• Genomics & Informatics
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• 제4권3호
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• pp.129-132
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• 2006

Toxicogenomics has recently emerged in the field of toxicology and the DNA microarray technique has become common strategy for predictive toxicology which studies molecular mechanism caused by exposure of chemical or environmental stress. Although microarray experiment offers extensive genomic information to the researchers, yet high dimensional characteristic of the data often makes it hard to extract meaningful result. Therefore we developed toxicant enrichment analysis similar to the common enrichment approach. We also developed web-based system graPT to enable considerable prediction of toxic endpoints of experimental chemical.

• International Journal of Computer Science & Network Security
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• 제23권12호
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• pp.107-114
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• 2023

The attack technique by the malware distribution form is a dangerous, difficult to detect and prevent attack method. Current malware detection studies and proposals are often based on two main methods: using sign sets and analyzing abnormal behaviors using machine learning or deep learning techniques. This paper will propose a method to detect malware on Endpoints based on Event IDs using deep learning. Event IDs are behaviors of malware tracked and collected on Endpoints' operating system kernel. The malware detection proposal based on Event IDs is a new research approach that has not been studied and proposed much. To achieve this purpose, this paper proposes to combine different data mining methods and deep learning algorithms. The data mining process is presented in detail in section 2 of the paper.

• 대한환경공학회지
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• 제39권3호
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• pp.132-139
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• 2017

내분비계 장애물질 (EDCs)은 생물체내에 유입되면 내분비계의 정상적 기능을 방해하는 특징이 있으며, 일반화학물질과는 다른 독성기전을 보이기 때문에 기존의 생태독성기법과 달리 EDCs만의 독성을 평가하기 위한 생태독성기법 및 독성종말점의 개발을 위한 연구가 필요하다. OECD, ASTM 및 USEPA와 같은 신뢰성 있는 국제기관에서는 EDCs의 생태독성기법들을 제안하고 있는 상황이다. EDCs가 유해성이 알려진 만큼 국내에서도 EDCs관련 정부지원 사업이 일부 EDCs에 대해 사업장에의 배출량, 환경매체에서 검출농도를 지속적으로 모니터링하고 있으며, EDCs관련 연구들이 보고되고 있다. 그러나 국내에는 EDCs를 대상으로 하는 생태독성기법이 부재한 상황이다. 본 연구에서는 국외 EDCs의 생태독성기법을 조사 및 분석하여 제안된 생물종과 독성종말점의 종류 및 시험조건 파악하고자 하였다. 그 결과, ISO에서는 아직 EDCs 생태독성기법을 따로 제안하고 있지 않은 상태이며, OECD, ASTM, USEPA에서만 수서생물종인 어류 양서류, 물벼룩 및 요각류, 토양생물종인 지렁이, 애지렁이, 톡토기, 진드기, 토양선충, 그리고 퇴적물서식종인 지렁이와 깔따구에 대한 EDCs 평가기법이 제시되어 있고, 생식, 호르몬, 성장, 비탈로제닌, 성비 및 발달 등과 관련된 독성종말점으로 제안되어 있었다. 결론적으로 EDCs 대상의 생태독성 평가방법은 매우 제한적이며, 생태독성 기법 개발 및 독성종말점을 개발하기 위한 연구가 필요한 것으로 판단된다.

• 정보처리학회논문지C
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• 제8C권6호
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• pp.821-830
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• 2001

H.323은 이동 단말에 핸드오프(Handoff)를 지원하기 위해 Mobile IP와 H.323 다자간 회의(Multi-point conference) 시그널링을 사용할 것을 제안하고 있다. 하지만 다자간 회의 시그널링은 단말이 복잡한 시그널링을 수행해야 하고 이에 따른 핸드오프 시간이 길어진다는 단점이 있다. 본 논문에서는 H.323 리라우팅(Third party initiated Pause and Rerouting)이 이용된 핸드오프 시그널링을 제안한다. H.323 리라우팅 시그널링은 H.323 단말(Endpoint)이 기본적인 스택만으로 미디어 채널을 재설정하기 때문에 H.323 제품 간의 연동(Inter-Operability)을 쉽게 할 뿐 아니라 빠른 핸드오프를 제공한다. H.323 GK는 H.323 리라우팅 시그널링을 이용하기 위해 패스트커넥트(Fast Connect) 호를 포함한 모든 호에 대해서 터널링을 사용하여 H.245 제어 채널을 유도한다. 제안된 핸드오프 시그널링을 평가하기 위해 H.323 리라우팅이 이용된 호전환(Call Transfer)과 다자간 회의 시그널링을 연동과 시그널링 시간 측면에서 비교하였다. 성능을 평가한 결과 리라우팅이 사용된 호전환은 5개의 제품 중 4개의 제품과 연동이 되었으며 시그널링 시간은 평균 1.4초 빨랐다.

• 셀메드
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• 제10권2호
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• pp.17.1-17.5
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• 2020

Background: Chronic kidney disease (CKD) is affective a large portion of the world population prompting the need for extensive healthcare resources such as lifelong dialysis or kidney transplantation. The beneficial effect of conventional therapy in controlling the CKD progression remains a challenge due to their relative efficacy, safety, and accessibility. On the other hand, Unani medicine provides a therapeutic regimen that consists of a combination of treatment from rehabilitation to herbal pharmacotherapy. Methods: Two cases of chronic kidney disease were treated with dietotherapy, regimenal therapy ('bukhoor aam') and oral herbal drugs for 2-3 weeks. Endpoints of evaluation were symptoms and signs of the CKD, kidney function test, urine albumin, urine RBC, hemoglobin and liver function test. Result: Notable improvement was observed in the endpoints. Conclusion: Unani treatment was observed preliminarily beneficial in the treatment of chronic kidney disease. Rigorous pharmacological and clinical studies should be performed to warrant their efficacy and safety in CKD individuals.

• 한국환경성돌연변이발암원학회지
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• 제21권2호
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• pp.113-117
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• 2001

The screening of various molecular descriptors for predicting carcinogenic, mutagenic and teratogenic activities of chlorinated aliphatic compounds as drinking water disinfection byproducts (DBPs) has been investigated for the application of quantitative structure-activity relationships (QSAR). The present work embodies the study of relationship between molecular descriptors and toxicity parameters of the genotoxicity endpoints for the screening of relevant molecular descriptors. The toxicity Indices for 29 compounds constituting the testing set were computed by the PASS program and active values were chosen. We investigate feasibility of screening descriptors and of their applications among different genotoxic endpoints. The correlation to teratogenicity of all 29 compounds was significantly improved when the same analysis was done with 20 alkanes only without alkene compounds. The HOMO (highest occupied molecular orbital) energy and number of Cl parameters were dominantly contributed.

• 환경생물
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• 제29권1호
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• pp.23-30
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• 2011

In this study, the Comet assay (evaluation of DNA damage) used the fish hepatocellular carinoma cell, PLHC-1, was tried to the sediment extract obtained from freshwater to understand its applicability as a tool for monitoring sediment toxicity. In parallel, induced EROD (7-ethoxyresorufin- O-deethylase) activity and DNA damage (TEM values) in PLHC-1 cells were measured for establishing the tandem endpoints of the PLHC-1cell test to test the ecotoxicity of sediment. Among several study sites in a small river passed through downtown and industrial park area, one of them, site B, showed a higher level of EROD activity and DNA damage than other sites. It indicates that a tandem endpoints of PLHC-1 cells could be useful tools for assessing the toxicity of sediment. The sensitivity of Comet assay with PLHC-1 cells was a little higher than that with a blood cell of frog tadpoles to the solvent extract of sediment. According to the results, a PLHC-1 cell-Comet assay could be used as a useful tool for evaluating ecotoxicity of the freshwater sediment. In addition, more detailed studies are needed to the contaminated site.

• 한국자원식물학회지
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• 제28권4호
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• pp.371-381
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• 2015

The object of this study was to obtain single oral dose toxicity of Arisaema Rhizome (Arisaema amurense f. serratum (Nakai) Kitag) aqueous extracts. Arisaema Rhizome (Chunnamsong in Korean) is one of the most important folk remedy plants used in Asia. In the study, a 28-day rat oral gavage study has been conducted with the extracts from Arisaema Rhizome at dose of 1,250, 2,500 and 5,000 ㎎/㎏/day. The following endpoints were evaluated: clinical observations, body weight, gross and microscopic pathology, clinical chemistry, and hematology. Based on the analysis of these endpoints, it was estimated that NOEL (no observed effect level) for male rats and NOAEL (no observed adverse effect level) for female rats are 5000 ㎎/㎏/day of the water-extracts from Arisaema Rhizome.

• International Journal of Arrhythmia
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• 제19권3호
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• pp.235-284
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• 2018

In this part the writing group will cover strategies, techniques, and endpoints of atrial fibrillation (AF) ablation. Prior to all, electrical isolation of the pulmonary veins is recommended during all AF ablation procedures. In addition, techniques to be used for ablation of persistent and long-standing persistent AF, adjunctive ablation strategies, nonablative strategies to improve outcomes of AF ablation, and endpoints for ablation of paroxysmal, persistent, and long-standing persistent AF will be reviewed. Currently many technologies and tools are employed for AF ablation procedures. Radiofrequency energy, cryoablation, and other energy sources and tools are in various stages of development and/or clinical investigation. Finally, anticoagulation strategies pre-, during, and postcatheter ablation of AF and technical aspects of ablation to maximize safety are discussed in this section.

• 한국정보기술학회논문지
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• 제17권8호
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• pp.75-83
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• 2019

본 논문에서는 Median flow와 영상의 Depth 정보를 이용하여 산업 현장의 다양한 환경 조건에서 실시간 철근의 끝점 추적 및 검출이 가능한 방법을 제안한다. 영상의 Depth 정보에 Median filter, Binarization, Morphology, Blob의 알고리즘을 사용하여 2개의 철근 끝점을 검출하는 방법을 제안하였다. 실시간 철근 끝점 추적을 위해서는 Median flow의 알고리즘을 이용하여 철근의 움직임 방향과 위치 추적을 제안하였다. 그리고 Depth 영상에서 검출된 철근 끝점 좌표와 Median flow를 이용한 철근의 위치추적 좌표를 서로 비교하여 최종 위치 좌표를 결정하였다. 그 결과 기존 Median flow 방식만 적용하였을 때 75% 정도의 철근의 최종 위치 판단 성공률이 Depth의 철근 끝점 정보까지 활용하였을 때는 95%까지 추적 성공률이 높아졌다.