• Journal of the Korean Society of Costume
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• v.63 no.5
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• pp.102-114
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• 2013

This study performed the evaluation of skin temperature, heart rate, humidity and temperature inside clothing, and subjective sensation to estimate the physiological responses of the human body and its feeling of comfort for developing value-added dox fabric. Experiments were performed on five healthy adult women whose average age was 21, at climate chamber in which temperature, relative humidity and air current were set up below $28{\pm}5^{\circ}C$, $50{\pm}10%$, 0.2m/s, respectively. Two kinds of clothes were used for the experiments: 100% cotton and dox clothes. The clothes were identical in size and form, and the attire consisted of long-sleeved shirts, long trousers, and socks. The experiment was performed for 30 minutes using ergometer. The results are as follows. 1) It showed low skin temperature of forearm, breast, back, forehead and lower leg in exercise, but high skin temperature of them in recovery. However skin temperature of thigh and foot increased from rest to recovery. 2) It showed significant difference (p<0.001, p<0.01) in average skin temperature between cotton and dox clothes. Cotton clothes had a higher average skin temperature compared to dox. Not only was there a significant difference in temperature inside clothing (p<0.001), this was also the case with humidity inside the clothing (p<0.001).

• BMB Reports
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• v.50 no.6
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• pp.335-340
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• 2017

Although doxorubicin (Dox)-induced oxidative stress is known to be associated with cytotoxicity, the precise mechanism remains unclear. Genotoxic stress not only generates free radicals, but also affects actin cytoskeleton stability. We showed that Dox-induced RhoA signaling stimulated actin cytoskeleton alterations, resulting in central stress fiber disruption at early time points and cell periphery cortical actin formation at a later stage, in HeLa cells. Interestingly, activation of a cofilin phosphatase, chronophin (CIN), was initially evoked by Dox-induced RhoA signaling, resulting in a rapid phosphorylated cofilin turnover leading to actin cytoskeleton remodeling. In addition, a novel interaction between CIN and $14-3-3{\zeta}$ was detected in the absence of Dox treatment. We demonstrated that CIN activity is quite contrary to $14-3-3{\zeta}$ binding, and the interaction leads to enhanced phosphorylated cofilin levels. Therefore, initial CIN activation regulation could be critical in Dox-induced actin cytoskeleton remodeling through RhoA/cofilin signaling.