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Analysis of Liquiritigenin, an Aglycone of Liquiritin in Licorice by High Performance Liquid Chromatography (감초 중 리퀴리티게닌 분석법 개발 및 함량분석)

  • Lee, Jong-Hwa;Ze, Keum-Ryon;Kim, Do-Hoon;Park, Ju-Young;Shim, Young-Hoon;Kim, Jong-Hwan;Lim, Sook;Shin, Jin-Seon;Kim, In-Seon;Kim, Ji-Yeon;Seong, Sang-Hyun;Jang, Seung-Yeup;Kim, Dong-Seup;Seong, Rack-Seon
    • Korean Journal of Pharmacognosy
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    • v.40 no.4
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    • pp.309-314
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    • 2009
  • Licorice(Glycyrrhizae Radix et Rhizoma) is recorded as the root of Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne or Glycyrrhiza inflata Bat.(Leguminosae) in Korean Pharmacopoeia $9^{th}$ edition (KP9) and Chinese Pharmacopoeia 2005(CP2005), Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne in Japanese Pharmacopoeia 2005(JP2005). It is established the content standard of Glycyrrhizin 2.5 % and liquiritin 1% in KP9 and CP2005. But, according to the reports, all Licorice species were not sufficient for content standard of liquiritin 1.0% for licorice in KP9 and CP2005. It shows different content of liquiritin among G. uralensis, G. glabra and G. inflata. Also, it was reported liquiritin, liquiritin apioside are transformed into liquiritigenin by human internal flora. Therefore, we have studied for the pre-treatment condition and analytical method of liquiritigenin; It was good efficinet in 2M HCl reflux(1 hr) for hydrolysis and in methylene chloride for solvent fractionation. And 1% acetic acid in DW(A) and acetonitrile(B) with gradient condition as a mobile phase was most effective in HPLC analytical condition. According to these experimental methods, we have anlayzed content of liquiritigenin about 77 Licorice sample. In this research, it was also examined the content of liquiritin and liquiritigenin for Glycyrrhizae Radix related growing area. According to the results, we suggested the content standard of glycyrrhizin more than 2.5%, liquiritigenin more than 0.7%(after hydrolysis) of licorice.

Localization of Text-development on Regional Learning in Social Studies (사회과 지역학습 교재개발의 지역적 적합화 연구 -경남 산청과 충남 서산의 지역학습을 사례로-)

  • Son, Il;Jeon, Jong-Han
    • Journal of the Korean association of regional geographers
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    • v.10 no.2
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    • pp.466-478
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    • 2004
  • Regional learning in social studies has an important educational meaning in that it is a tabloid edition of social studies and it also satisfies the regionalization of national curriculum. Social studies in Korea have mainly been led by the social study curriculum of elementary school. But the local textbook which was currently used in elementary school is structured in a negative meaning of regionalization rather than positive one. It is suggested in this study that the regional learning of social studies in middle school should be pursued by the co-work of teachers and students. For this purpose, the theoretical and practical processes to develop the local textbook are compared between two distinctive localities such as Sancheong and Seosan. At first, the relative ratio among the six strands is decided to develop several themes for regional learning, considering the landscape, region-related discourses and ecological environments in each region. Secondly, several themes are extracted to organize the contents of local textbook in each region. Lastly, examples of content-organization are suggested in each region. The processes above are just an example of content-organization, not a fixed one. The process, themes extracted, and the content-organization for each region may be changed according to the school location, local situation, and the quality of classroom.

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Archaeomagnetic Dating of a Layer of Baked Earth on Daegu Buinsa Site (대구 부인사 유적 소토층의 고고지자기 연대)

  • Sung, Hyong Mi
    • Journal of Conservation Science
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    • v.28 no.3
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    • pp.185-192
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    • 2012
  • Issues of chronology on archaeological remains or relics have been a storm-center of controversy when various archaeological researches have been done. Sometimes there is a limit for figuring out issues of chronology by archaeological research. In that case, the field of natural science is often needed to work out issues of chronology. Among various subjects in natural science, archaeomagnetism plays an important role in dating archaeological remains for baked earth bearing relics. In particular, archaeomagnetism is of use for sites where directly excavated dating proxy is unavailable. Terrestrial magnetism changes along with the passage of time and leaves trace by many kinds of residual magnetization which could be called fossil of terrestrial magnetism. Archaeomagnetic dating method is used to assign a date to the archaeological remains in which baked earth is found by measuring the changes of terrestrial magnetism through the thermal remanent magnetization retained in baked earth. This study aims to constrain the age of fire at Buinsa, Daege, Korea using 27 samples that were collected from a layer of baked earth. Buinsa is famous for the place where kept the first edition of Tripitaka Koreana, which was lost in fire at the second invasion of mongolia. In addition, there is a record that there was revolt around this region in A.D.1203. According to archaeomagnetic dating, ages of A.D.1150~1200 and A.D.1130~1210 were assigned for the two building sites in Buinsa, respectively. To this end, it can be concluded that the layer of baked earth on the two building sites in Buinsa recorded the vestige of fire caused by revolt.

DDC문학류의 조합식 분류시스템 분석 - 20판을 중심으로

  • 윤희윤
    • Journal of Korean Library and Information Science Society
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    • v.20
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    • pp.351-381
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    • 1993
  • The purpose of this study is to analyze the various processes and patterns to build or synthesize class numbers in the 800 class of the Dewey Decimal Classification, Edition 20(1989). The results of the analysis are as follows: 1. The 800(Literature and rhetoric) class in the DDC system is the main class added analytico-synthetic principle positively to an enumerative scheme. 2. The facets to be a n.0, pplied in literature are language literary form literary period ; kind, scope, or medium ; notation 08(collection) or 09(criticism) literary feature, subject, author, etc. 3. In the 800 class, there are the five tables of precedence for literary forms aspects ; specific kinds of persons ; literary, period in relation to the aspects for works treating more than one literary form subforms, aspects and literary periods in the works treating a specific literary form. 4. The basic number synthesis of literary works proceeds through the various facets in the following sequence, as far as necessary for the item : base no. + literary form + literary time or period + kind, scope, or medium + notation 08 or 09 + subform + additional notation from T3C and other tables. 5. In view of the multiplicity of facets, their synthesis formulas take the following order : (1) Works about the literature : base no.(schedule) + language(T6) or form(T3B) (2) Works by or about individual author : base no.(schedule) + form (T3A) + period(schedule) + subform(T3A) (3) Works by or about more than one author, not restricted by language facet : base no.(schedule) + period(T1) ; base no.(schedule) + kind, scope, medium(T3B), or feature(T3C), or person(T5). (4) Works by or about more than one author, restricted by language facet : base no.(schedule) + form (T3B) + period(schedule) + subform(T3B) + notation 08 or 09(T3B) ; base no.(schedule) + notation 08 or 09(T3B) + 9(T3C) + area notation(T2) : base no.(schedule) + form (T3B) + notation 008 or 009(T3B) : base no.(schedule) + form (T3B) + kind, scope, medium(T3B) + notation 08 or 09(T3B) + period(schedule). (5) Affiliated literatures for which period numbers are not us base no.(schedule) + form (T3A or T3B), or notation 08 or 09(T3B) : base no.(schedule) + kind, scope, medium(T3B), feature(T3C), or person(T5) 6. The problems in the number building of the 800 class are the complexity and difficulty of number synthesis, the intrinsic weakness of from distinction and the inconvenience of retrieval inherent in the form class. In order to solve these problems, therefore, the citation orders and methods of DDC should be improved and synthesis patterns simplified from the point of view of its applicability and its usefulness in the "literature class".

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The Dispersion Phenomenon of Journal Citations in a Digital Environment (디지털 환경에서 학술지 인용의 분산화 현상에 관한 연구)

  • Shin, Eun-Ja
    • Journal of the Korean Society for information Management
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    • v.26 no.2
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    • pp.211-222
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    • 2009
  • Electronic publishing has influenced, and in some ways changed, information seeking, reading patterns and citation behaviours. This study collected the Cited Half-Lives, the indicator implies the life-span of scholarly journals, from JCR Social Science edition the before and after of the prevalence of electronic journals, and observed if there are some changes in these two periods. The analysis results of eight disciplines show that the average Cited Half-Lives increased in 2007 than in 1994 for seven disciplines except the demography. Especially in the four disciplines of economics, education, finance and sociology, the average Cited Half-Lives increased significantly. This results show that the concentration, researchers cite more recent articles and concentrate their citations on fewer ones, is lightening and the dispersion of citations is actually increasing. With the online availability of articles and journals the old online materials can be often accessed, used and cited more frequently, the more growth potential of Cited Half-Lives are made in a digital environment. Further research needs to investigate if the phenomenon will become more obvious in various disciplines after a few years.

A Comparison of Structural Organization of English Textbooks between Pre and Post North Korean 2013 Curriculum Revision (북한의 2013교육과정 개정 전·후 영어 교과서 구성 체제 비교)

  • Yoo, Hee-yeon;Kim, Jeong-ryeol
    • The Journal of the Korea Contents Association
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    • v.18 no.7
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    • pp.412-422
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    • 2018
  • The purpose of this research was to compare structural organization of North Korean English textbooks pre and post North Korean 2013 curriculum revision. 5 revised textbooks were selected and compared with old textbooks. First, revised textbooks are dramatically changed into colored printed edition. Second, there appears phrases related to Kim Jong Un for the very first time in the preface. Third, while old textbooks emphasized only reading and writing skills, new textbooks integrate 4 skills. Fourth, new textbooks follow united organization system according to the kinds of school; 7 sub skills of Reading, Listening, Speaking, Writing, Grammar, Vocabulary, Pronunciation for general high middle textbooks and 5 sub skills of Listening, Speaking, Reading, Writing, English in Use for the first high middle textbooks. Also, new textbooks integrate English and other subject contents such as science, geography or computer. Finally, the changed structure organization of new textbooks seems to be similar with the ones of English books in the reference which is presented for the first time in North Korean textbooks.

Association between compliance with dietary guidelines and Alzheimer's disease in Korean elderly (한국 노인의 식생활 지침 실천도와 알츠하이머형 치매의 관련성)

  • Kim, Ji Eun;Shin, Sangah;Lee, Dong Woo;Park, Joon Hyun;Hong, Eun Joo;Joung, Hyojee
    • Journal of Nutrition and Health
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    • v.48 no.3
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    • pp.221-227
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    • 2015
  • Purpose: Confronting the growing burden of dementia requires understanding the causes and predictors of dementia in order to develop preventive strategies. In Korea a large proportion (71%) of dementia is Alzheimer's disease, and the risk factors have not yet been elucidated. Dietary factors may be possible risk factors, however research on the relationship between Alzheimer's disease and dietary behaviors has been insufficient. The purpose of this study was to investigate the association between compliance with the "Dietary Guidelines for Elderly (The Ministry of Health and Welfare, 2011)" and Alzheimer's disease among Korean elderly. Methods: Elderly persons who visited a University hospital or a dementia center of Seoul and agreed to participate in the examinations were selected. Among 277 subjects, 89 Alzheimer patients were selected with diagnosis and 118 subjects were assigned to the control group. Diagnosis of Alzheimer's disease was based on Alzheimer's disease criteria of Diagnostic and Statistical manual of Mental Disorders, 4th edition (DSM-IV) and criteria of National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and related Disorders Association (NINCDS-ADRDA). Information on the general characteristics, health related behaviors and compliance with the dietary guidelines for Korean elderly was collected by face to face interview using a structured questionnaire. Anthropometric variables were measured during the survey. Results: Total compliance score of dietary guidelines was significantly lower in the Alzheimer's disease group than in the control group (p = 0.0001). The odds ratio of Alzheimer's disease was significantly decreased in the group with the highest dietary guideline compliance score (OR = 0.47, 95 % CI = 0.18~1.09) compared to the group with the lowest compliance score. Conclusion: The results indicate that increasing compliance with the dietary guidelines could be an effective strategy to decrease the risk of Alzheimer's disease among Korean elderly.

A Design Suggestion of Fairy Tales for the Silver Applying to the Service Design (서비스디자인을 적용한 실버대상 동화책의 디자인적 제안)

  • Li, Shu;Oh, Chi-Guy
    • The Journal of the Korea Contents Association
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    • v.16 no.9
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    • pp.491-501
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    • 2016
  • As the population of silver generation is increased, there are emerged the aging society and the silver industry as social issues. Previous studies in the fields of library & information science, education, the industrial art science suggested the need for fairy tale books for the silver generation, and from the design perspective, the characteristics of fairy tale books for the silver generation were analyzed. A fairy tale book is not only a medium delivering some information, but also a platform that a writer provides services to readers. Therefore, the purpose of this study aimed to suggest the importance of sensual experience on the design of fairy book for the silver generation, and to analyze such kind of fairy book's format, grid, typography, type, edition structure, image, layout, cover, paper, printing and production on the basis of five senses. According to the findings of this study, it was found that fairy tale books for the silver generation had different characteristics(type, picture, color, paper, etc.) from those for children, and it would be desirable to make designs for fairy tale books for the silver generation under the silver generation's esthetics standards with considering the silver generation's physiological, psychological factors. It is expected that this study would become a good foundation for more intensive researches for fairy tale books for the silver generation in future and would also be theoretically helpful in developing fairy tale books for the silver generation in future.

Catalog use study : with reference to universities in Daegu (대학도서관의 목록이용연구)

  • 최달현
    • Journal of Korean Library and Information Science Society
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    • v.9
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    • pp.241-266
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    • 1982
  • This paper gives a summary and overview of a survey conducted at the catalogues of five universities in Daegu during November 1982. The major objective of this study was to secure information about user needs in order to improve the catalogue in Korean university libraries. Data was collected by a combined method of questionnaire and interview. A total of 379 respondents were taken on a randomly selected sample of catalogue users. Results of the survey can be summarized as follows: 1. Eighty-eight percent of the students answered that they had used the library more than twice a month. Nevertheless the number of students consulting the catalogue with the same frequency was only 220, or a n.0, pproximately 58 percent. Those who used the library most tended to use the catalogue more than those who rarely came to the library. 2. Those who had been shown how to use their own catalogue were only 32.5percent of which the students found the instruction sufficient for them to be able to use the catalogue were only 37.5 percent. In particular, they stated that instructions by printed materials and/or library orientation were so poor that they didn't give much help in using the catalogue. This problem makes many libraries to review their own method of instruction in order to encourage patrons to use the catalogue more effectively. 3. Most of the students consulted the catalogue in order to locate library materials. Known-item searches and subject searches were 84 and 16 percent respectively. While 70.5 percent of the students used the author-title catalogue without any difficulties, only 35.5 percent of those stated that using the classed catalogue was easy. 4. It was surprising that the number of students using title access in the search was far greater than that of students using author access. In contrast with this, other studies conducted by many earlier overseas investigators revealed that the great majority of patrons tended to use the latter first. Therefore, we should put more emphasis on the title entries in the catalogue itself as well as cataloging rules. 5. Most useful bibliographic elements in the entry were author, title, call number, date and publisher whereas edition, series statement and the location of publisher were rarely used compared with the other elements. Content note was the most desirable element in the entry to be involved, for many catalogers were used not to describe it on the note area. 6. The chief reason given for not using the catalogue was "I can manage without it" with "It's difficult to understand contents of the card entry." The other one was "It's useless to search materials by the catalogue because I've failed so many times to obtain them out of the stock." In response to this, circulation and acquisition system should be improved not to make such complaints any more.

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Change of Quality of Life in Children with ADHD after 12 Weeks OROS-Methylphenidate Treatment (12주 OROS-Methylphenidate 약물 치료 후 ADHD 아동의 삶의 질 변화)

  • Kim, Hyung-In;Kim, Bung-Nyun;Cho, Soo-Churl;Shin, Min-Sup;Yoo, Hee-Jeong;Kim, Jae-Won;Kim, Ji-Hoon;Son, Jung-Woo;Shin, Yun-Mi;Chung, Un-Sun;Han, Doug-Hyun
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.23 no.3
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    • pp.103-108
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    • 2012
  • Objectives : The aim of this study is to investigate the effectiveness of treatment with osmotic-release oral system methylphenidate (OROS-MPH) on quality of life (QOL) in children with attention-deficit hyperactivity disorder (ADHD). Another aim is to assess the relationship between change in QOL and other factors including children's symptoms and academic performance or parents' depression and parenting stress. Methods : A total of 111 medication-naive children with ADHD in a multicenter, open-label, 12-week trial of OROS-MPH completed an evaluation using diverse rating scales at two time points; at baseline and after 12 weeks of treatment. Scales for investigation of children included the Parent Report Form-Children's Health and Illness Profile-Children's Edition (PRF-CHIP-CE) on QOL, the ADHD Rating Scale-IV on symptoms, and the Academic Performance Rating Scale (APRS). The Beck Depression Inventory and Parenting Stress Index were used for assessment of their parents. Results : Total scores for mean PRF-CHIP-CE increased from $207.9{\pm}26.7$ at baseline to $226.3{\pm}25.9$ after 12 weeks of treatment (p<.001). The change of APRS showed the strongest correlation with the increment of PRF-CHIP-CE scores (Pearson coefficient=0.561, p<.001), even after controlling for other factors (partial correlation coefficient=0.420, p<.001). Conclusion : Treatment with MPH-OROS results in improvement of QOL in children with ADHD in Korea. The advance in academic performance plays a key role in this change of QOL.