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Network Structure of Depressive Symptoms in General Population (일반 인구 집단의 우울증상 네트워크 구조)

  • Seon il, Park;Kyung Kyu, Lee;Seok Bum, Lee;Jung Jae, Lee;Kyoung Min, Kim;Hyu Seok, Jeong;Dohyun, Kim
    • Korean Journal of Psychosomatic Medicine
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    • v.30 no.2
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    • pp.172-178
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    • 2022
  • Objectives : Although subclinical depression symptoms are associated with suicidal idea, most research have focused on clinical depression such as major depressive disorder or dysthymia. The aim of this study is to investigate network structure of depressive symptom and to reveal which symptoms are associated with suicidal ideation. Methods : We used part of data from the seventh Korea National Health and Nutrition Examination Survey. Participants were between 19 and 65 years of age (N=8,741). Network analysis with Isingfit model is used to reveal network structure of depressive symptoms and most central symptom and edges assessed by patient health questionnaire (PHQ-9). Results : The most two central symptoms were psychomotor activity and suicidal ideation. The strongest edge was psychomotor activity-suicidal ideation. Suicidal ideation also has strong association with depressive mood and worthlessness. Conclusions : These results suggest that psychomotor activity and suicidal ideation can serve as treatment target for subclinical depression and psychomotor activity, worthlessness and depressed mood may be important factor for early intervention of suicidal ideation.

SAR(Synthetic Aperture Radar) 3-Dimensional Scatterers Point Cloud Target Model and Experiments on Bridge Area (영상레이더(SAR)용 3차원 산란점 점구름 표적모델의 교량 지역에 대한 적용)

  • Jong Hoo Park;Sang Chul Park
    • Journal of the Korea Society for Simulation
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    • v.32 no.3
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    • pp.1-8
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    • 2023
  • Modeling of artificial targets in Synthetic Aperture radar (SAR) mainly simulates radar signals reflected from the faces and edges of the 3D Computer Aided Design (CAD) model with a ray-tracing method, and modeling of the clutter on the Earth's surface uses a method of distinguishing types with similar distribution characteristics through statistical analysis of the SAR image itself. In this paper, man-made targets on the surface and background clutter on the terrain are integrated and made into a three-dimensional (3D) point cloud scatterer model, and SAR image were created through computational signal processing. The results of the SAR Stripmap image generation of the actual automobile based SAR radar system and the results analyzed using EM modeling or statistical distribution models are compared with this 3D point cloud scatterer model. The modeling target is selected as an bridge because it has the characteristic of having both water surface and ground terrain around the bridge and is also a target of great interest in both military and civilian use.

Antirapakivi Mantled Feldspar of the Albong Trachyandesite from Ulleung Island, Korea (울릉도 알봉조면안산암에서 산출되는 안티라파키비조직 장석의 성분)

  • Sung-Hyo Yun
    • Journal of the Korean earth science society
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    • v.43 no.6
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    • pp.737-748
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    • 2022
  • In this study, the composition of feldspar phenocrysts observed in the Ulleungdo Albong trachyandesite lava dome was identified by performing point and X-ray element mapping surface analysis (EPMA). Plagioclase, which appears as a phenocryst in the Albong trachyandesite, corresponds to bytownite and labradorite, and andesine, and lath in the microphenocrysts and the matrix corresponds to andesine to oligoclase. Alkali feldspar mantled around plagioclase phenocrysts and microphenocrysts correspond to anorthoclase and sanidine. Plagioclase phenocrysts with a distinct zonal structure represent a normal structure in which the An content of the zoning decreases from bytownite to labradorite or andesine as it moves from the center of the phenocrysts to the edge. The edge of the phenocryst is surrounded by alkali feldspar, showing an antirapakivi texture. X-ray mapping of feldspar phenocrysts showed a typical antirapakivi texture. Normal zoning with distinct zoning showing a difference in component composition was clearly shown. The edges were mantled with alkali feldspar, and antirapakivi represents the texture. The antirapakivi texture of feldspar in the Albong trachyandesite may have been formed in the mixing system when alkali feldspar crystallized and mantled around plagioclase phenocrysts and microphenocrysts. This is because plagioclase phenocrysts and microphenocrysts in magma that had already crystallized are more mafic than trachyandesite magma.

Network pharmacology-based prediction of efficacy and mechanism of Chongmyunggongjin-dan acting on Alzheimer's disease (네트워크 약리학을 기반으로한 총명공진단(聰明供辰丹) 구성성분과 알츠하이머 타겟 유전자의 효능 및 작용기전 예측)

  • Bitna Kweon;Sumin Ryu;Dong-Uk Kim;Jin-Young Oh;Mi-Kyung Jang;Sung-Joo Park;Gi-Sang Bae
    • The Journal of Korean Medicine
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    • v.44 no.2
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    • pp.106-118
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    • 2023
  • Objectives: Network pharmacology is a method of constructing and analyzing a drug-compound-target network to predict potential efficacy and mechanisms related to drug targets. In that large-scale analysis can be performed in a short time, it is considered a suitable tool to explore the function and role of herbal medicine. Thus, we investigated the potential functions and pathways of Chongmyunggongjin-dan (CMGJD) on Alzheimer's disease (AD) via network pharmacology analysis. Methods: Using public databases and PubChem database, compounds of CMGJD and their target genes were collected. The putative target genes of CMGJD and known target genes of AD were compared and found the correlation. Then, the network was constructed using Cytoscape 3.9.1. and functional enrichment analysis was conducted based on the Gene Ontology (GO) Biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms. Results: The result showed that total 104 compounds and 1157 related genes were gathered from CMGJD. The network consisted of 1157nodes and 10034 edges. 859 genes were interacted with AD gene set, suggesting that the effects of CMGJD are closely related to AD. Target genes of CMGJD are considerably associated with various pathways including 'Positive regulation of chemokine production', 'Cellular response to toxic substance', 'Arachidonic acid metabolic process', 'PI3K-Akt signaling pathway', 'Metabolic pathways', 'IL-17 signaling pathway' and 'Neuroactive ligand-receptor interaction'. Conclusion: Through a network pharmacological method, CMGJD was predicted to have high relevance with AD by regulating inflammation. This study could be used as a basis for effects of CMGJD on AD.

New Record of Alien Plants, Stellaria pallida, S. ruderalis, and Cerastium pumilum (Caryophyllaceae) (미기록 외래식물 모래별꽃(Stellaria palida), 들별꽃(S. ruderalis), 애기점나도나물(Cerastium pumilum)의 보고)

  • Eun Su Kang;Jin Suk Kim;Seon Min Kim;Kang-Hyup Lee;Dong Chan Son
    • Korean Journal of Plant Resources
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    • v.36 no.4
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    • pp.299-313
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    • 2023
  • Stellaria pallida (Dumort.) Crép., S. ruderalis M. Lepší, P. Lepší, Z. Kaplan & P. Koutecký, and Cerastium pumilum Curtis are unrecorded alien species of Caryophyllaceae found in Seoul and Gyeonggi-do in the Republic of Korea. Stellaria pallida is readily distinguished from other taxa in the same genus by its petals, as it's considerably smaller than the sepals or absent. In contrast, S. ruderalis is difficult to identify as it has intermediate traits between S. media L. and S. neglecta (Lej.) Weihe. However, S. ruderlais clearly identified by seed morphology, and S. ruderalis, unlike S. media and S. neglecta, has conical shape of outer periclinal wall and papillate on the basely surface of that. Cerastium pumilum is similar to C. glomeratum Thuill. and belongs to the same subgenus (Sub gen. Fugacia); however, it has some distinct characteristics, including stamens that are primarily 8 (5-10), upper bracts with membranous edges, and the length of the pedicels and petals being longer than that of the sepals. The three of alien plants was recorded for the first time in this study, and information of their habitat, distribution map, description and photographs are presented.

Taxonomic Status of Acheilognathus sp. HR (Cypriniformes: Acheilognathidae) Found in the Dalcheon River, a Tributary of Hangang River, Korea (한강 지류 달천에서 발견된 Acheilognathus sp. HR (Cypriniformes: Acheilognathidae)의 분류학적 위치)

  • Yong Hwi Kim;Bong Han Yun;Mu Sung Sung;In-Chul Bang
    • Korean Journal of Ichthyology
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    • v.34 no.4
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    • pp.231-243
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    • 2022
  • To investigate the taxonomic status of undescribed species Acheilognathus sp. HR from Korean Acheilognathidae discovered from the Dalcheon River, a tributary of the Hangang River, molecular phylogenetic and morphological characteristics were compared and analyzed with previous studies. As a result of molecular phylogenetic analysis, A. sp. HR formed the same genetic clade as the five subspecies of Acheilognathus tabira, but formed a separate monophyletic group based on the unique genotype, showing clear differences. As a result of morphological analyses, the dorsal fin color in males is grayish and the nuptial coloration of the outer edge of the anal fin is white. The outer edges of the dorsal and anal fins are convexly rounded. A black blotch is present on the dorsal fin of the juvenile, but there is a black blotch absent on the dorsal fin of the small adult female. In the counts, the number of branched dorsal rays is 12~13. In the measurements, the length of the barbels is short and the body depth is deep. Therefore, the A. sp. HR of Hangang River is considered at the level of a distinct species distinguished from each other by the five subspecies of A. tabira by molecular phylogenetic, morphological, and limited distributional characteristics.

Field Evaluation of Traffic Wandering Effect on Asphalt Pavement Responses (차량의 횡방향 주행이격에 의한 아스팔트 콘크리트 포장의 응답특성 분석)

  • Seo, Youngguk;Kwon, Soon-Min;Lee, Jae-Hoon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.26 no.3D
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    • pp.453-459
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    • 2006
  • This paper presents an experimental evaluation of wandering effect on asphalt concrete pavement responses. A laser-based wandering system has been developed and its performance is verified under various field conditions. The portable wandering system composed of two laser sensors with Position Sensitive Devices can allow one to measure the distance between laser sensors and tire edges of moving vehicle. Therefore, lateral position of each wheel on the pavement can be determined in a real time manner. Pavement responses due to different loading paths are investigated using a roll over test which is carried out on one of asphalt surfaced pavements in the Korea Highway Corporation test road. The pavement section (A5) consists of 5 cm thick surface course; 7 cm intermediate course; and 18 mm base course, and is heavily instrumented with strain gauges, vertical soil pressure cells and thermo-couples. From the center of wheel paths, seven equally-spaced lateral loading paths are carefully selected over an 140 cm wandering zone. Test results show that lateral horizontal strains in both surface and intermediate courses are mostly compressive right under the loading path and tensile strains start to develop as the loading offset becomes 40 cm from the wheel path. The development of the vertical stresses in the top layers of subbase and anti-frost is found to be minimal once the loading offset becomes 50 cm.

Optimized Hardware Design using Sobel and Median Filters for Lane Detection

  • Lee, Chang-Yong;Kim, Young-Hyung;Lee, Yong-Hwan
    • Journal of Advanced Information Technology and Convergence
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    • v.9 no.1
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    • pp.115-125
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    • 2019
  • In this paper, the image is received from the camera and the lane is sensed. There are various ways to detect lanes. Generally, the method of detecting edges uses a lot of the Sobel edge detection and the Canny edge detection. The minimum use of multiplication and division is used when designing for the hardware configuration. The images are tested using a black box image mounted on the vehicle. Because the top of the image of the used the black box is mostly background, the calculation process is excluded. Also, to speed up, YCbCr is calculated from the image and only the data for the desired color, white and yellow lane, is obtained to detect the lane. The median filter is used to remove noise from images. Intermediate filters excel at noise rejection, but they generally take a long time to compare all values. In this paper, by using addition, the time can be shortened by obtaining and using the result value of the median filter. In case of the Sobel edge detection, the speed is faster and noise sensitive compared to the Canny edge detection. These shortcomings are constructed using complementary algorithms. It also organizes and processes data into parallel processing pipelines. To reduce the size of memory, the system does not use memory to store all data at each step, but stores it using four line buffers. Three line buffers perform mask operations, and one line buffer stores new data at the same time as the operation. Through this work, memory can use six times faster the processing speed and about 33% greater quantity than other methods presented in this paper. The target operating frequency is designed so that the system operates at 50MHz. It is possible to use 2157fps for the images of 640by360 size based on the target operating frequency, 540fps for the HD images and 240fps for the Full HD images, which can be used for most images with 30fps as well as 60fps for the images with 60fps. The maximum operating frequency can be used for larger amounts of the frame processing.

Analysis of a Compound-Target Network of Oryeong-san (오령산 구성성분-타겟 네트워크 분석)

  • Kim, Sang-Kyun
    • Journal of the Korea Knowledge Information Technology Society
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    • v.13 no.5
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    • pp.607-614
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    • 2018
  • Oryeong-san is a prescription widely used for diseases where water is stagnant because it has the effect of circulating the water in the body and releasing it into the urine. In order to investigate the mechanisms of oryeong-san, we in this paper construct and analysis the compound-target network of medicinal materials constituting oryeong-san based on a systems pharmacology approach. First, the targets related to the 475 chemical compounds of oryeong-san were searched in the STITCH database, and the search results for the interactions between compounds and targets were downloaded as XML files. The compound-target network of oryeong-san is visualized and explored using Gephi 0.8.2, which is an open-source software for graphs and networks. In the network, nodes are compounds and targets, and edges are interactions between the nodes. The edge is weighted according to the reliability of the interaction. In order to analysis the compound-target network, it is clustered using MCL algorithm, which is able to cluster the weighted network. A total of 130 clusters were created, and the number of nodes in the cluster with the largest number of nodes was 32. In the clustered network, it was revealed that the active compounds of medicinal materials were associated with the targets for regulating the blood pressure in the kidney. In the future, we will clarify the mechanisms of oryeong-san by linking the information on disease databases and the network of this research.

Detecting Adversarial Examples Using Edge-based Classification

  • Jaesung Shim;Kyuri Jo
    • Journal of the Korea Society of Computer and Information
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    • v.28 no.10
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    • pp.67-76
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    • 2023
  • Although deep learning models are making innovative achievements in the field of computer vision, the problem of vulnerability to adversarial examples continues to be raised. Adversarial examples are attack methods that inject fine noise into images to induce misclassification, which can pose a serious threat to the application of deep learning models in the real world. In this paper, we propose a model that detects adversarial examples using differences in predictive values between edge-learned classification models and underlying classification models. The simple process of extracting the edges of the objects and reflecting them in learning can increase the robustness of the classification model, and economical and efficient detection is possible by detecting adversarial examples through differences in predictions between models. In our experiments, the general model showed accuracy of {49.9%, 29.84%, 18.46%, 4.95%, 3.36%} for adversarial examples (eps={0.02, 0.05, 0.1, 0.2, 0.3}), whereas the Canny edge model showed accuracy of {82.58%, 65.96%, 46.71%, 24.94%, 13.41%} and other edge models showed a similar level of accuracy also, indicating that the edge model was more robust against adversarial examples. In addition, adversarial example detection using differences in predictions between models revealed detection rates of {85.47%, 84.64%, 91.44%, 95.47%, and 87.61%} for each epsilon-specific adversarial example. It is expected that this study will contribute to improving the reliability of deep learning models in related research and application industries such as medical, autonomous driving, security, and national defense.