• Journal of Pharmaceutical Investigation
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• 제33권2호
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• pp.145-149
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• 2003

Manufacturing facilities of the pharmaceuticals must meet certain level of the cleanness required so that foreign substances such as dust, moisture, heat, microorganism, or virus do not contaminate the product. In case of radiopharmaceuticals for medical treatment and diagnosis, not only should the operators and environment be protected from radiation but also need to be isolated from the foreign contaminant. Therefore, manufacturing facilities for radiopharmaceuticals must satisfy the design standards of both hot cell and clean room which are specified by GMP. However, standards of maintaining negative pressure for preventing spread of radioactive contaminant in isolated facilities conflict with the standards of maintaining positive pressure for keeping cleanness. To solve this problem, air pressure of hot cell was designed lower than in the adjacent area to meet standards of the radiation safety. To keep higher cleanness in certain part of the hot cell for filling, minimal relative positive pressure allows. In order to effectively maintain the cleanness that is required for production of Tc-99m generator, which takes 70% of whole demand of radiopharmaceuticals, the rooms placed in each side of production room are used as a buffer area and three lead hot cells are installed in production room. In this research, we established the appropriate engineered design concept for Tc-99m generator manufacturing facility, which satisfies both GMP cleanness standard for preventing particles, bacteria, other contaminants and the regulations of radiation safety for supervising and controlling the amount of radiation exposure and exhausted radioactivity. And the concept of multi-barrier buffer zones is introduced to apply negative air pressure for hot cell with first priority and to continue relative positive air pressure for clean room.

• 보건교육건강증진학회지
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• 제30권3호
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• pp.59-73
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• 2013

Objectives: The study is aimed at examining the individual reasons and regional/environmental factors of online search on suicide using social big data to predict practical behaviors related to suicide and to develop an online suicide prevention system on the governmental level. Methods: The study was conducted using suicide-related social big data collected from online news sites, blogs, caf$\acute{e}$s, social network services and message boards between January 1 and December 31, 2011 (321,506 buzzes from users assumed as adults and 67,742 buzzes from those assumed as teenagers). Technical analysis and development of the suicide search prediction model were done using SPSS 20.0, and the structural model, nd multi-group analysis was made using AMOS 20.0. Also, HLM 7.0 was applied for the multilevel model analysis of the determinants of search on suicide by teenagers. Results: A summary of the results of multivariate analysis is as follows. First, search on suicide by adults appeared to increase on days when there were higher number of suicide incidents, higher number of search on drinking, higher divorce rate, lower birth rate and higher average humidity. Second, search on suicide by teenagers rose on days when there were higher number of teenage suicide incidents, higher number of search on stress or drinking and less fine dust particles. Third, the comparison of the results of the structural equation model analysis of search on suicide by adults and teenagers showed that teenagers were more likely to proceed from search on stress to search on sports, drinking and suicide, while adults significantly tended to move from search on drinking to search on suicide. Fourth, the result of the multilevel model analysis of determinants of search on suicide by teenagers showed that monthly teenagers suicide rate and average humidity had positive effect on the amount of search on suicide. Conclusions: The study shows that both adults and teenagers are influenced by various reasons to experience stress and search on suicide on the Internet. Therefore, we need to develop diverse school-level programs that can help relieve teenagers of stress and workplace-level programs to get rid of the work-related stress of adults.

• 한국입자에어로졸학회지
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• 제16권3호
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• pp.65-72
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• 2020

본 연구에서는 초미세먼지 주의보가 발효된 2019년 3월 4일~7일까지 약 80시간 동안 국내 지식산업센터 사무실 내 실내 미세먼지와 초미세먼지 농도를 측정하였다. 측정이 이루어지는 동안 공기청정기와 환기장치의 구동에 의한 영향을 확인하였고, 초미세먼지 주의보 날의 실내와 실외의 입자 크기분포를 분석하였다. 사무실의 테라스 쪽 이중 창문과 복도쪽 입구 출입문을 모두 닫은 밀폐 조건에서 실외 대비 실내의 초미세먼지 농도비는 약 40% 정도를 유지했다. 초미세먼지 주의보의 시기에 중성능급 필터가 장착된 환기장치의 풍량을 1단이나 2단으로 운전한 경우에도 외기 대비 실내 초미세먼지 농도는 환기하지 않고 밀폐만 했을 때의 조건과 비슷했다. 환기장치를 구동하지 않고, 문을 닫아둔 조건에서 공기청정기를 가동하면 실내 초미세먼지 농도를 초미세먼지 주의보 시에도 대기 초미세먼지 농도대비 약 20% 수준으로 감소시킬 수 있었지만, 환기장치의 풍량을 증가시켜 가동하면, 상대적으로 환기를 통해 미세먼지를 공급하는 공기량이 증가하여, 공기청정기의 효과가 감소하였고, 실내외 농도비를 약 36%로 유지하는 것을 확인하였다. 사무실 내 실내 부유 먼지의 크기분포의 분석 결과 1 ㎛ 보다 큰 입자의 농도는 매우 낮았다. 대기의 입자 크기분포는 1 ㎛ 이하의 입자의 봉우리와 1~10 ㎛ 입자의 봉우리의 두 부분으로 나타나는데 비해, 실내 입자의 크기분포에서는 1~10 ㎛ 입자의 봉우리가 사라지고 1 ㎛ 이하의 입자의 봉우리만 남는 형태로 상대적으로 큰 입자의 농도가 미미했다. 사무실의 밀폐가 초미세먼지 농도의 감소에 효과가 있었지만, 대부분은 1 ㎛ 보다 큰 입자가 제거되었고, 인체에 더 영향을 미치는 1 ㎛ 이하의 입자는 실내로 쉽게 침투하였다. 결국 밀폐된 사무실 실내에서 공기청정기의 사용은 1 ㎛ 이하의 인체에 더 해로운 크기의 입자를 제거하는데 큰 효과를 얻을 수 있음을 확인하였다. 본 연구는 단지 80시간의 짧은 시간의 실증 데이터를 분석한 결과이지만, 초미세먼지 주의보가 1년 중 1주일 이내로 발생하는 한정된 기간에 발생한다는 점에서 측정 및 분석 데이터가 중요한 의미를 갖는다고 생각된다. 또한 실내 초미세먼지 농도에 영향을 미치는 다양한 변수들을 고려하여 측정 계획을 작성하여 실증 측정이 이루어졌기 때문에 비교적 신뢰성 있는 분석데이터를 제시할 수 있었다.

• 대한기계학회논문집B
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• 제38권4호
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• pp.337-346
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• 2014

본 연구는 주기적 강제 진동이 가해지는 표면의 액적 모드 특성과 표면에 놓인 액적의 제거에 대한 조건을 실험적으로 이해하는 것을 목적으로 하고 있다. 액적의 거동을 명확하게 관찰하기 위해 아크릴 표면에 Teflon 코팅을 진행하여 접촉각을 높였고, 히스테리시스는 25도 이내로 진행하여 액적의 거동이 보다 쉽게 진행되도록 하였다. 본 실험은 먼지가 적은 청정실에서 실험이 진행되었다. 제작된 소수성 표면에 놓인 액적의 실제 공진 주파수를 예측하기 위해 이론 및 실험적 해석을 통해 두 접근방법의 타당성을 파악하였으며, 두 개의 초고속카메라를 액적의 상면과 측면에 설치하여 2가지 측면에서 액적의 다양한 형상 변형 특성- 모드 형상, 분리, 미소 액적의 발생, 그리고 좌우 비틀림의 특성을 관찰하였다. 이론 값 비교결과 실제 공진 주파수 값들의 차이가 약 18% 이하로 관찰되었으며, 이러한 차이는 접촉선 마찰, 비선형 벽 고착, 실험의 불확실성 등에 가장 큰 영향을 받는 것으로 판단된다. 사용된 스피커에 상대적으로 낮은 전압을 인가할 경우 액적의 접촉선은 고정된 상태에서 좌우 대칭적인 액적 형상진동이 나타났다. 반면, 높은 전압을 인가할 경우 액적의 접촉선은 비고정된 상태가 되면서 더 활발한 형상 진동이 나타났다. 가진 주파수가 모드 주파수와 일치할 경우에는 액적의 로브 크기가 주변부 주파수 일 때 보다 비교적으로 컸으며, 같은 전압을 인가 할 경우, 표면에 놓인 액적의 미소 액적 발생 및 완전한 제거는 2차 모드에서만 진행되는 것을 실험을 통해 규명하였다.

• 한국산업보건학회지
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• 제24권3호
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• pp.263-271
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• 2014

Objectives: Along with the several cases of pulmonary disorders caused by exposure to indium that have been reported in Japan, China, and the United States, cases of Korean workers involved in processes that require handling of indium compounds with potential risk of exposure to indium compounds have also been reported. We performed biological monitoring for workers in various target manufacturing processes of indium, indium oxide, and indium tin oxide(ITO)/indium zinc oxide(IZO) in domestic factories. Materials: As biological exposure indices, we measured serum concentrations of indium using inductively coupled plasma mass spectrometry, and Krebs von den Lungen 6(KL-6) and surfactant protein D(SP-D) using enzyme-linked immunosorbent assays. We classified the ITO/IZO target manufacturing process into powdering, mixing, molding, sintering, polishing, bonding, and finishing. Results: The powdering process workers showed the highest serum indium level. The mixing and polishing process workers also showed high serum indium levels. In the powdering process, the mean indium serum concentration in the workers exceeded $3{\mu}g/L$, the reference value in Japan. Of the powdering, mixing, and polishing process workers, 83.3%, 50.0%, and 24.5%, respectively, had values exceeding the reference value in Japan. We suppose that the reason of the higher prevalence of high indium concentrations in powder processing workers was that most of the particles in the powdering process were respirable dust smaller than $10{\mu}m$. The mean KL-6 and SP-D concentrations were high in the powdering, mixing, and polishing process workers. Therefore, the workers in these processes who were at greater risk of exposure to indium powder were those who had higher serum levels of indium, as well as KL-6 and SP-D. We observed significant differences in serum indium, KL-6, and SP-D levels between the process groups. Conclusions: Five among the seven reported cases of "indium lung" in Japan involved polishing process workers. Polishing process workers in Korea also had high serum levels of indium, KL-6, and SP-D. The outcomes of this study can be used as essential bases for establishing biological monitoring measures for workers handling indium compounds, and for developing health-care guidelines and special medical surveillance in Korea.

• 한국산학기술학회논문지
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• 제11권7호
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• pp.2719-2726
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• 2010

본 연구는 포항지역 환경오염물질의 보건 환경 위해성 평가를 위한 기초연구의 일환이며, 이를 위하여 포항시에 소재한 지역대기자동측정 자료를 이용하여 연별, 계절별 $PM_10$ 농도분포에 대한 현황, 기상특성 및 오염물질 농도분포 분석을 수행하였고, 대기확산 모델(CALPUFF)을 이용하여 농도분포 특성에 대해 정성적, 정량적으로 확인하였다. 포항지역의 $PM_10$ 농도분포를 확인한 결과, 포항지역의 계절별 $PM_10$ 평균농도는 봄($75.7{\mu}g/m^3$)>여름($56.8{\mu}g/m^3$)>겨울($53.6{\mu}g/m^3$) >가을($52.7{\mu}g/m^3$) 순으로 봄에는 빈번히 발생하는 황사의 영향으로 높은 농도를 나타내었다. 포항지역 오염원별 $PM_10$ 배출량은 점오염원 62%>이동오염원 33%>면오염원 5% 순이며, 점오염원 중 전체 97%가 철강산업인 제철제강업에서 발생되었다. 포항지역은 $PM_10$의 영향을 많이 받고 있는 지역으로 포항철강공단지역에 대한 환경오염물질 원인배출원에 대한 감시체계의 보완 및 집중관리와 함께 포항지역 주민의 건강 보호를 위하여 보건 및 환경에 악영향을 미치는 위해인자 및 오염물질을 원천적으로 차단하는 작업이 지속적으로 수행되어야 할 시점이다.

• 한국산업보건학회지
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• 제29권1호
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• pp.42-49
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• 2019

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Iron deficiency is associated with chronic inflammation, such as COPD. The aim of this study was to evaluate the relationship among iron deficiency, iron homeostasis, and inflammation in retired miners with COPD. Methods: The serum levels of ferritin, soluble transferrin receptor(sTfR), and transferrin saturation(TSat) as biomarkers for iron deficiency and high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation and hepcidin as a biomarker for iron homeostasis were measured in 93 male subjects. Iron deficiency was defined as any one or more of (1) sTfR>28.1 nmol/L, (2) TSat<16%, and (3) ferritin< $12{\mu}g/L$. Results: Iron deficiency was found 28% of the study subjects. Median levels of serum hsCRP was significantly increased related to airflow limitation of COPD(GOLD 1, $0.09{\mu}g/dL$ vs. GOLD 2, $0.17{\mu}g/dL$ vs. GOLD $3{\leq}$, $0.30{\mu}g/dL$, p=0.010), and was positively correlated with hepcidin(p=0.009). Mean level of serum hepcidin was lower in COPD subjects with iron deficiency(p=0.004) and serum levels of hepcidin was negatively correlated with %$FEV_1$ predicted(p=0.030). Conclusions: These results suggest that high serum levels of hepcidin are related to severe airflow limitation or inflammation and can decrease iron availability, regardless of iron status.

• 한국농공학회논문집
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• 제64권3호
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• pp.25-32
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• 2022

To understand the distribution characteristics of PM_2.5 concentration in the Saemangeum Reclamation Area and nearby areas, three points of the background area, the occurrence area, and the affected area were selected and samples were collected for each season. The chemical composition was determined. As a result of analyzing the chemical composition contained in PM_2.5, NO₃^- (7.2 ㎍/m³), SO₄^2- (4.3 ㎍/m³), NH₄+ (4.3 ㎍/m³), OC (2.5 ㎍/m³), Si (1.3 ㎍/m³) m³) and EC (0.5 ㎍/m³) seemed to be the main components, and NO₃-, SO₄^2-, NH₄⁺, which are components that form secondary particles, occupied a large proportion. The composition ratio of PM_2.5 was investigated in the order of ion component (56.8%) > Unknown (27.4%) > carbon component (11.8%) > heavy metal component (4.0%). During the PM_2.5 high concentration case days, the ionic component accounted for 90.7% during atmospheric stagnation cases, whereas the chemical composition ratio was in the order of ionic component (51.7%) > heavy metal component (41.5%) > carbon component (6.8%) during yellow dust cases. It was found that the characteristic of PM_2.5 in the Saemangeum reclaimed land and surrounding areas is mainly influenced by outside (domestic and overseas) throughout the year. Ion components accounted for the largest portion of PM_2.5 components in this area, but there were few sources of SOx and NOx emission in the Seamangeum area, which are precursors for secondary particle formation. Therefore, it is judged that most of these are generated and influenced as a secondary reaction in the atmosphere from the outside.

• 한국작물학회지
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• 제22권2호
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• pp.121-127
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• 1977

본 시험은 수도본답에 널리 사용되고 있는 제초제Nitrofen (TOK) 입제가 포장ㆍ운송ㆍ보관ㆍ분배 등의 유통과정을 거쳐 실제로 사용될 때의 입도조성을 조사하고 수도에서 Nitrofen특유의 갈변약반형성이 본제품의 입도, 시용방법, 제형, 수심, 수도재배양식에 따라 어떻게 달라지는 가를 알고저 수행되었으며 그 결과는 다음과 같다. 1. 시판중인 3kg들이 Nitrofen입제는 중량기준으로 98.91%가 9∼35mesh범위의 입자들이었고 100mesh 보다 작은 미분말함유율은 0.08%에 불과하였다. 2. Nitrofen의 처리에 의하여 수도체에 나타나는 갈변약반은 제형, 시용방법, 입도, 수심을 달리하여도 모두 지표면에서부터 5∼7cm 높이의 도체부위에 나타났으므로 미립말이 수면에 부유하다가 도체에 부착되어 약반형성에 직접적으로 관여한다고는 할 수 없었다. 3. 100mesh보다 미분말인 경우 3mesh이상의 큰 입자들에 비하여 이앙도에 대해 약반형성위치 및 약반의 크기를 증가시키지 않았으나 개체당 약반수는 증가시켰다. 4. 입제의 수면철포, 입제의 토양표층혼화시용후 관개, 수화제의 토양표면시용 후 관개등의 모든 경우에 약반형성위치, 약반의 크기 및 약반발현엽수에 있어서 차이가 없었다. 5. 100mesh이하의 미분말을 시용할 경우 이앙도는 약반형성이 뚜렷이 많았으나, 3cm수심으로 천수관개하면 약반형성이 현저히 감소되었고, 식상이 없는 직파도는 이앙도에 배해 약반형성이 현저히 적었다.

• 천문학회보
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• 제46권2호
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• pp.58.1-59
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• 2021

Exploration of asteroids' internal structure is essential for understanding their evolutional history. It also provides a fundamental information about the history of coalescence and collision of the solar system. Among several models of the internal structures, the rubble-pile model, confirmed by the near-Earth asteroid (25143) Itokawa by Hayabusa mission [1], is now widely regarded as the most common to asteroids with size ranging from 200 m to 10 km [2]. On the contrary, monolithic and core-mantle structures are also possible for small asteroids [3]. It is, however, still challenging to look through the interior of a target object using remote-sensing devices. In this presentation, we introduce our ongoing research conducted at Seoul National and propose an idea to infer the internal structure of Apophis using available instruments. Itokawa's research provides an important benchmark for Apophis exploration because both asteroids have similar size and composition [4][5]. We have conducted research on Itokawa's evolution in terms of collision and space weathering. Space weathering is the surface alteration process caused by solar wind implantation and micrometeorite bombardment [6]. Meanwhile, resurfacing via a collision acts as a counter-process of space weathering by exposing fresh materials under the matured layer and lower the overall degree of space weathering. Therefore, the balance of these two processes determine the space weathering degrees of the asteroid. We focus on the impact evidence on the boulder surface and found that space weathering progresses in only 100-10,000 years and modifies the surface optical properties (Jin & Ishiguro, KAS 2020 Fall Meeting). It is important to note that the timescale is significantly shorter than the Itokawa's age, suggesting that the asteroid can be totally processed by space weathering. Accordingly, our result triggers a further discussion about why Itokawa indicates a moderately fresh spectrum (Sq-type denotes less matured than S-type). For example, Itokawa's smooth terrains show a weaker degree of space weathering than other S-type asteroids [7]. We conjecture that the global seismic shaking caused by collisions with >1 mm-sized interplanetary dust particles induces granular convection, which hinders the progression of space weathering [8]. Note that the efficiency of seismic wave propagation is strongly dependent on the internal structure of the asteroid. Finally, we consider possible approaches to investigate Apophis's internal structure. The first idea is studying the space weathering age, as conducted for Itokawa. If Apophis indicates a younger age, the internal structure would have more voids [9]. In addition, the 2029 close encounter with Earth provides a rare natural opportunity to witness the contrast between before and after the event. If the asteroid exhibits a slight change in shape and space weathering degree, one can determine the physical structure of the internal materials (e.g., rubble-pile monolithic, thick or thin regolith layer, the cohesion of the materials). We will also consider a possible science using a seismometer.