• 한국유기농업학회지
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• 제28권4호
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• pp.535-553
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• 2020

In this study, the characteristics of the waste sector CDM project were analyzed through cluster analysis of the waste sector CDM project and the analysis of the CDM investment cost in waste sector using CDM project data registered with UNFCCC since 2008 when EU ETS phase 2 began. As of September 2020, 772 cases of CDM projects in waste disposal and disposal are registered. Biogas technology is the largest, followed by livestock manure processing and biomass production technology. The results of the cluster analysis are summarized as follows: First, on average, projects utilizing AWMS technology are small in size and relatively low in investment costs. This is judged to be relatively low investment costs due to previously attracted foreign investment capital. Second, the average investment cost of CDM projects considered along with waste (No.13), the energy industry (No.1) and agriculture (No.15) was higher than those involving only waste. The analysis of the factors determining the investment cost of the waste sector CDM project showed that, as with cluster analysis, the AWMS technology, which is a livestock manure treatment technology, was lower in the investment cost than those that use other technologies. As a result of multiple regression analysis, the investment cost of the CDM project was analyzed lower in the order of biomass, AWMS, LFG and biogas. Also, the higher the investment cost for CDM projects linked to waste, energy and agriculture, and the better the investment environment, the higher the investment cost. Although no statistical feasibility was obtained, the larger the annual emission reduction, the lower the CDM investment cost.

• 한국기후변화학회지
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• 제7권3호
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• pp.283-288
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• 2016

In this study, applicability of GHG ETS Offset Program in Korea for a refrigerant sector was analyzed by reviewing foreign management policy and project status in progress related to refrigerants in the disposal stage. In order to derive the implication of the domestic Offset Program, it was looked into approved offset projects and certified offset credits current state in Korea. Offset Program has approved 22 methodologies up to the present, so it is necessary to enhance the accessibility to GHG reduction in various industrial sector including the refrigerant sector by developing appropriate methodologies. In this study firstly, it was investigated that management regulation of countries are managing the refrigerants in the disposal stage such as United States, Japan, Australia. Secondly, of CDM methodologies there were two methodologies associated with the refrigerant reduction(treatment), which were decomposition HFC-23 and destruction of HFC-134a. Also there were a non-registered methodology about destruction of HFC-134a of end of life vehicles. Lastly, in California according to Compliance Offset Program, there was Compliance Offset Protocol in ODS Projects that provided eligible conditions. Based on the review, it was examined the possible conditions for domestic offset project for refrigerant sector

• 인터넷정보학회논문지
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• 제23권1호
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• pp.11-17
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• 2022

Data mining is the task of accessing useful information from a large capacity of data. It can also be referred to as searching for correlations that can provide clues about the future in large data warehouses by using computer algorithms. It has been used in the tourism field for marketing, analysis, and business improvement purposes. This study aims to analyze the tourist profile in Turkey through data mining methods. The reason relies behind the selection of Turkey is the fact that Turkey welcomes millions of tourist every year which can be a role model for other touristic countries. In this study, an anonymous and large-scale data set was used under the law on the protection of personal data. The dataset was taken from a leading tourism company that is still active in Turkey. By using the k-means clustering algorithm on this data, key parameters of profiles were obtained and people were clustered into groups according to their characteristics. According to the outcomes, distinguishing characteristics are gathered under three main titles. These are the age of the tourists, the frequency of their vacations and the period between the reservation and the vacation itself. The results obtained show that the frequency of tourist vacations, the time between bookings and vacations, and age are the most important and characteristic parameters for a tourist's profile. Finally, planning future investments, events and campaign packages can make tourism companies more competitive and improve quality of service. For both businesses and tourists, it is advantageous to prepare individual events and offers for the three major groups of tourists.

• Biomolecules & Therapeutics
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• 제30권6호
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• pp.593-602
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• 2022

The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates tumour development by inactivating pRb. However, this alone cannot explain the various characteristics acquired by HPV infection. Therefore, we examined other molecules that could help explain the acquired cancer properties during E7-induced cancer development. Using the yeast two-hybrid (Y2H) method, we found that the Elk-1 factor, which is crucial for cell proliferation, invasion, cell survival, anti-apoptotic activity, and cancer development, binds to the E7. By determining which part of E7 binds to which domain of Elk-1 using the Y2H method, it was found that CR2 and CR3 of the E7 and parts 1-206, including the ETS-DNA domain of Elk-1, interact with each other. As a result of their interaction, the transcriptional activity of Elk-1 was increased, thereby increasing the expression of target genes EGR-1, c-fos, and E2F. Additionally, the colony forming assay revealed that overexpression of Elk-1 and E7 promotes C33A cell proliferation. We expect that the discovery of a novel E7 function as an Elk-1 activator could help explain whether the E7 has novel oncogenic activities in addition to p53 inactivation. We also expect that it will offer new methods for developing improved strategies for cervical cancer treatment.

• 자원ㆍ환경경제연구
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• 제31권1호
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• pp.51-83
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• 2022

2012년부터 재생에너지 확대 정책을 위한 주요 정책 수단으로서 채택하고 있는 신재생에너지 공급의무화 제도(RPS)는 발전원별 경쟁을 유도함과 동시에 정부의 재정부담을 줄일 수 있다는 명백한 장점을 가지고 있지만, 높은 가중치 및 국가 공급인증서(REC) 남용 등으로 양적 통제정책으로서의 정책 왜곡을 초래하였다. 이는, REC 인플레이션과 그에 상응하는 MWh 단위의 실질 신재생에너지발전 실적 하락으로 이어졌고, 그 결과 RPS 기간 전체 신재생 의무이행량의 27.8%가 실제로는 충족되지 못했음을 본고에서 최초로 밝힌다. 뿐만 아니라 현재의 REC 가치왜곡은 인접제도라고 할 수 있는 RE100과 온실가스 배출권거래제와의 상호호환이 불가능해지게 하는 문제도 초래한다.

• Molecules and Cells
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• 제46권4호
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• pp.191-199
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• 2023

The Golgi apparatus modifies and transports secretory and membrane proteins. In some instances, the production of secretory and membrane proteins exceeds the capacity of the Golgi apparatus, including vesicle trafficking and the post-translational modification of macromolecules. These proteins are not modified or delivered appropriately due to the insufficiency in the Golgi function. These conditions disturb Golgi homeostasis and induce a cellular condition known as Golgi stress, causing cells to activate the 'Golgi stress response,' which is a homeostatic process to increase the capacity of the Golgi based on cellular requirements. Since the Golgi functions are diverse, several response pathways involving TFE3, HSP47, CREB3, proteoglycan, mucin, MAPK/ETS, and PERK regulate the capacity of each Golgi function separately. Understanding the Golgi stress response is crucial for revealing the mechanisms underlying Golgi dynamics and its effect on human health because many signaling molecules are related to diseases, ranging from viral infections to fatal neurodegenerative diseases. Therefore, it is valuable to summarize and investigate the mechanisms underlying Golgi stress response in disease pathogenesis, as they may contribute to developing novel therapeutic strategies. In this review, we investigate the perturbations and stress signaling of the Golgi, as well as the therapeutic potentials of new strategies for treating Golgi stress-associated diseases.

• 대한토목학회논문집
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• 제30권3B호
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• pp.233-242
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• 2010

Bastiaanssen(1995)에 의해 개발된 SEBAL(Surface Energy Balance Algorithm for Land) 모형은 25개의 sub model들을 이용하여 지표의 증발산량과 기타 여러 에너지 교환을 계산하는 이미지-프로세싱 모형이다. SEBAL 모형은 Landsat 또는 기타 여러 위성영상을 통해 얻을 수 있는 열적외선 방사, 표시 및 근적외선 측정 자료 등을 사용한다. 본 연구에서는 한강유역의 주 지류인 경안천 유역에 모형을 적용시켰다. 증발산량(ET)은 4개년의(2001년-2004년) Landsat과 MODIS 위성영상을 입력자료로 사용하여, 에너지 균형원리를 통해 pixel-by-pixel을 기준으로 계산되었다. Landsat(30 m)과 MODIS(1 km) 사이의 비교 결과도 평가되었으며, Landsat과 MODIS 결과들은 FAO Penman-Monteith 증발산량과 비교하였다. 위성영상 ET들과 FAO Penman-Monteith ET 간의 절대 오차는 12% 이내로 확인되었으며, 유역 분포 증발산량의 시공간분포특성 또한 분석하였다.

• Clinical and Experimental Reproductive Medicine
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• 제50권4호
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• pp.277-284
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• 2023

Objective: In this retrospective study, we analyzed factors influencing the ongoing pregnancy rate (PR) in women with repeated implantation failure (RIF) undergoing embryo transfer with endometrial receptivity array (ERA). Methods: Eighty-three consecutive personalized embryo transfers (pETs) with ERA, from 54 women with RIF, were selected from June 2020 to April 2022. Vitrified blastocyst transfer was timed based on ERA results. Results: The ongoing PR per pET was 33.7%. Using ERA, the endometrium was identified as pre-receptive in 26 cycles, early receptive in 25 cycles, receptive in 31 cycles, and late receptive in one cycle. With cycles categorized into three receptivity phases (pre-receptive, early receptive, or receptive), no significant differences were found in the clinical PR (27.3%, 55.6%, and 40%, respectively) or ongoing PR (9.1%, 55.6%, and 40%, respectively) after a single blastocyst transfer. Similarly, no significant differences were observed in the clinical PR or ongoing PR after the transfer of two or more blastocysts. Among women with ongoing pregnancy relative to those without, age at first pET was significantly lower (35 years vs. 39 years, p=0.001), while blastocyst score (23 vs. 18, p=0.012) and the proportion of blastocyst scores >18 (71.4% vs. 38.9%, p=0.005) were significantly higher. In multiple logistic regression analysis, the woman's age (odds ratio [OR], 0.814; 95% confidence interval [CI], 0.706 to 0.940; p=0.005) and blastocyst score >18 (OR, 3.052; 95% CI, 1.075 to 8.665; p=0.036) were identified as significant factors influencing ongoing pregnancy. Conclusion: In pET with ERA, ongoing pregnancy was closely associated with woman's age and blastocyst quality.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.844-852
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• 1997

연구배경 : 최근의 기관지천식 병인과 관련한 여러 연구에서 천식 발작중에 폐장에서 과도하게 유리된 endothelin(ET)이 기관지 수축을 유발시키는 주요한 펩티드임이 확인되었다. 이 연구의 목적은 급성발작의 경과에 따른 혈장 몇 요중치의 변동 및 상호 연관성을 관찰함에 있다. 방 법 : 연구대상은 16명의 급성 천식악화로 입원한 환자에서 내원당일과 치료 2주후의 2회의 혈장 및 24시간 요를 채취하였다. 정상대조군은 신체건강한 성인 10명으로 정하였다. 모든 천식환자는 입원당시 부신피질호르몬제, 베타-2 교감신경작동제, 아미노필린 제제를 투약받았다. ET은 방사면역측정법에 외해 측정되었으며 교차반응성에 있어 ET-1과는 100%, ET-2와 67%, ET-3와 84%, Big-ET과 8% 이었다. 결 과 : 혈장 ET은 천식환자의 및대조군의 수치와 비교하여 천식악화시 유의하게 증가하였다. 그러나 요중 ET은 천식악화시 및 치료후에 유의한 감소가 관찰되지 않았으나 정상대조군에 비해서는 둘다 유의하게 증가되어 있었다. 혈중 및 요중 ET치는 폐기능 및 저산소혈증 등과 유의한 상관관계는 없었다. 결 론 : 천식의 급성악화시에 증가한 혈장의 ET은 폐장에서의 ET 유리의 증가에 기인한 것으로 사료된다. 천식발작 환자는 정상인에 비해 요중 ET의 배설이 증가하여 있었으나 치료 2주후까지는 유의한 감소가 관찰되지 않았다. 따라서 천식발작시의 요중 ET의 변동을 관찰하기 위해서는 좀더 긴 관찰기간 및 많은 환자를 대상으로 포괄적인 연구가 되어야 할 것으로 생각된다.

• Clinical and Experimental Pediatrics
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• 제46권12호
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• pp.1186-1193
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• 2003

목 적 : 염색체 취약부위는 세포를 특정의 화학물질에 노출시키거나 특수한 배양조건에서 배양 할 때 쉽게 파열되는 염색체상의 특정구역이다. 취약부위는 유전성질환 및 악성종양과 관련이 있으며, 현재에는 분자생물학적 실험기법의 개발로 분자수준에서 이해가 되고 있다. 새로운 취약부위 및 취약부위의 발현을 높이거나 쉽게 관찰할 수 있는 실험실적 조건을 알아보기 위하여 항암제로 사용되는 Ara-C를 이용하여 염색체파열을 조사하여 보았다. 한편 염색체 취약부위가 종양형성과 관련이 있다는 사실에 기초하여 Ara-C에 의해 발열되는 취약부위와 암유전자가 위치하는 부위 및 종양에서 일정하게 염색체변이가 관찰되는 특정의 염색체 부위와의 상관관계도 알아보고자 하였다. 방 법 : 정상 성인 남녀 각각 3명의 말초혈액 내 T-림프구를 세포배양 후 Ara-C를 첨가하고 다시 caffeine을 처리한 뒤 종전에 시행했던 방법과 동일하게 검체 처리하여 염색체파열 부위를 관찰하였다. 염색체 취약부위는 염색체상의 일정부위에서 100개의 염색체파열 당 2회 이상의 염색체파열이 6명 중 4명 이상에서 관찰되는 경우로 정의하였다. 결 과 : 1) T-림프구를 엽산이 부족한 MEN-FA 배지에서 배양 시 Ara-C는 100개의 분열세포 당 252.1개의 염색체파열을 유도하였으며, Ara-C를 처리하지 않은 대조군에서 25.2개가 관찰되어 Ara-C를 처리한 경우에 염색체파열이 의미 있게 많았다(P<0.05). 2) Ara-C에 의한 염색체파열은 엽산이 부족한 MEM-FA 배지에서 엽산이 충분한 RPMI 1640 배지에서 보다 많이 되었다(P<0.05). 한편, 2.0 mM 농도의 caffeine은 엽산만 부족한 배양 배지에서는 염색체파열을 상승시키지 못했으나, Ara-C와 병행사용 시 상승시켰다. 3) Ara-C에 의해 가장 많이 파열된 부위는 3p14.2.이었으며, 발현된 취약부위는 20부위였다. 4) 발현된 취약부위 중 7 부위는 JUN, SKI, REL, N-MYC, FHIT, MET, ETS-1, FOS의 암유전자가 위치하는 부위와 일치하였으며, 15부위는 급성림프구성백혈병, 급성골수성백혈병, 만성림프구성백혈병, 골수이형성성증, 악성흑색종, 신경모세포종, 소세포성폐암, 난소암, 유전성 신장암, 혼합성 지방육종시 염색체상에 이상이 있는 부위와 일치하였다. 결 론 : S기 특이성 항암제인 Ara-C는 정상성인의 T-림프구를 엽산이 부족한 MEM-FA배지에서 배양시 염색체 파열을 대조군에 비해 의미 있게 유도하였다. 한편으로 Ara-C 특이성 염색체 취약부위는 암유전자가 위치하는 부위 및 특정 종양에서 관찰되는 특이한 염색체변이가 있는 부위와 상당 예에서 일치하여 아직 알려지지 않은 암유전자를 찾거나 분석하는데 기초적인 자료를 제공할 뿐 아니라 염색체변화와 종양형성과정의 상관관계를 이해하는데 도움이 될 것으로 사료된다.