Background: A comprehensive, traceable, and easy-to-understand radiation risk indicator is desired for radiological protection. The early-onset hypothesis could be used for this purpose. Materials and Methods: An indicator for early death (IED) was developed and calculated using the epidemiological dataset from the 14th Report of the Life Span Study (LSS) of Hiroshima and Nagasaki. By clarifying the calculation process, IED for all-cause mortality was estimated. In addition, the characteristics of IED for solid cancer mortality and cardiovascular mortality as well as those of men and women, and their dependence on age at exposure were investigated for detailed analysis. Results and Discussion: The IED for all-cause mortality was estimated to be approximately 4 years for an acute radiation exposure of 1 Gy regardless of the fitting dose range. The cumulative death rate for all solid cancers also indicated the early-death tendency (approximately 7-10 years at 1 Gy). Although, there is a slight difference in the characteristics of the risk obtained from the LSS study and this study, it is considered that the IED in a unit of years can also be used to show the overall picture of risk due to radiation exposure. Conclusion: We developed and calculated the indicator for early death, IED, for the cumulative mortality rate of all causes of death, all solid cancers, and circulatory diseases. The quantitative values of IED were estimated to be 4 years for all causes of death, 7-10 years for all solid cancers. IED has an advantage for intuitively understanding the meaning of radiation risk since it can be obtained by a simple and traceable method.
ESG has become a necessity for all companies, and major Korean banks are actively practicing ESG management. Banks are playing a role in providing ESG finance as intermediaries in the supply of funds. Recently, they have launched ESG digital banking products that offer preferential interest rates for eco-friendly activities in combination with digital technologies. However, indiscriminate provision of preferential interest rates can adversely affect profitability of banks, and they may face the problem of 'Greenwashing' if they do not contribute to improving environmental awareness. Therefore, this study selected ESG digital savings products linked to electricity savings as the subject of the study, and empirically analyzed consumers' environmental awareness and savings behavior through actual data of consumers (N=2,478). The main findings of this study are as follows First, the analysis of the consumer status of ESG digital banking products shows that the 30-50s are the main consumer base, and the MZ generation shows relatively high performance in achieving preferential interest rates through electricity saving practices. Second, consumers' environmental awareness has a significant impact on achieving the goals of ESG banking products. ESG banking products can contribute to environmental awareness while fulfilling the basic function of saving. Third, environmental awareness did not drive consumers' savings contribution behavior, suggesting the need for continued consumer engagement. Based on environmental awareness and the theory of saving behavior, this study provides a theoretical explanation in ESG financial products. The results suggest that the appropriateness of the preferential interest rate design of ESG financial products is important.
As studies on welfare systems for military families were only focused and limited on improvements of welfare facilities and military apartments, or psycho-therapies for families living apart, the supporting policies and efforts on creating jobs for military families(spouses) were insufficient till now. The best welfare for military spouses is the active well-being through the provision of employment opportunities, rather than providing certain rewards. Especially, South Korea should boost national competitiveness through increasing the engagement rate of women's economic activities. To expand these kinds of employment chances, actual plans to overcome the factors that restrict job opportunities for the families living apart, moving frequently, or living in rural areas should be urged. Accordingly, there should be a change of recognition toward military welfare service, enactment of applying discharged soldier's expanded employment programs for military spouses, cooperation with municipal governments and relevant institutions for creating jobs, and provision of promising job openings in association with a military reform. To achieve these, the cooperation of the government agencies, municipal governments, and military units are being emphasized.
This work studies the flow behaviors in the gap between the friction pad and separator in wet-clutch systems. The fluid volume of the lubricant is modeled using the entire system of wet-clutch pack of a dual clutch transmission that has larger outer radius of odd gear shifts and smaller inner radius of even gear shifts. Flow behaviors in the gap of the clutch pad are computed using the gear shift modes that consider the real relative velocities between the friction pad and separator. Flow behaviors in the gap of the disengaged clutch pad are mainly investigated for the wet-clutch system, whereas the engaged clutch pad is modeled with no fluid rate through the contacting surfaces. The developed hydrodynamic fluid pressures and velocity fields in the clutch pad gap are computed to obtain the relevant information for managing flow rates in wet-clutch packs under dual operating conditions during gear shifts. These hydrodynamic pressures and velocity fields are compared on the basis of each gear level and gap location, which is necessary to determine the effects of groove patterns on the friction pad. Shear stresses in the gap locations are also computed on the basis of the gear level for the inner and outer clutch pads. The computed results are compared and used for the design of cooling capacity against frictional heat generation in wet-clutch pack systems.
The Transactions of The Korean Institute of Electrical Engineers
/
v.57
no.9
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pp.1669-1673
/
2008
A new cycle ergometer using a Magneto-Rheological (MR) rotary brake system has been developed for rehabilitation of hemiplegia patients to reduce uneven pedaling characteristics. For this purpose, a control method to adjust the resistance of the MR rotary brake in real time based on the magnitude of the muscular force exerted by the subject has been devised so that the mechanical resistance to the pedaling can be minimized when the affected leg was engaged for pedaling. A series of experiments were carried out with and without the engagement of this real-time control mode of MR rotary brake at different pedaling rate to find out the effect of the real-time control mode. The characteristics of the pedaling for these specific conditions were analyzed based on the variations in angular velocities of the pedal unit. The results showed that the variations in the angular velocities were decreased by 42.9% with the control mode. The asymmetry of pedaling between dominant and non-dominant leg was 19.63% in non-control mode and 1.97% in the control mode. The characteristics of electromyography(EMG) in the lower limbs were also measured. The observation showed that Integrated EMG(IEMG) reduced with the control mode. Therefore, the new bicycle system using MR brake with the real time control of mechanical resistance was found to be effective in recovering the normal pedaling pattern by reducing unbalanced pedaling characteristics caused by disparity of muscular strength between affected and unaffected leg.
In this study, it propose what the landscape elements is to be improved urgently and how to improve landscape by reflecting the rural village characteristics away from the spatial integrated landscape planning. The study area for landscape research is selected as the 9 rural villages in Chungcheongbuk-do, and research is done by using village unit landscape diagnostic index(VULDI). the result is shown that average VULDI value of the rural village zones is bigger than one of the town village zones with difference of 15%. Two zones of Chilseong-myeon and Sangchon-myeon among the town village zones are appeared to be similar with the rural village zones in landscape level by VULDI value. Generally, the rural villages to maintain the good landscape have the low population and high engagement rate in agriculture. Looking political support criteria at the landscape level, the seven zones except Deoksan-myeon and Maengdong-myeon have high VULDI value more than 60%, which means that it seems unnecessary to support political landscape improvement. However, when it is divided into two parts of the village inside landscape and the surrounding landscape, 8 rural village zones except one zone of Sangchon-myeon have low VULDI value less than 60%, which means it is necessary to support political landscape improvement. It is important to give the intensive support of ever urgent landscape improvements and high priority landscape elements on the results of the diagnostic before planning of the rural landscape formation.
Drag torque reduction in a wet clutch pack is a key aspect of the design process of the dual clutch transmission (DCT) system. In order to reduce the drag torque caused by lubricant shear resistance, recently developed wet clutch pack systems of DCT, as well as automatic transmission and other four-wheel drive (4WD) couplings, frequently utilize wavy wet clutch pads. Therefore, wavy shape of friction pad are made on the groove patterns like waffle pattern for the reduction of drag torque. Additionally, the groove patterns are designed with larger channels at several locations on the friction pad to facilitate faster outflow of lubricant. However, channel performance is a function of the waviness of the friction pad at the location of the particular channel. This is because the discharge sectional area varies according to the waviness amplitude at the location of the particular channel. The higher location of the additional channel on the friction pad results in a larger cross-sectional area, which allows for a larger flow discharge rate. This results in reduction of the drag torque caused by the shear resistance of DCTF, because of marginal volume fraction of fluid (VOF) in the space between the friction pad and separator. This study computes the VOF in the space between the friction pad and separator, the hydrodynamic pressure developed, and the shear resistance of friction torque, by using CFD software (FLUENT). In addition, the study investigates the dependence of these parameters on the location and waviness amplitude of the channel pattern on the friction pad. The paper presents design guidelines on the proper location of high waviness amplitude on wavy friction pads.
Chimeric antigen receptor T (CAR-T) cell therapy is one of the promising anticancer treatments. It shows a high overall response rate with complete response to blood cancer. However, there is a limitation to solid tumor treatment. Additionally, this currently approved therapy exhibits side effects such as cytokine release syndrome and neurotoxicity. Alternatively, bispecific antibody is an innovative therapeutic tool that simultaneously engages specific immune cells to disease-related target cells. Since programmed death ligand 1 (PD-L1) is an immune checkpoint molecule highly expressed in some cancer cells, in the current study, we generated αCD3xαPD-L1 bispecific antibody (BiTE) which can engage T cells to PD-L1+ cancer cells. We observed that the BiTE-bound OT-1 T cells effectively killed cancer cells in vitro and in vivo. They substantially increased the recruitment of effector memory CD8+ T cells having CD8+CD44+CD62Llow phenotype in tumor. Interestingly, we also observed that BiTE-bound polyclonal T cells showed highly efficacious tumor killing activity in vivo in comparison with the direct intravenous treatment of bispecific antibody, suggesting that PD-L1-directed migration and engagement of activated T cells might increase cancer cell killing. Additionally, BiTE-bound CAR-T cells which targets human Her-2/neu exhibited enhanced killing effect on Her-2-expressing cancer cells in vivo, suggesting that this could be a novel therapeutic regimen. Collectively, our results suggested that engaging activated T cells with cancer cells using αCD3xαPD-L1 BiTE could be an innovative next generation anticancer therapy which exerts simultaneous inhibitory functions on PD-L1 as well as increasing the infiltration of activated T cells having effector memory phenotype in tumor site.
Thomas R Williamson;Patrick G Robinson;Iain R Murray;Andrew D Murray;Julie M McBirnie;C Michael Robinson;Deborah J MacDonald;Nicholas D Clement
Clinics in Shoulder and Elbow
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v.26
no.2
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pp.109-116
/
2023
Background: Golf is a popular sport involving overhead activity and engagement of the rotator cuff (RC). This study aimed to determine to what level golfers were able to return to golf following RC repair, the barriers to them returning to golf and factors associated with their failure to return to golf. Methods: Patients preoperatively identifying as golfers undergoing RC repair at the study centre from 2012 to 2020 were retrospectively followed up with to assess their golf-playing status, performance and frequency of play and functional and quality of life (QoL) outcomes. Results: Forty-seven golfers (40 men [85.1%] and 7 women [14.9%]) with a mean age of 56.8 years met the inclusion criteria, and 80.1% were followed up with at a mean of 27.1 months postoperatively. Twenty-nine patients (76.3%) had returned to golf with a mean handicap change of +1.0 (P=0.291). Golf frequency decreased from a mean of 1.8 rounds per week preinjury to 1.5 rounds per week postoperatively (P=0.052). The EuroQol 5-dimension 5-level (EQ-5D-5L) index and visual analog scale (EQ-VAS) score were significantly greater in those returning to golf (P=0.024 and P=0.002), although functional outcome measures were not significantly different. The primary barriers to return were ipsilateral shoulder dysfunction (78%) and loss of the habit of play (22%). Conclusions: Golfers were likely (76%) to return to golf following RC repair, including mostly to their premorbid performance level with little residual symptomatology. Return to golf was associated with a greater QoL. Persistent subjective shoulder dysfunction (78%) was the most common barrier to returning to golf.
Jiyoung Kim;Young-Hoon Ko;Ho-Kyoung Yoon;Boram Chae;Rayoung Han;Nayoung Chae;Jongha Lee
Journal of the Korean Academy of Child and Adolescent Psychiatry
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v.35
no.3
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pp.210-217
/
2024
Objectives: South Korea has the highest suicide rate among Organisation for Economic Co-operation and Development countries; there is an increasing trend in suicide attempts among middle and high school students. Various factors contribute to the risk of suicide among adolescents, and the perception of suicide prevention has emerged as a significant factor. This study aimed to investigate the association between emotional and behavioral difficulties among middle and high school students and their perceptions of suicide prevention and to explore differences in suicide perception according to age. Methods: A survey was conducted among community middle and high school students, including 530 participants, between 2020 and 2021. Emotional and behavioral difficulties were assessed using the Strengths and Difficulties Questionnaire-Korean version, and participants were asked to complete a questionnaire on the importance and possibility of suicide prevention. A correlation test and analysis of variance were used to examine the relationships between the variables, and suicide awareness was compared according to age. Results: The participants who displayed higher strength or lower difficulty were more likely to respond positively to suicide prevention measures. They also exhibited high strength and low difficulty levels, thus agreeing with the importance of suicide prevention. Regarding age-related perceptions of suicide, adults aged 20-29 years reported the lowest probability of suicide prevention. Conclusion: Suicide perceptions influence the incidence of suicide. Therefore, active societal engagement through suicide prevention campaigns and related education is essential to improve such perceptions. Continuous attention and support are required to address this issue.
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