• Journal of Chest Surgery
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• 제34권2호
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• pp.180-183
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• 2001

Oncocytic carcinoid는 매우 드문 종양으로 단지 몇 례만이 문헌상 보고되고 있다. 본 저자들은 좌폐 상엽에 발생한 oncocytic carcinoid 1례를 치험하였는데 환자는 56세된 여자환로 특이한 증상은 없었다. 흉부 전산화 단층촬영상 좌폐상엽에 3$\times$3.5 cm 크기의 동종의 종괴를 보이고 있었다. 수술전 검사후 외과적절제술을 시행하였는데 육안적소견상 4$\times$3cm 크기의 경계가 명확한 황갈색의 종괴였으며, 병리조직학적 검사상 괴립성 호산성 세포질이 풍부한 양상을 보였으며 면역조직학적 검사에서는 cytokeratin에 양성반응을 보였으며 EMA와 chromograin에 국소적인 양성반응을 보여, 폐에 발생한 oncocytic carcinoid로 진단하였다. 수술후 환자의 상태는 양호하였으며, 현재 외래추적관찰중이다.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.114-115
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• 2006

We investigated the effects of annealing on the rearrangement of H-bonding structure and its influence on the thermal and rheological properties of $2^{nd}\;and\;4^{th}$ pseudo-generation aliphatic hyperbranched (HB) polyesters based on 2,2-bis(methylol)propionic acid. During annealing of amorphous HB polyesters, the structure becomes more ordered as a consequence of multiple H-bonds formation between linear sequences. Structure ordering is more pronounced for the lower pseudo-generation HB polyester with low molar mass, low degree of branching and incompletely reacted core hydroxyl groups which greatly increases the possibility for multiple H-bond interactions.

• Corrosion Science and Technology
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• 제6권6호
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• pp.297-303
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• 2007

This paper discusses the chloride-induced corrosion of reinforcement in marine concrete structures focusing on the variability in the progress of deterioration. Through tests and analyses of reinforced concrete slabs taken out from existing open-pile structures that have been in service for 30 to 40 years, the following topics were particularly discussed: variation in chloride ion profiles of concrete, variation in corrosion properties of reinforcement embedded in concrete, and influence of the reinforcement corrosion on the load-carrying capacity of the concrete slabs. As a result, their variability was found to be very large even in one reinforced concrete slab with almost the same conditions. It was also discussed how to determine the calculation parameters for prediction of decreasing in load-carrying capacity of concrete members with chloride-induced corrosion of reinforcement.

• Asian-Australasian Journal of Animal Sciences
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• 제19권10호
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• pp.1404-1408
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• 2006

In order to investigate the genetic marker associated with economic performance in Hanwoo (Korean Brown Cattle), proteomic approach was used. Breeding values were estimated from performance tested steers. The top 20 and bottom 19 steers based on carcass weight (CW), eye muscle area (EMA), backfat thickness (BF) and marbling score (MS) evaluation for one progeny testing period was used. Meat samples dissected from longissimus dorsi muscles were taken from the slaughter house and analyzed for two-dimensional gel electrophoresis. A total of 102 significant spots out of total 146 on each gel were detected and compared with the reference gel (synthetic gel) to be evaluated. Four candidate spots for marbling score were identified: 205, 84, 204 and 198. The study confirmed the relationship between breeding values of economic traits of Hanwoo cattle and spot intensity.

• 한국임상약학회지
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• 제26권2호
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• pp.150-162
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• 2016

Objective: First-in-human dose estimation is an essential approach for successful clinical trials for drug development. In this study, we systematically compared first-in-human dose and human pharmacokinetic parameter estimation approaches. Methods: First-in-human dose estimation approaches divided into similar drug comparison approaches, regulatory guidance based approaches, and pharmacokinetic based approaches. Human clearance, volume of distribution and bioavailability were classified for human pharmacokinetic parameter estimation approaches. Results: Similar drug comparison approaches is simple and appropriate me-too drug. Regulatory guidance based approaches is recommended from US Food and Drug Administration (FDA) and European Medicines Agency (EMA) regarding no-observed-adverse-effect level (NOAEL) or minimum anticipated biological effect level (MABEL). Pharmacokinetic based approaches are 8 approaches for human clearance estimation, 5 approaches for human volume of distribution, and 4 approaches for human bioavailability. Conclusion: This study introduced and compared all methods for first-in-human dose estimation. It would be useful practically to estimate first-in-human dose for drug development.

• Journal of Korean Neurosurgical Society
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• 제39권2호
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• pp.136-140
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• 2006

The authors report three microcystic meningiomas with its characteristic immunohistochemical findings and chromosomal pattern. Three patients with surgically treated microcystic meningioma were studied for its radiological, histopathological findings, and chromosomal analysis was done in the one patient. Tumors were convexity meningioma in the frontal area. The tumors were enhanced homogenously in the two, and enhanced in homogenously with multiple small cysts in the other one on preoperative magenetic resonance image. Pathological examination showed marked nuclear pleomorphism, many small cysts, hyaline thickening in blood vessel wall, and mucinous background, compatable to microcystic type. EMA and vimentin were positive on the immunohistochemical stain. Chromosomal analysis showed tetrasomies of chromosome 5, 13, 17, and 20, and trisomies of chromosome 6, 7, 9, 11, 12, 16, 19, and 21, which are quite different from those of benign meningioma.

• 대한기계학회논문집A
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• 제27권2호
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• pp.255-261
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• 2003

It is advantageous to use NDE methods to assess the mechanical properties of materials since the conventional method is time-consuming and sometimes requires cutting of sample from the component. The NDE parameters such as ultrasonic velocity and attenuation, electric resistivity, and magnetic coercive force and remanance have been utilized to evaluate changes of material properties due to heat treatment condition. It has been found that changes of materials properties under quenched and tempered/PWHT treatments could not be detected using EMAT and Electrical resistivity methods. However, victors hardness and magnetic hysteresis loop decreased with heat treatment procedures. These results were obtained using 3Cr-lMo-0.25V steel. The magnetic parameters were found to be most sensitive to changes of material properties.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.660-664
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• 2014

A diesel forklift truck under 3-ton class has disadvantages in the vibration transmission path. Because the weight ratio of body structure to powertrain which is source of excitation force is lower th an a mid-class forklift. In addition, the torsional and bending vibration mode frequencies of body structure are within the engine excitation frequency range, then high idle vibration generated by resonance. In this paper vehicle body structure design and optimization technique considering idle vibration reduction are presented. Design sensitivity analysis is applied to search the sensitive of design parameters in body structure. The design parameters such as thickness and pillar cross section were optimized to increase the torsional and bending vibration mode frequencies.

• 대한세포병리학회지
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• 제18권1호
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• pp.81-86
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• 2007

Desmoplastic small round cell tumor (DSRCT) is a rare malignant mesenchymal neoplasm. It mainly involves the abdominal or pelvic peritoneum of male adolescents. We report here the imprint cytologic features of a case of DSRCT occurring in the intraabdominal cavity of a 21-year-old man. A microscopic examination showed moderate cellularity. The tumor cells were singly arranged and arranged in clusters. The cells had round to oval nuclei with finely granular chromatin, inconspicuous nucleoli and scanty cytoplasm. Some tumor cells showed nuclear molding, and some cells had an epitheloid appearance with a large amount of lightly eosinophilic cytoplasm. A rosette-like pattern was present. Spindle-shaped, fibroblastic stromal cells were occasionally found. The tumor cells were immunoreactive for the markers cytokeratin (AE1/AE3), epithelial membrane antigen (EMA), desmin, vimentin and neuron specific enolase (NSE).

• Journal of Pharmaceutical Investigation
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• 제28권1호
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• pp.1-5
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• 1998

The effect of synthetic polymer membranes on the permeation rate of dideoxynucleoside-type anti-HIV drugs through hairless rat skin was studied using ethylene/vinyl acetate copolymer (EVA) and ethylene/methyl acrylate copolymer (EMA) membranes fabricated by solvent casting method. In vitro skin permeation kinetics study of DDC (2',3'-dideoxythymidine), DDI (2',3'-dideoxyinosine) and AZT (3'-azido-3'-deoxythymidine) across the (membrane/skin) composite was conducted for 24 hours at $37^{\circ}C$ using the Valia-Chien skin permeation system. The results showed that skin permeation rate of each drug across the (skin/membrane) composite was mainly dependent on the property of the membrane. Proper selection of the polymeric membrane which resembles hydrophilicity/lipophilicity of the delivering drug was important in controlling the skin permeation rate.