• Clinical and Experimental Pediatrics
• /
• 제49권8호
• /
• pp.898-901
• /
• 2006

소아에서 교착성 심낭염은 매우 드문 질환으로 이에 의하여 단백 소실성 장병증이 동반되는 경우는 더욱 드물다. 저자들은 교착성 심낭염의 주요 증상의 하나로 단백 소실성 장병증을 보인 여아 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제18권1호
• /
• pp.60-65
• /
• 2015

We report a pediatric patient admitted with abdominal pain, diffuse lower extremity edema and watery diarrhea for two months. Laboratory findings including complete blood count, serum albumin, lipid and immunoglobulin levels were compatible with protein losing enteropathy. Colonoscopic examination revealed diffuse ulcers with smooth raised edge (like "punched out holes") in the colon and terminal ileum. Histopathological examination showed active colitis, ulcerations and inclusion bodies. Immunostaining for cytomegalovirus was positive. Despite supportive management, antiviral therapy, the clinical condition of the patient worsened and developed disseminated cytomegalovirus infection and the patient died. Protein losing enteropathy and disseminated cytomegalovirus infection a presenting of feature in steroid-naive patient with inflammatory bowel disease is very rare. Hypogammaglobulinemia associated with protein losing enteropathy in Crohn's disease may predispose the cytomegalovirus infection in previously healthy children.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제3권2호
• /
• pp.199-205
• /
• 2000

저자들은 만성 분비성 설사와 성장부진을 주소로 내원한 10개월된 남아에서 소장생검조직소견과 Western blot과 면역조직화학검사로 장상피세포에 대한 자가항체를 확인함으로써 자가면역성 장병증으로 진단하고, 코르티코스테로이드와 FK506으로 성공적으로 치료한 1례를 경험하였기에 이를 보고하는 바이다.

• Journal of Veterinary Science
• /
• 제21권4호
• /
• pp.47.1-47.12
• /
• 2020

Background: Homocysteine (HCY) was evaluated in healthy and chronic enteropathic dogs, however no studies on dogs with immunosuppressant-responsive enteropathy are available. Objectives: The aim was to evaluate serum HCY concentrations and its prognostic role in dogs with immunosuppressant-responsive enteropathy compared to healthy dogs. Methods: Serum HCY concentration was statistically compared between 24 healthy dogs and 29 dogs with immunosuppressant-responsive enteropathy. Correlation analyses between serum total protein, albumin (ALB), C-reactive protein (CRP), folate and cobalamin, and serum HCY concentration were performed in immunosuppressant-responsive enteropathic dogs. Results: The associations between serum HCY concentration and clinical, histological, endoscopic scores and follow-up were evaluated. Mean serum HCY concentration was higher in immunosuppressant-responsive enteropathic dogs compared to control dogs (30.22 ± 8.67 µmol/L vs. 5.26 ± 2.78 µmol/L; p < 0.0001). No association between serum HCY concentration and total protein, ALB, CRP, folate concentration as well as, clinical score, histological and endoscopic scores was found. A negative correlation between serum HCY concentration and cobalamin was noted (p = 0.0025, r = -0.54). No significant difference in HCY was found between responsive and non-responsive dogs or between survivors and non-survivors. Conclusions: Although, serum HCY concentration was higher in immunosuppressant-responsive enteropathy, its prognostic value remains unclear. However, further prospective, large-scale studies are warranted to better investigate the possible prognostic role of HCY in immunosuppressant-responsive enteropathic dogs.

• 대한수의학회지
• /
• 제55권1호
• /
• pp.61-63
• /
• 2015

Proliferative enteropathy caused by Lawsonia intracellularis is one of the most common enteric diseases in pigs. The objective of this study was to determine the prevalence of serum antibodies against L. intracellularis in the general swine population of Korea from 2005 to 2008. In total, 8,008 swine serum samples obtained from 1,001 herds were tested. The samples were analyzed with an immunoperoxidase monolayer assay to detect anti-L. intracellularis antibodies. The overall 4-year average true prevalence was 40.0% (CI: 39.4 - 40.6%) at the individual animal level and 71.9% (CI: 70.3-73.4%) at the herd level.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제6권2호
• /
• pp.208-214
• /
• 2003

저자들은 전신부종과 심한 저알부민혈증으로 내원한 환아에서 테그네슘표지 인혈청알부민 스캔을 이용하여 결장에서 단백이 소실되는 것을 확인하고, 바륨 관장 대장 조영술 검사, 상부 위장관 촬영, 소장 조영술, 대장과 십이지장 내시경 검사를 통해 단백 소실 장증으로 발현한 연소성 용종증을 진단하여, 전대장 절제술 후 단백 소실 장증이 호전된 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Parasites, Hosts and Diseases
• /
• 제50권4호
• /
• pp.333-337
• /
• 2012

We encountered an indigenous case of intestinal capillariasis with protein-losing enteropathy in the Republic of Korea. A 37-year-old man, residing in Sacheon-si, Gyeongsangnam-do, admitted to the Gyeongsang National University Hospital (GNUH) due to long-lasting diarrhea, abdominal pain, anasarca, and weight loss. He recalled that he frequently ate raw fish, especially the common blackish goby (Acanthogobius flavimanus) and has never been abroad. Under the suspicion of protein-losing enteropathy, he received various kinds of medical examinations, and was diagnosed as intestinal capillariasis based on characteristic sectional findings of nematode worms in the biopsied small intestine. Adults, juvenile worms, and eggs were also detected in the diarrheic stools collected before and after medication. The clinical symptoms became much better after treatment with albendazole 400 mg daily for 3 days, and all findings were in normal range in laboratory examinations performed after 1 month. The present study is the 6th Korean case of intestinal capillariasis and the 3rd indigenous one in the Republic of Korea.

• Journal of Yeungnam Medical Science
• /
• 제22권2호
• /
• pp.253-258
• /
• 2005

Generalized edema and hypoalbuminemia are relatively common presenting manifestations in many clinical situations. The differential diagnosis of hypoalbuminemia include: Kwashiorkor, synthetic dysfunction of the liver, and excessive protein loss as in nephrotic syndrome. In systemic lupus erythematosus (SLE), hypoalbuminemia and generalized edema are most commonly due to protein loss associated with lupus nephritis; gastrointestinal involvement is uncommon, and therefore protein loss through the gastrointestinal tract is quite rare. We report a case of a protein losing enteropathy (PLE) associated with SLE. The patient was referred to our hospital for generalized edema, arthralgia and facial rash. After clinical evaluation, the patient met the criteria for the SLE diagnosis; hypoalbuminemia with general edema was consistent with a protein losing enteropathy. After two weeks of therapy with parenteral high dose glucocorticoid, the patients was improved in laboratory findings as well as clinical symptoms.

• 한국동물위생학회지
• /
• 제42권4호
• /
• pp.301-304
• /
• 2019

The objective of this study was to determine the in vitro intracellular and extracellular minimum inhibitory concentrations (MICs) of 13 antimicrobials against one recently isolate Lawsonia intracellularis, the etiological agent of proliferative enteropathy (PE). The final MICs were assessed by counting the number of heavily infected cells (HICs;>30 bacteria per cell) using an immunoperoxidase monolayer assay. Enrofloxacin (InMIC; 1~2 ㎍/mL and ExMIC; 16 ㎍/mL) still presented the most notable antimicrobial susceptibility, and marbofloxacin (2 ㎍/mL and 8 ㎍/mL) was followed. Colistin (0.25 ㎍/mL and 2 ㎍/mL) presented a susceptibility followed by tylvalosin (1 ㎍/mL and 2 ㎍/mL). Florfenicol and lincomycin had the weakest susceptibility and amoxicillin, penicillin G, chlortetracycline, oxytetracycline, tiamulin, tilmicosin, and tylosin displayed weak susceptibility. Although some antibiotics showed decreased susceptibility patterns, they showed similar patterns to recent antibiotic susceptibility patterns in Korea. In addition, these results could be one of contributions in clinical fields.

• Clinical and Experimental Pediatrics
• /
• 제48권2호
• /
• pp.224-227
• /
• 2005

Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 복통과 혈변이 가장 흔한 위장관계 침범 증상이며, 주요 위장관계 합병증은 발생빈도가 매우 낮다. 특히 국내 소아에서 단백소실장증이 합병된 보고 예는 아직까지 없다. 저자들은 Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 경과 중에 단백소실장증이 합병된 6세 여아를 경험하였기에 문헌고찰과 함께 보고한다.