• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.66-68
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• 2012

본 논문에서는 자체 개발한 Java Platform 기반의 뇌파 분석 도구와 Android 기반의 Mobile 기기를 연계하여 중증 장애인의 상태 및 상황 등을 모니터링 할 수 있는 시스템을 제시한다. 제안된 시스템은 뇌파 측정기, 뇌파 분석 툴(PC Client) 그리고 Mobile 기기(Android)로 크게 3부분으로 구성된다. 뇌파 측정기로부터 수집된 원 주파수에서 저주파 대역의 잡음을 제거하기 위해 고주파 필터를 적용한 후, 적용된 데이터를 주파수 영역에서 분석하기 위해 FFT를 적용한다. FFT를 적용한 데이터를 Power Spectrum 분석 기법을 이용하여 Theta, Delta, Alpha, SMR, Beta 파형의 값을 추출하고, 14 채널의 뇌파 측정 위치에 따른 상관관계 분석기법을 통해 중증 장애인의 상태를 표현한다. 본 논문에서 제안한 방법으로 실험한 결과, 중증 장애인 모니터링 시스템에 효율적으로 적용되는 것을 확인하였다.

• Journal of Pharmacopuncture
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• v.22 no.3
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• pp.166-170
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• 2019

Objectives: Attentional and memory functions are important aspects of neural plasticity that, theoretically, should be amenable to pharmacopuncture treatments. A previous study from our laboratory suggested that quantitative electroencephalographic (qEEG) measurements of theta/beta ratio (TBR), an index of attentional control, may be indicative of academic performance in a first-semester medical school course. The present study expands our prior report by extracting and analyzing data on frontal theta and beta asymmetries. We test the hypothesis that the amount of frontal theta and beta asymmetries (fTA, fBA), are correlated with TBR and academic performance, thereby providing novel targets for pharmacopuncture treatments to improve cognitive performance. Methods: Ten healthy male volunteers were subjected to 5-10 min of qEEG measurements under eyes-closed conditions. The qEEG measurements were performed 3 days before each of first two block examinations in anatomy-physiology, separated by five weeks. Amplitudes of the theta and beta waveforms, expressed in ${\mu}V$, were used to compute TBR, fTA and fBA. Significance of changes in theta and beta EEG wave amplitude was assessed by ANOVA with post-hoc t-testing. Correlations between TBR, fTA, fBA and the raw examination scores were evaluated by Pearson's product-moment coefficients and linear regression analysis. Results: fTA and fBA were found to be negatively correlated with TBR (P<0.03, P<0.05, respectively) and were positively correlated with the second examination score (P<0.03, P=0.1, respectively). Conclusion: Smaller fTA and fBA were associated with lower academic performance in the second of two first-semester medical school anatomy-physiology block examination. Future studies should determine whether these qEEG metrics are useful for monitoring changes associated with the brain's cognitive adaptations to academic challenges, for predicting academic performance and for targeting phamacopuncture treatments to improve cognitive performance.

• Proceedings of the KIEE Conference
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• 2006.04a
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• pp.51-53
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• 2006

This paper proposes a portable ECG monitoring system, which integrates uptodate PDA and RF communication technology. The aim of the study is to acquire the subject's biomedical signal without any constraint. It has two types of transmission mode, which are total signal transmission mode and HR(heart rate)/SC(step count) transmission mode. In audition, wireless communication technology uses Zigbee Wireless PAN and can work in low-power mode, which is one of the advantages of ZiBbee communication technology. The developed system is composed of a transmitter and a receiver. The transmitter has three-axial acceleration sensor. ECG amplifier and Zigbee communication controller. In total signal transmission mode, it can send data 50 packets per second whose transmission speed corresponds to 300 ECG samples and 60 acceleration samples. In HR/SG transmission mode, it can calculate heart rate from EEG data with 216 samples per second and step count from acceleration data and send a packet every cardiac cycle. The receiver forwards the received data to PDA, where the data can be stored and displayed. Therefore, the developed device enables to continuous monitoring for Activities of Daily Living(ADL). Also, this method will reduce medical costs in the aged society.

• Korean Journal of Clinical Laboratory Science
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• v.44 no.4
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• pp.184-198
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• 2012

The purpose of intra-operative neurological monitoring (INM) is to minimize surgically induced nerve damage, sensory nerves and motor neurons without affecting the operations to proceed during surgery such as evoked potentials (EP), electromyography (EMG), electroencephalography (EEG), transcranial doppler (TCD), etc. During the course of checking a patient's condition, surveillance of ambulatory patients is a very different thing to check if the test is done under general anesthesia. INM can be possible or impossible depending on the type of drugs used and their concentrations because the monitoring is performed under anesthesia. Therefore, it is emphasized on the necessity of reviewing anesthesia which influences on INM.

• Proceedings of the KIEE Conference
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• 2001.11c
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• pp.176-179
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• 2001

A portable bio-signal measurement system for 24-hours continuous health monitoring of the elderly and the disabled is presented. The measurement system has the functions of acquisition of various bio-signals such as ECG, EMG and EEG, wireless data transmission/receive and adjustment of parameters such as gain and cut-off frequency. The data is sent to a host computer or other device via a Bluetooth. The design targets of the developing system for volume and power consumption are $20{\times}30{\times}5(mm^3)$ and 8mW.

• Korean Journal of Psychosomatic Medicine
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• v.4 no.1
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• pp.64-70
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• 1996

The prevalence rate of psychiatric symptoms of the refractory epileptic patients was evaluated according to the location of the epileptic focus. The subjects were 91 patients admitted to Epilepsy Monitoring Unit of Seoul National University Hospital. The psychiatric symptoms were assessed by Korean version of Symptom Checklist-90-R(SCL-90-R). The locus of epileptic focus was assessed by clinical features, 2-hour interictal EEG, long-term video-EEG monitoring, brain MRI, interictal and ictal brain SPECT, and interictal brain PET The subjects were divided into three groups according to the epileptic focus, non-temporal(N=29), left temporal (N=26), and right temporal(N=32). There were no statistical differences in demographic and seizure-related variables among groups. The number of patients with $T-score {\geq} 65$ at any subscale of the SCL-90-R were compared by $X^2-test$ among groups. The mean T-scores of each subscale of the SCL-90-R were compared by oneway-ANOVA among groups. The prevalence rate of psychiatric symptoms of the refractory epileptic patients was 38.5%. There was no statistical difference in the prevalence rate of psychiatric symptoms among groups. However, the patients with non-temporal or right temporal epileptic foci showed statistically significant higher mean T-scores of interpersonal sensitivity, depression, hostility, and phobic subscales than the patients with left temporal epileptic foci. These results suggest that the epileptic focus plays an important role in the production of interictal psychiatric symptoms of the refractory epileptics.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.3
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• pp.671-677
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• 2012

A black-box program was implemented in order to monitor abnormal symptoms of human body irregularly occurring during sleep. The system consists of sensor probing body signals, auxiliary devices such as the alarm, lamp, network camera, and signal monitoring computer. Various types of sensors, PPG, ECG, EEG, temperature, respiration sensor, G-sensor, and microphone were used to more exactly identify the causes of abnormal symptoms. If a symptom occurs, the system records the patient's condition to provide information being utilized in the treatment. The sensors are attached on some locations of body being proper to check a specific type of abnormal reaction. Based on the normal range and type of measurement data, criteria of signal levels were set to distinguish abnormal reaction. An abnormal signal being probed, the program starts to operate the lamp, alarm, and network camera at the same time and stores the signal and video data.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.10
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• pp.887-895
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• 2014

Drowsy driving is a large proportion of the total car accidents. For this reason, drowsiness detection and warning system for drivers has recently become a very important issue. Monitoring physiological signals provides the possibility of detecting features of drowsiness and fatigue of drivers. Many researches have been published that to measure electroencephalogram(EEG) signals is the effective way in order to be aware of fatigue and drowsiness of drivers. The aim of this study is to extract drowsiness-related features from a set of EEG signals and to classify the features into three states: alertness, transition, and drowsiness. This paper proposes a drowsiness detection system using errors-in-variables(EIV) for extraction of feature vectors and multilayer perceptron (MLP) for classification. The proposed method evaluates robustness for noise and compares to the previous one using linear predictive coding (LPC) combined with MLP. From evaluation results, we conclude that the proposed scheme outperforms the previous one in the low signal-to-noise ratio regime.

• Journal of Korean Neurosurgical Society
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• v.41 no.5
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• pp.283-290
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• 2007

Objective : This study was designed to analyze seizure outcome and to investigate the prognostic factors for predicting seizure outcome according to the preoperative evaluations, surgical procedures, topectomy sites and histopathological findings in patients with extratemporal lobe epilepsy [ETLE]. Methods : This study comprised 63 patients with ETLE who underwent surgery. Preoperative evaluations included semiologic analysis, chronic video-EEG monitoring, and neuroimaging studies. Surgical procedures consisted of topectomy in 51 patients, corpus callosotomy in 9, functional hemispherectomy in 2, and vagus nerve stimulation [VNS] in 1. Histopathological findings were reviewed. Postoperative seizure outcomes were assessed by Engel's classification at the average follow up period of 66.8 months. Chi-square test was used for statistics. Results : Total postoperative seizure outcomes were class I in 51 [80%] patients, class II in 6 [10%], class III in 6 [10%]. Patients with structural abnormalities on neuroimaging study showed class I in 49 [88%] patients [p<0.05]. Patients with focal and regional ictal EEG onset revealed class I in 47 [90%] patients [p<0.05]. Semiologic findings, surgical procedures, topectomy sites and histopathological findings did not show statistical correlation with seizure outcome [p<0.05]. Conclusion : A good seizure outcome was obtained in patients with ETLE. The factors for favorable seizure outcome are related to the presence of structural abnormalities on neuroimaging study, and focal and regional ictal EEG onset.

• Journal of Yeungnam Medical Science
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• v.35 no.2
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• pp.192-198
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• 2018

Background: Chronic inflammation can lower the seizure threshold and have influence on epileptogenesis. The components of red ginseng (RG) have anti-inflammatory effects. The abundance of peripherally derived immune cells in resected epileptic tissue suggests that the immune system is a potential target for anti-epileptogenic therapies. The present study used continuous electroencephalography (EEG) to evaluate the therapeutic efficacy of RG in intrahippocampal kainic acid (IHKA) animal model of temporal lobe epilepsy. Methods: Prolonged status epilepticus (SE) was induced in 7-week-old C57BL/6J mice via stereotaxic injection of kainic acid (KA, 150 nL; 1 mg/mL) into the right CA3/dorsal hippocampus. The animals were implanted electrodes and monitored for spontaneous seizures. Following the IHKA injections, one group received treatments of RG (250 mg/kg/day) for 4 weeks (RG group, n=7) while another group received valproic acid (VPA, 30 mg/kg/day) (VPA group, n=7). Laboratory findings and pathological results were assessed at D29 and continuous (24 h/week) EEG monitoring was used to evaluate high-voltage sharp waves on D7, D14, D21, and D28. Results: At D29, there were no differences between the groups in liver function test but RG group had higher blood urea nitrogen levels. Immunohistochemistry analyses revealed that RG reduced the infiltration of immune cells into the brain and EEG analyses showed that it had anticonvulsant effects. Conclusion: Repeated treatments with RG after IHKA-induced SE decreased immune cell infiltration into the brain and resulted in a marked decrease in electrographic seizures. RG had anticonvulsant effects that were similar to those of VPA without serious side effects.