicals. Classification of toxicity was realized based upon the chemicals' mode of action using DNA-, oxidative-, protein, and membrane-damage sensitive strains. As well, a simple double-layered cell culture system using Caco-2 cells and Hep G2 cells, which mimic the metabolic processes occurring in humans, such as adsorption through the small intestine and biotransformationin both the small intestine and the liver, was developed to investigate the toxicity of hazardous materials to humans. For a more in-depth analysis, a DNA microarray was used to study the transcriptional responses of Caco-2 and Hep G2 cells to benzo〔a〕pyrene.

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INCENTIVE/DISINCENTIVE PROJECT SUCCESS FACTORS DURING MACARTHUR MAZE I-580 BRIDGE SPAN REPLACEMENT

  • Jae-Ho Pyeon;Marc Zomoradi
    • 국제학술발표논문집
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    • The 5th International Conference on Construction Engineering and Project Management
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    • pp.328-331
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    • 2013
  • Incentive/Disincentive (I/D) contracting experiences in many states have been evaluated in terms of time and cost performance and substantial project time savings were found in many project cases. However, there is little understanding on individual project success factors for I/D projects during construction. This paper explores the significance of I/D clause in the success of the MacArthur Maze reconstruction project and summarizes a list of group causes that explains and elaborates on the detailed factors. The methods used for carrying out this study started with a search of online media and news reports and contract documents were also obtained from Caltrans. After review of the preliminary information, Interviews were performed with the Caltrans Resident Engineer and the contractor's project manager who were in charge of the MacArthur Maze reconstruction. In conclusion, the evaluation of their responses hinted at six significant cause groups responsible for the project's success. These groups can be listed as: 1) Motivation, 2) Policy, 3) Teamwork, 4) Communication, 5) Expectation, and 6) Resource Management.

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