• Pediatric Infection and Vaccine
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• 제15권2호
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• pp.202-205
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• 2008

림프절염과 안면신경마비가 동반된 MRSA에 의한 세균성 중이염의 병력이 있는 생후 78일된 영아가 원발성 결핵성 중이염과 림프절염 및 폐결핵으로 확진된 증례를 경험하였다. 저자들은 세균성 중이염의 재발로 판단하고 결핵성 질환의 가능성을 간과하여 진단과 치료가 늦어졌다. 영아에게서 세균성 중이염으로 치료 종결 되었으나 재발 후 원발성 결핵성 중이염으로 확진된 증례는 매우 드물지만, 이와 같은 경우에도 반드시 결핵성 중이염의 가능성을 반드시 고려하여야 한다.

• Journal of the Korean Wood Science and Technology
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• 제42권5호
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• pp.579-589
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• 2014

Atopic dermatitis (AD) syndrome is one of the most common and severe skin diseases in Korea; a large population has this disease. We examined the effects of the extract from the leaf and sprig of Camellia sinensis on the development of AD by using NC mice as a model of atopic dermatitis. Oral administration of the extract to NC/Nga mice treated with 2,4?dinitrochlorobenzene (DNCB) inhibited the development of AD-like skin lesions as shown by a significant decrease in the skin symptoms of the disease and a decrease in ear thickness and levels of immunoglobulin E (IgE) and thymus-and activation-regulated chemokine (TARC) level in the skin. Administration of the extract markedly suppressed the DNCB-induced mRNA expression of interleukin 4 (IL-4) and tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$). The findings suggest that transdermal application of the extract may modulate in the skin of NC/Nga mice. The extract was effective for the prevention and treatment of AD.

• 한방비만학회지
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• 제4권1호
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• pp.213-219
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• 2004

Obesity is the condition that excess fat stored in the body. Nowadays, the prevalence of obesity has greatly increased due to westernized dietary habits and changes in lifestyle. It has been proved that obesity is a risk factor of many diseases. Many methods were developed to find curative means for obesity and exercise and controlling diet were considered very effective ones. In order to find the theraputic effect of the exercise and food diary, we examined patients treated by electric accupuncture and ear accupuncture because of obesity. We observed 16 patients with obesity who visited KyungHee Univ., Kangnam Hospital of Oriental Medicine from November, 2002 to March, 2003. To rule out an bias, we excluded the patients who were treated for other disease or took medicine. Exercise in hospital was not effective for treatment of obesity, but keeping diary of diet was effcetive for the decrease of body weight(p<0.05).

• Korean Journal of Acupuncture
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• 제26권4호
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• pp.107-118
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• 2009

Objectives : This study was performed to investigate physiology, pathology and clinical applications for cosmetology in Traditional Chinese Medicine. We hope most clinicians practicing cosmetic acupuncture to understand theoretical background well and to treat cosmetic diseases more diversely by this paper. Methods : We collected useful informations from 35 papers in Chinese at website www.cnki.net about TCM treatments including acupuncture, moxibustion and herbal medicine. And we could see important factors connected with physiology, pathology and clinical applications within this field. Conclusions : Liver, lung, stomach, mental disorders and yin-deficiency constitution were connected each other in cosmetic physiology. Blood stasis and congestion were thought highly in cosmetic pathology. In clinical applications, wet cupping therapy on the acupoints located in the back line of Governor Vessel(GV), ear-acupuncture, acupuncture using local facial acupoints, pharmacopuncture, moxibustion were used diversely for each case with cosmetic disorders. Especially, local acupoints and remote acupoints were selected at the same time for wrinkle care. And studies on plastic surgery sequelae, dark skin, acne and melasma were more published than those on wrinkle care.

• 임상이비인후과
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• 제29권2호
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• pp.240-244
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• 2018

Granulomatosis with polyangiitis (GPA) and Immunoglobulin (Ig) $G_4$-related disease ($IgG_4$-RD) are rare diseases and early diagnosis and proper management are imperative to prevent multi-organ damage. The authors present a case of a 60 years old woman who had facial paralysis and hearing loss. Lt intact canal wall tympanomastoidectomy, Lt facial nerve decompression and ossiculoplasty with partial ossicular replacement prosthesis (PORP) was done. During operation, middle ear tissue was biopsied and GPA with $IgG_4$-RD was diagnosed. After methyl prednisolone (MPD) pulse therapy and azathioprine therapy, the severity of paralysis was improved. We present this case because common otologic symptoms like facial palsy and hearing loss could be initial symptoms of rare systemic disease.

• 생약학회지
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• 제50권3호
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• pp.175-184
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• 2019

Mast cells are crucial as effector cells in the immediate-type allergic reaction. Lentinus edodes has been the popular edible mushroom in oriental countries and reported to have immunomodulatory, anti-tumor, anti-atherogenic, anti-viral, and anti-allergic activities. However, the roles of L. edodes in mast cell-mediated anaphylactic reaction have not been fully elucidated. In this research, we have demonstrated the effects of the methanol extract of L. edodes (MELE) on mast cell-mediated anaphylaxis-like and anaphylactic reactions. MELE suppressed systemic anaphylaxis-like reaction, plasma histamine levels, and ear swelling response in mice treated with compound 48/80. MELE also suppressed passive systemic and cutaneous anaphylaxis mediated by anti-dinitrophenyl IgE. In accordance with these findings, MELE dose-dependently decreased histamine release from RPMC evoked by compound 48/80 or the antigen-antibody reaction. To clarify the mechanism of degranulation system, intracellular cAMP levels as well as calcium influx in RPMC was evaluated. In compound 48/80-treated RPMC, MELE blocked calcium uptake into the cells. In addition, MELE elevated the intracellular cAMP content and significantly attenuated compound 48/80-induced cAMP reduction in RPMC. Taken together, we propose the clinical use of MELE in mast cell-mediated immediate-type allergic diseases.

• Natural Product Sciences
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• 제25권3호
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• pp.261-267
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• 2019

The rhizomes of Dioscorea japonica Thunb. are widely consumed as food and also used to treat diabetes and polyuria in Korea. This study was undertaken to study the anti-atopic dermatitis effects of a 95% ethanolic extract (DJE) of D. japonica in an oxazolone-stimulated murine model of atopic dermatitis (AD). The therapeutic effects of DJE on AD-like skin lesions were assessed on both ears. DJE (1%) or dexamethasone (0.5%; the positive control) were applied to skin lesions for three weeks. Serum levels of IgE and IL-4 were assessed by ELISA (enzyme-linked immunosorbent assay). Histopathological examinations were performed by hematoxylin and eosin (H&E) and toluidine blue staining and revealed DJE significantly reduced dermal thickness and inflammatory cell infiltration when applied to oxazolone-treated ear skin. DJE-treated AD mice also showed lower serum levels of IgE and IL-4 than oxazolone-stimulated controls. Our findings demonstrate DJE might be a useful safe, topical agent for the treatment of atopic diseases.

• BMB Reports
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• 제42권12호
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• pp.794-799
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• 2009

The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu $\beta$-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and cyclooxygenase-2 (COX-2) expression in murine macrophage Raw 264.7 cells as well as 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. The polysaccharide significantly inhibited (P < 0.01) LPS-induced iNOS and COX-2 expression levels in the cells. Furthermore, topical application of polysaccharide resulted in markedly inhibited (P < 0.01) TPA-induced ear edema in mice. These results suggest that this polysaccharide may be used for NO- and COX-2-related disorders such as inflammation and cancer.

• 한국유기농업학회지
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• 제26권4호
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• pp.629-647
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• 2018

1. 유기재배구의 토양조건은 배수가 약간 불량한 미사질 양토인 전북통 보통답으로 유효규산이 높은 것을 제외하고는 우리나라 논토양의 화학적 성분과 평균 함량이 유사하였다. 2. 관행재배구와 유기재배구 간에 생육은 초장, 분얼수, 이삭수, 이삭길이 모두 관행재배구에서 높은 것을 확인하였으며 이삭당 입수와 등숙율은 유기재배구에서 다소 높게 나타났다. 3. 병해충 발생정도는 물바구미, 잎집무늬마름병, 혹명나방, 도열병이 유기재배구에서 많이 발생하였고, 이삭누룩병은 관행재배구에서 조금 더 많이 발생하였다. 4. 주요 관리대상 병해충인 잎집무늬마름병(y=-0.2848x+199.57, $R^2=0.704^*$), 혹명나방 발생(y=-0.1361x+92.535, $R^2=0.8049^*$)과 쌀 수량과의 관계에서 유의성이 높은 부의 상관관계가 나타났다. 5. 백미 품질은 유기재배구에서 파쇄미의 증가로 완전립 비율이 낮았지만, 단백질함량이 관행재배구에 비해 낮아 전반적인 품질 및 윤기치가 높아졌다. 6. 쌀 재배 순수익은 관행재배구에서 36만원/10a, 유기재배구에서 61만원/10a로 유기재배구의 순수익이 68% 높게 나타났다.

• Pediatric Infection and Vaccine
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• 제26권2호
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• pp.112-117
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• 2019

Eikenella corrodens는 구강 상재균으로 두경부 감염을 주로 일으키나 면역력이 정상인 소아청소년에게 감염을 일으키는 경우는 흔하지 않다. 저자들은 발열, 두통, 구토를 증상으로 입원한 이전까지 건강하였던 13세 남자에게서 E. corrodens 감염에 의한 중추신경계 경막 외 농양을 진단하여 보고하는 바이다. 초기에 시행한 신체검진에서 경부 강직은 없었으나, 우측 이루가 관찰되었다. 뇌 magnetic resonance imaging (MRI) 영상소견에서 4.5 cm 크기의 경막 외 농양이 우측 측두엽 부근에서 발견되었고, 양측 사골동염 및 접형동염, 우측 유양돌기염과 중이염이 동반되었다. Vancomycin과 cefotaxime 투약 중에도, 임상증상이 호전되지 않고 추적 MRI에서 경막 외 농양의 크기가 증가하고, 우측 접형동에 농양이 형성되어 항균요법과 함께 천두술과 내시경적 접형동 절개술을 시행하였다. 수술 시 경막 외 농양과 접형동에서 악취가 나는 고름이 다량 흡인되었으며 두 부위에서 흡인된 검체 모두에서 E. corrodens가 배양되었다. 수술 이후 3주 동안 cefotaxime 정맥주사로 치료받고 합병증 없이 회복하였다. 결론적으로, E. corrodens는 건강한 소아청소년에서 치료되지 않은 세균성 부비동염에 합병하여 중추신경계 농양의 원인이 될 수 있다.