• Title/Summary/Keyword: Duke University

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Tracing the Architectural Origin of the Bosung College Library (1935~37) (보성전문학교 도서관(1935~37)의 건축적 연원 탐구)

  • Kim, Hyon-Sob
    • Journal of architectural history
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    • v.21 no.4
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    • pp.47-58
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    • 2012
  • The purpose of this paper is to trace the architectural origin of the Bosung College Library (1935~37), which is currently used as Graduate School Building of Korea University. So far, numerous books have repeatedly described that the library was modelled on a Duke University library, but without any serious consideration. Through literature review, field-trip and archives investigation, this research discovered new critical facts concerning the origin of the building. First, Dong-Jin Park, the architect for Bosung College, saw a photograph of the Duke library in a Duke University catalog possessed by Chun Suk Auh, Professor of the college at that time. Second, the Duke library that he saw in the catalog, which might possibly be Bulletin of Duke University (Feb. 1931), is certainly the present Perkins Library (1930) in Duke University West Campus. Third, the architect probably referred not only to the library but also to other Duke buildings such as School of Medicine and The Union, of which photographs were also published impressively in the Bulletin. Although the Bosung College Library was inspired by the Duke buildings, however, it is undoubtedly a creative design work by the architect Park. Arguably, these findings broaden our view of Korean architectural history in the modernization period, and it is more than a confirmation of just one building's origin.

Identifying Barriers Faced by Applicants without a Home Residency Program when Matching into Plastic Surgery

  • Steven L. Zeng;Gloria X. Zhang;Denisse F. Porras;Caitrin M. Curtis;Adam D. Glener;Andres Hernandez;William M. Tian;Emmanuel O. Emovon;Brett T. Phillips
    • Archives of Plastic Surgery
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    • v.51 no.1
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    • pp.139-145
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    • 2024
  • Background Applying into plastic surgery (PS) is competitive. Lacking a home residency program (HRP) is another barrier. Our goal is to characterize challenges faced by PS applicants without HRPs and identify solutions. Methods Surveys were designed for current integrated PS residents and applicants in the 2022 Match without HRPs. Surveys were distributed electronically. Only U.S. allopathic graduate responses were included. Results Of 182 individuals surveyed, 74 responded (39%, 33 residents, 41 applicants). Sixty-six percent reported feeling disadvantaged due to lack of an HRP. Seventy-six percent of applicants successfully matched. Of these, 48% felt they required academic time off (research year) versus 10% of unmatched applicants. Ninety-seven percent of matched applicants identified a mentor versus 40% of unmatched applicants (p < 0.05). Matched applicants identified mentors through research (29%) and cold calling/emailing (25%). Matched versus unmatched applicants utilized the following resources: senior students (74 vs. 10%, p < 0.05) and social media (52 vs. 10%, p < 0.05). Among residents, 16 had PS divisions (48%). Thirty-six percent with divisions felt they had opportunities to explore PS, compared with 12% without divisions. Residents without divisions felt disadvantaged in finding research (94 vs. 65%, p < 0.05), delayed in deciding on PS (50 vs. 28%), and obtaining mentors (44 vs. 35%) and letters of recommendation (31 vs. 24%). Conclusion PS residents and applicants without HRPs reported feeling disadvantaged when matching. The data suggest that access to departments or divisions assists in matching. We identified that external outreach and research were successful strategies to obtain mentorship. To increase awareness for unaffiliated applicants, we should increase networking opportunities during local, regional, and national meetings.

Anti-oxidative Effect of Blueberry Duke Extract in Caenorhabditis elegans (블루베리 듀크 추출물의 예쁜꼬마선충 내의 항산화 효과)

  • Kim, Jun Hyeong;An, Chang Wan;Kim, Yeong Jee;Noh, Yun Jeong;Kim, Su Jin;Jeong, Seong-Yeop;Jeong, Do-Youn;Hwang, In Hyun;Kim, Dae Keun
    • Korean Journal of Pharmacognosy
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    • v.48 no.3
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    • pp.219-225
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    • 2017
  • We investigated the anti-oxidative effect of the blueberry duke (Vaccinium corymbosum L., Ericaceae) ethanol extract in Caenorhabditis elegans model. The ethanol extract of blueberry duke showed relatively significant DPPH radical scavenging and superoxide quenching activities. To prove antioxidant activity of the extract, we checked the activities of superoxide dismutase (SOD), catalase, intracellular ROS, and oxidative stress tolerance in C. elegans. In addition, to verify if the increased stress tolerance of C. elegans by treating with the extract was due to regulation of stress-response genes, we checked SOD-3 expression using a transgenic strain. As a consequence, the blueberry duke ethanol extract increased SOD and catalase activities of C. elegans, and reduced intracellular ROS accumulation in a dose-dependent manner. Besides, blueberry duke ethanol extract-treated CF1553 worms showed higher SOD-3::GFP intensity.

Promoted rooting of softwood cuttings of highbush blueberry 'Duke', 'Elizabeth', 'Elliot' (Vaccinium corymbosum L.) as affected by indole-3-butyric acid(IBA) dipping treatment (Indole-3-butyric acid(IBA) 침지처리에 의한 highbush blueberry 'Duke', 'Elizabeth', 'Elliot' (Vaccinium corymbosum L.)의 녹지삽목 발근 촉진)

  • Kang, S.K.
    • Journal of Practical Agriculture & Fisheries Research
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    • v.17 no.1
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    • pp.145-155
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    • 2015
  • To investigate the practicality of a small scale softwood propagation plastic film tent and the rooting promoting effect of indole-3-butyric acid(IBA) for northern highbush blueberry, softwood cuttings of 3 varieties (Duke, Elizabeth, Elliot) were made after dipping in the IBA solutions of 100ppm, 300ppm, 500ppm, 1,000ppm for 2 hour, and 3,000ppm for 20 seconds, respectively. Two-way ANOVA confirmed the significant differences in the percentage of rooting of cutting, longest root length and rooting volume index (RVI) induced by IBA treatment, as well as the percentage of rooting of cutting and RVI among examined varieties. In particular, the highly significant difference was observed in th RVI for IBA treatment. However, there was no interactions between the auxin treatments and varieties. Spontaneous rooting ability (control) depends on the varieties, showing that the lowest rooting ability was observed in the 'Duke' (45%) followed by 'Elliot'(85%) and 'Elizabeth' (90%). In addition, the rooting of the examined 3 varieties were enhanced by both of short time (20sec) dipping treatment of low level solutions, and long time (2hr) dipping treatment of high level solution, with the remarkably promoted rooting of the 'Duke' cuttings.

HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

  • Cohen, Todd J.;Choi, Moon-Chang;Kapur, Meghan;Lira, Vitor A.;Yan, Zhen;Yao, Tso-Pang
    • Molecules and Cells
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    • v.38 no.4
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    • pp.343-348
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    • 2015
  • Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. The cytoplasmic localization is associated with HDAC4 hyper-phosphorylation in slow/oxidative-fibers. Genetic reprogramming of fast/glycolytic fibers to oxidative fibers by active CaMKII or calcineurin leads to increased HDAC4 phosphorylation, HDAC4 nuclear export, and an increase in markers associated with oxidative fibers. Indeed, HDAC4 represses the MEF2-dependent, PGC-$1{\alpha}$-mediated oxidative metabolic gene program. Thus differential phosphorylation and localization of HDAC4 contributes to establishing fiber type-specific transcriptional programs.

The Relationship of Socioeconomic and Behavioral Risk Factors With Trends of Overweight in Korea

  • Shin, Jin Hee;Dupre, Matthew E.;Ostbye, Truls;Murphy, Gwen;Silberberg, Mina
    • Journal of Preventive Medicine and Public Health
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    • v.48 no.6
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    • pp.310-318
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    • 2015
  • Objectives: Previous studies have shown that overweight (including obesity) has increased significantly in Korea in recent decades. However, it remains unclear whether this change has been uniform among all Koreans and to what extent socioeconomic and behavioral factors have contributed to this increase. Methods: Changes in overweight were estimated using data from the 1998, 2001, 2005, 2007-2009, and 2010-2012 Korea National Health and Nutrition Examination Survey (n=55 761). Results: Overweight increased significantly among men but not among women between 1998 and 2012. Changes in socioeconomic and behavioral factors over the time period were not associated with overall trends for both men and women. However, we found significant differences in the prevalence of overweight relative to key risk factors. For men, overweight increased at a significantly greater rate among the non-exercising (predicted probability [PP] from 0.23 to 0.32] and high-calorie (PP from 0.18 to 0.37) groups compared to their active and lower-calorie counterparts, respectively. For women, overweight increased only among the non-exercising (PP from 0.27 to 0.28) and low-income (PP from 0.31 to 0.36) groups during this period. Conclusions: These findings suggest that programs aimed at reducing overweight should target Korean men and women in specific socioeconomic and behavioral risk groups differentially.

Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders

  • Chung, Leeyup;Bey, Alexandra L.;Jiang, Yong-Hui
    • The Korean Journal of Physiology and Pharmacology
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    • v.16 no.6
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    • pp.369-378
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    • 2012
  • Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and to find therapeutic targets. Abnormalities of specific types of synaptic plasticity have been revealed in numerous genetically modified mice that have molecular construct validity to human autism spectrum disorders. Constrained by the feasibility of technique, the common regions analyzed in most studies are hippocampus and visual cortex. The relevance of the synaptic defects in these regions to the behavioral abnormalities of autistic like behaviors is still a subject of debate. Because the exact regions or circuits responsible for the core features of autistic behaviors in humans are still poorly understood, investigation using region-specific conditional mutant mice may help to provide the insight into the neuroanatomical basis of autism in the future.