• 핵의학기술
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• 제15권1호
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• pp.94-100
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• 2011

1-day protocol method는 DIAMOX 영상에서 basal 영상을 감산시키는 방법으로 혈관 예비능을 평가하는데 있어서 매우 유용한 검사지만, 검사시간이 길기 때문에 움직임에 의한 불가피한 재검사율이 높다. 기하학적으로 차이가 있는 fan-beam 콜리메이터와 parallel 콜리메이터 중 임상적으로 1-day protocol method에 가장 효율적인 콜리메이터가 무엇인지 알아보았다. 삼중 헤드 감마카메라인 triad XLT 9 (TRIONIX)와 세 가지 콜리메이터(low energy high resolution-parallel beam: LEHR-par, ultra resolution-fan beam: LEUR-fan, super fine-fan beam: LESR-fan)를 사용하였다. PET/SPECT performance phantom, Hoffman 3D phantom, volunteer 실험을 실시하여 세 가지 콜리메이터의 감도, 대조도, 해상력, 영상의 질을 비교 측정하였다. Pixel size를 fan-beam 콜리메이터와 동일하게 하기 위하여 parallel 콜리메이터 실험 시 zoom factor를 2.0으로 변경하였다. Scan time은 50 kcounts/frame을 만족하게 하였으며 filtered back projection (FBP)의 재구성 방법을 사용하였고 각 콜리메이터 별 최적의 영상을 위하여 cut off 값을 변화하면서 비교 측정하였다. 총 획득 계수가 동일한 조건에서 해상력과 percent background variability는 LESR과 LEUR이 LEHR보다 우수한 결과를 나타내었고, 영상의 육안평가에서 선호도는 LESR, LEUR, LEHR 순이었다. 영상 획득 시간은 LESR이 낮은 감도로 인하여 LEUR과 LEHR보다 약 2배 더 길게 소요됐다. Volunteer 실험의 결과 LESR을 사용할 때보다 LEUR 또는 LEHR을 사용 할 때 약 10-14분 정도 시간이 감소했다. 1-day protocol method는 단 한 번의 움직임에도 재검사가 불가피하기 때문에 적절한 분해능뿐만 아니라 높은 감도의 유지를 위해 적절한 검사 방법의 확립이 중요하다 할 수 있다. 본 연구에서 동일한 계수를 획득할 경우 LEUR은 LESR보다 2배의 시간을 감소시킬 수 있었고 영상의 육안평가나 해상력도 LESR과 임상적으로 큰 차이를 보이지 않았으므로 Brain SPECT의 1-day protocol method에 가장 적합할 것으로 사료된다.

• 한국작물학회지
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• 제64권4호
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• pp.414-421
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• 2019

콩의 내탈립성은 성숙기 수량 손실의 주요인이며 기계수확 시 장애요인으로서 개량되어야 할 불량형질로 간주된다. 국립식량과학원에서 개발된 '대원콩'은 성숙기 탈립에 매우 강한 특성을 나타내어 현재까지도 가장 널리 보급되어 있는 콩 품종이다. 향후 육종 프로그램에서는 '대원콩' 수준의 내탈립성을 가지면서도 수량성, 품질 등이 개선된 품종을 개발하는 것을 목표로 하고 있다. 따라서 본 연구는 '대원콩' 유래의 내탈립성에 대한 변이 양상을 조사하고, '대원콩' 수준의 유색콩 및 단기성 콩을 선발하기 위해 수행되었다. '대원콩'을 모본으로 하고, 감수성인 검정콩 품종 '다원콩'과 단기성 콩 품종인 '새올'을 각각 부본으로 하는 두개의 고세대 RIL 집단을 활용하여 '16년부터 '18년 3년간 실내 내탈립성 검정을 수행하였다. 그 결과 건조 시간별, 연차별 내탈립성 변이가 두 집단에서 모두 저항성 계통과 감수성 계통이 뚜렷하게 구분되는 비슷한 분포를 나타내었고, 이에 따라 '대원콩'의 내탈립성은 기존 보고와 같이 소수의 유전자에 의해 조절되고 특히 가장 강하게 관여하는 유전자가 존재함을 알 수 있었다. 또한 '대원콩' 유래의 내탈립성은 연차 간에 안정적인 형질이었으며, 건조 시간이 오래될수록 안정적이었다. 따라서 건조 72시간 후의 터진 협의 비율을 지표로 성숙기 탈립에 저항성인 총 47계통을 선발할 수 있었으며, 생육조사 결과와 종합하여 최종적으로 내탈립 유색콩 및 단기성콩 6계통을 선발할 수 있었다. 선발된 6개 계통은 '대원콩' 수준의 내탈립성을 가지면서도 성숙기가 빠르고, 경장, 마디수, 협수 등이 높아 추후 육종프로그램에서 내탈립성인 유색콩, 단기성콩 품종개발의 모본으로서 유용하게 활용될 것으로 기대된다.

• 한국산림과학회지
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• 제108권1호
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• pp.40-49
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• 2019

고사목(CWD)은 산림생태계 구성요소의 하나로서 산림의 에너지 흐름과 물질순환에서 주요한 역할을 한다. 특히 고사목은 탄소를 격리하는 장기 저장고로서, 산림에서 대기로 방출되는 탄소의 속도를 지연시키는 측면에서 고사목의 호흡속도를 구명하는 것은 의의가 크다. 따라서 본 연구는 온대중부지역의 일본잎갈나무와 리기다소나무 고사목을 대상으로 호흡속도를 측정하고, 호흡속도에 영향을 미치는 인자(밀도, 함수율, 탄소농도, 질소농도 및 C/N비)의 영향력을 파악하였다. 2018년 여름, 우리나라 중부지역 14개 임분에서 부후등급 별로 시료를 채취하고, 실험실에서 휴대용 이산화탄소 센서를 부착한 밀폐형 챔버를 이용하여 고사목 호흡을 측정하였다. 두 수종 모두 부후가 진행함에 따라 고사목 밀도는 감소하였으며, 함수율은 증가했다. 또한 탄소농도는 부후등급에 따라 유의성을 나타내지 않았으나, 질소농도는 증가하고 C/N비는 감소하는 경향을 보였다. 일본잎갈나무의 경우 부후 IV등급까지 고사목의 호흡속도가 유의하게 증가하였지만, 리기다소나무에서는 부후 II등급까지 증가 후 평형상태를 보였다. 따라서 탄소농도를 제외하고, 모든 인자들이 호흡속도와 유의한 상관관계를 나타냈으며, 단계적 회귀분석의 결과, 두 수종 모두 함수율이 고사목 호흡속도에 가장 영향을 미치는 인자로 나타났다. 이와 같이 고사목의 수분은 미생물의 활성도를 높여 호흡속도에 영향을 미치며, 온도와 광 환경 등 복잡하게 연결된 환경인자들과 밀접한 관계에 있으므로 향후 이들의 상호관계 및 수분의 시계열적패턴 추정에 대한 지속적인 연구가 필요하다.

• Journal of Nutrition and Health
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• 제55권3호
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• pp.359-375
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• 2022

성인 남성은 주된 경제활동 인구로서 앉아서 보내는 시간이 상대적으로 길어 이들의 좌식 시간과 건강의 연관성에 대한 관심과 연구가 필요하다. 본 연구의 목적은 성인 남성의 좌식 시간과 영양, 식이 및 건강 행태의 차이와 관련성에 대해 알아보고 건강 위험 요인을 예방하기 위한 가이드라인의 기초자료로 활용하는 것이다. 피험자 (n = 1,068)는 평소 하루 앉아서 보내는 시간 (시간 및 분)에 따라 4개 그룹으로 분류하였다. 좌식 시간이 가장 긴 그룹의 대상자는 평균 연령이 가장 낮았고 허리둘레가 유의적으로 가장 컸다. 또한 좌식 시간이 가장 긴 그룹의 교육수준과 White collar의 비율이 높았고, 이에 따라 업무 중 고강도와 중강도 신체활동을 하지 않는 비율 또한 높았다. 최근 1년의 음주 빈도는 그룹 간 유의적인 차이는 있었으나, 좌식 시간이 가장 짧은 그룹과 가장 높은 그룹에서 가장 빈번하였으며, 이는 좌식 시간보다는 평균 근로시간과 비슷한 경향이었다. 걷기와 근육 운동 횟수에는 그룹 간 차이가 없었지만, 유산소 운동 실시 비율은 좌식 시간이 긴 그룹에서 더 낮게 나타났다. 식이습관, 평일 수면시간 및 정신건강은 유의적인 차이가 없었다. 당뇨병 의사 진단을 받은 사람은 좌식 시간이 가장 긴 그룹에 가장 많았으나, 골다공증, 관절염, 골관절염, 류마티스성 관절염은 유병 빈도가 미미하였고 그룹 간 유의적인 차이가 없었다. 심혈관질환과 관련된 요인 중 LDL-콜레스테롤만 유의적인 차이가 있었는데, 좌식 시간이 가장 긴 그룹의 혈중 LDL-콜레스테롤 농도가 가장 높았다. 에너지 및 영양소 섭취량의 경우 좌식 시간이 가장 긴 그룹의 비타민 B₁과 칼슘 섭취량이 가장 적었고, 비타민 C를 EAR보다 적게 섭취한 분율이 가장 높았다. 본 연구 결과는 한국 성인 남성의 건강 및 영양상태 등이 좌식 시간과 관련이 있다는 것을 시사하므로 좌식 시간을 건강 위험요인으로 인지하고 이를 예방하고 해결할 수 있는 가이드라인을 개발하여야 할 것으로 사료된다.

• 한국식품영양과학회지
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• 제35권1호
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• pp.68-77
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• 2006

본 연구의 조사대상자는 전남 신안군 완도면 지역의 46세에서 83세사이의 남자 88명과 여자 99명 총 187명을 대상으로 한 연구결과를 요약하면 다음과 같다. 조사대상자의 남녀 평균 연령은 각각 65.14세, 64.92세 였고 평균 신장은 161.16cm, 151.64 crn, 평균 체중은 63.03 kg, 56.46 kg, 평균 BMI는 $24.33 kg/m^2,\;24.48 kg/m^2$, 평균 WHR은 0.94, 0.94였다. 조사 대상자 남녀 평균 총 섭취에너지는 1869.06 kcal, 1943.95 kcal로 남녀 모두 연령 증가에 따른 차이는 없었지만 남자는 60대까지는 증가하였고 70대 이후에 감소하였다. 여자는 60대가 가장 적게 섭취하는 것으로 조사되었다. 탄수화물 섭취량의 평균은 남녀 각각 368.26 g, 391.36 g로 유의적 차이는 없었으나 여자가 남자보다 많이 섭취하였고 연령증가에 따른 차이는 보이지는 않았다. 단백질 섭취량의 평균은 남녀 각각 28.08 g, 30.45 g으로 성별에 따른 차이는 없었고 연령이 증가함에 따라서 남녀 모두 증가하는 경향을 보였고 권장량에 비해 적게 섭취하는 것으로 조사되어 계절적인 요인도 관련이 있는 것으로 보이나 앞으로 이 지역에 대한 세밀한 연구가 필요할 것으로 생각된다. 지방 섭취량은 각각 31.57g, 28.51 g으로 성별과 연령에 따른 차이가 없는 것으로 조사되었다. Vit. A, Vit. $B_1$, Vit. $B_2$, Vit. D는 성별과 연령 증가와는 관련이 없는 것으로 조사되었다. Vit. C는 성별에 따른 차이는 없었고 연령이 증가함에 따라 남자는 유의적으로 감소하였고 여자는 유의성은 없지만 증가하는 경향을 보였다. Vit. E는 여자가 유의적으로 많이 섭취하였다. 엽산, 인, 철분 섭취는 남자가 유의적으로 많이 섭취하였으며 남자는 연령 증가에 따라 감소하는 경향을 보였으며 남녀 모두 한국인의 영양권장량을 상회하였다. 식사 중 콜레스테롤은 성별과 연령 증가에 따른 차이는 없었다. 조사대상자의 혈청 중성지방 농도의 남녀 각각 평균은 $149.53{\pm}8.22 mg/dL$, $143.83{\pm}5.07mg/dL$로 남녀간에 유의적인 차이는 없었으며, 남자의 경우 59세 이하, 60대, 70대 이상군에서 각각 129.6 mg/dL, 159.7 mg/dL, 157.4 mg/dL, 여자의 경우 각각 133.4 mg/dL, 149.4 mg/dL, 150.0 mg/dL로 59세 이하에서만 여자가 높고 다른 연령 군에서는 남자가 높았으며 연령증가와 함께 유의성은 없으나 증가하는 경향을 보였다. 혈청 총 콜레스테롤농도의 평균은 $189.53{\pm}4.73 mg/dL$, $157.93{\pm}4.96 mg/dL$이었고 남자가 유의적으로 높았다(p<0.05). 남녀 각각 59세 이하, 60대, 70대 이상군에서 185.0 mg/dL, 199.3 mg/dL, 180.9 mg/dL과 161.4 mg/dL, 180.9 mg/dL, 164.8 mg/dL였다. $40\~50$대는 남자가 유의적으로 높았으며 (p<0.05) 유의성은 없지만 남녀 모두 식사중의 콜레스테롤 섭취량이 가장 많은 것으로 조사된 60대의 혈청 총 콜레스테롤 농도가 가장 높은 것으로 나타나 식사중의 콜레스테롤이 혈청 총콜레스테롤에 영향을 미치는 것을 알 수 있었다. 혈청 LDL-콜레스테롤 농도의 평균은 $120.63{\pm}2.70 mg/dL$, $112.23{\pm}3.03 mg/dL$로 남녀 모두정상범위에 속하였으며 남자가 여자에 비해 유의적으로 높았고(p<0.05)남녀 각각 59세 이하, 60대, 70대 이상군에서 118.4 mg/dL, 118.8 mg/dL, 125.5 mg/dL과 108.6 mg/dL, 112.5 mg/dL, 112.9 mg/dL로 연령증가와 함께 증가하는 경향을 보였다. 혈청 HDL-콜레스테롤 농도의 평균은 $52.98{\pm}1.42 mg/dL$, $50.36{\pm}1.51 mg/dL$로 성별, 연령간에 유의적인 차이는 없었다. 심혈관 질환 예측 인자인 atherogenic index는 남녀 각각 평균 $2.13{\pm}0.08$, $2.49{\pm}0.11$로 여자가 유의적으로 높았고(p<0.05) 또한 여자는 유의성은 없지만 연령 증가와 함께 증가하는 경향을 보였고 $70\~80$대는 여자가 유의 적으로 높게 나타나(p<0.05) 여자는 연령증가와 함께 호르몬의 영향으로 심혈관계질환 위험성이 높은 것을 확인할 수 있었다. 공복시 혈당농도는 평균 $86.51{\pm}3.25 mg/dL$, $91.16{\pm}2.89 mg/dL$로 모두 정상 범위에 있었으며 $70\~80$대는 여자가 유의적으로 높게 나타났다(p<0.05). 본 연구에서는 2000년 International Obesity Task Force(IOTF)가 아시아인을 대상으로 제시한 기준에 따라 3단계(저체중 BMI<19, 정상체중 $19{\leq}BMI<25$, 과체중 $BMI\geq25$)로 분류한 결과 혈청 중성 지방은 남자 저체중군, 상체중군, 과체중군이 각각 114.1 mg/dL, 134.8 mg/dL, 176.5 mg/dL, 여자는 각각 106.7 mg/dL, 140.2 mg/dL, 157.1 mg/dL로 모든 연령 군에서 200 mg/dL보다는 낮았으나 과체중군이 다른 두 군에 비해 유의적으로 높은 것으로 조사되었다(p<0.05). 혈청 총콜레스테롤의 남녀 저체중군, 정상체중군, 과체중군이 각각 114.5mg/dL, 192.0 mg/dL, 203.4 mg/dL과 112.9 mg/dL, 156.7 mg/dL, 193.7 mg/dL로 BMI가 높을수록 두군 모두 유의적으로 증가하였다(p<0.05). LDL-Cholesterol은 남녀 저체중군, 정상체중군, 과체중군이 각각 104.6 mg/dL, 123.2 mg/dL, 120,8 mg/dL과 79.8 mg/dL, 105.9 mg/dL, 123.7 mg/dL로 BMI가 높을수록 유의적으로 높아졌다(p<0.05). 동맥경화지수는 남녀 각각 저체중군, 정상체중군과 과체중군이 2.48, 1.98, 2.23과 1.66, 2.22, 2.98로 저체중군에서는 남자가 높았으나 정상체중군과 과체중군에서는 여자가 높았고 BMI가 증가함에 따라 남자는 뚜렷한 경향을 보이지 않았으나 여자는 유의적으로 증가하여 (p<0.05) 동맥경화를 비롯한 심혈관계질환의 위험도가 여자가 높다는 것을 알 수 있었다. 혈당은 남자는 저체중군, 정상체중군과 과체중군이 각각 68.1 mg/dL, 96.0 mg/dL, 78.4 mg/dL로 정상체중일 때 다른 두 군에 비해 유의적으로 높았는데(p<0.05)여자는 87.5 mg/dL, 88.5 mg/dL, 94.8 mg/dL로 유의성은 없지만 BMI가 증가할수록 혈당이 높아졌다. 본 조사대상자의 연령을 보정한 후 WHR에 따른 혈청 지질 및 혈당 수준은 남자는 WHR이 높을수록 혈청 중성 지방과 혈당은 유의적으로 증가 하였고(p<0.05) 혈청 총 콜레스테롤, LDL-cholesterol, 동맥경화지수는 유의성은 없지만 증가하는 경향을 보였다. 여자는 WHR이 높을수록 혈중 중성지방, 혈당, 혈청 총 콜레스테롤, LDL-cholesterol, 동맥 경화지수가 유의적으로 높아졌다(p<0.05). HDL-Cholesterol은 WHR이 높을수록 남자는 유의성은 없지만 낮아지는 경향을 보였고 여자는 유의적으로 낮아졌다(p<0.05). 이상의 결과에서 연령, BMI, WHR이 높을수록 심혈관계 질환의 위험인자인 혈청 중성지방, 혈청 총콜레스테롤, LDL-cholesterol의 수준이 높아졌지만 혈청 지질의 평균이 대부분 한국인의 정상수준에 속하였고 비정상자의 비율도 다른 지역에 비해서 낮은 편으로 조사되어 앞으로 도서지역의 식생활과 만성질환 위험인자와의 관련성에 대한 지속적인 연구가 필요할 것으로 보인다.

• 한국식품영양과학회지
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• 제38권6호
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• pp.694-708
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• 2009

본 연구는 서울시에 거주하는 남자 중 고생을 대상으로 흡연과 음주 현황을 조사하여 흡연 유무에 따라 비흡연군 (199명), 흡연군(11명), 흡연 음주군(52명)으로 분류하였으며, 설문을 통해 흡연과 음주습관, 식생활 관련사항 및 영양섭취상태 등을 조사하여 흡연과 음주습관이 식생활 습관, 영양소 섭취상태 및 건강상태에 어떠한 영향을 미치는지를 조사하였다. 전체 조사대상자의 신장 및 체중은 각각 $173.5{\pm}6.8\;kg$, $64.83{\pm}11.8\;cm$로 신장은 한국인 체위 기준치에 비해 1.5 cm 이상 더 컸으며, 체중은 1.0 kg 정도 높게 조사되었고, 전체 조사대상자의 체질량지수의 평균값은 $21.4{\pm}3.7\;kg/m^2$정도로 나타났다. 전체 조사대상자의 89% 이상이 건강에 대해 관심이 있는 것으로 조사되었으며, 43.5%의 청소년이 자신만의 건강유지 비결로 규칙적인 운동을 가장 많이 손꼽았다. 또한 66.0%의 청소년이 실제로 운동을 하고 있었으며, 일주일에 평균 3번 정도한다고 답한 전체 응답자는 37.3%로 가장 많은 비율을 차지하였다. 1회 운동 시 평균 운동시간은 30분${\sim}$1시간 정도가 가장 많은 비율(46.3%)을 차지하였다. 흡연자 63명 중 음주를 하는 학생이 52명 82.5%이었으며, 11명 17.5%만은 흡연만 하여 본 연구결과에서 보면, 흡연을 하는 경우 음주를 동시에 하는 것으로 조사되었다. 55.6%의 남자 중 고생은 중학교 때 흡연을 시작하였으며, 흡연 동기는 38.1%가 호기심으로 시작했다고 답하였다. 특히 배고플 때 흡연욕구를 강하게 느꼈으며, 흡연 장소로는 화장실이라고 답하였다. 흡연기간은 6개월에서 1년 사이가 가장 많은 비율을 차지하였고, 하루 흡연량은 하루에 $5{\sim}10$개피를 핀다고 답한 비율이 가장 많이 차지하였다. 금연을 하기 위해 시도했던 방법으로는 그냥 참은 경우가 69.0%였으며, 금연에 실패한 이유로는 의지부족이 44.4%로 가장 많은 비율을 차지하였다. 금연의 의향을 묻는 질문에는 전체 조사대상자의 87.1%가 금연을 하고 싶다고 답하였으나, 금연 프로그램을 실시하면 참여하겠느냐는 질문에는 단지 56.7%만이 참여하길 원하였다. 흡연 음주군에서 음주 시작 시기는 50.0%가 고등학교 때 시작하였으며, 사교적 필요성에 의해서 음주를 시작하였다고 답하였다. 음주는 주로 지정된 장소에서 하였으며, 조사대상자의 반 이상의 남자 중 고생이 한 번에 마시는 술의 양은 소주 한 병이하라고 답하였다. 음주의 욕구를 강하게 느낄 때는 친구가 술을 먹을 때라고 답하였으며, 금주 의향을 묻는 질문에는 단지 40.4%만이 금주를 하겠다고 답하였다. 34.4%의 아동이 매일 아침식사를 하는 것으로 조사되었으며, 아침식사를 전혀 하지 않는 결식률도 16.4%나 되었다. 아침식사를 거르는 이유로는 47.0%가 '아침시간이 바빠 시간이 없어서'라고 답하였으며, 건강상의 문제를 고려해 볼 때 결식의 방안을 마련하는 것이 시급한 과제라고 사료된다. 과식을 하는 이유로는 전체 조사대상자의 52.5%가 좋아하는 음식이 많아서 과식을 하는 것으로 조사되었으며, 흡연 음주군에서 과식을 자주하는 것으로 나타났다(p<0.05). 간식의 경우 하루에 $1{\sim}2$회 한다는 전체 청소년의 비율이 72.6%를 차지하였으며, 간식으로 섭취하는 식품으로는 비흡연군에서는 빵류 및 감자 40.2%, 패스트푸드 및 튀김식품을 30.7%로 많이 섭취하고 있었으며(p<0.05), 흡연군에서는 탄산음료 및 빙과류를 간식으로 섭취하는 비율이 36.4%나 되었고, 흡연 음주군에서는 과일류(38.5%)와 패스트푸드 및 튀김식품(26.9%)을 간식으로 가장 많이 섭취하는 것으로 조사되었다. 남자 중 고생이 주식으로 섭취하는 탄수화물 식품의 섭취비율 중 비흡연군에서는 다른 군에 비해 잡곡과 현미를 각각 45.7%와 36.2%로 유의하게 높았다(p<0.05). 흡연 음주군에서는 과일을 자주 섭취하는 비율이 9.6%로 매우 낮았으며(p<0.05), 50.0%가 패스트푸드를 섭취하는 것으로 조사되었다. 식생활 평가에서는 흡연군에서 삼겹살, 갈비 등 지방이 많은 육류를 주 2회 이상 먹는 비율이 높았으며, 아이스크림이나 과자, 탄산음료를 주 2회 이상 간식으로 자주 먹는 비율도 54.3%로 유의하게 높았다(p<0.05). 전체적인 영양소 섭취상태는 $15{\sim}19$세 청소년의 영양섭취기준에 제시한 기준치에 비해 현저히 높았으며, 열량 섭취의 경우 비흡연군에 비해 흡연군과 음주 흡연군에서 유의하게 높았다(p<0.05). 특히 흡연 음주군에서는 다른 군에 비해 인이 유의하게 높은 것으로 조사되었으며(p<0.05), 콜레스테롤(p<0.05)과 소디움(p<0.05) 섭취량은 흡연군에서 가장 높았다. 본 연구결과 청소년들이 흡연과 음주를 하게 되는 가장 큰 이유가 친구나 학교 선 후배 등 또래 집단의 영향을 받는 것으로 조사되었으며, 충동적인 호기심에 의해 시작하는 경우가 많아 흡연과 음주가 건강에 미치는 유해성에 대한 인식이 부족하였다. 또한 흡연을 하는 경우 음주를 동시에 하는 남자 중 고생이 82%가 넘는 것으로 나타나 청소년들의 흡연과 음주 실태는 심각한 사회 문제라 할 수 있으며, 식생활 습관도 음주 흡연군에서는 과일 섭취가 낮은 반면 고열량 식품 선호 및 과식을 하는 것으로 조사되었고, 흡연군에서는 육류 및 가공식품등의 섭취가 높았다. 따라서 선행연구(6)에서도 지적했듯이 친구들의 흡연과 음주의 권유를 단호하게 거절할 수 있는 대처방법을 습득시키거나 흡연과 음주의 욕구를 느낄 때의 실질적인 대처 수단 및 금연을 하는 구체적인 방법 등의 현실적인 교육이 필요하다고 사료된다. 흡연과 음주로 인해 발생되는 편식이나 과식 등의 잘못된 식습관을 바로 잡아 청소년의 성장 발달에 도움을 줄 수 있는 균형적인 영양섭취가 중요하며, 영양적인 중요성을 인식할 수 있는 교육도 뒷받침되어야 할 것이다. 또한 청소년 시기에 먹거리의 중요성을 인식시켜 건강에 유익하고, 안전한 식품을 선택할 수 있는 감각을 습득시키는 것도 중요할 것으로 사료된다.

• 대한의용생체공학회:의공학회지
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• 제6권2호
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• pp.1-8
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• 1985

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70$\pm$1.32mmHg/min)compared to CF dialyzers(4.32$\pm$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500, 550, 570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500, 550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100, 300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3, 000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.SpO2 with Plethysmograph.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
• /
• 한국우주과학회 1993년도 한국우주과학회보 제2권2호
• /
• pp.17-17
• /
• 1993

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70${\pm}$1.32mmHg/min)compared to CF dialyzers(4.32${\pm}$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500,550,570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500,550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100,300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3,000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.