• 제목/요약/키워드: Engineering Center

검색결과 30,083건 처리시간 0.057초

Genome-wide association study for loin muscle area of commercial crossbred pigs

  • Menghao Luan;Donglin Ruan;Yibin Qiu;Yong Ye;Shenping Zhou;Jifei Yang;Ying Sun;Fucai Ma;Zhenfang Wu;Jie Yang;Ming Yang;Enqin Zheng;Gengyuan Cai;Sixiu Huang
    • Animal Bioscience
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    • 제36권6호
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    • pp.861-868
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    • 2023

  • Objective: Loin muscle area (LMA) is an important target trait of pig breeding. This study aimed to identify single nucleotide polymorphisms (SNPs) and genes associated with LMA in the Duroc×(Landrace×Yorkshire) crossbred pigs (DLY). Methods: A genome-wide association study was performed using the Illumina 50K chip to map the genetic marker and genes associated with LMA in 511 DLY pigs (255 boars and 256 sows). Results: After quality control, we detected 35,426 SNPs, including six SNPs significantly associated with LMA in pigs, with MARC0094338 and ASGA0072817 being the two key SNPs responsible for 1.77% and 2.48% of the phenotypic variance of LMA, respectively. Based on previous research, we determined two candidate genes (growth hormone receptor [GHR] and 3-oxoacid Co A-transferase 1 [OXCT1]) that are associated with fat deposition and muscle growth and found further additional genes (MYOCD, ARHGAP44, ELAC2, MAP2K4, FBXO4, FBLL1, RARS1, SLIT3, and RANK3) that are presumed to have an effect on LMA. Conclusion: This study contributes to the identification of the mutation that underlies quantitative trait loci associated with LMA and to future pig breeding programs based on marker-assisted selection. Further studies are needed to elucidate the role of the identified candidate genes in the physiological processes involved in LMA regulation.

  • https://doi.org/10.5713/ab.22.0407 인용 PDF

Grouting effects evaluation of water-rich faults and its engineering application in Qingdao Jiaozhou Bay Subsea Tunnel, China

  • Zhang, Jian;Li, Shucai;Li, Liping;Zhang, Qianqing;Xu, Zhenhao;Wu, Jing;He, Peng
    • Geomechanics and Engineering
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    • 제12권1호
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    • pp.35-52
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    • 2017

  • In order to evaluate the grouting effects of water-rich fault in tunnels systematically, a feasible and scientific method is introduced based on the extension theory. First, eight main influencing factors are chosen as evaluation indexes by analyzing the changes of permeability, mechanical properties and deformation of surrounding rocks. The model of evaluating grouting effects based on the extension theory is established following this. According to four quality grades of grouting effects, normalization of evaluation indexes is carried out, aiming to meet the requirement of extension theory on data format. The index weight is allocated by adopting the entropy method. Finally, the model is applied to the grouting effects evaluation in water-rich fault F4-4 of Qingdao Jiaozhou Bay Subsea Tunnel, China. The evaluation results are in good agreement with the test results on the site, which shows that the evaluation model is feasible in this field, providing a powerful tool for systematically evaluating the grouting effects of water-rich fault in tunnels.

  • https://doi.org/10.12989/gae.2017.12.1.035 인용 KSCI

A spiral variable section capillary model for piping hydraulic gradient of soils causing water/mud inrush in tunnels

  • Lin, P.;Li, S.C.;Xu, Z.H.;Li, L.P.;Huang, X.;He, S.J.;Chen, Z.W.;Wang, J.
    • Geomechanics and Engineering
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    • 제13권6호
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    • pp.947-961
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    • 2017

  • An innovative spiral variable-section capillary model is established for piping critical hydraulic gradient of cohesion-less soils causing water/mud inrush in tunnels. The relationship between the actual winding seepage channel and grain-size distribution, porosity, and permeability is established in the model. Soils are classified into coarse particles and fine particles according to the grain-size distribution. The piping critical hydraulic gradient is obtained by analyzing starting modes of fine particles and solving corresponding moment equilibrium equations. Gravities, drag forces, uplift forces and frictions are analyzed in moment equilibrium equations. The influence of drag force and uplift force on incipient motion is generally expounded based on the mechanical analysis. Two cases are studied with the innovative capillary model. The critical hydraulic gradient of each kind of sandy gravels with a bimodal grain-size-distribution is obtained in case one, and results have a good agreement with previous experimental observations. The relationships between the content of fine particles and the critical hydraulic gradient of seepage failure are analyzed in case two, and the changing tendency of the critical hydraulic gradient is accordant with results of experiments.

  • https://doi.org/10.12989/gae.2017.13.6.947 인용 KSCI