• 동의생리병리학회지
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• 제24권1호
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• pp.42-47
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• 2010

The pulse diagnosis is an important method in Oriental Medicine. Recently, there have been continuous attempts to replace the finger palpation by Oriental medical doctors (OMDs) by more objective tools based on machines, e.g., pulse analyzers. To improve the performance of the pulse analyzers, both the machine-appropriate interpretations for the pulse images appeared in the literature and the improvement in the repeatability and reproducibility of the measurement sensors are to be developed. As an attempt towards the transformation of the pulse images in terms of machine-appropriate language, in this work, we suggest an upgraded algorithm for the solid/deficient pulses, which are the two representative pulse images informing us how strong the pulse pressure is. It has been argued that one could determine the solid/deficient pulses by the maximum pulse pressure from pulse analyzers. However, by a clinical test, we found that the maximum pulse pressure alone is not sufficient to determine the solid/deficient pulses. In addition to the maximum pulse pressure, the mean pulse pressure averaged over for five different hold-down pressures(3-D MAC) is needed to improve the agreement with the OMD's decision for the solid/deficient pulse. We found that, among the data diagnosed with having either the solid pulse or deficient pulse by OMDs, the novel algorithm showed 86.0% diagnosis rate and 81.6% concordance rate.

• 열처리공학회지
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• 제7권1호
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• pp.44-52
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• 1994

In order to investigate the effect of tempring treatment on the mechanical properties of ausformed martensite in Fe-30%Ni-0.35%C alloy, the hardness, yield strength and elongation were examined by tensile test. 1. The strength of deformed austenite in Fe-30%Ni-0.35%C alloy was increased due to the work hardening induced from the dislocation density increased during deformation. The strength of ausformed martensite was increased because of defects inherited from deformed austenite by martensitic transformation. 2. The ductility of ausformed martensite was shown a nearly constant values independent of deformation degrees because of the interaction of multiple factors such as increased retained austenite, formation of void and decrement of twin in ausformed martensite. 3. The strength of ausformed martensite by tempering treatment was shown a little decrement up to $340^{\circ}C$, especially showed remarkable softening resistance in higher deformation degrees. 4. Virgin martensite and ausformed martensite were shown a maximum yield strength by clustering in tempering at $100^{\circ}C$ and above $100^{\circ}C$, yield strength was very small decreased due to the decrement of solute carbon by the destruction of clustering. 5. The decomposition of retained austenite was not shown up to $450^{\circ}C$ in ausformed martensite with tempering treatment, and the matrix was rapidly softening because of the decomposition of martensite and the formation of reversed austenite with tempering above $400^{\circ}C$.

• 한국초지조사료학회지
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• 제17권1호
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• pp.43-50
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• 1997

The aim of the study is to describe the fate and transformation of nitrogen in grassland ecosystems. Field experiments were conducted using sandyloam soil under variabling conditions: Zen, fertilization, reduced slurry application(l20kg N $ha^{-1}\;yr^{-1}$), usual sluny application (240 kg N $ha^{-1}\;yr^{-1}$).Soil water samples were gathered with 120cm ceramic cups with initial pressure of 0.5 bar. Samples were collected twice a month and analysed for NO, colormetrically. Percolation was calculated as the difference between precipitation and potential evapotranspiration, and leaching as the product of percolation and nitrate content of the water h m the ceramic cups. The N$H_4$-N content in soil had no significant effect on slurry application, but high slurry application on grassland resulted in high N$O_3$-N content in soil. The NO, concentration in soil water was remarkably variable during the year. The average N$O_3$, concentration during experiment became the lowest(8.5 mg/e ) without slurry application and highest with 240kOa cattle sluny(25.3 mg4 ). For each of the three different amounts of cattle sluny applied (0, 120, and 240kOa), the amount of N$O_3$-N leached per year were 12, 23 and 29kg/ha respectively. On grassland under the climatic conditions of Allgau showed enormous nitrate leaching, which has a p a t potential of polluting the ground water. The high pool of mineral N in the soil are the source for N$O_3$ leaching. The leaching of N$O_3$ cannot be avoided completely, but minimized by optimizing N fertilization rate.

• Toxicological Research
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• 제33권2호
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• pp.79-96
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• 2017

A variety of xenobiotic chemicals, such as polycyclic aromatic hydrocarbons (PAHs), aryl- and heterocyclic amines and tobacco related nitrosamines, are ubiquitous environmental carcinogens and are required to be activated to chemically reactive metabolites by xenobiotic-metabolizing enzymes, including cytochrome P450 (P450 or CYP), in order to initiate cell transformation. Of various human P450 enzymes determined to date, CYP1A1, 1A2, 1B1, 2A13, 2A6, 2E1, and 3A4 are reported to play critical roles in the bioactivation of these carcinogenic chemicals. In vivo studies have shown that disruption of Cyp1b1 and Cyp2a5 genes in mice resulted in suppression of tumor formation caused by 7,12-dimethylbenz[a]anthracene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, respectively. In addition, specific inhibitors for CYP1 and 2A enzymes are able to suppress tumor formation caused by several carcinogens in experimental animals in vivo, when these inhibitors are applied before or just after the administration of carcinogens. In this review, we describe recent progress, including our own studies done during past decade, on the nature of inhibitors of human CYP1 and CYP2A enzymes that have been shown to activate carcinogenic PAHs and tobacco-related nitrosamines, respectively, in humans. The inhibitors considered here include a variety of carcinogenic and/or non-carcinogenic PAHs and acethylenic PAHs, many flavonoid derivatives, derivatives of naphthalene, phenanthrene, biphenyl, and pyrene and chemopreventive organoselenium compounds, such as benzyl selenocyanate and benzyl selenocyanate; o-XSC, 1,2-, 1,3-, and 1,4-phenylenebis(methylene)selenocyanate.

• Plant Biotechnology Reports
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• 제3권2호
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• pp.157-165
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• 2009

Human erythropoietin (EPO) is a leading product in the biopharmaceutical market, but functional EPO has only been produced in mammalian cells, which limits its application and drives up the production costs. Using plants to produce human proteins may be an alternative way to reduce the cost. However, a recent report demonstrated that overexpression of the human EPO gene (EPO) in tobacco or Arabidopsis rendered males sterile and retarded vegetative growth, which raises concern whether EPO might interfere with hormone levels in transgenic plants. In the present study, we demonstrated that overexpressing EPO with additional 5'-His tag and 3' ER-retention peptides in tobacco did not cause any developmental defect compared to GUS plants. With our method, all 20 transgenic plants grew on selective medium and, further confirmed by PCR, were fertile. Most of them grew similarly compared to GUS plants. Only one transgenic plant (EPO2) was shorter in plant height but had twice the life span compared to other transgenic plants. When 11 randomly selected EPO plants, along with the abnormal plant EPO2, were subjected to RT-PCR analysis, all of them had detectable EPO transcripts. However, their protein levels varied considerably; seven of them had detectable EPO proteins analyzed by western blot. Our results indicate that overexpressing human EPO protein in plants does not have detrimental effects on growth and development. Our transformation systems allow us to further explore the possibility of glycoengineering tobacco plants for producing functional EPO and its derivatives.

• 한국해안·해양공학회논문집
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• 제28권6호
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• pp.350-360
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• 2016

겨울철 해운대 해역에서 발생하는 파랑 및 흐름에 대한 공간적 변화특성을 살펴보기 위하여, 평면 2차원 파랑변형 모델(SWAN)과 수심평균 2차원 해수유동 모델(Delft3D)을 사용하여 수치실험을 수행하였다. 2014년 2월 중 해운대 여러 정점에서 관측한 현장자료를 사용하여 수치모델을 검증하였다. 두 모델의 보정결과로부터 발견된 파랑 및 흐름의 특징 중 하나는, 해저면에 곳곳에 돌출되어 자리잡고 있는 암반지형의 영향으로 파고 및 파향 뿐만 아니라 유속 및 유향도 만내로 들어올수록 외해역과 다르게 크게 변형되어 나타난다는 것이다. 두 모델의 커플링을 통하여 겨울철 입사파를 고려한 연안 해수유동 모델링 결과, 해안선 인근 천해에서는 겨울철에 발생하는 동쪽(E)계열의 입사파의 영향으로 파고가 높을수록 동에서 서로 흐르는 연안류도 크게 발달하고 조석에 의한 조류의 세기는 상대적으로 약한 것으로 나타났다.

• 디지털산업정보학회논문지
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• 제14권1호
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• pp.45-55
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• 2018

Recently, because the arrival of the fourth industrial revolution era, many information and telecommunication services have grown rapidly in the mobile business market. So, companies are based Mobile Apps on user customized services and expanding their services. From the standpoint of the business, to generate revenue, the company needs to maintain the existing current computer environment and develop Mobile Apps to offer convenience in various areas such as finance, admiration, e-commerce and sales support. However, as the number of users increase due to expansion of various Mobile services, security threats that are related to Mobile Apps are increasing and its damage is also increasing. Due to the rapid technological transformation of Mobile devices using the Internet, the level of security threats to Smartphones are rising and getting more advance, so this thesis is structured as follows. In Chapter 2, it will look at the overall trends of Mobile Apps as related research. In Chapter 3, it will discuss various security concerns that related to the latest Mobile Apps and learn about the threatening factors. In Chapter 4, it will compare and analyze the threatening factors. Then it will find and suggest the possible plan. In Chapter 5, it will end with conclusion. Finally, to protect mobile devices from security threats, the environment of operating system which manages the resources and data of Apps needs to be protected. Also, it is important that users to have awareness and check activation FinTech technology security in the process of simple payment with fingerprint or IC card.

• 센서학회지
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• 제22권2호
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• pp.162-173
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• 2013

The purpose of this paper is to classify VOC gases by emulating the characteristics found in biological olfaction. For this purpose, we propose new signal processing method based a polymeric chemical sensor array consisting of 4096 sensors which is created by NEUROCHEM project. To remove unstable sensors generated in the manufacturing process of very large scaled chemical sensor array, we used discrete wavelet transformation and cosine similarity. And, to remove the supernumerary redundancy, we proposed the method of selecting candidates of representative sensor representing sensors with similar features by Fuzzy c-means algorithm. In addition, we proposed an improved algorithm for selecting representative sensors among candidates of representative sensors to better enhance classification ability. However, Classification for very large scaled sensor array has a great deal of time in process of learning because many sensors are used for learning though a redundancy is removed. Throughout experimental trials for classification, we confirmed the proposed method have an outstanding classification ability, at transient state as well as steady state.

• 한국콘텐츠학회논문지
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• 제11권5호
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• pp.291-301
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• 2011

본 연구는 비교구매의 효과성 측정을 위한 모형을 제시하고 이를 통해 비교구매의 역할과 그 효과성을 설명한다. 또한 판매자 주도형 비교도전이 보다 효율적인 비교구매 정보의 제공 방법임을 증명한다. 구매자의 구매만족도(S)는 판매자의 제품경쟁력 벡터(P)와 구매자의 제품정보 인지수준 벡터(B)간의 상호작용으로 정의할 수 있으며, 구매자의 제품정보 인지수준은 제품 정보 분석을 통한 제품 간의 비교행렬(C)에 의해 변화된다. 비교구매 효과성은 비교 전과 후의 구매만족도의 변화량으로 측정되며, 비교구매의 역할은 비교행렬을 제공해 구매자의 제품정보 인지수준을 변화시키는 것이다. 보다 효율적인 방법은 판매자가 비교행렬의 구성요소 중에서 비교 효과성이 큰 경쟁 제품들에 능동적으로 비교하도록 하는 비교도전방법이다. 예제실험을 통해 일반적인 비교구매와 비교도전 전략이 모두 효과성 향상을 보였으며, 상대적으로 비교도전을 사용하는 비교구매 활용전략이 더 큰 효과성 향상을 보임을 확인하였다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제7권1호
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• pp.43-51
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• 2002

The cloning and expression of $\beta-glucosidase$ II, encoded by the gene ${\beta}glu2$, from thermotolerant yeast Pichia etchellsii into Escherichia coli is described. Cloning of the 7.3 kb BamHI/SalI yeast insert containing ${\beta}glu2$ in pUC18, which allowed for reverse orientation of the insert, resulted in better enzyme expression. Transformation of this plasmid into E. coli JM109 resulted in accumulation of the enzyme in periplasmic space. At $50^{\circ}C$, the highest hydrolytic activity of 1686 IU/g protein was obtained on sophorose. Batch and fed-batch techniques were employed for enzyme production in a 14 L bioreactor. Exponential feeding rates were determined from mass balance equations and these were employed to control specific growth rate and in turn maximize cell growth and enzyme production. Media optimization coupled with this strategy resulted in increased enzyme units of 1.2 kU/L at a stabilized growth rate of $0.14\;h^{-l}$. Increased enzyme production in bioreactor was accompanied by formation of inclusion bodies.