• Anatomy and Cell Biology
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• v.57 no.1
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• pp.85-96
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• 2024

Glioblastoma is the most common primary malignant brain tumor in adults. Temozolomide (TMZ) is an FDA-approved drug used to treat this type of cancer. Cinnamaldehyde (CIN) is a derivative of cinnamon extract and makes up 99% of it. The aim of this study was to investigate the in vitro combined effect of CIN and TMZ on human glioblastoma multiforme T98G cell line viability. In this study, we used 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl-tertazolium bromide (MTT) method to evaluate the extent of IC₅₀, acridine orange, Giemsa and Hoechst staining to evaluate the manner of apoptosis and the Western blotting method to examine the expression change of apoptotic proteins. Our results show that TMZ has an inhibitory effect on CIN when both used in combination at concentrations of 300 and 100 µM (P<0.05) and has a cytotoxic effect when used alone at the same concentrations (P<0.05). The western blotting result showed that TMZ at concentrations of 2,000 and 1,000 µM significantly increased Bax expression and decreased Bcl2 expression (P<0.05), indicating that TMZ induced apoptosis through the mitochondrial pathway. However, CIN had no effect on Bax and Bcl2 expressions, thus causing apoptosis from another pathway. Also, the Bax:Bcl2 expression ratio at concentrations combined was lower than that for TMZ 1,000 µM and higher than that for CIN 150 and 100 µM (P<0.05), which confirms the inhibitory effect of TMZ on CIN. From the present study, we conclude that TMZ in combination with CIN has an inhibitory effect on increasing the cytotoxicity rate.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.50 no.8
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• pp.359-364
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• 2001

This paper presents the influence of the lightning overvoltage and the shielding effect of lightning arresters and overhead grounding wires on the DC railroad systems. Modeling of railroad system is established in ATPDraw to perform the simulation and the line constants of railroad were calculated using ATP_LCC. When a direct lightning strikes to the DC railroad, the result of simulation reveals that the shielding effect of arresters is reduced at messenger, trolly-wire, and the shielding effects of overhead grounding wire is over 90% than the case which does not include it. Therefore it is evaluated that overhead grounding wires should be installed in the DC railroad line.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10a
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• pp.346-349
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• 1996

In this paper development of a CAD of control systems is introduced which enables us to do not only analysis of control systems, design of controllers but also real-time implementation of controllers. By utilizing this software, the control engineer is able to repeat the procedure of modification of controllers and experiments without recompile to attain better performance. The software also offers the facility to update the parameters of controllers without stopping real-time control, which helps on-line tuning of controllers. If some parameters of the controller is changed on-line, the control input may change discontinuously. It has serious effect on the control systems. A method for on-line tuning of state feedback controller with state observer is proposed and verified through the experiment with an inverted pendulum.

• Proceedings of the KIPE Conference
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• 2001.10a
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• pp.808-815
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• 2001

The three-phase diode rectifier with a capacitive filter is highly sensitive to line voltage unbalance, and may cause significantly unbalanced line currents even under slightly unbalanced voltage condition. This paper presents an analysis of this 'unbalance amplification' effect for an ideal rectifier circuit without ac-and dc-side inductors. The voltage unbalance is modeled by introducing a deviation voltage superimposed on balanced three-phase line voltages. With proper approximations, closed-form expressions for symmetrical components of the line current and current unbalance factor are derived in terms of the voltage unbalance factor, filter reactance, and load current. The validity of analytical predictions is confirmed by simulation.

• 한국정보통신설비학회:학술대회논문집
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• 2007.08a
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• pp.223-226
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• 2007

This paper first outlines the technology used in Power Line Communications(PLC) systems, and the political support being offered to the technology, from the point of view of its effect on electromagnetic compatibility (EMC). The radio spectrum needs protection from other interferers, and there is a regime in place to provide this interference avoidance/mitigation. Nevertheless, PLC has several features that mean that it is capable of creating such interference. These features are discussed, and some published field trial results are reviewed. Difficulties in achieving compatibility between the requirements for radio protection and the requirements for operation of the PLC system mean that there is no consensus as yet as to how PLC system components can be made compliant with EMC requirements. It is concluded that there is little prospect of an accommodation between the competing demands, so that if PLC is to become widespread it will be at the expense of the radio environment.

• Journal of the Korean Magnetic Resonance Society
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• v.3 no.1
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• pp.27-35
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• 1999

Quadrupolar interaction is a strong line broadening agent for nuclei of half-integer spin except the central line. The two-pulse quadrupolar echo technique is widely used, which refocuses the quadrupolar broadening. Echo formation is due to the cancellation of quadrupolar broadening effect by the applied two pulses. Since the central line is not quadrupolar broadened, it should not be involved in the echo formation. However, the central line peak always appears in experiments. This is explained qualitatively here by close examination on the time development of individual coherence. This explanation is used to predict the number of echoes that will be formed with 2 pulse sequence for nuclei of I=3/2, 5/2, 7/2, 9/2 with ease.

• Structural Engineering and Mechanics
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• v.6 no.6
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• pp.633-641
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• 1998

Finite element solutions are presented for the optimal design of symmetrically laminated rectangular plates with various types of internal line supports. These plates are subject to a combination of simply supported, clamped and free boundary conditions. The design objective is the maximisation of the biaxial buckling load. This is achieved by determining the fibre orientations optimally with the effects of bending-twisting coupling taken into account. The finite element method coupled with an optimisation routine is employed in analysing and optimising the laminated plate designs. The effect of internal line support type and boundary conditions on the optimal ply angles and the buckling load are numerically studied. The laminate behavior with respect to fibre orientation changes significantly in the presence of internal line supports as compared to that of a laminate where there is no internal supporting. This change in behavior has significant implications for design optimisation as the optimal values of design variables with or without internal supporting differ substantially.

• Journal of The Korean Astronomical Society
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• v.48 no.3
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• pp.203-206
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• 2015

The masses of supermassive black holes in active galactic nuclei (AGN) can be derived spectroscopically via virial mass estimators based on selected broad optical/ultraviolet emission lines. These estimates commonly use the line width as a proxy for the gas speed and the monochromatic continuum luminosity, λL_λ, as a proxy for the radius of the broad line region. However, if the size of the broad line region scales with the bolometric AGN luminosity rather than λL_λ, mass estimates based on different emission lines will show a systematic discrepancy which is a function of the color of the AGN continuum. This has actually been observed in mass estimates based on Hα/Hβ and C_IV lines, indicating that AGN broad line regions indeed scale with bolometric luminosity. Given that this effect seems to have been overlooked as yet, currently used single-epoch mass estimates are likely to be biased.

• Journal of Korean Society of Water and Wastewater
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• v.22 no.3
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• pp.281-288
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• 2008

Cake resistance is influenced by floc size deposited on membrane surface. Enlarging floc size can reduce cake resistance. The small particles are enlarged by coagulation and flocculation process in conventional mixing tank at membrane filtration system. Fully-grown flocs for reducing the cake resistance, however, are ruptured while passing through a pump. In light of this fact, this study aims to experimentally look at the reaggregation phenomenon of mixing system. In addition, reaggregation phenomenon of mixing system is compared with first-aggregation of in-line injection system in which coagulant is injected just before a pump. These results suggest that first-aggregation of in-line injection system is better than reaggregation of mixing system for G-value above $3100sec^{-1}$. Since G-value in pipe of actual membrane filtration system are usually larger than $3100sec^{-1}$. The performance of in-line injection system is expected to be better than the conventional mixing tank system.

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.420-421
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• 2015

Recently construction of new transmission line is getting harder because of social hostility to transmission tower. Howevere, load is converged in metropolitan area and power plants near this area are old and life of generator will end soon. Therefore, power to supply load in this area should be transmitted from east coast area and southern area. For these reasons, securement of transmission capacity without new transmission line construction is important. In this paper, effect of one circuit AC line change to DC transmission at the same transmission tower on the system available transfer capacity is analyzed.