• Title/Summary/Keyword: Drug contents

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Determination of Antioxidants Contents in Various Plants Used as Tea Materials (다류소재 식물류 중의 황산화물질 함량 분석)

  • Kim, Mee-Hye;Kim, Myung-Chul;Park, Jong-Seok;Park, Eun-Ji;Lee, Jong-Ok
    • Korean Journal of Food Science and Technology
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    • v.31 no.2
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    • pp.273-279
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    • 1999
  • Forty plants used as tea materials were chosen for determining the contents of total phenolics, selenium (Se), ${\beta}-carotene$, ${\alpha}-tocopherol$ and ascorbate. Total phenolics and ascorbate contents were analyzed colorimetrically. The Se contents were measured by hydride-atomic absorption spectrometry. The contents of ${\beta}-carotene$ and ${\alpha}-tocopherol$ were simultaneously determined by high performance liquid chromatography using separate detectors, UV for ${\beta}-carotene$ and FL for ${\alpha}-tocopherol$ analyses. The contents of these antioxidants were as follows (per 100 g dry plant); Contents of total phenolics in green tea leaf, black tea leaf, oolong tea leaf and instant coffee were about 7 g and the Se contents in corni fructus and arrowroot were found to be about $4{\mu}g$, which were the highest among all plants used. Contents of ${\beta}-carotene$ in eucommiae cortex, persimmon leaf and green tea leaf were 8587, 6222 and $3652\;{\mu}g$ respectively. The persimon leaf contained the highest ${\alpha}-tocopherol$ content (33 mg) and then followed by eucommiae cortex (26 mg), green tea leaf (16 mg) and black tea leaf (13 mg) in order. Ascorbate contents were found to be high in green tea leaf (199 mg) and black tea leaf (117 mg).

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Critical Discourse Analysis on Drug Addiction (마약 중독에 대한 비판적 담론 분석)

  • Shin, Seon-Hee
    • The Journal of the Korea Contents Association
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    • v.22 no.9
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    • pp.712-726
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    • 2022
  • The purpose of this study is to find out what discourse the newspaper's articles produce and distribute about 'drug addiction' and to reveal the topography and meaning of the discourse. Data were collected by searching 'drug' 'drug addiction' as keywords for news articles in four daily newspapers in Korea. As a result of analyzing using Norman Fairclough's critical discourse analysis, first, the 'crime-punishment' discourse was dominant in textual analysis. Drug addiction is a social evil and a serious crime such as sex crimes, child crimes, and violence, so it should be strictly punished. Second, in the discourse practice analysis, drug addiction is a mental disease that needs treatment, so systematic management by the state is required. Third, in the socio-cultural practice analysis, drug addiction is a means of making money for economic benefit, is related to corruption of political power, and is an object that should be strongly controlled to prevent drug crimes from threatening the foundation of the state. Culturally, drug addiction stems from the motivation of pleasure seeking, and is the result of moral degradation. Through this analysis, the conversion to the 'disease-treatment' discourse and drug policies centered on treatment and rehabilitation were suggested as alternatives.

Swelling Behavior and Drug Release of Poly(vinyl alcohol) Hydrogel Cross-Linked with Poly(acrylic acid)

  • Byun, Hong-Sik;Hong, Byung-Pyo;Nam, Sang-Yong;Jung, Sun-Young;Rhim, Ji-Won;Lee, Sang-Bong;Moon, Go-Young
    • Macromolecular Research
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    • v.16 no.3
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    • pp.189-193
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    • 2008
  • Thermal cross-linking method of poly(vinyl alcohol) (PVA) using poly(acrylic acid) (PAA) was carried out on PVA/PAA hydrogels. The level of gelation was measured in the PVA/PAA hydrogels with various PAA contents. The swelling behavior at various pHs showed that the swelling kinetics and water contents of the PVA/PAA hydrogels reached equilibrium after 30 h, and the time to reach the equilibrium state decreased with increasing PAA content in the hydrogel. The water content increased with increasing pH of the buffer solution. The permeation and release of the drug were tested using indomethacin as a model drug. The permeated and released amounts of the drug increased with decreasing the PAA content because of the low free volume in the hydrogel due to the higher cross-linking density. The kinetic profile of drug release at various pHs showed that all samples reached the equilibrium state within the 5 h.

Comparison of The Taste Compounds of Wild and Cultured Eel, Puffer and Snake head (천연산 및 양식산 뱀장어, 복어, 가물치의 맛 성분에 대한 연구)

  • Kim, Hee-Yun;Shin, Jae-Wook;Sim, Gyu-Chang;Park, Hee-Ok;Kim, Hyun-Sook;Kim, Sang-Moo;Cho, Jae-Sun;Jang, Young-Mi
    • Korean Journal of Food Science and Technology
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    • v.32 no.5
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    • pp.1058-1067
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    • 2000
  • In this study, eel, puffer and snake head fish, which are widely taken and highly valued for processing into baked fish, soup or fish juice were studied by classifying them into wild fish and cultured fish, and evaluated in terms of taste. The samples were gathered in the area including Kimhae, Samchonpo and Haman in Kyungsangnam-do, Kangsu-Gu in Pusan and Bukcheju-Gun in Cheju-do. Proximate compositions, the content of nucleotides and their related compounds, total and free amino acids, organic acids and fatty acids of the fishes were analysed. Generally, as for the compositions, wild fish had a higher crude fat content and a lower moisture content as compared with cultured fish, while there was no great difference between them in terms of crude protein and ash contents. Nucleotides and their related compounds including ATP, ADP, AMP, IMP, HxR, Hx were detected, and the amounts of which were nearly the same with respect to the growth conditions. IMP content was high in all of the samples, while ATP content was extremely low. Total 17 amino acids were detected from the samples, and most of the samples had high contents of glutamic acid, aspartic acid, lysine, leucine, glycine, alanine and arginine, and low contents of cystein, isoleucine and methionine. As for the other amino acids, generally same level of contents were detected for each samples. In cases of eel and snake head fish, the wild fish had higher total amino acid contents in comparison with cultured fish. And the result to the contrary was obtained for the case of puffer. Sample fishes had nearly the same compose distribution of free amino acid though the contents of which were a little different according to the samples. Each sample had high contents of taurine, hydroxyproline, glutamic acid, glycine, cystathionine, ${\beta}-aminoisobutyric$ acid and lysine. Total organic acid contents of cultured fish was higher than that of wild fish. All fishes commonly had high contents of lactic acid, iso-valeric acid, oxalic acid and fumaric acid. High levels of $C_{16:0},\;C_{16:1},\;C_{18:1(cis)},\;C_{18:3},\;and\;C_{22:6}$ were shown in all of the samples and ${\omega}-3$ polyunsaturated fatty acid content of cultured fish was higher than that of wild fish, and as for the essential fatty acid, wild fish has higher content in comparison with cultured fish.

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Contents of Toxic Metals in Crustaceans Consumed in Korea (유통 갑각류 중 중금속 함량)

  • Kim, Mee-Hye;Lee, Yun-Dong;Park, Hyo-Jung;Kim, Eun-Joung;Lee, Jong-Ok
    • Korean Journal of Food Science and Technology
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    • v.36 no.3
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    • pp.375-378
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    • 2004
  • There are few studies on toxic metals in crustaceans available in Korea. Therefore, this study was conducted to estimate content of toxic metals in crustaceans (n=58). Samples were digested with acids and analysed by inductively coupled plasma spectrometer (ICP) or atomic absorption spectrometer (AAS) for lead (Pb), cadmium (Cd), and arsenic (As). Mercury (Hg) contents were determined using mercury analyzer. Toxic metal contents [minimum-maximum (mean), mg/kg] in crustaceans were as follows; Hg 0.004-0.28 (0.06), Pb ND-0.31 (0.03), Cd 0.003-0.92 (0.14), and As 0.01-35.9 (6.63). Our results demonstrated that metal contents in crustaceans on Korean markets were similar to those reported in other countries. Our average weekly intakes of Pb, Cd, and Hg from crustaceans were lower than 1% of Provisional Tolerable Weekly Intakes (PTWI) set by Joint FAO/WHO Expert Committee for food safety evaluation.

Preparation and Release Characteristics of Polymer-Reinforced and Coated Alginate Beads

  • Lee, Beom-Jin;Min, Geun-Hong
    • Archives of Pharmacal Research
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    • v.18 no.3
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    • pp.183-188
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    • 1995
  • Polymeric reinforcement and coatings of alginate beads were carried out to control the release rate of drug from alginate beads. A poorly water-soluble ibuprofen (IPF) was selected as a model drug. A commercially available $Eudragit^{\circledR}$ RS100 was also used as a polymer. Effects of polymeric contents, the presence of plasticizers and amount of drug loading on the release rate of drug were investigated. The release rate of drug from alginate beads in the simulated gastric fluid did not occur within 2 h but released immediately when dissolution media were switched to the simulated intestinal fluid. No significant difference of release rate from polymer-reinforced alginate bead without plasticizers was observed when compared to plain (simple) beads. However, the release rate of drug from polymer-reinforced alginate beads was further sustained and retarded when aluminium tristearate (AT) as a plasticizer was added to polymer. However, polyethylene glycol 400 (PEG400) did not change the release rate of drug from alginate beads although PEG400 was used to improve dispersion of polymer and sodium alginate, and plasticize $Eudragit^{\circledR}$ RS100 polymer. The presence of plasticizer was crucial to reinforce alginate gel matrices using a polymer. As the amount of drug loading increased, the release rate of drug increased as a result of decreasing effects of polymer contents in matrices. The significantly sustained release of drug from polymer-coated alginate beads occurred as the amount of polymer increased because the thickness of coated membrane increased so that cracks and pores of the outer surface of alginate beads could be reduced. The sustained and retarded action of polymer-reinforced and coated beads may result from the disturbance of swelling and erosion (disintegration) of alginate beads. From these findings, polymeric-reinforcement and coatings of alginate gel beads can provide an advanced delivery system by retarding the release rate of various drugs.

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Diffusional Behaviors of the Fabricated Polymeric Films Containing Various Excipients (다양한 첨가제를 함유하는 고분자 필름의 확산거동)

  • Lee, Beom-Jin;Jung, Hyun;Cui, Jing-Hao;Kim, Soo-Hee
    • Journal of Pharmaceutical Investigation
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    • v.29 no.3
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    • pp.185-191
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    • 1999
  • The polymeric films containing drug and various excipients were fabricated using aqueous-based $Eudragit^{\circledR}$ RS 30D dispersions. The diffusional behaviors and mechanism of the fabricated polymeric film were investigated using Keshary-Chien diffusion cell. The melatonin was used as a model drug. The diffusion behaviors of drug through the fabricated polymeric films were highly dependent on drug concentration in donor part, polymer contents and drug concentration, and the types of plasticizers and solubilizers. The fabricated polymeric films containing excipients and solubilizers could be applied for the controlled release of poorly water-soluble drug and for the preparation of drug-containing latex films for topical or oral drug delivery.

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Heavy Metal Contents in Beverages Consumed in Korea (국내 유통 음료류 중 유해중금속 함량)

  • Kim, Mee-Hye;Lee, Yun-Dong;Kim, Eun-Joung;Chung, So-Young;Park, Sung-Kug;Lee, Jong-Ok
    • Korean Journal of Food Science and Technology
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    • v.35 no.3
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    • pp.342-346
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    • 2003
  • This study was conducted to examine the contents of heavy metals in beverages and to estimate their intakes. The contents of lead (Pb), cadmium (Cd), arsenic (As), and tin (Sn) were determined in a total of 207 samples of beverages using atomic absorption spectrophotometer(AAS) and inductively coupled plasma spectrometer(ICP). Also a mercury analyzer was utilized for analysis of mercury. The values of heavy metals in beverages were as follows [min-max (mean), mg/kg]; Hg 0.0001-0.0025 (0.0004), As ND-0.0245 (0.0003), Pb ND-0.089 (0.004), Cd ND-0.006 (0.001), Sn ND-45.36 (1.97). Our results were similar to those reported by other countries. Our weekly intakes of heavy metals from beverages take $0.01%{\sim}0.06%$ of PTWI (Provisional Tolerable Weekly Intake) established by FAO/WHO.

Quantitative Analysis and Preformulation of Extracts from Alnus Japonica

  • Baek, Jong-Suep;Kang, Hee-Chul;Keum, Chang-Gu;Lim, Ji-Ho;Hwang, Chan-Ju;Na, Young-Guk;Tung, N.H.;Kim, Young-Ho;Cho, Cheong-Weon
    • Journal of Pharmaceutical Investigation
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    • v.41 no.4
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    • pp.227-232
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    • 2011
  • Alnus japonica has been known to exert antioxidative, anti-inflammatory, anti-cancer and immune response inhibitory effects. The aim of this study was to figure out the characteristics of extracts obtained with different extraction solvent such as water, 100% ethanol, 70% ethanol or 70% methanol because characteristic components such as oregonin and hirsutanone extracted from Alnus japonica might be essential for the biological activity. For this purpose, oregonin and hirsutanon of four extracts, index ingredient of Alnus japonica, were analyzed with HPLC and physicochemical studies such as SEM, particle size and zeta potential were conducted. In cell cytotoxicity study, extract of water showed the highest cytotoxicity among four extracts. In case of oregonin, 70% MeOH and water extracts showed high contents and in case of hirsutanone, all extracts showed similar contents except 70% EtOH extracts. The extract of 70% MeOH from Alnus japonica for both oregonin and hirsutanone appeared to have the highest content. Both oregonin and hirsutanone extracted from Alnus japonica using 70% methanol showed stability in pH 1.2.