• Genomics & Informatics
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• 제17권3호
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• pp.24.1-24.8
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• 2019

Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being recognized as a major contributor that may permanently program change of organ structure and function toward the development of diseases, in which epigenetic mechanisms are involved. Recent researches indicate early-life environmental factors modulate the microbiome development and the microbiome might be mediate diet-epigenetic interaction. This review aims to define which nutrients involve microbiome development during the critical window of susceptibility to disease, and how microbiome modulation regulates epigenetic changes and influences human health and future prevention strategies.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.386-392
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• 2020

3D 프린팅 콘크리트는 연속 적층 시 적층고가 높아짐에 따라 콘크리트의 자중이 증가되기 때문에 연속 적층성 확보를 위해 하단부 콘크리트가 적정 시간에 경화되어야 한다. 특히, 기온이 낮은 동절기의 경우 콘크리트의 경화속도가 늦어지게 되는데, 3D 프린팅 콘크리트 시공 중 하단부 콘크리트의 강도발현이 낮아 콘크리트의 자중을 버티지 못하게 되면 적층된 콘크리트가 무너지게 되는 문제가 발생된다. 이러한 문제점을 해결하기 위해서는 저온환경에서의 3D 프린팅 콘크리트의 초기강도를 증진이 필수적이다. 국내외 문헌에서는 Amine계, Nitrate계, Sodium계, Calcium계 등의 무기계 화학 첨가제를 사용하여 콘크리트의 초기강도를 증진시킨 사례가 보고되고 있다. 이에 본 연구에서는 Amine계, Nitrate계 및 Sodium계 조강형 첨가제 샘플 5종을 제작하여 그 성능을 평가하였고, 우수한 성능을 보인 샘플을 선별하여 이를 적용한 3D 프린팅 콘크리트의 초기강도 특성을 확인하였다. 그 결과 Nitrate계 첨가제 사용 시 10 ℃ 환경에서 기존 20 ℃ 환경의 3D 프린팅 콘크리트 배합대비 동등 이상의 초기강도 발현이 가능한 것을 확인할 수 있었다.

• 생명과학회지
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• 제13권1호
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• pp.34-41
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• 2003

The hatching of fertilized egg and early development of larval black seabream, Acanthopngrus schlegeli by immersion of 3,5,3'-triiodo-L-thyronine ($T_3$) with doses of 0.01~0.5 ppm in tank were examined for early development periods and compared with control fish immersed by 0.1 N NaOH and 99% alcohol. Larvae were fed with rotifers for first 5 days during experimental period. Yolk absorption of larvae from $T_3$ immersion groups were significantly faster than that of control. Although hatching times among each groups were not significant difference. the hatching rates of larvae in higher doses (0.1 ppm and 0.5 ppm $T_3$ groups) were significantly lower than control. The results of $T_3$ immersion experiments to newly hatching larvae indicated that exogenous $T_3$induced significant faster the absorption of yolk and oil globule, faster the development of myotome and digestive duct and higher the growth rate of larvae than larvae of control. These results indicate that $T_3$ immersion supplements appear to confer a distinct advantage to eggs and larvae of black seabream, which is in early fragile developmental stage.

• 한국가축번식학회지
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• 제18권3호
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• pp.183-189
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• 1994

We examined early development in loach(Misgurnus mizolepis) embryos with parthenogenetic agents well-known in mammals. Female loach was superovulated with an intraperitoneal injection of 15 IU human chorionic gonadotrophin (hCG) per gram body weight. After 13 h of hCG injection, the oocytes were obtained from the abdomen. The oocytes were activated with 10% ethanol in tap water or fish Ringer's solution for 5, 10 and 15 minutes(eTW5, 10, 15 and eFRS5, 10, 15), respectively. The activation rates were 29% and 10% in eFRS10 and eFRS15, 5% and 6% in eTW10 and eTW15 by judging the cleaved blastomeres. Whereas, no parthenogenetic embryo was produced by tap water or fish Ringer's solution alone. The activation rate with the fish Ringer's solution was higher than that of tap water. No embryonic development was observed by calcium ionophore, A23187, at concentrations of 10, 20, 40 and 100$\mu$M when treated for 1, 2.5 and 5 minutes, respectively. The activation agents did not cause early development as in mammalian eggs. Therefore, the results suggest that fresh water fish may have a different egg activation pathway from that of mammals.

• 한국군사과학기술학회지
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• 제22권6호
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• pp.824-831
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• 2019

For effective development in consideration of the maintainability of the weapon system, it is necessary to understand whether the maintainability design requirements are satisfied at the early phase of development. This requires the application of an early design phase maintainability prediction process to provide opportunities for improvement. By defining the ambiguity group definition, fault isolation level, fault isolation probability, and countermeasures for faults, it was possible to predict early phase development. The MTTR of the initial design phase applying Procedure V to the artillery system was 3.46H, which is about 16 % higher than 2.98H, the MTTR using Procedure II. This is a result of system design ambiguity that has not been specified in the early phase of development.

• The Journal of Korean Physical Therapy
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• 제5권1호
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• pp.95-99
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• 1993

We must diagnose and treat as early as possible to the children that have been danger factor and have delayed development, therefore, we shall decrease to disability, shall able to ADL and shall have could live to normal living. Since the children are most fast grow to development during 1 year after birth, the soft sign of cerebral palsy is transverse to the hard sign.

• 대한수의학회지
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• 제37권3호
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• pp.647-659
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• 1997

To overcome the difficulties of collecting and culture of primary cell from genital tract on embryonic development, the present study was carried out to investigate the critical effect of cell lines, such as BRL and Vero cell and its conditioned medium on the development of early Korean native cattle embryos in vitro. Oocytes collected from slaughterhouse ovaries were matured in TCM199 containing FSH, estradiol-$17{\beta}$ and FBS with granulosa cell monolayer for 24 hours and then fertilized in vitro using frozen-thawed, heparin-treated spermatozoa in TALP for 30 hours. And then early embryos (1-2cell) were cultured in TCM199 containing 10% FBS with BOEC, Granulosa, BRL, Vera cell monolayers and conditioned medium for 2~3 days. Development to morulae and blastocysts were recorded, also examined the number of blastomeres presented a valuable parameter for the evaluation of embryonic development. The early cleavage rates of in vitro fertilized embryos co-cultured, there was no differences between primary cell and cell lines(p<0.05). The rate of development to the later stage, coculture of BRL cell was significantly higher than that of the primary cell(p<0.05). The rates of development to morula and blastocyst were significantly higher in vero cell than BRL, Granulosa, Oviduct epithelial cell conditioned medium. In the result of effect of serum on development of early bovine embryos, the use of media containing serum were significantly higher than the use of not containing one on development of early and later stage of embryos. The result of number of blastomeres in blastocysts, there is no differences between primary cell and cell lines. The blastocysts from coculture were higher than from conditioned medium in blastomere cells. In summary, these experments have proved that the culture system in TCM199 with BRL, Vero cell monolayers is effective on in vitro development of early bovine embryos, In addition, it is effective to development of bovine embryos that containing serum in conditioned medium, or in co-culture rather than in conditioned medium alone. The use of cell lines opponent to primary cells is effective in bovine embryo culture.

• 한국패류학회지
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• 제29권2호
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• pp.97-103
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• 2013

In the present study, we monitored the early development of Saccostrea kegakia subtropical oyster species distributing on rocky intertidal off the northern Jeju Island using scanning electron microscope (SEM). The female oyster collected in early August, 2012 were fully mature exhibiting relatively small eggs ($46.5{\pm}1.4{\mu}m$ in diameter) in the gonad, while testis of the mature male oysters were filled with fully developed sperms of 36.9 ${\mu}m$ in length. The fertilized eggs developed into 2-cell stage with polar body after 1 hr 20 min of fertilization, then followed by Morula stage (3 hr 20 min), Blastula stage (4 hr 50 min), Gastrula stage (7 hr), and trochophore larvae stage (9 hr 30 min). The observed early development of S. kegaki in this study was similar the early development of other oysters, although size of the fertilized eggs were somewhat smaller.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2002년도 가을 학술발표회 논문집
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• pp.795-798
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• 2002

Recently. the properties of early-age concrete are increasingly important because these properties directly influence the behavior of early-age concrete structures including stress and cracking behavior. Nevertheless, the studies on early-age concrete are limited to strength and temperature development. The purpose of present study is to propose a simple and rational method which can predict the stress and strain behavior of young age concrete. A series of test have been done to measure the temperature development, strains and stresses in concrete members. The concept of equivalent age was used to define the degree of hydration and this degree of hydration was used to calculate the strength and elastic modulus. The present study indicates that the calculated stresses correlate fairly well with measured stresses. The consideration of critical degree of hydration in calculating stresses gives more accurate results. The present study provides useful method and data in evaluating early-age behavior of concrete structure.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1999년도 학회창립 10주년 기념 1999년도 가을 학술발표회 논문집
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• pp.179-182
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• 1999

A protections from the frost damage at early ages is one of the serious problems to be considered in cold weather concreting. Frost damage at early ages brings about the harmful influences on the concrete structures such surface cracks and the loss of strength. Therefore, in this paper, the protecting durations of frost damage at early ages according to the standard specifications provided in KCI(Korean Concrete Institute) are suggested by appling logistic curve, which evaluates the strength development of concrete with maturity. According to the results, as W/C and compressive strength for protecting from frost damages at early ages increased, longer protecting duration is required. It shows that the protecting durations of FAC(Fly Ash Cement) are longer than those of OPC(Ordinary Portland Cement).