• The KIPS Transactions:PartC
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• v.14C no.6
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• pp.481-492
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• 2007

The ubiquitous environment allows users to communicate with others and to have access to computing service any time, any place. Multipoint VoIP is expected to be one of the loading applications in this environment. The paper compares various conference models for efficient VoIP service in ubiquitous environment and shows why the endpoint mixing model performs effectively in this environment. However, the endpoint mixing model has its own drawbacks as well and we propose solutions to solve the problems.

• The Journal of the Acoustical Society of Korea
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• v.22 no.3E
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• pp.113-123
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• 2003

One of the most important problems in speech recognition is to detect the presence of speech in adverse environments. In other words, the accurate detection of speech boundary is critical to the performance of speech recognition. Furthermore the speech detection problem becomes severer when recognition systems are used over the telephone network, especially wireless network and noisy environment. Therefore this paper describes various speech detection algorithms for continuous digit recognition system used over wire/wireless telephone networks and we propose a algorithm in order to improve the robustness of speech detection using useful band selection under noisy telephone networks. In this paper, we compare some speech detection algorithms with the proposed one, and present experimental results done with various SNRs. The results show that the new algorithm outperforms the other speech detection methods.

• 제어로봇시스템학회:학술대회논문집
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• 1992.10b
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• pp.1-6
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• 1992

A principle of "orthogonalization" is proposed as an extended notion of hybrid (force and position) control for robot manipulators under geometric endpoint constraints. The principle realizes the hybrid control in a strict sense by letting position and velocity feedback signals be orthogonal in joint space to the contact force vector whose components are exerted at corresponding joints. This orthogonalization is executed via a projection matrix computed in real-time from a gradient of the equation of the surface in joint coordinates and hence both projected position and velocity feedback signals become perpendicular to the force vector that is normal to the surface at the contact point in joint space. To show the important role of the principle in control of robot manipulators, three basic problems are analyzed, the first is a hybrid trajectory tracking problem by means of a "modified hybrid computed torque method", the second is a model-based adaptive control problem for robot manipulators under geometric endpoint constraints, and the third is an iterative learning control problem. It is shown that the passivity of residual error dynamics of robots follows from the orthogonalization principle and it plays a crucial role in convergence properties of both positional and force error signals.force error signals.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.311-311
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• 2000

We propose a DP-based formulation for matching line patterns by defining a robust and stable geometric representation that is based on the conceptual organizations. Usually, the endpoint proximity and collinearity of image lines, as two main conceptual organization groups, are useful cues to match the model shape in the scene. As the endpoint proximity, we detect junctions from image lines. We then search for junction groups by using geometric constraint between the junctions. A junction chain similar to the model chain is searched in the scene, based on a local comparison. A Dynamic Programming-based search algorithm reduces the time complexity for the search of the model chain in the scene. Our system can find a reasonable matching, although there exist severely distorted objects in the scene. We demonstrate the feasibility of the DP-based matching method using both synthetic and real images.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.193-193
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• 2001

A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for contact sensitization potential. However, a disadvantage of the LLNA is the need for the use of radioactive material. In this study, we aimed to investigate the development of non-radio isotopic endpoint for LLNA using immunohistochemistry.(omitted)

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.124-124
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• 1995

Cisplatinum is often effective in cancer treatment, but potent nephrotoxicity limits its clinical use. We have, therefore, developed new anticancer drugs that contain platinum. We have synthesized six new platinum compounds based on Figure 1. Drugs were initially administrated at 5${\times}$10$\^$-4/M with 48 hours exposure in monolayer cultures of primary rabbit proximal tubular cells and human renal cortical cells with the M.T.T. endpoint to measure toxicity. Drug concentrations of 10$\^$-3/M, 10$\^$-4/M, and 10$\^$-5/M with 72 hours exposure were used for human renal cortical tissues in 7 weeks histoculture with toxicity measured by the glucose-consumption endpoint. From these studies, we determined that the new platinum drugs have lower nephrotoxicity than cisplatinum. Drugs D, E, and H. have lower nephrotoxicity than the other new drugs. We are currently measuring the anticancer efficacy of drugs D, E, and H.

• Journal of Communications and Networks
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• v.13 no.6
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• pp.612-620
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• 2011

Recently, one of the problems with the Internet is the issue of scalability. To this end, locator/identifier separation protocol (LISP), which separates end-system identifiers and routing locators, has been proposed as a solution. In the LISP deployed network, the ingress and egress nodes of inter-AS traffic is determined by edge router selection (ERS) and endpoint identifier-routing locator mapping assignment (ERMA). In this paper, joint optimizations of ERS and ERMA for stub networks with and without predetermined link weights are studied and the mixed integer linear programming (MILP) formulations for the problems are given. To make the problem with optimizable link weights tractable, a revised local search algorithm is also proposed. Simulation results show that joint optimization of ERS and ERMA enables better network performance.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.185-185
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• 2002

A murine local lymph node assay (LLNA) has been developed as an alternative test to guinea pig maximization test. The disadvantage of LLNA is the need for the use of radioactive material. In this study, we aimed to investigate the development of non-radio isotopic endpoint for local lymph node assay in Balb/c mice using Enzyme-linked immunosorbent assay (ELISA) based on Bromodeoxyuridine (BrdU) incorporation.(omitted)

• Journal of the Korean Mathematical Society
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• v.43 no.3
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• pp.623-634
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• 2006

Various methods have been studied to construct a fuzzy regression model in order to present a fuzzy relation between a dependent variable and an independent variable. However, in the fuzzy regression analysis the value of the center point of estimated fuzzy output may be either greater than the value of the right endpoint or smaller than the value of the left endpoint. In the case, we cannot predict the fuzzy output properly. This paper presents sufficient conditions to construct the fuzzy regression model using several methods investigated by some authors and then introduces the censored fuzzy regression model using the censored samples to manipulate the problem of crossing of the center and the end points of the estimated fuzzy number. Examples show that the censored fuzzy regression model is an extension of the fuzzy regression model and also it improves the problem of crossing.

• Communications for Statistical Applications and Methods
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• v.26 no.2
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• pp.163-173
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• 2019

Simon's two-stage designs are frequently used in phase II single-arm trials for efficacy studies. A concern of safety studies is too many patients who experience an adverse event. We show that Simon's two-stage designs for efficacy studies can be similarly used to design a two-stage safety study by modifying some of the design parameters. Given the type I and II error rates and the proportion of adverse events experienced in the first stage cohort, we prescribe a procedure whether to terminate the trial or proceed with a stage 2 trial by recruiting additional patients. We study the relationship between a two-stage design with a safety endpoint and an efficacy endpoint as well as use simulation studies to ascertain their properties. We provide a real-life application and a free R package gen2stage to facilitate direct use of two-stage designs in a safety study.