• Bulletin of the Korean Chemical Society
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• 제33권5호
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• pp.1681-1685
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• 2012

A sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to determine valproic acid in human red blood cell (RBC). It is important to measure the drug concentration of the RBC as well as that of the plasma because of drug partitioning for pharmacokinetic and pharmacodynamic study. The method was linear over the dynamic range of 1-100 ${\mu}g$/mL with a correlation coefficient $r$ = 0.9997. The linearity of this method was established from 1 to 100 ${\mu}g$/mL for valproic acid in red blood cell with accuracy and precision within 15% at all concentrations. The intra-run and inter-run assay accuracy and coefficient of variations are all within 15% for all QC samples prepared in plasma and red blood human samples. Then, valproic acid amount by protein precipitation in plasma was quantified by LC-MS/MS mass spectrometry. The distribution ratio of VPA in RBC and plasma was analyzed by clinical samples. Based on measurement of the valproic acid in human red blood cell, this method has been applied to clinical research for study of distribution ratio of valproic acid in blood.

• 대기
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• 제25권2호
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• pp.309-322
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• 2015

The objective of this study is to evaluate the impact of the high resolution topographies and landuses data on simulated meteorological variables (wind speed at 10 m, temperature at 2 m and relative humidity at 2 m) in WRF. We compare the results with WRF simulation using each resolution of the topographies and landuses, and with 37 AWS observation data on the Seoul metropolitan regions. According to results of using high-resolution topography, WRF model gives better topographical expression over domain. And we can separate more detail (Low intensity residential, high intensity residential, industrial or commercial) using high resolution landuses data. The result shows that simulated temperature and wind speed are generally higher than AWS observation data. However, simulation trend with temperature, wind speed, and relative humidity are similar to observation data. The reason for that is that the high precipitation event occurred in CASE 1 and 2. Temperature have correlation of 0.43~0.47 and standard deviation of $2.12{\sim}2.28^{\circ}C$ in CASE 1, while correlation of more than 0.8 and standard deviation of $3.05{\sim}3.18m\;s^{-1}$ in CASE 2. In case of wind speed, correlation have lower than 0.5 and Standard Deviation of $1.88{\sim}2.34m\;s^{-1}$ in CASE 1 and 2. In statistical analysis shows that using highest resolution (U01) results are more close to the AWS observation data. It can be concluded that the topographies and landuses are important factor that affect model simulation. However, the tendency to always use high resolution topographies and landuses data appears to be unjustified, and optimal solution depends on the combination of scale effect and mechanisms of dynamic models.

• 한국농공학회지
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• 제45권7호
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• pp.57-69
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• 2003

To evaluate nutrient dynamics with different fertilization in paddy field and develop water quality model, mass balance analysis was performed during growing season of 2001-2002 in field experimental plots irrigated with groundwater. As a result of water balance analysis, most of outflow was surface drainage as about half of total outflow and about 500mm was lost by evapotranspiration. The water budget was well balanced. The runoff from paddy field was influenced by rainfall and forced drain. Especially runoff during early cultural periods more depends on the forced drain. As a result of mass balance analysis, most of nutrient was input by fertilization and lost by plant uptake. Significant amount of nitrogen were supplied by precipitation and input from upper paddy field, comprising 12%∼28% of total inflow. Nutrient loading by surface drainage was occurred showing about 15%∼29% for T-N and 6%∼13% for T-P. The response of rice yield with different fertilization was not significant in this study. Water quality model for paddy field developed using Dirac delta function and continuous source was calibrated and validated to surface water quality monitoring data. It demonstrates good agreement between observed and simulated. The nutrient concentration of surface water at paddy field was significantly influenced by fertilization. During early cultural periods when significant amount of fertilizer was applied, surface drainage from paddy field can cause serious water quality problem. Therefore, reducing surface drainage during fertilization period can reduce nutrient loading from paddy fields. Shallow irrigation, raising the weir height in diked rice fields, and minimizing forced surface drainage are suggested to reduce surface drainage outflow.

• 한국환경과학회지
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• 제21권12호
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• pp.1511-1521
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• 2012

An attempt is made to analyse characteristic features of heavy rainfalls which occur at the metropolitan area of the Korean peninsular the on- and off- Changma season. For this, two representative heavy rainfall episodes are selected; one is the on-Changma season wherein a torrential rain episode happened at Goyang city on 12 July 2006, and the other is the off-Changma season, a heavy rainfall event in Seoul on 21 September 2006. Both recorded considerable amounts of precipitation, over 250mm in a half-day, which greatly exceeded the amount expected by numerical prediction models at those times, and caused great damage to property and life in the affected area. Similarities in the characteristics of both episodes were shown by; the location of upper-level jet streak and divergence fields of the upper wind over heavy rainfall areas, significantly high equivalent potential temperatures in the low atmospheric layer due to the entrainment of hot and humid air by the low-level jet, and the existence of very dry air and cold air pool in the middle layer of the atmosphere at the peak time of the rainfall events. Among them, differences in dynamic features of the low-level jet and the position of rainfall area along the low-level jet are remarkable.

• Membrane and Water Treatment
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• 제8권1호
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• pp.51-71
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• 2017

Antimicrobial polyethersulfone ultrafiltration membranes containing zerovalent iron ($Fe^0$) and magnetite ($Fe_3O_4$) nanoparticles were synthesized via phase inversion method using polyethersulfone (PES) as membrane material and nano-iron as nanoparticle materials. Zerovalent iron nanoparticles (nZVI) were prepared by the reduction of iron ions with borohydride applying an inert atmosphere by using $N_2$ gases. The magnetite nanoparticles (nMag) were prepared via co-precipitation method by adding a base to an aqueous mixture of $Fe^{3+}$ and $Fe^{2+}$ salts. The synthesized nanoparticles were characterized by scanning electron microscopy, X-ray powder diffraction, and dynamic light scattering analysis. Moreover, the properties of the synthesized membranes were characterized by scanning electron microscopy energy dispersive X-ray spectroscopy and atomic force microscopy. The PES membranes containing the nZVI or nMag were examined for antimicrobial characteristics. Moreover, amount of iron run away from the PES composite membranes during the dead-end filtration were tested. The results showed that the permeation flux of the composite membranes was higher than the pristine PES membrane. The membranes containing nano-iron showed good antibacterial activity against gram-negative bacteria (Escherichia coli). The composite membranes can be successfully used for the domestic wastewater filtration to reduce membrane biofouling.

• 대기
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• 제18권4호
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• pp.441-458
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• 2008

A TP/WVP-3000A, ground-based microwave radiometer, that was first introduced to South Korea has been operated since August 22, 2007 at the National Center for Intensive Observation of Severe Weathers (NCIO). Using the dual-band, the radiometer provides temperature and humidity soundings from the surface up to 10 km height with the high-temporal resolution of a few minutes. In this study, the performance of the radiometer on the predictability of the high impact weathers was evaluated and various practical applications were investigated. To verify the retrieved profile data from the radiometer, temperature and relative humidity soundings are compared with those from the rawinsonde launched at the NCIO and Gwangju station. The root mean squared errors for temperature and relative humidity soundings were smaller under rainy weather conditions. The correlation coefficient between PWVs (Precipitable Water Vapors) obtained from the radiometer and Global Positioning System satellite at Mokpo station is 0.92 on average. In order to investigate the structure and characteristics of precipitation, stability indexes related to rainfall such as the Convective Available Potential Energy (CAPE), K-index, and Storm RElative Helicity (SREH) were calculated using windprofiler at the NCIO from 14 to 16 September, 2007. CAPE and K-index tended to be large when the thermodynamic unstability was strong. On the other hand, SREH index was dominantly large when the dynamic unstability was strong due to the passage of the typhoon 'Nari'.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 1996년도 특별강연 및 춘계학술발표 개요집
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• pp.186-189
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• 1996

A study was made to examine the characteristics of base metal and stress relief cracking(SRC) of heat affected zone(HAZ) for HY-100 and Cu-bearing HSLA-100 steels. The Gleeble thermal/mechanical simulator was used to simulate the SRC/HAZ. The details of mechanical properties of base plate and SRC tested specimens were studied. The specimens were aged at $650^{\circ}C$ for HSLA-100 steel and at 66$0^{\circ}C$ for HY-100 steel and thermal cycled from 135$0^{\circ}C$ In $25^{\circ}C$ with a cooling time of $\Delta$ $t_{800^{\circ}50}$ $0^{\circ}C$/=21sec. corresponds to the heat input of 30kJ/cm. The thermal cycled specimens were stressed to a predetermined level of 248~600MPa and then reheated to the stress relief temperatures of 570~62$0^{\circ}C$. The time to failure( $t_{f}$) at a given stress level was used as a measure of SRC susceptibility. The strength, elongation and impact toughness of base plate were greater in HSLA-100 steel than in HY-100 steel. The time to failure was decreased with increasing temperature and/or stress. HSLA-100 steel was more susceptible to stress relief cracking than HY-100 steel under same conditions. It is thought to be resulted from the precipitation of $\varepsilon$-Cu phase by dynamic self diffusion of solute atoms. Therefore, greater strain concentration at grain boundary of HSLA-100 steel results in the increased SRC susceptibility.y.

• 한국자기학회지
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• 제16권3호
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• pp.163-167
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• 2006

초음파 조사 및 계면활성제 첨가에 따른 입자의 변화를 연구하기 위하여 침전법, 음향화학적 침전법 그리고 게면활성제를 첨가한 음향화학적 침전법으로 나노 입자를 합성하였고, X-선 회절실험을 통하여 마그네타이트가 합성된 것을 확인하였다. 침전법, 음향화학적 침전법으로 합성한 입자의 크기는 계면활성제를 첨가한 음향화학적 침전법으로 합성한 입자보다 크게 얻어졌고, 초음파 출력이 증가 할수록 크기는 증가하였다. 계면활성제로 올레인 산을 첨가한 음향화학적 기법에서는 게면활성제의 농도에 따라 입자 크기를 선택적으로 조절하여 합성할 수 있었고, 단순 침전법이나 음향화학적 기법에서 보다 생성되는 입자의 크기 분포가 좁게 나타났다. 마그네타이트 나노 입자들의 자기적 특성을 SQUID를 통하여 분석한 결과, 실온에서 모두 초상자성 거동을 보이는 것으로 나타났다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 춘계학술발표회
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• pp.93-93
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• 2018

This study disclosed the aqueous fruits extract of Rubus coreanus as a sustainable agent for the synthesis of Rubus coreanus zinc oxide nanoparticle (Rc-ZnO Nps) using as a reducing and capping precursor for co-precipitation method. The development of Rc-ZnO was assured by white precipitated powder and analyzed by spectroscopic and analytical instruments. The UV-visible (UV-Vis) studies indicate the maximum absorbance at 357nm which confirmed the formation of ZnO Nps and the purity, functional group and monodispersity were assured by field emission transmission electron microscopy (FE-TEM), Fourier Transform Infrared (FTIR) Spectroscopy and dynamic light scattering (DLS). The X-ray powder diffraction (XRD) data revealed the Nps is 23.16 nm in size, crystalline in nature and possess hexagonal wurtzite structure. The Rc-ZnO Nps were subjected for catalytic studies. The Malachite Green dye was degraded by Rc- ZnO NPs in both dark and light (100 W tungsten) conditions and it degraded about 90% at 4 hours observation in both cases. The biodegradable, low cost Rc-ZnO NPs can be a better weapon for waste water treatment.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2018년도 학술발표회
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• pp.154-154
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• 2018

To interpret the climate projections for the future as well as present, recognition of the consequences of the climate internal variability and quantification its uncertainty play a vital role. The Korean Peninsula belongs to the Far East Asian Monsoon region and its rainfall characteristics are very complex from time and space perspective. Its internal variability is expected to be large, but this variability has not been completely investigated to date especially using models of high temporal resolutions. Due to coarse spatial and temporal resolutions of General Circulation Models (GCM) projections, several studies adopted dynamic and statistical downscaling approaches to infer meterological forcing from climate change projections at local spatial scales and fine temporal resolutions. In this study, stochastic downscaling methodology was adopted to downscale daily GCM resolutions to hourly time scale using an hourly weather generator, the Advanced WEather GENerator (AWE-GEN). After extracting factors of change from the GCM realizations, these were applied to the climatic statistics inferred from historical observations to re-evaluate parameters of the weather generator. The re-parameterized generator yields hourly time series which can be considered to be representative of future climate conditions. Further, 30 ensemble members of hourly precipitation were generated for each selected station to quantify uncertainty. Spatial map was generated to visualize as separated zones formed through K-means cluster algorithm which region is more inconsistent as compared to the climatological norm or in which region the probability of occurrence of the extremes event is high. The results showed that the stations located near the coastal regions are more uncertain as compared to inland regions. Such information will be ultimately helpful for planning future adaptation and mitigation measures against extreme events.