• Title/Summary/Keyword: Dry Eye

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Efficacy of Lens Shielding Device to Prevent Cataract with Radiotherapy for Orbit or Ocular Adnexal Tumor (안와 및 안부속기 종양의 방사선치료에서 백내장의 예방을 위한 렌즈보호 장치의 효용성)

  • Cho, Jung-Keun;Cho, Hyun-Sang;Han, Tae-Jong
    • The Journal of the Korea Contents Association
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    • v.7 no.12
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    • pp.139-144
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    • 2007
  • Radiotherapy which is the most effective for orbit lymphoma has been used increasingly due to the increase of orbit or ocular adnexal tumor patients. Curative effects and convalescence have been being more satisfied thanks to remarkable development of cancer chemotherapy and medical treatments, but side effects such as cataract, dry eye and retinopathy still break out. Thus, in this study, a Lens Shielding Device (LSD hereafter) was designed to prevent occurring of cataract due to radiation therapy for orbit lymphoma and its efficacy through dosimetry were evaluated. And in this paper, its manufacturing process was also explained. LSD is composed of a cover body covering the lens and a side fixing part supporting the cover body. To measure radiation, the patient therapy conditions were simulated and the measurement of the radiation was conducted with Thermo Luminescence Detector (TLD) and Markus chamber. The average TLD value was 5.7% and the TLD value and Markus chamber value were acquired as 4.2% and 5.1% respectively at 6 mm depth where zero lens center was located. Only 1.5Gy ($300Gy{\times}\;5%$) or 5% of total 30Gy with 9 MeV electron beam is estimated to affect on patient's lens. That is smaller dose than the threshold value of cataract (2GY) or the value (5Gy) that was reported to cause cataract in clinical conditions. Thus, these findings suggest that LSD be very useful for prevention of cataract during radiotherapy for malignant lymphoma of orbit and ocular adnexa. Furthermore, it might be possible to reduce patient's discomfort caused by alien substances and to make it easier to fix the device with customized manufacturing manners.

Special quality research about action output waveform change by gap (1.0mm and 1.6mm)difference of skin excessive expense $CO_2$ Laser (피부과용$CO_2$ 레이저의 공극(1.0mm및 1.6mm)차이에 따른 동작출력 파형변화에 관한 특성 연구)

  • Kim, Whi-Young
    • Journal of the Korea Computer Industry Society
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    • v.8 no.2
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    • pp.107-112
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    • 2007
  • Laser wave length can have evaporation effect by absorption because outer skin or tissue of focus is consisted of water almost though absorption of water occurs more than 90% almost in formation thickness of very thin floor. Can operate outer skin, steam by floor and correct incision of formation is available. Suture surgical operation is available to vein or lymph system and surgical operation region can dry and see as eye and radish bleeding surgical operation is available. Specially, stability of tube both end output about pulse by weight very, this research can cause various curative effect because can reduce bulk and control easily current wave style of medical laser using electric power conversion device of high frequency way. If introduce ZVS (Zero Voltage Switching) or ZVZCS (Zero Voltage and Zero Current Switching), is more profitable because can reduce switching damage. Because electric power department of proposed medical laser can do stable soft-switching in wide subordinate extent introducing ZVZCS technique by the first help and control department composes microcontroller, output current waveform user have free form make Result that experiment because design and manufacture, brought result that improve of 20% than existing equipment, and will be bought to get into superior result if supplement as systematic late.

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DA-6034 Induces $[Ca^{2+}]_i$ Increase in Epithelial Cells

  • Yang, Yu-Mi;Park, Soonhong;Ji, HyeWon;Kim, Tae-Im;Kim, Eung Kweon;Kang, Kyung Koo;Shin, Dong Min
    • The Korean Journal of Physiology and Pharmacology
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    • v.18 no.2
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    • pp.89-94
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    • 2014
  • DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be considered as a drug for the treatment of dry eye. However, whether DA-6034 induces $Ca^{2+}$ signaling and its underlying mechanism in epithelial cells are not known. In the present study, we investigated the mechanism for actions of DA-6034 in $Ca^{2+}$ signaling pathways of the epithelial cells (conjunctival and corneal cells) from human donor eyes and mouse salivary gland epithelial cells. DA-6034 activated $Ca^{2+}$-activated $Cl^-$ channels (CaCCs) and increased intracellular calcium concentrations ($[Ca^{2+}]_i$) in primary cultured human conjunctival cells. DA-6034 also increased $[Ca^{2+}]_i$ in mouse salivary gland cells and human corneal epithelial cells. $[Ca^{2+}]_i$ increase of DA-6034 was dependent on the $Ca^{2+}$ entry from extracellular and $Ca^{2+}$ release from internal $Ca^{2+}$ stores. Interestingly, these effects of DA-6034 were related to ryanodine receptors (RyRs) but not phospholipase C/inositol 1,4,5-triphosphate ($IP_3$) pathway and lysosomal $Ca^{2+}$ stores. These results suggest that DA-6034 induces $Ca^{2+}$ signaling via extracellular $Ca^{2+}$ entry and RyRs-sensitive $Ca^{2+}$ release from internal $Ca^{2+}$ stores in epithelial cells.

Study on the Productivity of Hanwoo Steers with Self-product Organic Rice Straw (자가 생산 유기볏짚을 이용한 거세한우 생산성 연구)

  • Cho, Won-Mo;Jeon, Byung-Su;Kim, Hyeng-Chul;Yang, Seung-Hak;Kim, Sang-Bum;Lee, Hyun-June;Ki, Kwang-Seok;Yeo, Joon-Mo
    • Korean Journal of Organic Agriculture
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    • v.17 no.3
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    • pp.393-403
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    • 2009
  • This study was conducted to investigate the productivity of Hanwoo steers by feeding self-product organic rice straw and concentrates(conventional, T1 and organic T2). Sixteen Hanwoo steers(8 months on the average) were randomly assigned to two treatment groups. Feeding trail was carried out in 2 treatment(8 heads/ treatment) by Hanwoo steers for 600 days form 8 to 28 months in age. The range of average daily gains of T1 and T2 were 0.76 to 0.77kg in the growing stage, 0.93 to 0.90kg in the first fattening stage, 0.99 to 0.84kg in the middle fattening stage, and 0.59 to 0.64kg in the latter fattening, respectively, and the gains for overall period was higher in T1 than in T2. Concentrates and total digestive nutrients(TDN)(T1) intakes per unit of kg gains were higher than T2 without significant difference. In carcass characteristics, the carcass weight in T1 were higher about 5% than in T2. According to the above results, it may be concluded that dry matter(DM) intakes, crude protein(CP) and TDN contents of feedstuff between treatments was no significant difference. but marbling in T2 score was higher than in T1 about 20%. There were no significant differences rib-eye area, back fat thickness and fat color(p>0.05).

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Intake, digestibility, and performance of lambs fed spineless cactus cv. Orelha de Elefante Mexicana

  • Lopes, Levi Auto;de Andrade Ferreira, Marcelo;Batista, Angela Maria Vieira;Maciel, Michel do Vale;Barbosa, Rodrigo de Andrade;Munhame, Joana Albino;da Silva, Tomas Guilherme Pereira;Cardoso, Daniel Barros;Veras, Antonia Sherlanea Chaves;de Carvalho, Francisco Fernando Ramos
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.8
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    • pp.1284-1291
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    • 2020
  • Objective: To evaluate the effects of the carmine cochineal-resistant spineless cactus genotypes cv. Orelha de Elefante Mexicana (Opuntia) and Miúda (Nopalea) on the intake and digestibility of nutrients, ingestive behavior, performance, and ultrasound measurements of growing lambs. Methods: Thirty-six male (non-castrated) Santa Inês lambs were used, with an average age of 6 months and an initial average weight of 22.0±2.9 kg. They were distributed in a completely randomized design with 3 treatments (Tifton hay, Nopalea and Opuntia) and 12 replications, using initial weight as a covariate. The experimental period was 86 days, with the first 30 days used for the adaptation of the animals to the facilities, diets and management, and the remaining 56 days used for evaluation and data collection. Results: The intake and apparent digestibility of dry matter (DM), organic matter (OM), crude protein (CP), neutral detergent fiber (NDF), total carbohydrates (TC), non-fibrous carbohydrates (NFC), and total digestible nutrients (TDN) showed a significant difference (p<0.05) as a function of the diets, with the Nopalea treatment (p<0.05) increasing DM intake (g/kg and % body weight [BW]), CP, TDN, and TC digestibility, whereas the Tifton hay diet led to a high (p<0.001) neutral detergent fiber corrected for ash and protein (NDFap) g/d intake, NDFap (BW %) and digestibility of said nutrient. There was no effect of treatments (p>0.05) on feeding time, however, rumination time and total chewing time were higher (p<0.05) for animals fed Tifton hay. The performance of the animals was similar (p>0.05). For the ultrasound measurements, Nopalea promoted an increase in the final loin eye area, compared to Tifton hay. Conclusion: The use of spineless cactus variety Miúda leads to the greater intake and digestibility of nutrients. The evaluated carmine cochineal-resistant spineless cactus genotypes are alternatives for semi-arid regions as they do not negatively affect the performance of growing lambs.

Effects of Total Mixed Rations on Growth Performance and Carcass Charcteristics of Hanwoo Steers (섬유질배합사료 급여가 거세한우의 발육 및 도체특성에 미치는 영향 미치는 영향)

  • Cho, Young Moo;Kwon, Eung Gi;Chang, Sun Sik;Kim, Tae Il;Park, Byung Ki;Kang, Su Won;Paek, Bong Hyun
    • Journal of Animal Science and Technology
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    • v.50 no.3
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    • pp.363-372
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    • 2008
  • To investigate the effects of total mixed ration(TMR) on growth performance and carcass characteristics of Hanwoo steers, sixty steers were randomly assigned to one of four treatment groups; separate feeding of concentrate and rice straw(control), wet TMR(TMRⅠ), dry TMR with 20%(TMRⅡ) and 40%(TMRⅢ) barley bran from 6 to 28 month of age. In growth performance, average daily gains of TMRⅡ group was the highest(0.70kg/day) but significant differences between treatments were not found(p>0.05). Average feed required for kg body weight gain of control group was 11.63kg. Those of TMRⅠ through TMRⅢ were 9.29, 10.46 and 10.71kg, respectively. Dressing percentage and retailed cut percentage were 59% and 63%, without any significant differences between treatments(p>0.05). There were no significant differences in rib-eye area, back fat thickness, meat color and fat color (p>0.05). Average marbling score was higher(p<0.05) in TMRⅠ than in control group.

Effect of Feed Type on Feed Efficiency and Carcass Characteristics of Hanwoo Steers (사료의 형태가 한우 거세우의 사료효율 및 도체성적에 미치는 영향)

  • Lee, Gui-Ye;Cho, Woong-Gi;Moon, Yea-Hwang
    • Journal of agriculture & life science
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    • v.45 no.4
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    • pp.95-103
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    • 2011
  • Ninety five Hanwoo steers averaging 226kg of body weight were used to investigate the effect of dietary type on feed efficiency, carcass characteristics and economical analysis in Hanwoo feeding over 22 months. Treatments were composed of commercial formula feed (formula feed), TMR and Fermented-TMR (F-TMR). Intakes of dry matter and TDN were greater in the F-TMR than the other treatments during each growing and fattening phase (p<0.05). Although daily body gain of the F-TMR was lowest during the growing phase, but was 48% greater than those of other treatment during the finishing phase (p<0.05). Feed efficiency of the F-TMR was maintained constantly during whole growing and fattening phases. Carcass weight and rib-eye area of the F-TMR were greatest (p<0.05) among treatments. However, meat yield index and the rate of grade A in meat yield were highest in the formula feed having the thinnest back fat. Marbling score was hugely (p<0.05) increased when steers fed F-TMR, and therateofgrade 1+andoverinmeatqualitywas96%intheF-TMR. Although feed cost in the F-TMR was increased by 40% compare to the formula feed, but net income was increased by 29% due to improvement of meat quality and body gain.

A New Potato Cultivar "Jayoung", with High Concentration of Anthocyanin (Anthocyanin 함량이 높은 감자 신품종 "자영")

  • Park, Young Eun;Cho, Ji Hong;Cho, Hyun Mook;Yi, Jung Yun;Seo, Hyo Won;Chung, Myoung Gun
    • Korean Journal of Breeding Science
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    • v.41 no.1
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    • pp.51-55
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    • 2009
  • Jayoung was bred within the potato breeding program of Highland Agriculture Research Center (HARC), National Institute of Crop Science. It was originated from a cross made between Atlantic as a female and AG34314 as a male parent in 2003. Jayoung was evaluated as a clone number Daegwan 1-104 for the growth and tuber characteristics, yielding ability, and resistance to major potato diseases in the regional yield trials from 2006 to 2007. Finally, this clone was renamed as Jayoung and was presented to Korean Seed & Variety Service in 2007 for registration as a new potato cultivar. Jayoung has a oval shape, shallow eye depth, dark purple skinned and fleshed tuber characteristics. Its mean tuber yields from the regional yield trials was 37.3 MT/ha, and it showed the highest yield in spring cropping. Jayoung showed high resistance to both common scab (Streptomyces scabies) and potato leaf roll virus (PLRV), however it was susceptible to late blight (Phytophthora infestans). The dry matter content of Jayoung was fairy high 20.3%, therefore it is suitable for both chip processing and table usage. Its anthocyanin content was the highest in autumn cropping as 43.7 mg/100 g fresh weight and its mean anthocyanin content was 4.7 times higher than that of Jasim.

A New Potato Cultivar "Hongyoung", with Red Skin and Flesh Color, and High Concentrations of Anthocyanins (껍질과 속색이 붉고 Anthocyanin 함량이 높은 감자 "홍영")

  • Park, Young Eun;Cho, Ji Hong;Cho, Hyun Mook;Yi, Jung Yun;Seo, Hyo Won;Choung, Myoung Gun
    • Korean Journal of Breeding Science
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    • v.41 no.4
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    • pp.502-506
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    • 2009
  • "Hongyoung" was bred within the potato breeding program of National Institute of Highland Agriculture (NIHA). It was originated from a cross made between Atlantic as a female and AG34314 as a male parent in 2003. "Hongyoung" was evaluated as a clone number Daegwan 1-102 for the growth and tuber characteristics, yielding ability, and resistance to major diseases in the regional yield trials from 2006 to 2007. Finally, this clone was renamed as "Hongyoung" and was presented to Korean Seed & Variety Service in 2007 for registration as a new potato cultivar. "Hongyoung" has a round shape, shallow eye depth, red skinned and fleshed tuber characteristics. Its mean tuber yields from the regional yield trials was 37.4 MT/ha, and it showed the highest yield in spring cropping. "Hongyoung" showed high resistance to common scab (Streptomyces scabies) and potato leaf roll virus (PLRV), however it was susceptible to both potato virus Y (PVY) and late blight (Phytophthora infestans). The dry matter content of "Hongyoung" was low to medium 17.7%, therefore it is suitable for table use. Its anthocyanin content was the highest in autumn cropping with 31.8 mg/100g fresh weight and it contained 3.6 times higher anthocyanin than the control, Jasim.

Application of Pine Needle Extract as Cosmetic Material (솔잎 열수(熱水) 추출물의 화장품 소재로의 응용)

  • Park, Jang-Soon
    • Journal of Digital Convergence
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    • v.17 no.7
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    • pp.395-400
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    • 2019
  • Contemporary society, the era of the 4th industrial revolution, has been enjoying a boom in the cosmetics industry due to the launch of cosmetics through new technology development due to the interest in the beauty industry. However, the cosmetics industry is booming, but dry eye syndrome, skin trouble, Hormonal disturbances, and many other side effects. In order to prove the universal use value of pine needles as a natural cosmetic material that can complement the side effects of existing chemical ingredients cosmetics harmful to human body, and to propose a roll model of desirable natural cosmetics, DPPH radical scavenging activity, ABTS assay, and flavonoid content were studied. The results showed that both the DPPH radical and ABTS radical scavenging activity increased in both the $70^{\circ}C$ and $100^{\circ}C$ pine water hot water extracts. The extracts from the pine tree extracts at $70^{\circ}C$ and $100^{\circ}C$ showed $32.0{\pm}2.5mg\;QE/ml$ and 116.8 A total flavonoid of ${\pm}5.5mg\;QE/ml$ was detected. Therefore, it is considered that the pine needle hydrothermal extract having a large amount of antioxidant which is advantageous to human body is highly applicable as a natural cosmetic material harmless to the human body.