• Journal of Ginseng Research
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• 제44권3호
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• pp.483-489
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• 2020

Background: Korean Red Ginseng (KRG) has been known to possess many ginsenosides. These ginsenosides are used for curing cardiovascular problems. The present study show the protective potential of KRG against doxorubicin (DOX)-induced myocardial dysfunction, by assessing electrocardiographic, hemodynamic, and biochemical parameters and histopathological findings. Methods: Animals were fed a standard chow and adjusted to their environment for 3 days before the experiments. Next, the rats were equally divided into five groups (n = 9, each group). The animals were administered with KRG (250 and 500 mg/kg) for 10 days and injected with DOX (20 mg/kg, subcutaneously, twice at a 24-h interval) on the 8th and 9th day. Electrocardiography and echocardiography were performed to study hemodynamics. Plasma levels of superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde were measured. In addition, the dose of troponin I and activity of myeloperoxidase in serum and cardiac tissue were analyzed, and the histopathological findings were evaluated using light microscopy. Results: Administration of KRG at a dose of 250 and 500 mg/kg recovered electrocardiographic changes, ejection fraction, fractional shortening, left ventricular systolic pressure, the maximal rate of change in left ventricle contraction (-dP/dt_max), and left ventricle relaxation (-dP/dt_max). In addition, KRG treatment significantly normalized the oxidative stress markers in plasma, dose dependently. In addition, the values of troponin I and myeloperoxidase were ameliorated by KRG treatment, dose dependently. And, KRG treatment showed better histopathological findings when compared with the DOX control group. Conclusion: These mean that KRG mitigates myocardial damage by modulating the hemodynamics, histopathological abnormality, and oxidative stress related to DOX-induced cardiomyopathy in rats. The results of the present study show protective effects of KRG on cardiac toxicity.

• Clinical and Experimental Pediatrics
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• 제46권12호
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• pp.1274-1278
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• 2003

배뇨 후 실신은 신경 매개성 반사에 의한 실신으로 사태실신의 한 종류이며 건강한 남성에서 아침에 기립 배뇨시에 잘 일어난다. 실신의 원인은 다양하기 때문에 배뇨후 실신의 진단을 위해 정확한 병력과 심전도, 운동부하검사, 심초음파, 기립경사검사, 뇌파, 뇌 자기공명영상, 요류 동태 검사 등이 사용된다. 배뇨후 실신의 기전은 부교감 신경계의 반사 자극으로 서맥과 말초혈관 확장이 일어나고 Valsalva 효과에 의해 심실로 정맥환류가 감소하게 되어서 대뇌 혈류감소가 일어나 실신하게 된다. 실신시 뇌파는 대뇌 혈류감소에 의해 고진폭의 서파와 평탄화 소견이 나타나게 되고 심한 허혈시에는 허혈성 경련을 일으킬 수도 있다. 저자들은 9세 남아로 기립배뇨시 실신을 보인 후 저혈압을 보이고 특징적인 뇌파소견을 보인 환아를 경험하였기에 보고하는 바이다.