• Proceedings of the Korean Society of Applied Pharmacology
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.265-265
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• 1994

본 연구는 간염 바이러스의 X 및 elongated X 유전자를 클로닝하여 E. coli에서 대량 발현시진 후, 그 기능을 여러 측면에서 연구하교 지금까지 알려진 oncogene products, tumor suppressor, 그리고 그 밖의 다른 암 유발인자와의 interaction에 대해 분석함으로써 간암 생성의 분자적 기작을 이해하고 더 나아가 간암의 예방 및 치료제의 개발을 목표로 하였다. 그 일차적 연구로서 이전에 플로닝된 mutant hepatitis Bvirus genome으로부터 X 및 elongated X 유전자를 클로닝하였으며, E. coli에서 대량 발현시키기 위하여 T7 bacteriophage promoter아래에 재 클로닝하였다. 이러한 X 및 ebngated X 유전자를 E. coli에서 대량 발현시킨 후, rabbit anti-X antibody를 이용하여 western blotting을 수행함으로서 이를 확인하였으며 DEAE-cellulose와 heparin-agarose chromategraphy를 이용하여 순수분리하였다. 순수분리된 X 및 etongated X 단백질을 highly differentiated hepatoma cell인 HepG$_2$ cell에 처리하여 transactivation activity를 측정하였다. 그 결과 순수분리된 단백질들이 SV4O promoter를 transactivation 함을 할 수 있었으며, 이로부터 클로닝된 유전자들이 모두 정상적인 기능을 가짐을 확인하였다. 그러고 X 유전자의 작용기작을 규명하기위하여 restriction endonuclease를 이용하여 5 개의 mutant X 유전자를 구성하였으며 현재 이를 HepG2 cell에 transfection 하여 그 기능을 연구하고 있다.

• Journal of Powder Materials
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• 제6권3호
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• pp.246-250
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• 1999

The effects of the ${\beta}-Si_3N_4$ starting particle size and $\alpha$/$\beta$ phase transformation during sintering process on the microstructure evolution of Yttrium $\alpha$-Sialon ceramics were investigated. As-received ${\beta}-Si_3N_4$ powder (mean particle size: 0.54$\mu$m) and classified ${\beta}-Si_3N_4$ powder(mean particle size: $0.26\mu{m}$) were used as starting powders. With decreasing the starting particle size, the growth of elongated grains was enhanced, which resulted in the whisker -like microstructure with elongated grains. These results were discussed in relation to the two-dimensional nucleation and growth theory. In the specimen heat treated at $1600^{\circ}C$ for 10h before sintering at $1950^{\circ}C$for 1h under 40atm(2-step sintering), the grain size was smaller than of the 1-step sintering at 195$0^{\circ}C$ for 1h. However, bimodal microstructure evolution were not not remarkable in both sample, which is ascribed to the $\alpha$-phase contents existing in ${\beta}-Si_3N_4$ starting powder.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 한국정밀공학회 2002년도 추계학술대회 논문집
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• pp.796-799
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• 2002

The stress of the rotating disc with several types of hole was investigated in detail in this paper. Maximum circumferential stress of rotating disc by changing hole shape with same area, were studied using FEM. The results obtained were as follows: 1. The disc which rotates at high speed is subjected to circumferential stress remarkably. 2. When the number of circular holes in rotating disc is four, stress reduction effect is maximum. 3. When shape of holes in rotating disc is cylindrical elongated hole, maximum circumferential stress of the rotating disc decreased most.

• Journal of Powder Materials
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• 제5권1호
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• pp.22-27
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• 1998

The effect of the $\alpha$/$\beta$ phase fraction on the mechanical properties in silicon nitrides was investigated in part 1. In part II, we describe the role of microstructure on the mechanical properties and contact damage of silicon nitrides with coarse/equiaxed and coarse/elongated microstructures. Grain sizes and shapes were controlled by starting powder. Hertzian indentation using spherical indenter was also used to investigate contact damage behavior. Cone cracks from the spherical indentation were suppressed when the silicon nitride contains coarse and elongated grains. Coarse and elongated grains played an important role of cone crack suppression. The size of quasi-plastic zone does not depend on grain size or shape but depends on the fraction of $\alpha$/$\beta$ phase. A quasi-plastic zone was consisting of microcracks by shear stress during indentation.

• Journal of the Korean Ceramic Society
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• 제36권8호
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• pp.799-804
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• 1999

Composites of SiC-Si3N4 consisted of uniformly distributed elongated $\beta$-Si3N4 grains and equiaxed $\beta$-SiC grains were fabricated with $\beta$-SiC,. $\alpha$-Si3N4 Al2O3 and Y2O3 powders. By hot-pressing and subsequent annelaing elongated $\beta$-Si3N4 grains were grown via$\alpha$longrightarrow$\beta$ phase transformation and equiaxed $\beta$-Si3N4 composites increased with increasing the Si3N4 content owing to the reduced defect size and enhanced crack deflection by elongated $\beta$-Si3N4 grains and the grain boundary strengthening by nitrogen incorporation. Typical flexural strength and fracture toughness of SiC-40 wt% Si3N4 composites were 783 MPa and 4.2 MPa.m1/2 respectively.

• Proceedings of the KIEE Conference
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• 대한전기학회 1990년도 하계학술대회 논문집
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• pp.199-201
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• 1990

The trap depth and its density of highly elongated polyethylene have been studied by thermally stimulated current measurements. Three discrete traps with depth of 0.13 0.3 and 0.5 eV have been evaiuated using the initial rise method in the temperature region 77 to 390 K ; these change slightly with the elongation ratio. A trap density of the order of $10^{13}-10^{14}/cm^3$ has been calculated from the area of TSC peaks.

• Proceedings of the Optical Society of Korea Conference
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• 한국광학회 2003년도 하계학술발표회
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• pp.276-277
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• 2003

계측분야에서 물체의 변형정도를 알아내는 광학적인 방법으로 물체에 격자를 부착하여 격자의 변위에 의한 무아레 무늬(moir fringes)를 이용하여 물체의 변형정도를 알아내는 방법이 있다. 최근에 본 그룹에서 물체의 변형정도를 피치간격으로 측정할 수 있고, 한 피치 내의 세밀한 부분은 유사한 두 개의 격자가 겹쳐서 형성되는 버니어 무아레 무늬를 이용하여 세부적인 변위 정도를 알아낼 수 있는 방법을 제안하였다. (중략)

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제40권1호
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• pp.43-47
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• 2014

Eagle's syndrome is a disease caused by an elongated styloid process or calcified stylohyoid ligament. Eagle defined the disorder in 1937 by describing clinical findings related to an elongated styloid process, which is one of the numerous causes of pain in the craniofacial and cervical region. The prevalence of individuals with this anatomic abnormality in the adult population is estimated to be 4% with 0.16% of these individuals reported to be symptomatic. Eagle's syndrome is usually characterized by neck, throat, or ear pain; pharyngeal foreign body sensation; dysphagia; pain upon head movement; and headache. The diagnosis of Eagle's syndrome must be made in association with data from the clinical history, physical examination, and imaging studies. Patients with increased symptom severity require surgical excision of the styloid process, which can be performed through an intraoral or an extraoral approach. Here, we report a rare case of stylohyoid ligament bilaterally elongated to more than 60 mm in a 51-year-old female. We did a surgery by extraoral approach and patient's symptom was improved.

• Wind and Structures
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• 제37권6호
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• pp.399-412
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• 2023

Previous studies have shown that the integrated transfer function (ITF) is independent of turbulence characteristics and can be effectively applied to predict the buffeting response of elongated structures, assuming that the strip hypothesis is valid. However, existing research has not effectively identified the ITF through segment model vibration tests, and the influence of the 3D effect on the accuracy of the strip hypothesis and the characteristics of the ITF in wind tunnel tests has not been quantitatively studied. A segment model vibration measurement device that can change a test model's span-width ratio was designed in this study. An airfoil section and a streamlined box girder section structure were taken as the background, and their ITFs were effectively identified under different L/B (L denotes the turbulent integral scale and B denotes the structural width) and model span-width ratios. The influence laws of the 3D effect on the accuracy of the strip hypothesis and ITF identification in wind tunnel tests were systematically investigated. The results showed that L/B and the structural span-width ratio are two significant controlling factors that affect the accuracy of the strip hypothesis and ITF identification. The research provides an effective experimental method for accurately predicting the buffeting response of elongated structures based on ITFs identified through segment model vibration tests.

• Imaging Science in Dentistry
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• 제43권2호
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• pp.129-134
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• 2013

Turner syndrome (TS) is one of the most common chromosomal abnormalities, with an estimated frequency among female live births of 1/2,000-3,000. The syndrome is characterized by the partial or complete absence of one X chromosome (45,X karyotype). We reported a unique case of a 40-year-old woman with TS accompanying unexpected elongated styloid process specific to Eagle syndrome (ES) and followed up-prolactinoma. The present article is the first report to define the cone-beam computed tomographic (CBCT) features of TS accompanying ES. Patients with TS carry various risks that make treatment more complicated; thus advanced imaging techniques for proper treatment and follow-up are extremely important. In the light of CBCT examination, craniofacial abnormalities specific to TS and accompanying syndromes such as the crowding of teeth especially in the maxillary anterior region caused by maxillary narrowness, micrognatic maxilla and mandible, relative mandibular retrusion, malocclusion, open-bite, and an elongated styloid process (length of 32.7 mm) on the right side were illustrated in detail.