• The Korean Journal of Physiology and Pharmacology
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• v.21 no.5
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• pp.555-563
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• 2017

Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted FB filter for artifact subtraction. From the extracted retinae of rd1 mice, we recorded RGC spikes with $8{\times}8$ multielectrode array (MEA). The recorded signals were classified into four groups by distances between the stimulation and recording electrodes on MEA (200-400, 400-600, 600-800, $800-1000{\mu}m$). Fifty cathodic phase-$1^{st}$ biphasic current pulses (duration $500{\mu}s$, intensity 5, 10, 20, 30, 40, 50, $60{\mu}A$) were applied at every 1 sec. We compared false positive error and false negative error in FB filter and TP-adopted FB filter. By implementing TP-adopted FB filter, short-latency spike can be detected better regarding sensitivity and specificity for detecting spikes regardless of the strength of stimulus and the distance between stimulus and recording electrodes.

• Journal of Electrical Engineering and Technology
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• v.7 no.3
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• pp.451-458
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• 2012

The voluntary EMG (vEMG) signal from electrically stimulated muscle is very useful for feedback control in functional electrical stimulation. However, the recorded EMG signal from surface electrodes has unwanted stimulation artifact and M-wave as well as vEMG. Here, we propose an event-synchronous adaptive digital filter for the suppression of stimulation artifact and M-wave in this application. The proposed method requires a simple experimental setup that does not require extra hardware connections to obtain the reference signals of adaptive digital filter. For evaluating the efficiency of this proposed method, the filter was tested and compared with a least square (LS) algorithm using previously measured data. We conclude that the cancellation of both primary and residual stimulation artifacts is enhanced with an event-synchronous adaptive digital filter and shows promise for clinical application to rehabilitate paretic limbs. Moreover because this algorithm is far simpler than the LS algorithm, it is portable and ready for real-time application.