• 한국광학회:학술대회논문집
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• 한국광학회 2000년도 하계학술발표회
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• pp.36-37
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• 2000

정밀 지상관측 위성인 다목적실용위성 1호기에는 해상도 6.6 m인 전자광학카메라(EOC)가 탑재되어 현재 우수한 영상을 보내오고 있으며 2003년 발사예정인 2호기를 위하여 해상도 1 m의 Multispectral Camera(MSC)가 개발중이다. 미 TRW 사가 제작한 EOC 개발에 항우연의 연구진은 그 설계 및 시험의 각 단계별 검토와, 탑재, 위성전체 시험과 보정을 포함한 궤도운용 등의 수행과 함께, 개발기간 동안 현지에서 수행된 별도의 현장교육을 통하여 동급의 위성카메라를 실제 개발할 수 있는 설계기술을 이전받았다. 수차례 대구경 비구면 광학계 제작 경험을 더한 항우연은 MSC 공동개발선인 이스라엘 ELOP 사와 현재 그 설계를 진행하고 있다. (중략)

• 대한원격탐사학회지
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• 제18권1호
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• pp.13-23
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• 2002

A radiometric correction method is developed to apply multi-temporal KOMPSAT-1 EOC satellite images for the detection of land-cover changes b\ulcorner recognizing changes in reflection pattern. Radiometric correction was carried out to eliminate the atmospheric effects that could interfere with the image properly of the satellite data acquired at different multi-times. Four invariant features of water, sand, paved road, and roofs of building are selected and a linear regression relationship among the control set images is used as a correction scheme. It is found that the utilization of panchromatic multi-temporal imagery requires the radiometric scene standardization process to correct radiometric errors that include atmospheric effects and digital image processing errors. Land-cover with specific change pattern such as paddy field is extracted by seasonal change recognition process.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7237-7242
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• 2015

Background: Epithelial ovarian cancer (EOC) is the commonest malignancy involving the ovaries. Maximum surgical cytoreduction (MCR) followed by adjuvant taxane-platinum chemotherapy are the standard of care treatments. Aims: To study treatment outcomes of EOC patients that were maximally cyto-reduced and received adjuvant paclitaxel-carboplatin (PC) chemotherapy. Materials and Methods: This retrospective cohort study included 174 patients with EOC treated at the Egyptian National Cancer Institute between 2006 and 2010. For inclusion, they should have had undergone MCR with no-gross residual followed by adjuvant PC chemotherapy. MCR was total abdominal hysterectomy/bilateral salpingo-oophorectomy [TAH/BSO] or unilateral salpingo-oophorectomy [USO] plus comprehensive staging. Results: The median age was 50 years. Most patients were married (97.1%), had offspring (92.5%), were postmenopausal (53.4%), presented with abdominal/pelvic pain and swelling (93.7%), had tumors involving both ovaries (45.4%) without extra-ovarian extension i.e. stage I (55.2%) of serous histology (79.9%) and grade II (87.4%). TAH/BSO was performed in 97.7% of cases. A total of 1,014 PC chemotherapy cycles were administered and were generally tolerable with 93.7% completing 6 cycles. Alopecia and numbness were the commonest adverse events. The median follow up period was 42 months. The 2-year rates for disease free survival (DFS) and overall survival (OS) were 70.7% and 94.8%, respectively. The respective 5-year rates were 52.6% and 81.3%. Advanced stage and high-grade were significantly associated with poor DFS and OS (p<0.001). Age >65 years was associated with poor OS (p =0.008). Using Cox-regression, stage was independent predictor of poor DFS and OS. Age was an independent predictor of poor OS.

• Radiation Oncology Journal
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• 제35권2호
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• pp.144-152
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• 2017

Purpose: The role of radiotherapy (RT) was largely deserted after the introduction of platinum-based chemotherapy, but still survival rates are disappointingly low. This study focuses on assessing the clinical efficacy of RT in relation to chemotherapy resistance. Materials and Methods: From October 2002 to January 2015, 44 patients were diagnosed with epithelial ovarian cancer (EOC) and treated with palliative RT for persistent or recurrent EOC. All patients received initial treatment with optimal debulking surgery and adjuvant platinum-based chemotherapy. The biologically effective dose (BED) was calculated with ${\alpha}/{\beta}$ set at 10. Ninety-four sites were treated with RT with a median BED of 50.7 Gy (range 28.0 to 79.2 Gy). The primary end-point was the in-field local control (LC) interval, defined as the time interval from the date RT was completed to the date any progressive or newly recurring disease within the RT field was detected on radiographic imaging. Results: The median follow-up duration was 52.3 months (range 7.7 to 179.0 months). The 1-year and 2-year in-field LC rates were 66.0% and 55.0%, respectively. Comparisons of percent change of in-field tumor response showed similar distribution of responses among chemoresistant and chemosensitive tumors. On multivariate analysis of predictive factors for in-field LC analyzed by sites treated, $BED{\geq}50Gy$ (hazard ratio, 0.4; confidence interval, 0.2-0.9; p = 0.025) showed better outcomes. Conclusion: Regardless of resistance to platinum-based chemotherapy, RT can be a feasible treatment modality for patients with persistent of recurrent EOC. The specific role of RT using updated approaches needs to be reassessed.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4275-4279
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• 2014

Background: The aim of this work is to assess the frequency of BRCA1 protein immunohistochemical (IHC) expression in epithelial ovarian cancer (EOC) and to evaluate the association of BRCA1 expression with clinical and pathological characteristics and the overall survival (OS) of patients treated with postoperative platinum-based chemotherapeutic agents. Materials and Methods: This retrospective study was conducted on 35 cases of epithelial ovarian cancer selected from the files of the Pathology Department, Faculty of Medicine, Mansoura University, Egypt. Immunohistochemistry (IHC) was performed for BRCA1 gene protein. BRCA1 expression was compared to patient's age, tumor histology, grade, stage and OS time. Statistical analysis was carried out with the SPSS version 16.0 to assess significant associations. Results: BRCA1 nuclear expression was detected in 40% of EOC, in which a mild increase in the percentage of positive cases was observed with serous histology, stage IV, and grade 3 carcinomas. There was a significant statistical difference in BRCA1 expression with regard to histological subtypes of EOC (p=0.048), but not grade or stage. Mean OS and survival rate were slightly better for BRCA1 expressing group, but there was no statistically significant difference (p=0.528). Conclusions: No association between BRCA1 immunohistochemical expression and tumor grade, stage or overall survival was noted in platinum-treated epithelial ovarian cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1445-1448
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• 2016

Purpose: The current study aimed at assessing the association between neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) for the prognosis of the surgical outcome of epithelial ovarian cancer (EOC). Materials and Methods: EOC patient medical records of surgical operations between January, 2005 and December, 2015 were reviewed and their data of clinicopathological complete blood counts (CBCs) and surgical outcomes were collected. To assess their effects on surgical outcomes, PLR and NLR optimal predictive values were determined and then compared with each other. Results: A statistically significant relation was found between surgical outcomes and NLR and PLR (p<0.001 and p<0.001), for which new cutoff points were gained (PLR: 192,3,293; NLR: 3). The sensitivity and specificity were 0.74 and 0.67, respectively for PLR and 0.74 and 0.58, for NLR. Conclusions: NLR and PLR seem to be useful methods for the prediction of surgical outcomes in patients with EOCs. Increased NLR and PLR proved to be beneficial for poor surgical outcomes. Moreover, PLR increase showed further help in the predicting outcome of EOC suboptimal debulking.

• 한국측량학회지
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• 제23권2호
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• pp.137-145
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• 2005

이 논문에서는 선형 푸시브룸 방식으로 촬영한 위성영상에 대한 다양한 센서모델들의 정확도를 비교분석하고자 한다. 특히 이 논문에서는 센서모델의 정확도를 번들조정의 정확도와 외부표정요소추정의 정확도로 분리하여 고찰하려고 한다. 번들조정 정확도는 수립된 센서모델이 얼마나 기준점에 잘 부합하는 가를 알려주는 척도로 이제까지 대부분의 센서모델 정확도 분석에 사용되어온 기준이다. 이에 반하여 외부표정요소추정의 정확도는 센서모델이 얼마나 정확하게 촬영당시의 위성의 궤도 및 자세를 예측할 수 있는 지의 척도로서 매우 중요한 요소임에도 불구하고 기존의 연구에서 간과해온 부분이다. 이 논문에서는 여러 센서모델 중에서 사진측량분야에서 주로 사용하는 변형된 공선방정식기반 모델과 위성지상국 또는 자세제어분야에서 주로 사용하는 궤도좌표계 및 자세각에 기반한 모델의 정확도를 비교분석하고자 한다. 실험은 다목적실용위성 1호 EOC 영상과 GPS 수신기에서 취득한 기준점을 사용하였다. 실험결과 번들조정 정확도는 두 모델이 큰 차이를 보이지 않는 것으로 나타났으나 외부표정요소추정 정확도는 궤도좌표계 및 자세각에 기반한 모델이 더 나은 성능을 보였다.

• 대한원격탐사학회지
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• 제18권6호
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• pp.337-344
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• 2002

일반적으로 위성영상으로부터 위치정보를 획득하기 위해서는 센서와 촬영대상간의 기하학적 관계를 규명하는 센서모델링이 선행되어야 한다. 그러나 Linear CCD (Charge Coupled Device) 배열에 의해 얻어지는 Pushbroom 위성영상은 Frame 센서에 의해 얻어지는 영상과 달리 영상을 획득하는 동안에 투영중심의 위치와 자세가 시간에 따라 변하기 때문에 정확한 센서모델링에 어려움이 있다. 또한 영상에 대한 궤도정보가 알려지지 않거나 불확실한 경우에는 물리적 센서모델의 적용에 어려움이 따르게 된다. 따라서 본 논문에서는 인공위성의 궤도정보가 알려지지 않거나 불확실한 경우에 Frame, Pushbroom, Whiskbroom, SAR 영상 등 다양한 영상자료에 적합한 센서모델로서 RFM(Rational Function Model)의 적용가능성을 검토하였다. 이를 위해서 KOMPSAT EOC 영상과 SPOT영상에 RFM을 적용하였으며, 지상기준점을 20개, 30개, 40개, 50개, 60개, 70개의 경우로 나누어 지상기준점의 개수와 배치 및 RFM 계수의 차수변화에 따른 RFM의 정확도를 분석하였다. 또한 수학적 모델 중에 하나인 DLT를 구현하여 RFM과 비교하였다.

• 감성과학
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• 제14권4호
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• pp.525-530
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• 2011

감성은 외부의 물리/화학적인 자극에 대한 인간 내부의 고차원적인 심리적 체험으로 기쁨, 슬픔, 쾌적, 불쾌 등에 대한 복합적인 감정이라 할 수 있다. 감성연구의 가장 큰 어려움은 측정의 문제이다. 기존 감성측정은 자기보고, 인터뷰, 뇌파 및 자율 신경계 반응, 심장혈관 활동도 등에 국한되어 있다. 최근 나노마이크로 기술의 발달과 함께 미래에는 체액 내 감성 바이오마커를 찾아내고 그것의 유무와 뇌 과학 연구결과와의 상관관계를 규명하고 피 한 방울로 인간의 심리상태를 정확히 파악할 수 있는 초소형 감성진단칩(emotion-on-a-chip)을 개발하게 할 수 있을 것으로 기대된다. 또한 종이를 이용한 종이 미세유체(paper microfluidic) 기술이 발달하고 이를 이용한 질병진단을 할 수 있음이 보고된 바 있다. 종이기반 미세유체채널은 그 제작비용이 저렴하며, 누구나 손쉽게 사용할 수 있어서 미래에 감성진단을 위한 도구로 활용할 수 있다. 본지에서는 아직까지 감성측정분야에 도입되지 않은 종이 미세유체 기술을 소개하고 향후 다양한 감성지표를 측정할 수 있는 아주 간단한 구조의 종이 기반 미세유체 디바이스의 설계 및 제작에 대해 기술한다.

• Journal of Preventive Medicine and Public Health
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• 제49권6호
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• pp.349-366
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• 2016

Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ${\geq}3$. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q = 59.46; $I^2=47.9%$). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p = 0.17; Q = 18.79, $I^2=25.5%$). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.