• Animal cells and systems
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• v.5 no.2
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• pp.157-161
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• 2001

Mice homozygous for the lethal autosomal recessive anorexia mutation (anx) present with premature death around postnatal day 22. The anorexia mutant mice also present phenotypes such as reduced body weight, decreased food intake, and abnormal behavior characteristics such as body tremors, hyperactivity, uncoordinated gait, and head weaving. In order to investigate the expression of c-Fos in the hippocampus of anorexia mutant mice, the immunohistochemistry was performed in this study. The anorexia mutant mice exhibited lower expression of c-Fos in the hippocampus regions thBn the control group. In the CA3 and dentate gyrus, the number of c-Fos-positive cells in anorexia mutant mice was noticeably lower than that in control mice. However, no significant difference was found in the number of c-Fos-positive cells in CA1 of the two groups. The result suggests that the phenotypic characteristics of anorexia mutant mice may be associated with the hippocampal deficits of c-Fos expression.

• Journal of architectural history
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• v.13 no.3
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• pp.97-117
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• 2004

The tradition of architecture in the East and the West are different in many ways. One of the basic cause of such difference, however, is the different ways of perception of space and time. This paper aims to identify the attitude of perception of space and time in the cultures of the East and the West, and its influence on architecture. Degrees of importance placed on either space or time, as well as the modes of perception of space and time are discussed in relation to architecture. Basically, the architecture of the West seems to be more spatially oriented than the East, and this have much to do with the fact that the tradition of Western architecture is visually oriented. On the other hand, East Asian architecture have been more conscious on bodily feeling and its movement in architecture. Spatial units of traditional Eastern architecture, are arranged in such a way in which man can experience the change of space that is supposed to be organized to form a sequential message. Thus, in the East, temporal dimension is more deliberately included in the course of architectural experience compared to the cases of the West. Although it is not easy to attempt any kind of value judgment on such aspects, it is necessary to understand how the different perception of space and time influenced architectural outcome, especially when one wants to understand the cultural cause that have made the architectures of the East and the West very different. Such understanding is particularly important in East Asia where their future of architecture depends much on how they harmonize the Eastern and Western background which are already built up as two cultural structure in their consciousness to be able to create more desirable architecture for themselves.

• The Journal of Internal Korean Medicine
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• v.30 no.4
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• pp.696-707
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• 2009

Objective : We designed this study to investigate differences between stroke reattack and stroke first attack group to establish fundamental data and prevent a secondary stroke. Methods : 826 subjects were recruited from the patients admitted to the department of internal medicine at Kyung Hee University Oriental Medical Center, Kyung Hee University East-West Neo Medical Center, Kyungwon University Incheon Oriental Medical Center, Kyungwon University Songpa Oriental Medical Center and Dongguk University Ilsan Oriental Medical Center from 1 April 2007 to 31 August 2009. We compared general characteristics, classification of diagnosis, subtypes of cerebral infarction, risk factors, Sasang constitution, diagnostic classifications between stroke reattck and stroke first attack groups. Results : 1. In general characteristics, age differed significantly between the reattck and first attack groups. 2. Classification of diagnosis differed significantly between reattck and first attack groups. 3. In risk factors, hypertension, diabetes mellitus, alcohol drinking, and stress were significantly different between reattck and first attack groups. 4. Diagnostic classifications were significantly different between reattck and first attack groups. Conclusion : To prevent recurrence of stroke, education on stroke risk factors associated with recurrence is needed. In addition, those who are diagnosed as Dampness-Phlegm need to be well-controlled.

• Natural Product Sciences
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• v.12 no.3
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• pp.119-121
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• 2006

Four 3,4-seco-lupane trierpenoids were isolated from the MeOH extract of the leaves of Acanthopanax divaricatus forma flavi-flos Yook by using various column chromatography. The chemical structures of isolates were identified as chiisanogenin, chiisanoside, isochiisanoside and 11-deoxyisochiisanoside on the basis of physico-chemical and spectroscopic date($^1H-NMR,\;^{13}C-NMR$M$, 2D-NMR and FAB-MS). These compounds were isolated for the first time from A. divaricatus forma flavi-flos.

• Proceedings of the KSCN Conference
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• 2001.05a
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• pp.460.1-460
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• 2001

• Proceedings of the Korean Nutrition Society Conference
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• 2002.11a
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• pp.139-139
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• 2002

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.208.3-209
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• 2002

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.113.2-113.2
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• 2002

• The Journal of Korean Medicine
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• v.27 no.4
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• pp.62-73
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• 2006

Objective : This study aimed to investigate the effect of SHD on myelosuppression using an animal model for therapeutic evidence supporting clinical positive results. Methods : After determining the optimal concentration of 5-FU as 300 mg/kg for developing the mouse model, ICR mice or BALB/c mice were administered with SHD, and several blood parameters, including hematopoietic cytokines, colony forming activity and histological findings, were examined to evaluate the effects. Results : SHD restored the WBC and hemoglobin, and showed effects on maintaining body weight, producing GM-CSF and IL-3 and stem cell colony forming activity in accordance with histological relative entirety on bone marrow. Conclusion : SHD is an herbal drug having therapeutic effects on myelosuppression. Thus, it could be prescribed to cancer patients undergoing chemo-therapies or radio-therapies in the process of cancer treatment.

• The Journal of Korean Medicine
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• v.28 no.3 s.71
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• pp.138-143
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• 2007

Objective : This study aimed to investigate differential cancer incidence among Sasangin comparing to healthy subjects in the Republic of Korea. Methods : The medical records of 169 patients who had taken diagnosis of Sasang constitution from October 2004 to January 2007 at the East-West Cancer Center in Dunsan Oriental Hospital of Daejeon University were reviewed. Diagnosis was done by Questionnaire for Sasang Constitution ClassificationII (QSCCII). Results : Among the 169 patients, 37.9%, 22.5% and 39.6% belonged to Soyangin, Taeumin and Soeumin, respectively. This is significantly different from the distribution rate of Sasang in amonghealthy subjects (29.1%, 46.9% and 24.0% respectively to Soyangin, Taeumin and Soeumin). This pattern appeared in a similar way among individual cancer analysis: breast cancer (37.5%, 21.9%, 40.6%), colon cancer (41.7%, 20.8% 37.5%), and HCC (35.0%, 20.0%, 45.0%). Stomach cancer typically showed remarkable incidence in Soeumin as high as 50.0% and lung cancer showed in Soyangin as high 46.7%, but it didn't have statistical significance. The mean age of 50.9 years was higher than for healthy people (46.3). Conclusion : Sasang distribution of cancer patients is different from that of healthy subjects. Further study is needed on individual cancers.