• Journal of Korean Society of Coastal and Ocean Engineers
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• v.12 no.4
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• pp.157-167
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• 2000

Korea Ocean Research and Development Institute performed the basic design of the Ear-Do Ocean Research Station in 1998. The design wave was taken to be the deep water wave which was obtained through wave hindcasting procedure. Wave forces acting on the structure were calculated by Morison formula utilizing the stream function theory of 5th. order. In the present study, a three dimensional hydraulic model testing was undertaken to investigate the validity of the basic design, measuring wave propagation over the Ear-Do, horizontal wave forces and air gaps. The measured forces were all compared by the corresponding values calculated by SACS program based on th design on the design wave. The results showed that in the three deep water wave directions (SSW, S, SE) the measured wave farces appeared less than the SACS calculated. But in the NNW wave direction, the measured forces generally exceeded the calculated values and showed a peculiar pattern very similar to the case that waves are superimposed by an unidirectional current. It was also found that the measured air gap underneath the structure appeared less than the values taken in the basic design for all wave directions.

• Journal of Radiation Protection and Research
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• v.30 no.1
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• pp.45-54
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• 2005

A dynamic compartment model was developed to appraise the level of the contamination of agricultural plants by accidentally released tritium from nuclear facility. The model consists of a set of inter-connected compartments representing atmosphere, soil and plant. In the model three categories of plant are considered: leafy vegetables, grain plants and tuber plants, of which each is modeled separately to account for the different transport pathways of tritium. The predictive accuracy of the model was tested through the analysis of the tritium exposure experiments for rice-plants. The predicted TFWT(tissue free water tritium) concentration of the rice ear at harvest was greatly affected by the absolute humidity of air, the ratio of root uptake, and the rate of rainfall, while its OBT(organically bound tritium) concentration the stowing period of the ear, the absolute humidity of air and the content of hydrogen in the organic phase. There was a good agreement between the model prediction and the experimental results lot the OBT concentration of the ear.

• Food Science and Biotechnology
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• v.17 no.4
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• pp.745-750
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• 2008

Anti-inflammatory potential of the enzymatic extract prepared by Kojizyme (ECK), a component of brown seaweeds Ecklonia cava (Alariaceae, Phaeophyta) in vivo was investigated. For the application of mouse ear edema model, 12-O-tetradecanoylphorbol acetate (TPA) was used, a topical inducer of a long-lasting inflammatory response. Our results demonstrated that ECK inhibited ear edema when topically applied to mouse ear skin. In histological evaluation, the inhibition activity of ECK on TPA-induced inflammation is similar to that of dexamethasone, although less strong. In addition, the mRNA expression levels of IL-$1{\beta}$, IFN-$\gamma$, TNF-$\alpha$, and cyclooxygenase-2 (COX2) and the immunoreactivity to inducible nitric oxide synthase (iNOS) and COX2 expressed mainly in inflammatory cells were down-regulated by ECK. These results indicate that ECK has anti-inflammatory effects through the inhibition of Th1 cytokines and 2 inducers of inflammation in TPA-induced ear skin edema.

• The Korea Journal of Herbology
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• v.21 no.1
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• pp.9-15
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• 2006

Objectives : Lonicerae Flos has been known as a useful plant with anti-inflammatory, antioxidative and immunosuppressive activity. To evaluate anti-inflammatory effect of Lonicerae Flos, we treated Lonicerae Flos-skin in animal model system induced contact hypersensitivity. Methods : Contact hypersensitivity, a local inflammatory response of the skin, was induced by spreading the right ear of BALB/c mouse with 1% DNCB. Lonicerae Flos-skin was prepared by dissolving 1% water extract of Lonicerae Flos in skin vehicle and treated everyday for 2 weeks on the right ear. Results : Lonicerae Flos-skin significantly reduced a mouse ear thickness swelled by 1% of DNCB treatment compared with skin vehicle-treated control group. Lonicerae Flos-skin also reduced IgG and IgE in serum obtained from blood of 1% DNCB-treated mouse. Conclusion : These results showed that Lonicerae Flos-skin could be used as a pharmaceutical material with antiinflammatory effects by reducing IgG and IgE in contact hypersensitivity mouse model by DNCB.

• Journal of Ginseng Research
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• v.30 no.3
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• pp.95-99
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• 2006

When the inhibitory effect of ginsenoside (G) Re isolated from ginseng and its metabolites G-Rg1, G-F1, G-Rh1 and protopanaxatriol in mouse ear skin psoriasis stimulated by oxazolone was investigated, G-Re and its metabolites suppressed mouse ear swelling stimulated by oxazolone. Among these agents tested, G-Rh1 most potently suppressed ear swelling as well as mRNA expression of COX-2 and proinflammatory cytokines $IL-1{\beta},\;TNF-{\alpha}$ and $interferon-{\gamma}$. These findings suggest that G-Rh1 may improve chronic dermatitis and psoriasis.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.693-694
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• 2015

This paper present a decision method of middle ear disease which is developed in children and adults. In the proposed method, features are extracted from the middle ear disease images and normal images using HOG(histogram of oriented gradient) descriptor and the extracted features are learned by SVM(support vector machine) classifier. Input images are classified by SVM classifier based on the model of learning features. Experimental results show that the method yields accuracy of over 90% in decision.

• Journal of the Ergonomics Society of Korea
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• v.21 no.1
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• pp.51-65
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• 2002

As the method of providing information is getting multimedia, the synthetic voice is used in not only CTI(Computer Telephony Integration), information service for the blind, but also applications on internet. But properties of synthetic voice, such as speech rate, pitch, timbre and so on, are not adjusted to customers' preference but providers' preference. In order to consider customers' preference, this study proposed four subjective factors of voice through the evaluation of voice using the method of sensibility ergonomics. And the relation synthetic voice to be agreeable to the ear with emotional images was formulated as a fuzzy model. Consequently, this study proposed the speech rate and pitch of synthetic voice which is agreeable to the ear.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.237-242
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• 2008

The effect of Picrorrhiza Rhizoma (PR) aqueous extracts were evaluated on 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Three different concentrations of PR extracts (300,150 and 75mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference materials; dexamethasone (15mg/kg, intraperitoneal treatment). End of 7 days oral administration of PR extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these DNFB-induced increases on ear and paw thicknesses, weights and scratching behaviors were decreased by treatment of all three different dosages of PR extracts and dexamethasone, respectively. In addition, the increases of anterior skin thicknesses were also dramatically inhibited by treatment of all three different dosages of PR extracts and dexamethasone at histopathological observations. The results obtained in this study suggest that oral treatment of PR extracts also has relatively favorable effects on allergic dermatitis.

• Herbal Formula Science
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• v.13 no.2
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• pp.59-69
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• 2005

Samyoyongantang (SMY), a herbal medicine, has been used as cure for gangrene. To evaluate anti-inflammatory effect of samyoyongantang, we treated samyoyongantang extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/c mouse. Samyoyongantang was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatm ent, but a mouse ear thickness was significantly reduced by samyoyongantang after 2 we eks treatment. Samyoyongantang reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by samyoyongantang treatment. From these results, anti-inflammatory effect of samyoyongantang, especially reduction of ear swell ing, might be partly due to reduction of IgG in serum.

• Korean Journal of Pharmacognosy
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• v.43 no.3
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• pp.243-249
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• 2012

Bee venom (BV), well known as a traditional Oriental medicine, has been widely used in the treatment of some immune-related diseases. However, the anti-allergic effect of BV have not been reported. In this study, we investigated the antiallergic effect of BV on triphasic cutaneous reaction (TpCR) and passive cutaneous anaphylaxis (PCA). Our results indicated that BV suppress ear swelling and vascular permeability on IgE mediated type I hypersensitivity response. Increase in ear thickness was significantly inhibited by BV in this model. BV also blocked the infiltration of immune cells into the ear. Moreover, BV suppressed expression of HDAC3, Tryptase, MCP-1 in ear tissue. These results demonstrated that BV has a suppressive effect on allergic reaction.