• Journal of Biomedical Engineering Research
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• v.19 no.1
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• pp.91-100
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• 1998

In magnetic resonance imaging, the fast spin echo imaging technique is a widely used clinical imaging method. since its scanning time is much shorter than the conventional spin echo imaging and it gives the almost same image quality. However, the fast spin echo technique has two times longer imaging time for the dual echo acquisition which can obtain a spin density image and a T-give the same qulity images at the single echo imaging time. T he proposed technique reduces the imaging time by overlapping most of were obtained at the 0.3T permanent MRI system are presented.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.6 no.2
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• pp.177-181
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• 2020

Dual-modality imaging strategy using near-infrared fluorescence (FLI) and photoacoustic imaging (PAI) demands a suitable probe to enable dual-modular signal production. Herein, we demonstrate a synthetic protocol of small molecular dye for dual-modular FLI and PAI. A condensation reaction between squaric acid and carboxypentyl benzoindolium, and followed by basic hydrolysis to give the benzoindole derived squaraine (BSQ) dye in 49% yield. Next, the carboxylic acid group of BSQ was further functionalized with N-hydroxysuccinimide or azide group for an efficient conjugation with a targeting biomolecule. BSQ showed a maximum fluorescent emission at around 680 nm and the photoacoustic signal reached a maximum intensity at 680-700 nm. Based on these results, we conclude that BSQ analogs will be useful probes for dual-modular (FLI/PAI) imaging studies in animal models.

• Investigative Magnetic Resonance Imaging
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• v.1 no.1
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• pp.75-78
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• 1997

A dual birdcage RF coil is proposed for MRI and MRA of the human leg. The proposed coil c can be used to cover the whole human leg by imaging upper and lower parts of the leg separately. In the conventional leg imaging scheme using a single RF coil, the leg has to be r relocated when changing the position of the RF coil thus causing problems in matching the i images from two sets of coils. When using the proposed dual RF coil, however, only the bed h has to be moved to select the imaging region while only one part of the dual coil is used each t time by using current switching and PIN diodes. The utility of proposed coil has been verified b by volunteer MRI and MRA and the imaging results show that the coil is useful for the clinical MRI and MRA of the leg.

• Journal of Microbiology and Biotechnology
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• v.24 no.9
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• pp.1291-1299
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• 2014

Recently, multifunctional nanomaterials have been developed as nanotherapeutic agents for cellular imaging and targeted cancer treatment because of their ease of synthesis and low cytotoxicity. In this study, we developed a multifunctional, two-component nanorod consisting of gold (Au) and nickel (Ni) blocks that enables dual-fluorescence imaging and the targeted delivery of small interfering RNA (siRNA) to improve cancer treatment. Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7. The Au block was modified with TAMRA-labeled thiolated siRNA in order to knock down the vascular endothelial growth factor protein to inhibit cancer growth. These two-component nanorods actively targeted and internalized into MCF-7 cells to induce apoptosis through RNA interference. This study demonstrates the feasibility of using two-component nanorods as a potential theranostic in breast cancer treatment, with capabilities in dual imaging and targeted gene delivery.

• 대한방사선방어학회:학술대회논문집
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• 2011.04a
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• pp.136-137
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• 2011

• Journal of the Korean Society for Nondestructive Testing
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• v.33 no.3
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• pp.283-288
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• 2013

This paper describes development of a high speed Doppler OFDI system for non-invasive vascular imaging. Doppler OFDI (optical frequency domain imaging) is one of the phase-resolved second generation OCT (optical coherence tomography) techniques for high resolution imaging of moving elements in biological tissues. To achieve a phase-resolved imaging, two temporally separated measurements are required. In a conventional Doppler OCT, a pair of massively oversampled successive A-lines is used to minimize de-correlation noise at the expense of significant imaging speed reduction. To minimize a de-correlation noise between targeted two measurements without suffering from significant imaging speed reduction, several methods have been developed such as an optimized scanning pattern and polarization multiplexed dual beam scanning. This research represent novel imaging technique using frequency multiplexed dual beam illumination to measure exactly same position with aimed time interval. Developed system has been verified using a tissue phantom and mouse vessel imaging.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.294-298
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• 1997

In the magnetic resonance imaging, the fast spin echo imaging technique is a widely used clinical imaging method, since its scanning time is much shorter than the conventional spin echo imaging and it gives the almost same image quality. However, the fast spin echo technique has two times longer imaging time or the dual echo acquisition which can obtain a spin density image and a $T_2$-weighted image simultaneously. To overcome such a drawback, this paper proposes a new fast dual echo imaging technique which can give the same quality images at the single echo imaging time. The proposed technique reduces the imaging time by overlapping most of echo train data for each image reconstruction. In order to verify its validity and usability the human head experimental results which were obtained at the 0.3T permanent MRI system are presented.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.3 no.1
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• pp.25-31
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• 2017

Liposomes are defined as spherical, self-closed structures formed by lipid bilayers containing aqueous phase. Most liposomes are composed of various amphipathic lipids such as phospholipids and cholesterol. We used amphipathic lipids (DPPC, DPPG) as liposome components and prepared around 100 nm liposomes by standard extrusion method. Nuclear/MR dual imaging agents based on liposome platform were prepared by adding radioactive $^{131}I$-HIB (hexadecyl-4-tributylstannylbenzoate) and Gd-DTPA into liposome bilayer and inside liposome, respectively. Gamma camera and MR imaging both showed signal increases in liver.

• Journal of Radiation Protection and Research
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• v.46 no.3
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• pp.112-119
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• 2021

Background: This work aims to develop a new imaging system based on a pulse shape discrimination-capable Cs₂LiYCl₆:Ce (CLYC) scintillation detector combined with the rotational modulation collimator (RMC) technique for dual-particle imaging. Materials and Methods: In this study, a CLYC-based RMC system was designed based on Monte Carlo simulations, and a prototype was fabricated. Therein, a rotation control system was developed to rotate the RMC unit precisely, and a graphical user interface-based software was also developed to operate the data acquisition with RMC rotation. The RMC system was developed to allow combining various types of collimator masks and detectors interchangeably, making the imaging system more versatile for various applications and conditions. Results and Discussion: Operational performance of the fabricated system was studied by checking the accuracy and precision of the collimator rotation and obtaining modulation patterns from a gamma-ray source repeatedly. Conclusion: The prototype RMC system showed reliability in its mechanical properties and reproducibility in the acquisition of modulation patterns, and it will be further investigated for its dual-particle imaging capability with various complex radioactive source conditions.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2009.10a
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• pp.240-240
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• 2009