• 한국위성정보통신학회논문지
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• 제11권1호
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• pp.26-31
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• 2016

본 논문에서는 이기종 통신 시스템에서 Empirical Mode Decomposition(EMD) 기법을 활용하여 통신 신호의 잡음을 완화시키는 방안을 제시하였다. EMD는 노이즈가 인가된 신호를 여러 개의 Intrinsic Mode Function(IMF)로 분할하여 노이즈가 포함된 IMF를 제거하는 방법으로 노이즈를 줄이는 방법이다. 본 논문에서는 EMD의 연산량을 줄이기 위해 새로운 반복 중지 규칙을 제시하였다. EMD의 적용 방법을 수식 및 알고리즘으로 구현하였다. 3종류의 잡음이 인가된 신호를 시뮬레이션을 통해 효과적으로 잡음이 완화되는 것을 확인하였다.

• 지능정보연구
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• 제4권1호
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• pp.115-131
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• 1998

Customer service process is one of the most important processes in today's competitive business environment. Among the various activities of customer service process, equipment malfunction diagnosis activity should be performed fast and accurately. When a customer calls the service center and reports the observed symptoms, he/she describes them in layman's terms. Therefore, the customer-reported symptoms have not been considered helpful information for service representatives. However, in order to perform diagnosis activity fast and accurately, we need to make use of the customer-reported symptoms actively. In this research, we developed three systems called R-EMD (Rule-based Equipment Malfunction Diagnostic system), C-EMD (Case-based Equipment Malfunction Diagnostic system) and R&C-EMD (Rule & Case-based Equipment Malfunction Diagnostic system), each of which diagnoses equipment malfunctions using the customer-reported symptoms. R&C-EMD is a hybrid system that utilizes both rule-based and case-based technologies. The diagnosis rules used in R&C-EMD and R-EMD were not acquired from service manuals or interviews with service representatives. Rater, we extracted them directly from the past diagnosis cases based on symptoms' frequencies. By this way, we were able to overcome the knowledge acquisition bottleneck. Using the real 100 malfunction diagnosis cases, we evaluated the performances of R&C-EMC, R-EMD and C-EMD in terms of speed and accuracy. In diagnosis time, R&C-EMD took longer than R-EMD and shorter than C-EMD. However, R&C-EMC was the best in accuracy.

• 한국정보통신학회논문지
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• 제19권2호
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• pp.279-286
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• 2015

EMD는 미리 정의된 어떠한 기저함수도 사용하지 않으며 사용자에 의해 미리 정의된 파라미터값도 필요치 않은 완전히 데이터에 기반한 신호 처리의 특징을 갖는다. 그러나 유사한 스케일을 갖는 신호 모드로 분해하는 것을 방해하는 모드 혼합이 발생하는 단점이 있다. 이를 해결하기 위해 EEMD 알고리즘이 도입되었으며, EEMD는 처리하고자 하는 신호에 가우시안 백색 잡음을 혼합하여 앙상블 수만큼 신호를 만들어 EMD 방법을 적용함으로써 모드 혼합 문제를 해결한다. 그럼에도 EEMD는 잡음이 추가된 신호 분해 시 원 신호와 상이한 모드 수를 만들어 내며, 분해된 신호들을 원 신호로 재구성 시에도 레지듀 잡음이 포함된다. 본 논문은 개선된 EEMD알고리즘으로 EMD의 모드 혼합 문제를 해결하고 원신호를 정확히 재구성하며 EEMD 보다 적은 연산 비용으로 신호 모드 분리를 제안한다. 실험결과는 EEMD 방법과 비교하여 적은 체과정의 반복으로 빠른 모드 분리를 보여 주었으며 EEMD 방법의 20.87%의 비용만으로 완전한 신호 분해가 가능하였고, 신호 복원에 있어서도 EEMD 보다 우수한 성능을 보여주었다.

• 한국결정학회지
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• 제14권2호
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• pp.79-83
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• 2003

Electrolytic MnO₂ (EMD)의 미세구조를 X선 회절 및 투과전자현미경 분석을 통해 연구하였다. 벌크에 대한 X선 회절 실험은 전헝적인 EMD 재료의 분말 회절패턴을 나타내었다. 투과전자현미경 분석은 EMD가 약 0.2㎛크기의 입자로 이루어져 있고, 각각의 입자가다시 10 nm 정도의 결정립으로 이루어진 이중 미세구조를 가짐을 나타내었다. 나노 결정립에 대한 전자빔 마이크로 회절 분석 결과, EMD 입자는 여러 상의 혼합체로서 약 50%의 Ramsdellite, 30%의 ε-MnO₂, 15%의 Pyrolusite 상으로 이루어져 있음을 확인하였다. 한편, X선 분말 회절패턴 상의 약 67°에 위치한 ｛1120｝ 피크와 (0001) 면에 대한 고분해능 이미지는 ε-MnO₂ 상의 존재를 입증하였다.

• Restorative Dentistry and Endodontics
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• 제39권3호
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• pp.187-194
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• 2014

Objectives: The effects of bone morphogenetic protein-2 (BMP-2) and enamel matrix derivative (EMD) respectively with mineral trioxide aggregate (MTA) on hard tissue regeneration have been investigated in previous studies. This study aimed to compare the osteogenic effects of MTA/BMP-2 and MTA/EMD treatment in MC3T3-E1 cells. Materials and Methods: MC3T3-E1 cells were treated with MTA (ProRoot, Dentsply), BMP-2 (R&D Systems), EMD (Emdogain, Straumann) separately and MTA/BMP-2 or MTA/EMD combination. Mineralization was evaluated by staining the calcium deposits with alkaline phosphatase (ALP, Sigma-Aldrich) and Alizarin red (Sigma-Aldrich). The effects on the osteoblast differentiation were evaluated by the expressions of osteogenic markers, including ALP, bone sialoprotein (BSP), osteocalcin (OCN), osteopontin (OPN) and osteonectin (OSN), as determined by reverse-transcription polymerase chain reaction analysis (RT-PCR, AccuPower PCR, Bioneer). Results: Mineralization increased in the BMP-2 and MTA/BMP-2 groups and increased to a lesser extent in the MTA/EMD group but appeared to decrease in the MTA-only group based on Alizarin red staining. ALP expression largely decreased in the EMD and MTA/EMD groups based on ALP staining. In the MTA/BMP-2 group, mRNA expression of OPN on day 3 and BSP and OCN on day 7 significantly increased. In the MTA/EMD group, OSN and OCN gene expression significantly increased on day 7, whereas ALP expression decreased on days 3 and 7 (p < 0.05). Conclusions: These results suggest the MTA/BMP-2 combination promoted more rapid differentiation in MC3T3-E1 cells than did MTA/EMD during the early mineralization period.

• 한국정보통신학회논문지
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• 제13권12호
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• pp.2671-2676
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• 2009

EMD(Empirical mode decomposition) 방법은 시간-주파수 분석의 새로운 방법으로 적응적이며 효율적으로 신호를 분해한다. EMD는 신호 그 자체에 의해 정의된 IMFs(Intrinsic mode functions)로 명명되는 함수의 집합으로 분해되며, 분해된 IMFs는 원신호의 고유한 속성을 보존하므로 기저함수 및 필터로 사용될 수 있다. EMD 방법에 의한 분해는 신호의 지역적인 시간 스케일 특성에 기반을 두고 있으므로 비선형(non-linear) 비정상(non-stationary) 신호처리에 적합하며 ECG와 같은 생체 신호처리에 유용하다. 본 논문은 EMD 방법을 이용하여 ECG 신호를 분해하고 분해된 신호의 특성을 이용하여 잡음 제거 필터를 구현하였다. 전통적인 저주파 필터가 퓨리에 변환을 이용하여 주파수 영역에서 신호를 해석하는 것과 달리 EMD 방법은 시간 영역에서 필터링하여 신호의 속성을 유지한다. 영상 향상의 정도를 측정하기 위한 PRMD와 SSR 평가지수를 사용하여 제안된 기법과 전통적인 저주파 필터의 결과를 비교 제시하였다.

• The Journal of Advanced Prosthodontics
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• 제6권5호
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• pp.406-414
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• 2014

PURPOSE. The objective of this study was to investigate the biologic effects of enamel matrix derivative (EMD) with different concentrations on cell viability and the genetic expression of human gingival fibroblasts (HGF) to zirconia surfaces. MATERIALS AND METHODS. Immortalized human gingival fibroblasts (HGF) were cultured (1) without EMD, (2) with EMD $25{\mu}g/mL$, and (3) with EMD $100{\mu}g/mL$ on zirconia discs. MTT assay was performed to evaluate the cell proliferation activity and SEM was carried out to examine the cellular morphology and attachment. The mRNA expression of collagen type I, osteopontin, fibronectin, and TGF-${\beta}1$ was evaluated with the real-time polymerase chain reaction (RT-PCR). RESULTS. From MTT assay, HGF showed more proliferation in EMD $25{\mu}g/mL$ group than control and EMD $100{\mu}g/mL$ group (P<.05). HGFs showed more flattened cellular morphology on the experimental groups than on the control group after 4h culture and more cellular attachments were observed on EMD $25{\mu}g/mL$ group and EMD $100{\mu}g/mL$ group after 24h culture. After 48h of culture, cellular attachment was similar in all groups. The mRNA expression of type I collagen increased in a concentration dependent manner. The genetic expression of osteopontin, fibronectin, and TGF-${\beta}1$ was increased at EMD $100{\mu}g/mL$. However, the mRNA expression of proteins associated with cellular attachment was decreased at EMD $25{\mu}g/mL$. CONCLUSION. Through this short term culture of HGF on zirconium discs, we conclude that EMD affects the proliferation, attachment, and cell morphology of HGF cells. Also, EMD stimulates production of extracellular matrix collagen, osteopontin, and TGF-${\beta}1$ in high concentration levels. CLINICAL RELEVANCE. With the use of EMD, protective barrier between attached gingiva and transmucosal zirconia abutment may be enhanced leading to final esthetic results with implants.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제31권4호
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• pp.281-286
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• 2009

Introduction: Enamel matrix derivative (EMD) is a protein which is secreted by Hertwig root sheath and plays a major role in the formation of cementum and attachment of peridontium. Several studies have shown that EMD promoted the proliferation and differentiation of preosteoblasts, osteoblasts and periodontal ligament cells in vitro: however, reports showing the inhibition of osteogenic differentiation by EMD also existed. This study was designed to simultaneously evaluate the effect of EMD on the two cell lines (human mesenchymal stem cells: hMSC, human periodontal ligament derived fibroblasts: hPDLCs) by means of quantitative analysis of some bone related matrices (Alkaline phosphatase : ALP, osteopontin ; OPN, osteocalcin ; OC). Materials and Methods: hMSCs and hPDLCs were expanded and cells in the 4${\sim}$6 passages were adopted to use. hMSc and hPDLCs were cultured during 1,2,7, and 14 days with 0, 50 and 100 ${\mu}g/ml$ of EMD, respectively. ALP activity was assessed by SensoLyte ALP kit and expressed as values of the relative optical density. Among the matrix proteins of the bony tissue, OC and OPN were assessed and quantification of these proteins was evaluated by means of human OC immunoassay kit and human OPN assay kit, respectively. Results: ALP activity maintained without EMD at $1,2^{nd}$ day. The activity increased at $7^{th}$ day but decreased at $14^{th}$ day. EMD increased the activity at $14^{th}$ day in the hPDLCs culture. In the hMSCs, rapid decrease was noted in $7^{th}$ and $14^{th}$ days without regard to EMD concentrations. Regarding the OPN synthesis in hPDLCs, marked decrease of OPN was noted after EMD application. Gradual decrease tendency of OPN was shown over time. In hMSCs, marked decrease of OPN was also noted after EMD application. Overall concentration of OPN was relatively consistent over time than that in hPDLCs. Regarding the OC synthesis, in both of hPDLCs and hMSCs, inhibition of OC formation was noted after EMD application in the early stages but EMD exerted minimal effect at the later stages. Conclusion: In this experimental condition, EMD seemed to play an inhibitory role during the differentiation of hMSCs and hPDLCs in the context of OC and OPN formation. In the periodontium, there are many kinds of cells contributing to the regeneration of oral tissue. EMD enhanced ALP activity in hPDLCs rather than in hMSCs and this may imply that EMD has a positive effect on the differentiation of cementoblasts compared with the effect on hMSCs. The result of our research was consistent with recent studies in which the authors showed the inhibitory effect of EMD in terms of the differentiation of mineral colony forming cells in vitro. This in vitro study may not stand for all the charateristics of EMD; thus, further studies involving many other bone matrices and cellular attachment will be necessary.

• 한국응급구조학회지
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• 제6권1호
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• pp.27-37
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• 2002

The health and medical service attracts more public attention as the economy of Korea is rapidly growing up and the standard of living is elevated. Especially, the interest and demand on the prehospital emergency medical service that consists of the important part of primary medical service that is directly related to the life of patients are gradually increased. However, as compared with other advanced countries such as America in this area, Korea actually fell behind in the utilization of IT (Information Technology) to maximize the efficiency of emergency service system as well as has a problem in the general service system. This study suggested the necessity to introduce EMD (Emergency Medical Dispatch) system that takes a great role as the core part in the prehospital emergency medical service that is not systemized in Korea yet. In addition, this study proposed the implementation model of EMD ASP system using ASP (Application Service Provider) in EMD system to flexibly deal with the change of IT and efficient implementation and integration of information system as well as to significantly reduce cost through wire/wireless high speed Internet network that is politically promoted in Korea on the basis of EMD. The system analysis and design was executed by HIPO (Hierarchy Plus Input Process Output) analysis that was the conceptual design technology for EMD information system modeling based on ASP and DFD (Data Flow Diagram). This study proposed DB table configuration and data schema to implement the application of web browser interface in EMD system through ERD(ER-Diagram) of EMD ASP system. Finally, this study described how to implement and utilize EMD information system. This study aims to facilitate the qualitative development of emergency medical service in the future as suggesting the concrete models for the implementation of high value-added prehospital emergency medical information system as applying ASP concept to EMD system of prehospital emergency medical service area.

• Restorative Dentistry and Endodontics
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• 제38권4호
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• pp.194-203
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• 2013

Objectives: To investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models. Materials and Methods: The authors searched MEDLINE, PubMed, EMBASE, Cochrane Library, Web of Knowledge and Scopus for articles published up to Oct 2012. Animal studies in which EMD was applied in transplanted or replanted teeth with adequate controls and histological data were considered. Normal periodontal healing or root resorption determined by histology after EMD was applied in replanted teeth with adequate controls was used as outcome measures. The following search strategy was used: ('Emdogain' OR 'enamel matrix proteins' OR 'enamel matrix derivative') AND ('avulsion' OR 'transplantion' OR 'autotransplantation' OR 'replantation'). Results: Six animal studies were included in the final review. There was great heterogeneity in study design among included studies. Two studies with similar study designs were identified and analyzed by a meta-analysis. The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups. Conclusions: With the limitations of this systematic review, the use of EMD led to greater normal periodontal healing and surface root resorption and less inflammatory and replacement root resorption in the presence of periodontal ligaments. However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.