• Journal of the Economic Geographical Society of Korea
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• v.7 no.2
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• pp.117-136
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• 2004

The main purpose of this paper is to review the research on the border region, especially herein to consider theoretical models critically and then to gain the implication for appropriate analytical framework or rather theoretical model on the basis of the findings. Through the review of various literature, major finding are as follows. First, the term of border or frontier was used in a rather ambiguous way. Second, the early models in the border region research have been developed to explain barrier effects, of which the border was considered to playa role. However, as border regions change from the closed regions to the opened ones, more adequate models have accordingly been developed. Third, there were several attempts to typify border regions and they tend to focus on the issue of regional development of the regions. Fourth, according to the case studies of the border region research, many border regions are not in isolation or peripheral position any more. Rather they are transformed into potentially prosperous regions through the support of authority as well as inter-regional cooperation.

• Plant Resources
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• v.4 no.3
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• pp.161-170
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• 2001

A major portion of drugs used in Ayurvedic system of medicine which has been practiced since the early human civilization in Indian subcontinent were of plant origin. It should be noted that 70% of the population in this region depends on Ayurveda for their medical treatment and 60% of the drug resources are obtained from the Himalayan region. Therefore, Nepal becomes a potential source of plant drug resource since it occupies a major portion of the Himalaya. In the present paper, in general a current status of medicinal plant resources of Himalayan region especially Nepal will be discussed. In addition to this, a typical example of antidiabetic activity of Shilajit will be taken for the discussion. Shilajit is one of the crucial elements in several formulations including those of Rasayana, a therapy in Ayurveda, which has been practiced in the prevention of ageing and mental disorder. Although, Shilajit is widely used for the treatment of diabetes, no satisfactory scientific reports are available up to now. The crude Shilajit in the market is a dark brown or black rock-like substance collected from the Himalayan region with a strong smell of cow's stale urine. In our studies, Shilajit (collected in the central Himalayan region) prevented the diabetes in nonobese diabetic (NOD) mice model. Shilajit also prevented the diabetes in the rats against the action of multiple low-dose (10 mg/kg, i.v., 5 times) of streptozotocin. On the other hand, Shilajit did not show antioxidative activity. The preventive action of Shilajit on diabetes is mainly focused on the Thl and Th2 cell activities, since Th2 cells activity was found to be significantly upregulated. Shilajit, however, showed a mild action in controlling the blood sugar level in young, old, and mild diabetic rats, but not in the severe diabetic rats. It also stimulated the nitric oxide production in macrophages. Based on these evidences, the antidiabetic activities of Shilajit appear to be immunomodulative probably by protecting or strengthening insulin-producing b-cells in the pancreas. Further systematic research on constituents of Shilajit and its quality evaluation is necessary to enable the use of natural medicines in the treatment of diabetes.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.11
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• pp.1484-1490
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• 2004

Mitochondrial DNA haplotypes from the displacement-loop (D-loop) region (436 bp) were genotyped and sequenced in Japanese Black beef cattle raised in the same herd. Correlation coefficients between mitochondrial DNA haplotypes, maternal lineage, birth weight, preweaning average daily gain, weaning weight, post weaning average daily gain and yearling weight were computed. The objective was to study the relationship between maternal and postnatal growth traits and to investigate if postnatal growth of calves to yearling age could be accurately predicted from mitochondrial DNA haplotypes. Results of the phylogenetic analysis revealed 17 maternal lineages and four mitochondrial DNA haplotypes. There were strong, positive and highly significant (p<0.001) correlations among maternal traits ranging from 0.52 to 0.98. Similarly, among postnatal growth traits, most of the correlations were also strong, positive and highly significant (p<0.001); the highest correlation of 0.94 was between preweaning average daily gain and weaning weight. However, correlations between mitochondrial DNA haplotypes and postnatal growth traits were very low, mostly negative and non-significant (p>0.05) ranging from -0.05 to 0.1. Prediction of postnatal growth from mitochondrial DNA yielded very low $R^{2}$ values ranging from 0.002 to 0.019. It was concluded that mitochondrial DNA polymorphism has no significant association with postnatal growth from birth to yearling age, and by implication, nuclear rather than cytoplasmic DNA, accounts for most of the genetic variation observed in postnatal growth of Japanese Black cattle. Therefore, mitochondrial DNA genotyping at an early age has no bearing on the accurate prediction of the future growth performance of calves.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.3C
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• pp.329-340
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• 2009

This paper proposes a novel code tracking scheme to track the fine code synchronization for BOC(pn,n) modulated spreading signals. The correlation function of BOC(pn,n) modulated spreading signals has been several peaks. In this paper, we observe that the correlation function in the advanced offset region remains almost unchanged, due to the multipath signals being received later than a line-of-sight signal. Based on this observation, we propose a novel code tracking scheme which is called the advanced region correlation (ARC) method for BOC(n,n) modulated spreading signals. And, we compare with the code tracking accuracy between the conventional and proposed methods in the static multipath and land mobile satellite system channels through the Monte-Carlo simulation. Then, base on the proposed scheme, we propose the generalized-ARC (ARC) scheme for BOC(pn, n) modulated spreading signals.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2001.11a
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• pp.20-33
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• 2001

A major portion of drugs used in Ayurvedic system of medicine which has been practiced since the early human civilization in Indian subcontinent were of plant origin. It should be noted that 70% of the population in this region depends on Ayurveda for their medical treatment and 60% of the drug resources are obtained from the Himalayan region. Therefore, Nepal becomes a potential source of plant drug resource since it occupies a major portion of the Himalaya. In the present paper, in general a current status of medicinal plant resources of Himalayan region especially Nepal will be discussed. In addition to this, a typical example of antidiabetic activity of Shilajit will be taken for the discussion. Shilajit is one of the crucial elements in several formulations including those of Rasayana, a therapy in Ayurveda, which has been practiced in the prevention of ageing and mental disorder. Although, Shilaiit is widely used for the treatment of diabetes, no satisfactory scientific reports are available up to now. The crude Shilajit in the market is a dark brown or black rock-like substance collected from the Himalayan region with a strong smell of cow's stale urine. In our studies, Shilajit (collected in the central Himalayan region) prevented the diabetes in nonobese diabetic (NOD) mice model. Shilajit also prevented the diabetes in the rats against the action of multiple low-dose (10 ㎎/㎏, i.v., 5 times) of streptozotocin. On the other hand, Shilajit did not show antioxidative activity. The preventive action of Shilajit on diabetes is mainly focused on the Th1 and Th2 cell activities, since Th2 cells activity was found to be significantly upregulated. Shilajit, however, showed a mild action in controlling the blood sugar level in young, old, and mild diabetic rats, but not in the severe diabetic rats. It also stimulated the nitric oxide production in macrophages. Based on these evidences, the antidiabetic activities of Shilajit appear to be immunomodulative probably by protecting or strengthening insulin-producing b-cells In the pancreas. further systematic research on constituents of Shilajit and its quality evaluation is necessary to enable the use of natural medicines in the treatment of diabetes.

• The KIPS Transactions:PartB
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• v.17B no.3
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• pp.239-248
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• 2010

Leukocyte in blood smear image provides significant information to doctors for diagnosis of patient health status. Therefore, it is necessary step to separate leukocyte from blood smear image among various blood cells for early disease prediction. In this paper, we present a saliency map and stepwise region merging based leukocyte segmentation method. Since leukocyte region has salient color and texture, we create a saliency map using these feature map. Saliency map is used for sub-image separation. Then, clustering is performed on each sub-image using mean-shift. After mean-shift is applied, stepwise region-merging is applied to particle clusters to obtain final leukocyte nucleus. The experimental results show that our system can indeed improve segmentation performance compared to previous researches with average accuracy rate of 71%.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.450-450
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• 2022

The study aims to develop scenarios for efficient groundwater use using existing wells in order to prepare for an eventual drought. In the recent decades, droughts are not only intensifying, but they are also spreading into territories where droughts used to be less intense and relatively infrequent. With the increasing disaster, efficient groundwater use is urgently needed not only to prevent the problem of groundwater depletion but also drought risk reduction. Thus, the research addressed the problem of efficient aquifer use as source of water during drought and emergencies. The research focused on well network system applied to Yanggok-ri in Korea using simulation models in visual MODFLOW. The approach consists to variate groundwater pumping rate in the most important wells used for irrigation across the study area and evaluate the pumping effect on water level fluctuation. From the evaluation, the pumping period, appropriate pumping rate of each well and the most vulnerable wells are determined for a better groundwater management. The project results divide the study area into two different regions (A and B), where the wells in the region A (western part of the region) show a crucial drop in water level from May to early July and in august as consequence of water pumping. While wells in region B are also showing a drawdown in groundwater level but relatively less compare to region A. The project suggests a scenarios of wells which should operate considering water demand, groundwater level depletion and daily pumping rate. Well Network System in relevant project, by pumping in another well where water is more abundant and keep the fixed storage in region A, is a measure to improve preparedness to reduce eventual disaster. The improving preparedness measure from the project, indicates its implication to better groundwater management.

• The Korean Journal of Ecology
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• v.17 no.1
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• pp.69-78
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• 1994

The acidic deposition (wet) was collected at three different locations; representative industrial (Kun-Jang industrial areas), semiindustrial (Kunsan City) and nonindustrial (Daeya areas) region between March, 1991 and June, 1993. Samples were analyzed for major chemical components along with pH. Also the responses of Hypnum filunzaeforme to the acidic deposition adjusted to pH 4.6, 3.6 and 2.6 with 1:4 molar ratio of nitric to sulfuric acid were investigated. Seasonal variation of pH showed the lowest in early spring and the highest in summer. The annual mean concentrations of $S0_4^{2-},\;NO_3^{-}\;and\;NH_4^{+}$ were 2.94 (81.0%), 0.48 (13.2%) and 0.21 (5.78%) mg/l in industrial region and 0.61 (64.21%), 0.25 (26.3%) and 0.9 (9.5%) mg /I in nonindustrial region, respectively. $S0_4^{2-}$ contents of industrial region was 4 times higher than those of nonindustrial region. The ratio of $S0_4^{2-}\;to\;NO_3^{-}$ was 4.75~7.35 in industrial region and 0.69-6.36 in nonindustrial region. The acidic deposition near industrial region was associated with excess ions, expecially $S0_4^{2-}$. Nitrate reductase activity(NRA) of mosses was inhibited by acidic deposition in both regions. The time required for the maximum NRA induction by 2mM $KNO_3$ was shortened in mosses collected from industrial region. Photosynthesis of H. plumaejorme began to decrease with acidic deposition by pH below 4.6, and was completely inhibited at pH 2.6 in both regions. Water potential of mosses treated with acidic deposition was almost constant during 18 days, however after withholding the supply of acidic deposition, it was rapidly decreased.

• Journal of The Korean Society of Grassland and Forage Science
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• v.27 no.2
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• pp.85-92
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• 2007

This study was carried out to select the promising forage crops fer forage production in paddy field of YARI, RDA, Milyang from 1999 to 2001. The species of forage crop used in this experiment were barley(5 varieties), wheat(2), rye(3) and Italian ryegrass(IRG, 3). Stages of heading, milk and yellow ripe of barley were $20{\sim}24$ April, $6{\sim}10$ May and $21{\sim}24$ May, respectively. In milk to yellow ripe stage, dry matter(DM) yield of barley was $7.89{\sim}9.66$ MT per ha, and averaged ADF and NDF contents were $26.9{\sim}33.3%\;and\;53.1{\sim}59.2%$, respectively. Albori and Naehanssalbori were the most promising varieties among the barley. The growth of wheat was a little late compared to that of barley, but it seemed to be crop having higher forage yield and nutritive value. In milk to yellow stage, DM yield of wheat was $9.13{\sim}10.38$ MT per ha, and nutritive value of wheat was very good(ADF $25.9{\sim}31.7%$ and NDF $53.3{\sim}55.8%$). Heading stage of rye was $20{\sim}24$ April, and it seemed to be suitable far harvest at heading to flowering stage because of heavy lodging after flowering. In flowering stage, DM yield of rye was 13.64 MT per ha, and nutritive value of rye was the lowest among 4 species(ADF $33.1{\sim}38.0%$ and NDF $56.4{\sim}65.0%$). Heading stage of early maturing IRG was 2 May and it seemed to be suitable for harvest at flowering stage of middle May in cropping system. In flowering stage, DM yield of early type IRG was 5.51 MT per ha, and averaged ADF and NDF contents were $30.1{\sim}34.7%\;and\;59.7{\sim}60.5%$, respectively. The results demonstrated that the promising forage crops far forage production in paddy field were rye, barley, early maturing IRG and wheat in Yeongnam region. In Southern region, rye harvesting at early May was recommended when considered middle May of rice transplanting period, and barley(Albori and Naehanssalbori) and early maturing IRG harvesting at middle May were recommended when considered late May of rice planting period. And also, wheat with high nutritive value and possibility for harvesting at late May were recommended in case of transplanting period at early June.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8319-8324
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• 2014

Although genetic markers identifying women at an increased risk of developing breast cancer exist, the majority of inherited risk factors remain elusive. Mutations in the BRCA1/BRCA2 gene confer a substantial increase in breast cancer risk, yet routine clinical genetic screening is limited to the coding regions and intronexon boundaries, precluding the identification of mutations in noncoding and untranslated regions. Because 3' untranslated region (3'UTR) polymorphisms disrupting microRNA (miRNA) binding can be functional and can act as genetic markers of cancer risk, we aimed to determine genetic variation in the 3'UTR of BRCA1/BRCA2 in familial and early-onset breast cancer patients with and without mutations in the coding regions of BRCA1/BRCA2 and to identify specific 3'UTR variants that may be risk factors for cancer development. The 3'UTRs of the BRCA1 and BRCA2 genes were screened by heteroduplex analysis and DNA sequencing in 100 patients from 46 BRCA1/2 families, 54 non-BRCA1/2 families, and 47 geographically matched controls. Two polymorphisms were identified. SNPs $c.^*1287C$ >T (rs12516) (BRCA1) and $c.^*105A$ >C (rs15869) (BRCA2) were identified in 27% and 24% of patients, respectively. These 2 variants were also identified in controls with no family history of cancer (23.4% and 23.4%, respectively). In comparison to variations in the 3'UTR region of the BRCA1/2 genes and the BRCA1/2 mutational status in patients, there was a statistically significant relationship between the BRCA1 gene polymorphism $c.^*1287C$ >T (rs12516) and BRCA1 mutations (p=0.035) by Fisher's Exact Test. SNP $c.^*1287C$ >T (rs12516) of the BRCA1 gene may have potential use as a genetic marker of an increased risk of developing breast cancer and likely represents a non-coding sequence variation in BRCA1 that impacts BRCA1 function and leads to increased early-onset and/or familial breast cancer risk in the Turkish population.