• Proceedings of the PSK Conference
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• 2003.10b
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• pp.236.3-237
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• 2003

Fine particles of water-soluble pharmaceuticals were prepared using a new micronization method, Carbon Dioxide Assisted Nebulization in a Bubble Dryer(CAN-BD). The process utilized mixtures of CO$_2$ in aqueous solution at supercritical conditions to form an emulsion. The aerosols were dried with pre-heated nitrogen, and the drying chamber was operated at near atmospheric pressure. The dry particles were collected on membrane filter at the bottom of the drying chamber. Several processing parameters such as flow rate, temperature, pressure, solid concentration and processing scale were accessed using NaCl, human serum albumin, and granulocyte-colony stimulating factor as model pharmaceuticals. (omitted)

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1996.06c
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• pp.668-678
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• 1996

A control system using fuzzy logic for a large capacity continuous dryer has been developed in order to minimize the damage of rice quality. The system has been verified in the case of 17% of object moisture content. With the initial input moisture contents of 20.46%(wb), 20.96%(wb) and 18.98%(wb), the final moisture contents of 17.99%(wb), 17.6%(wb) and 17.23%(wb) are obtained, respectively. The results show that the system controls the moisture content with the maximum error of 0.99% of the object moisture content.

• Food Engineering Progress
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• v.21 no.1
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• pp.42-48
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• 2017

The purpose of this study was to verify the drying characteristics of steamed sweet potato and to establish optimal drying conditions for far-infrared drying of steamed sweet potato. 4 kg of steamed sweet potato was sliced to thicknesses of 8 and 10 mm, and dried by a far-infrared dryer until a final moisture content of $25{\pm}0.5%$. The far-infrared dryer conditions were an air velocity of 0.6, 0.8 m/s and drying temperature of 60, 70, and $80^{\circ}C$. The results can be summarized as follows. The drying time tended to be reduced as temperature and air velocity for drying increased. The Lewis and Modified Wang and Singh models were found to be suitable for drying of steamed sweet potato by a far-infrared dryer. The color difference was 35.09 on the following conditions: Thickness of 8 mm, temperature of $80^{\circ}C$, and air velocity of 0.8 m/s. The highest sugar content ($59.11^{\circ}Brix$) was observed on the conditions of a thickness of 8 mm, temperature of 80, and air velocity of 0.8 m/s. Energy consumption decreased on the conditions of higher temperature, slower air velocity, and thinner steamed sweet potato.

• International Journal of Naval Architecture and Ocean Engineering
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• v.2 no.1
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• pp.14-23
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• 2010

A numerical model was developed for simulating a three-dimensional multilayer hydrodynamic and thermodynamic model in domains with irregular bottom topography. The model was designed for examining the interactions between flow and topography. The model was based on the three-dimensional Navier-Stokes equations and was solved using the fractional step method, which combines the finite difference method in the horizontal plane and the finite element method in the vertical plane. The numerical techniques were described and the model test and application were presented. For the model application to the northern part of Ariake Sea, the hydrodynamic and thermodynamic results were predicted. The numerically predicted amplitudes and phase angles were well consistent with the field observations.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.3
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• pp.755-761
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• 2014

Internal or external restraint of concrete strain due to drying shrinkage and creep in concrete structures causes mechanical strain and becomes a source of persistent change in creep-causing stress conditions. Mathematical modeling to incorporate the persistent change of creep-inducing stress is generally achieved with consideration of the ages of concrete and concrete properties at the times of loadings, and stress history. This paper presents an incremental format of creep model based on parallel creep concept to depict the creep under time-varying stress history in developing creep strain. Laboratory experiments are carried out to validate the performance of the presented creep model. Typical creep phenomena are addressed through the comparisons between the measured and predicted creep strains.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.35 no.5
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• pp.46-52
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• 2003

In this work we developed the closed-loop model of a paper machine during grade change with the intention to provide a reliable dynamic model to be used in the model-based grade change control scheme. During the grade change, chemical and physical characteristics of paper process change with time. It is very difficult to represent these characteristics on-line by using physical process models. In this work, the wet circulation part and the drying section were considered as a single process and closed-loop identification technique was used to develop the grade change model. Comparison of the results of numerical simulations with mill operation data demonstrates the effectiveness of the model identified.

• Journal of the Korean Ceramic Society
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• v.41 no.12 s.271
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• pp.873-879
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• 2004

In all major industries ranging from powder industries and advanced ceramics, to the food and pharmaceutical manufacture powder industries, the main production process is the spray dryers. In this paper, a systematic approach is used and six rules are obtained for the basis of the fuzzy model. A fuzzy model is based on the past behavior of the target system and expected to be able to reproduce the behavior of the target system. The output of the developed fuzzy model shows, graphically and statistically, a high level of face validity. Therefore, it is concluded that the developed fuzzy model mimics the actual process and can be considered, with confidence, as a reliable model to study, analyze, and improve the existing process.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2003.11a
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• pp.291-305
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• 2003

In this work we developed the closed-loop model of a paper machine during grade change with the intention to provide a reliable dynamic model to be used in the model-based grade change control scheme. During the grade change, chemical and physical characteristics of paper process change with time. It is very difficult to represent these characteristics on-line by using physical process models. In this work, the wet circulation part and the drying section were considered as a single process and closed-loop identification technique was used to develop the grade change model. Comparison of the results of numerical simulations with plant operation data demonstrates the effectiveness of the model identified.

• Journal of Korean Port Research
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• v.12 no.1
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• pp.105-111
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• 1998

A horizontal 2-D model which includes the wetting-drying treatment technique in the intertidal zone is applied for the prediction of tidal changes. The flow model is applied to Mokpo coastal zone and verified by measurement data. Comparing computation results with observed values for the M2 tidal constituent, agreeable correspondence is detected. The validity of the model is also proven by applying it to such areas which have narrow width and rapid velocity, irregular topography and complex geometry. Thus, this model can be used as the compatible prediction model for the tidal change and pollutant transport due to the development of Mokpo coastal zone.

• Journal of Pharmacopuncture
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• v.19 no.4
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• pp.303-311
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• 2016

Objectives: Allergic asthma generally presents with symptoms of wheezing, coughing, breathlessness, and airway inflammation. Seonpyejeongcheon-tang (SJT) consists of 12 herbs. It originated from Jeong-cheon-tang (JT), also known as Ding-chuan-tang, composed of 7 herbs, in She-sheng-zhong-miao-fang. This study aimed to evaluate the effects of local delivery of SJT via inhalable microparticles in an asthma mouse model. Methods: Microparticles containing SJT were produced by spray-drying with leucine as an excipient. SJT microparticles were evaluated with respect to their aerodynamic properties, in vitro cytotoxicity, in vivo toxicity, and therapeutic effects on ovalbumin (OVA)-induced asthma in comparison with orally-administered SJT. Results: SJT microparticles provided desirable aerodynamic properties (fine particle fraction of $48.9%{\pm}6.4%$ and mass median aerodynamic diameter of $3.7{\pm}0.3{\mu}m$). SJT microparticles did not show any cytotoxicity against RAW 264.7 macrophages at concentrations of 0.01 - 3 mg/mL. Inhaled SJT microparticles decreased the levels of IL-4, IL-5, IL-13, IL-17A, eotaxin and OVA-IgE in bronchoalveolar lavage fluid (BALF) in mice with OVA-induced asthma. These effects were verified by histological evaluation of the levels of infiltration of inflammatory cells and collagen, destructions of alveoli and bronchioles, and hyperplasia of goblet cells in lung tissues. The effects of SJT microparticles in the asthma model were equivalent to those of orally-administered SJT extract. Conclusion: This study suggests that SJT is a promising agent for inhalation therapy for patients with asthma.