• Archives of Pharmacal Research
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• 제15권1호
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• pp.58-61
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• 1992

Bacillus anthracis 590 having an inducibla resistance determinant to MLS antibiotics was isolated from a soli sample in Korea. The resistance gene (ernJ) was cloned by Southern blotting of chromosomal DNA fragment digested by various restriction enzymes and coloy hybridization method and the cloned plasmid was named as pBA423. The size of inserted DNA fragment of pBS42 vector was about 2.9 kb and the DNA sequence of the subcloned fragment (Hinc II-Hinc II, 1.4kb) WAS determined. The DNA sequence of ernJ was composed of 357 bp for leader region and 861 bp for the structural gene. Because the leader sequence of ernJ was homologous to that of ermK, the expression of ernJ is also thought to be controlled by a transcriptionl attenuation mechanism.

• 한국생산제조학회지
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• 제24권1호
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• pp.15-22
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• 2015

In the present paper we report the results of a study into Friction Stir Welds (FSWs) made in 13 mm-thick 12%-Cr steel plates. Based on residual strains obtained by diffraction techniques, eigenstrain analysis was performed using the Eigenstrain Reconstruction Method (ERM), which is a novel methodology for the reconstruction of full-field residual strain and stress distributions within engineering components. Significant eigenstrain distributions were found at around Thermo-Mechanically Affected Zone (TMAZ) where the most severe plastic deformation was occurred. Microstructure analysis was used to elucidate this phenomenon showing that the grain structure in TMAZ was bent and not successfully recrystallised, resulting in severe deformation behaviour. The reconstructed residual strain distributions by the ERM agree well with the experimental results. It was found that the approach based on theory of eigenstrain is a powerful basis for reconstructing the full-field residual strain/stress distributions in engineering components and structures.

• 한국지형공간정보학회:학술대회논문집
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• 한국지형공간정보학회 1994년도 세미나 개요집
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• pp.43-52
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• 1994

ER Mapper는 호주의 ERM(Earth Resource Mapping Ltd.)사에서 개발한 이미지 프로세싱 전문 소프트웨어로서 GIS/LIS 분야의 벡터자료와 인공위성 및 항공측량에 의한 래스터 이미지를 통합 관리함으로써 여러 활용분야별 분석 및 의사 결정시 효율성을 높있 수 있다. 1989년 설립된 ERM은 이피지 프로세싱 시스템 개발에 집중적으로 투자하여 90년 6월 ER Mapper의 첫 버젼을 발표한 이래 현재 버젼 4.2까지 발표하였다. 같은 용도의 타 경쟁제품에 비하여 가격 대 성능비와 사용 편의성, 융통성 등이 뛰어난 것으로 판명된 ER Mapper는 산업계 표준을 지향하며 주변기기 접속성 둥에서도 탁월한 성능을 발휘한다. 또한 모든 기능이 하나의 패키지에 포함 지원되므로 모듈별 기능 구성을 지향하는 경쟁 소프트웨어에 비해 사용자 지향적 구조를 지니고 있다. ER Mapper는 현재 호주 이미지 프로세싱 시장의 80%에 이르는 높은 점유율을 보유하고 있으며 아시아, 아메리카, 유럽 등 전세계 지역에 약 70여개의 판매망을 가지고 그 시장점유율을 높여가고 있다.

• 한국기록관리학회지
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• 제5권1호
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• pp.65-77
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• 2005

문서관리와 전자문서관리가 1990년대를 전후하여 변화 발전해 온 배경과 현재의 경향을 살펴보고, 전자문서관리 소프트웨어 디자인에 관련된 아카이브적인 기능과 업계의 기술표준, 현재 나와 있는 소프트웨어 등을 고찰함으로 전자문서관리의 현단계와 앞으로의 개발방향을 제시한다.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2008년도 International Meeting of the Microbiological Society of Korea
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• pp.56-58
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• 2008

• 미생물과산업
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• 제13권2호
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• pp.8-13
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• 1987

이글에서는 항생물질 내성의 생화학적 기전, MLS계 항생물질 내성기전, Post-transcriptional attenuation control, MLS계 항생물질 내성기전 연구방향, erm K의 cloning: transcriptional attenuation control의 가능성에 대해 논하였다.

• 한국대기환경학회:학술대회논문집
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• 한국대기환경학회 1998년도 한국대기보전학회 추계학술대회 발표 논문집
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• pp.188-189
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• 1998

• 동의생리병리학회지
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• 제27권1호
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• pp.92-98
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• 2013

Bee Venom(below BV) has been used in alternative medicine to treat the diseases, such as pain diseases. BV contains a variety of peptides, including melittin, apamin, adolapin, MCD peptide, enzymes(i.e. PLA2), amines(i.e. histamine and epinephrine), and nonpeptide components. The two main components of BV are melittin and PLA2. The cell cytotoxic effects through the activation of PLA2 by melittin have been suggested to be the critical mechanism for the depress of cancer cell. Melittin and PLA2 have been reported to induce apoptosis and to possess anti-cancer effects and neurite outgrowth in PC12 cells. Analysis of proliferation was confirmed by MTT assay. BV decreased cell number through dose- and duration-dependent manner and these effects are apparent at a concentration of 3 ${\mu}g/ml$. To observe which signaling molecules will be activated by BV, phosphorylation of ERK, p38 MAPK, JNK and ERM were examined by Western blot analysis. To study the long term effect of BV in human gastric adenocarcinoma cell lines, the image of cells treated with BV for 4 days were obtained. BV was shown to exhibit anti-cancer activity in human gastric adenocarcinoma cell lines at a broad range of concentrations of 3 ${\mu}g/ml$. ERK, p38 MAPK and JNK were found to increase in BV treated cells. However, ERM which known to be involved in the cell death, was gradually decreased to 30minutes after addition 3 ${\mu}g/ml$ of BV. These results provide a possible BV-induced inhibitory signal for cancer proliferation that is initiated by the decrease in ERM activity. Moreover, it is likely that the activation of ERK, p38 MAPK and JNK are required for the BV-induced inhibition of cancer proliferation.

• 한국문헌정보학회지
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• 제43권4호
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• pp.241-264
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• 2009

본 연구는 전자저널의 효율적인 검색과 이용을 위한 방안을 모색하기 위해 문헌조사와 96명을 대상으로 한 설문조사 및 두 개의 전자자원관리시스템(Verde와 Millennium)에 대한 사례조사를 수행하고, 이를 바탕으로 하여 전자저널 검색 모형을 설계한 후 평가하였다. 이 모형의 핵심은 택소노미 기반의 전자자원관리시스템에 폭소노미 태그 기능을 결합하여 시스템 중심의 서비스와 이용자 중심의 서비스를 상호 보완하였다는 점이다. 또한 이용자가 직접 부여하는 태그 이외에 시스템내의 로그파일을 이용하여 자동으로 태그를 생성하여 전자저널 검색의 접근점을 확장시키고, 태그의 비통제 어휘 문제를 극복하기 위해서 관리자가 시스템을 통해서 태그를 통제할 수 있는 기능도 포함시켰다.

• 한국동물위생학회지
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• 제45권3호
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• pp.171-180
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• 2022

The aim of this study was to investigate the prevalence of antimicrobial resistance and virulence factors in staphylococci isolated from canine otitis externa. A total 295 causative microorganisms were isolated. The most common isolated species were Staphylococcus (S) pseudintermedius (94 isolates) followed by Pseudomonas aeruginosa (60 isolates), S. schleiferi (25 isolates), Escherichia coli (23 isolates) and Proteus mirabilis (20 isolates). Staphylococci isolates were showed high resistance to penicillin (78.6%), erythromycin (55.9%), tetracycline (52.4%), clindamycin (51.7%) and ciprofloxacin (42.8%). Of the 145 staphylococci isolates, 49 (33.8%) methicillin-resistant staphylococci (MRS) were observed, distributed among S. pseudintermedius (n=34), S. schleiferi (n=6), S. epidermis (n=4), S. hominis (n=2), S. aureus, S. caprae and S. saprophyticus (n=1, respectively). Forty-three (87.8%) of 49 MRS and 10 (10.4%) of 96 methicillin-susceptibility staphylococci harbored mecA gene. About 80% of MRS were multidrug-resistant with resistance to at least one antibiotic in three or more antibiotic classes. Resistance genes blaZ (93/114, 81.5%), ermB (35/81, 43.2%), ermC (3/81, 3.7%), aacA-aphD (50/54, 92.5%), tetM (69/76, 90.7%) and tetK (6/76, 7.8%) were detected among resistant isolates. Virulence factors genes lukF and lukS were found in 100%(145/145) and 43.4%(63/145), respectively. Genes encoding ermA, eta, etb and tsst were not detected. To the best of our knowledge, this is the first study which investigated for the presence of genes encoding antimicrobial resistance and staphylococcal toxins in staphylococci isolated from canine otitis externa. A continuous monitoring and surveillance program to prevent antimicrobial resistance in companion animals is demanded.