• 근관절건강학회지
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• 제19권3호
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• pp.350-361
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• 2012

Purpose: The purpose of this study is to explore the level of bone mineral densities of the femur neck and to identify factors affecting bone mineral density of the femur in Parkinson's disease (PD) patients. Methods: Participants were 121 PD patients visiting the outpatient clinic of D University Hospital in B City. Bone mineral density was measured at the femur neck by using a dual-energy x-ray absorptiometry. The serum vitamin D level, the amounts of milk intake, caffeine intake, cigaret smoking, and alcohol consumption, and the number of steps taken daily were measured. Past and present disease history, the medication history, and duration of the disease were also collected. The level of disability was obtained by neurologists using the Hoehn and Yahr stage and the Unified Parkinson's Disease Rating Scale. Results: Among PD patients, 57% had osteopenia and 15.7% had osteoporosis. The bone mineral density of the femur was associated with weight, serum vitamin D level, age, and working status. Conclusion: The identification of weight and serum vitamin D level as important predictive factors emphasizes the importance of balanced nutrition for PD patients.

• 대한물리의학회지
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• 제19권1호
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• pp.43-51
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• 2024

PURPOSE: Sarcopenic obesity (SO) is a clinical condition that combines sarcopenia and obesity. This study examined the frequency of SO in young Korean females between 20 and 29 years of age. METHODS: The study involved 1,000 participants. The height, weight, body mass index (BMI), waist circumference, skeletal muscle mass index, fasting glucose, triglyceride, total cholesterol levels, systolic and diastolic blood pressure, alcohol consumption, and smoking status were the research variables. The skeletal muscle mass index was calculated as appendicular skeletal muscle mass (ASM) divided by the BMI. The ASM was assessed using dual X-ray absorptiometry. Complex sampling analysis and multiple logistic regression were used for analysis. RESULTS: A .74(.30-1.80) frequency of SO was observed. The statistically significant risk factors in females were height, weight, BMI, waist circumference, skeletal muscle mass index, total cholesterol, systolic blood pressure, and diastolic blood pressure (p < .05). CONCLUSION: Young Korean adults with SO have a .74(.30-1.80) frequency of occurrence that is linked to specific risk factors. Hence, primary care clinicians and health care professionals should consider these factors when patients require a referral for early detection and treatment. Healthcare professionals and clinicians can identify potential SO patients by acknowledging these risk factors.

• 대한방사선기술학회지:방사선기술과학
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• 제29권3호
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• pp.177-184
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• 2006

목 적: 성인들의 생활습관인 음주, 운동, 흡연 등의 유무와 골밀도와의 관계를 분석 해보고 연령, 성별, 신장, 체중, 체질량지수 등과 골밀도와의 상관관계를 알아보고자 한다. 대상 및 방법: 2006년 2월부터 4월까지 건강검진을 받기위해 우석대학교 한방병원을 내원한 321명을 대상으로 양 에너지 X-ray 골밀도 측정기(DEXA, DPX-IQ, Lunar. co)를 이용하여 대퇴경부 및 척추의 골밀도를 측정하였다. 결 과: 대상자중 남성은 160명 여성은 161명이었고 평균연령은 $45.10{\pm}11.54$세였다. 남성에 있어서 대퇴 경부의 골밀도는 20대에서 가장 높았고 척추는 40대에서 가장 높았으며 60대에서 대퇴경부와 척추의 골밀도가 가장 낮았다, 여성에서는 40대에서 대퇴경부와 척추의 골밀도가 가장 높았고 60대에서 대퇴경부와 척추의 골밀도가 가장 낮았다. 대상자들의 신체조건에서 신장과 체중이 클수록 골밀도가 높았다. 남성은 음주 및 운동, 흡연유무에 따른 집단별 비교에서 통계적으로 유의한 차이를 보이지 않았으나 여성은 음주집단이 비 음주집단에 비해 대퇴경부 및 척추의 골밀도가 유의하게 높았다(P<0.01). 결 론: 이는 건강한 직장인들이 건강검진을 받고자 내원한 사람들이 대부분이기에 위와 같은 결과가 나온 것으로 생각되며 앞으로 모든 성인들의 연령증가에 따른 골다공증의 위험으로부터 예방하기 위하여 골밀도에 영향을 미치는 다양한 요인들을 찾아서 많은 연구를 하고자 한다.

• Journal of Acupuncture Research
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• 제25권5호
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• pp.167-189
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• 2008

This study was conducted to investigate the factors which are related to Bone Mineral Density(BMD) of female for prevention of osteoporosis. We measured the BMD of lumbar spine(L2-L4) and femoral neck in 4802 female, using dual energy X-ray absorptionmetry(DEXA; DPX-alpha. Lunar, U.S.A.). and then analysed the 9 factors-age group, body mass index(BMI), amount of smoking, drinking, exercise, sleep, and fast blood sugar-which are related to BMD of female. The following results were obtained : 1. In age group, T-score was the highest at 36－42(六七) years group in lumbar spine(L2-L4) and at 15－21(三七) years group in femoral neck. and then it was decreased rapidly after 43－49(七七) years group in both lumbar spine(L2-L4) and femoral neck. Therefore we concluded that T-score of female in lumbar spine(L2-L4) and femoral neck change according to age group in $\ll$Hwangjaenaekyong Somun; 黃帝內經 素問$\gg$. 2. In BMI, T-score of lumbar spine(L2-L4) and femoral neck were increased according to BMI increase. 3. In amount of drinking and smoking, T-score was highest in heavy groups(women who have drunk soju more than 4 bottles for a week) in both lumbar spine(L2-L4) and femoral neck. But there t was no significant difference in comparison according to age group. 4. In exercise, T-score was higher in exercising group than non exercising group. And it appeared that women who have taken proper exercise had higher T-score than women who have taken exercise daily. 5. T-score was higher in women who ordinarily sleep well in both lumbar spine(L2-L4) and femoral neck than sleep badly. And there was significant difference in 43-56 years group. 6. T-score was low in the group that exceed 110mg/dl in fast blood sugar. Conclusions : The age group in $\ll$Hwangjaenaekyong Somun; 黃帝內經 素問$\gg$ is related to BMD of women. And risk factors-BMI, exercise, sleep, fast blood sugar, thyroid disease-are related to BMD of women. Therefore we expect that this study will help for prevention of osteoporosis of women, and further study will be achieved.

• 한국식품영양학회지
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• 제24권4호
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• pp.786-796
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• 2011

The purpose of this study was to investigate the relationship between bone mineral density(BMD), body composition and life styles of female college students. The subjects were 334 students with a mean age of 21.0 years. BMDs of forearm and calcaneus were measured by dual energy X-ray absorptiometry, and body composition was measured by bioelectrical impedence analysis. The means for weight, height, and body mass index(BMI) of the subjects were 55.7 kg, 161.0 cm, 21.5 kg/$m^2$, respectively. Grouping by the BMI, 13.2% of the subjects were classified as overweight, and 11.1% of the subjects as obese group. BMD in the forearm and calcaneus were 0.390 g/$cm^2$, 0.514 g/$cm^2$. In the forearm, 58.1% and 9.6% of the subjects were classified as osteopenia and osteoporosis, respectively, and in the calcaneus, 12.0% and 0.3% of the subjects were classified as osteopenia and osteoporosis, respectively. Body weight, skeletal muscle mass, lean body mass, fat mass and BMI were positively correlated with BMDs in the forearm and calcaneus($r$=0.180~0.495, $p$ <0.01~0.001), and height, % body fat and waist-hip ratio(WHR) were positively correlated with BMDs in the calcaneus($r$=0.213~0.239, $p$ <0.001), but not in the forearm. The factors such as beginning age of cigarette smoking and alcohol drinking and exercise had significant influence on BMD($p$ <0.05; p<0.001), whereas sleeping hours, activity level, frequency of exercise, meal times, frequency of snack and fried food intake, breakfast skipping and amount of meal had not significant influence on BMD. Therefore, the acquisition of balanced body composition is necessary through the increase of fat free mass and muscle mass, not through the increase of fat mass among female college students.

• 성인간호학회지
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• 제22권6호
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• pp.644-652
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• 2010

Purpose: The purpose of this study was to analyze the relationship among life style, body composition and Bone Mineral Density (BMD) in community dwelling Korean adults. Methods: Data were collected from 140 adults who participated in a health check-up program at community health departments in D city, Choong-chung providence. Subjects' life style was assessed with a structured interview survey. Body composition analyses were performed by the bioimpedence method and BMD was measured by peripheral dual energy X-ray absorptionmetry. Results: Among the subjects, 39.3% showed normal BMD values, 50.7% were osteopenic and 10% were assessed as osteoporotic. BMD was significantly different by gender, age, education, economic status and BMI. Subjects who had three or more meals/day had higher BMD then who had less than three meals (t=-2.273, p=.026). BMD was not influenced by regular exercise, alcohol consumption, or smoking. In terms of body composition, there was a significant relationship between fat free mass and BMD (r=.172, p=.043). Conclusion: Implementing an osteoporosis prevention program would be warrented considering the significant proportion of osteopenic or osteoporotic subjects. Regular eating habit with three meals for adequate nutrition need to be emphasized to prevent further bone loss in this population. Among the body composition, fat free mass seem to be the mostly predicting factor for BMD.

• Nutrition Research and Practice
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• 제10권2호
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• pp.206-211
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• 2016

BACKGROUND/OBJECTIVES: Obesity, which is a known risk factor for many chronic diseases, has also been associated with vitamin D deficiency. This study explored the relationship between serum 25-hydroxy-vitamin D [25(OH)D] concentrations and adiposity measures in a general Korean population using the most recent, nationally representative survey data. SUBJECTS/METHODS: The study sample consisted of 4,771 Korean adults (${\geq}19years$) who participated in the fifth Korean National Health and Nutrition Examination Surveys. Serum 25(OH)D was determined by radioimmunoassay. Body mass index (BMI), waist circumference (WC) and total body fat content were measured as adiposity measurements. Total body fat content was measured by dual-energy X-ray absorptiometry. RESULTS: The serum 25(OH)D level was significantly higher in men than in women. Serum 25(OH)D concentration was positively correlated with energy intake, and it was negatively correlated with total body fat content (P < 0.0001) and percentage body fat (P < 0.0001) after adjustment for age in both sexes, while was inversely correlated with BMI only in women. In multivariable regression analysis, serum 25(OH)D was inversely associated with the total body fat content after adjustment for age, BMI, education, region, smoking, alcohol consumption, physical activity, and energy intake only in men (P = 0.0047). However, the serum 25(OH)D concentration was not associated with WC or BMI, indicators of adiposity after adjustment for potential risk factors. CONCLUSIONS: Serum 25(OH)D concentration was independently associated with the total body fat content in a general Korean population, but it may be not associated with the indicators for estimating adiposity, such as WC or BMI.

• Journal of Preventive Medicine and Public Health
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• 제39권5호
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• pp.389-396
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• 2006

Objectives: A community-based, cross-sectional survey was conducted to determine theprevalence of osteoporosis and to evaluate the effects of body composition, health behaviors and reproductive history on bone density in postmenopausal women. Methods: The study subjects were 362 postmenopausal women, aged 45 years old or over, who were invited to the hospital. Information on their socio-demographic characteristics and the potential risk factors such as their past medical history, smoking, alcohol intake, exercise, diet and menstrual/reproductive histories were collected by trained interviewers. Weight, height, the body mass index ($kg/m^{2}$), and body composition variables were measured. Bone mineral density of the lumbar spine was measured by dual energy X-ray absorptiometry (DXA). Results: The prevalence of osteoporosis was 30.6% in the $45{\sim}64$ years old women, 52.5% in the elderly women aged $65{\sim}74$, and 68.7% in the women aged 75 years or over. After adjustment for the effect of potential covariates, those women in the highest 25% (4th quartile) of the lean body mass are less likely to have osteoporosis (aOR=0.31, 95% CI=0.12-0.76), compared with the lowest quartile group. More parity also had significantly detrimental effects on osteoporosis. Conclusions: These findings suggest that the prevalence of osteoporosis in postmenopausal women increased with age from 46.3% of those aged 45-64 to 68.7% for those aged 75 and over. Lean body mass and parity appeared significant contributor to bone mineral density in postmenopausal women in this population.

• Journal of Korean Medical Science
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• 제33권50호
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• pp.320.1-320.8
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• 2018

Background: Muscle mass and muscle function are related to depressed mood in studies of adults. Like adults, Korean students are highly likely to suffer from decreased muscle mass due to social conditions. In this study, we evaluated the muscle mass status of Korean adolescents and assess the effect of muscle on depressive mood. Methods: A total of 1,233 adolescent boys and girls participants from the Korea National Health and Nutrition Examination Survey were enrolled in our study. Participants underwent dual-energy X-ray absorptiometry for assessment of appendicular muscle mass and completed questionnaires regarding depressed mood, stress, suicidal ideations, and attempts. Results: There was no difference in depressive mood according to muscle mass among boys (P = 0.634); girls with decreased muscle mass had a greater tendency for depressed mood compared to girls with optimal muscle mass (P = 0.023). After adjusting for age, waist circumference-to-height ratio, smoking status, alcohol consumption, frequency of physical activity, self-reported obesity, weight-loss efforts, and monthly household income, girls with low muscle mass (LMM) were 2.60 times more at risk of developing depression than girls with normal muscle mass (95% confidence interval [CI], 1.05-6.49; P = 0.040). This trend was similar for girls with LMM with obesity (95% CI, 1.00-11.97; P = 0.049). Conclusion: Adolescent girls who have insufficient muscle mass are more likely to report depressed mood than girls who have ideal muscle mass. Interventions for maintaining proper muscle mass are required.

• Journal of Cancer Prevention
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• 제22권4호
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• pp.234-240
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• 2017

Background: Lung cancer is the leading cause of cancer-related death worldwide, for which smoking is considered as the primary risk factor. The present study was conducted to determine whether genetic alterations induced by radon exposure are associated with the susceptible risk of lung cancer in never smokers. Methods: To accurately identify mutations within individual tumors, next generation sequencing was conduct for 19 pairs of lung cancer tissue. The associations of germline and somatic variations with radon exposure were visualized using OncoPrint and heatmap graphs. Bioinformatic analysis was performed using various tools. Results: Alterations in several genes were implicated in lung cancer resulting from exposure to radon indoors, namely those in epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), NK2 homeobox 1 (NKX2.1), phosphatase and tensin homolog (PTEN), chromodomain helicase DNA binding protein 7 (CHD7), discoidin domain receptor tyrosine kinase 2 (DDR2), lysine methyltransferase 2C (MLL3), chromodomain helicase DNA binding protein 5 (CHD5), FAT atypical cadherin 1 (FAT1), and dual specificity phosphatase 27 (putative) (DUSP27). Conclusions: While these genes might regulate the carcinogenic pathways of radioactivity, further analysis is needed to determine whether the genes are indeed completely responsible for causing lung cancer in never smokers exposed to residential radon.